CATABOLISM OF THE CARBON SKELETON.ppt

CATABOLISM OF THECATABOLISM OF THE

CARBON SKELETONCARBON SKELETON

Lourdes L. Balcueva, M.D.Lourdes L. Balcueva, M.D.

Classification of amino acids Classification of amino acids according to the catabolism of the according to the catabolism of the carbon skeletoncarbon skeleton1. ketogenic – leucine and lysine1. ketogenic – leucine and lysine2. both glucogenic and ketogenic:2. both glucogenic and ketogenic: isoleucine phenylalanine isoleucine phenylalanine

tyrosine tryptophan tyrosine tryptophan threonine threonine3. glucogenic- all other amino 3. glucogenic- all other amino acids acids

Products forming a-Products forming a-ketoglutarate:ketoglutarate:

Glutamine and glutamateGlutamine and glutamateProlineProlineHistidineHistidineArginine and ornithineArginine and ornithine

Products that form pyruvate:Products that form pyruvate:GlycineGlycineSerineSerineAlanineAlanine

ThreonineThreonineCysteineCysteine