Case Study 1: Colpermin ® Commercial Manufacturing Process Colpermin ® capsules are commercially manufactured in two-piece hard-shell gelatine capsules exclusively by Tillotts Services using our liquid-fill encapsulation technology. Prior to the filling process, the formulation mixture is heated and agitated which produces a liquid form, however once injected into the capsule it cools and sets as a semi-solid gel. The capsules are then sealed with the characteristic blue band which also acts as a tamper proof mechanism. Each Colpermin ® capsule contains 187.2 mg (0.2 ml) of Peppermint oil within an oleo-gel formulation that provides a sustained delivery over 12-14 hours. Our Swissmedic approved GMP manufacturing facility, located near Basel, Switzerland produces over 150 million liquid-filled capsules per year and we can offer integrated formulation development as well as commercial scale manufacturing for global products. Our formulation development and drug delivery teams are supported by well equipped analytical, QA and QC functions. How it Works Colpermin ® capsules are enterically coated in order to release the active ingredient in the upper part of the ileum. The enteric coating offers some key benefits that include: The active ingredient, Peppermint oil is accurately delivered to its site of action. If it were not enterically coated most of the Peppermint oil would be absorbed in the proximal small intestine and metabolised. It removes the risk of drug release in the upper GI tract that could cause local irritation and relaxation of the oesophageal sphincter which can cause oesophageal reflux. Colpermin ® is the Gold Standard liquid-fill, hard-shell capsule product and is also one of the largest in terms of global production volume. It’s targeted delivery to its site of action in the distal small intestine and colon is achieved through its enteric coat that is applied to the capsule after filling and banding. Colpermin ® has a novel oleo-gel formulation that provides an optimal and sustained release of the active at the site of action.