SP Technical Research Institute of Sweden Catalysis Our Expertise and Capabilities in Homogeneous and Heterogeneous Catalysis Catalytic Process Development Mechanistic investigations Characterization of new catalysts Industrial catalytic process design and optimization Scale up/verification of designed/optimized catalytic processes Preparation of tailored catalysts for development and scale up Swedish Chemist Jöns Jacob Berzelius introduced the term ”Catalysis” in 1835 High-throughput Catalyst Screening Identification and development of optimal catalytic systems Rapid identification of fit for purpose conditions Enzyme catalyzed reactions through enzyme kit screening Methods for metal removal/recovery 0 10 20 30 40 50 60 70 80 90 100 ee ampy ee daipen ee dpen ee dach Catalytic cycle and reaction kinetics Metal-catalyzed reaction screen results Pd(II)L Br N O LPd(II) Br N O N O O Pd(II)L H Br N Br O N O O N O N O O Pd(0)L Et 3 N Et 3 NHBr Pd(0)L 2 k 1 k -1 k 2 k 3 k 4 k 5 BIPP BMAP • ChemSpeed™ reaction screening robot and glovebox for inert atmosphere handling and storage • Buchi™ and Parr™ high temperature and pressure autoclaves (up to 500°C and 345 bar) • Parr™ continuous reactor system (up to 500°C and 200 bar) • Parr™ multiple reactor screening system (300°C, 200 bar) • Endeavor™ multiple reactor screening system (200°C, 35 bar) • Programmable tube furnace for preparation and development of new heterogeneous catalysts Selected Experimental Capabilities Molecular structure of metal- organic catalyst determined by X-ray crystallography The Expert Team R2 N OH R2 NH 2 R1 R1 RuCl(Cymene)(ligand) 1mol% H 2 , NH 4 X, Methanol, 90 o C We provide • Design, development and mechanistic investigation of (new) catalytic systems • Screening and development of methods for the recovery of metals, ligands and/or support material for recirculation • Scale-up/verification of designed/optimized catalytic processes (10-100L) • Identification and development of optimal metal catalysts for chemical transformations • Rapid identification of fit for purpose conditions to enable first manufacture of a desired molecule • Industrial catalytic process design, development and optimization based on identified metal or enzyme catalysts