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Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale cancer modelling INI 9th December 2015 1 / 54
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Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

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Page 1: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Case Studies in Cancer Modelling:Connecting with the Clinic

Mark ChaplainSchool of Mathematics and Statistics

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 1 / 54

Page 2: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Talk Overview

Biology of cancer

Intracellular modelling

Cell-scale modelling

Tissue-scale modelling

Applications and Impact

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 2 / 54

Page 3: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Cancer: A Nonlinear Dynamical System

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 3 / 54

Page 4: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

The Hallmarks of Cancer

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 4 / 54

Page 5: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

The Hallmarks of Cancer

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 5 / 54

Page 6: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Cancer: A Multiscale System

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 6 / 54

Page 7: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Cancer: A Multiscale System

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 7 / 54

Page 8: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Cancer: A Multiscale System

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 8 / 54

Page 9: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Intracellular modelling: Gene regulatory networks

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 9 / 54

Page 10: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Gene regulatory networks: Transcription Factors andOscillations

Spatio-temporal oscillations in the NF-κB system

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 10 / 54

Page 11: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Gene regulatory networks: Negative feedback loops

A generic negative feedback loop: species x produces y which then inhibitsx, in turn reducing levels of y. . .

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 11 / 54

Page 12: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

The Hes1 Transcription Factor

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 12 / 54

Page 13: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Hes1 Spatial Stochastic Model

µp

!m

Pf Po

k1

k2

!m/"

mRNA

!p

#

#protein

µm

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 13 / 54

Page 14: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Hes1 Spatial Stochastic Model

Pf + proteink1−−k2

Po, (promoter, xm, nucleus)

Pfαm−−−→ mRNA, (promoter, xm, nucleus)

Poαm/γ−−−−−→ mRNA, (promoter, xm, nucleus)

mRNAαp−−→ mRNA + protein, (cytoplasm,Ωc)

mRNAµm−−−→ φ, (entire cell,Ω)

proteinµp−−→ φ, (entire cell,Ω)

proteiniD/h2

−−−−→ proteini+1, (entire cell,Ω)

mRNAiD/h2

−−−−→ mRNAi+1, (entire cell,Ω)

proteiniD/h2

−−−−→ proteini−1, (entire cell,Ω)

mRNAiD/h2

−−−−→ mRNAi−1, (entire cell,Ω)

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 14 / 54

Page 15: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Hes1: Experimental Data/Simulation Results

Experimental data from Kobayashi et al.1 showing Hes1 protein levels in murineembryonic stem cells.

1Kobayashi et al. (2009) The cyclic gene Hes1 contributes to diverse differentiationresponses of embryonic stem cells Genes Dev. 23, 1870 - 1875

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 15 / 54

Page 16: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Hes1: Experimental Data/Simulation Results

0 200 400 600 800 10000

100

200

300

400

time (min)

copy

num

ber

mRNAprotein

0 200 400 600 800 10000

100

200

300

400

500

time (min)

copy

num

ber

mRNAprotein

0 200 400 600 800 10000

20

40

60

80

time (min)

copy

num

ber

mRNAprotein

0 200 400 600 800 10000

20

40

60

80

time (min)

copy

num

ber

mRNAprotein

Corresponding simulation results from the spatial stochastic model1.

1Sturrock, Hellander, Matzavinos, Chaplain (2013) Spatial stochastic modelling ofthe Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonicstem cell differentiation. J. R. Soc. Interface 10, 20120988

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 15 / 54

Page 17: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Period Estimation

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 16 / 54

Page 18: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Intracellular modelling: p53-Mdm2 System

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 17 / 54

Page 19: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Intracellular modelling: p53-Mdm2 System

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 18 / 54

Page 20: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Intracellular modelling: p53-Mdm2 System

Experimental data from Lahav et al.2 showing p53 and Mdm2 protein levels inindividual cells.

2Lahav et al. (2004) Dynamics of the p53-Mdm2 feedback loop in individual cells.Nature Genetics 36, 147 - 150

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 19 / 54

Page 21: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Intracellular modelling: p53-Mdm2 System

Corresponding simulation results from a spatial stochastic p53 model.Mark Chaplain Multiscale cancer modelling INI 9th December 2015 19 / 54

Page 22: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Diffusion Causes Oscillations: Rigorous Proof

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 20 / 54

Page 23: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

A Force-based, Individual-based Model of Tumour Growth

cells modelled as elastic spheres

maximum radius of the cells: R= 5 µm

cells divide into two spheres of radius R

213

cell cycle length are uniformly distributed between 17h and 27h

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 21 / 54

Page 24: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

A Force-based, Individual-based Model of Tumour Growth

Cell-Cell Interaction

cell-cell repulsion calculated by the Hertz model

cell-cell adhesion calibrated with separation force measurements

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 22 / 54

Page 25: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

A Force-based, Individual-based Model of Tumour Growth

The potential Vij between two cells of radius Ri and Rj is given by

Vij = (Ri +Rj − dij)5/21

5Eij

√RiRj

Ri +Rj︸ ︷︷ ︸repulsive forces

+ εs︸︷︷︸adhesive forces

.

Eij is defined by

Eij =3

4

(1− σ2iEi

+1− σ2jEj

).

Ei, Ej are the elastic moduli of the cells i, j, σi, σj the Poisson ratios ofthe spheres.

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 23 / 54

Page 26: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Intercellular Adhesion: E-cadherin and β-catenin

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 24 / 54

Page 27: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Intercellular Adhesion: E-cadherin and β-catenin

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 25 / 54

Page 28: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Intercellular Adhesion: E-cadherin and β-catenin

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 26 / 54

Page 29: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

A Force-based, Individual-based Model of Tumour Growth

The interaction force results from deriving the potential function

F ij = −(∂Vij/∂dij)(d(dij)/dx, d(dij)/dy, d(dij)/dz)

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 27 / 54

Page 30: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Individual-based, Force-based Model

Cell movement:

Γfisvi︸ ︷︷ ︸

s-friction

+∑j nn i

Γfij

(vi − vj

)︸ ︷︷ ︸cell-cell friction

=∑i nn j

F ij︸ ︷︷ ︸forces

+ fi(t)︸︷︷︸

noise

+ χ∇Q(t)︸ ︷︷ ︸chemotaxis

+ ρ∇H(t)︸ ︷︷ ︸hapotaxis

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 28 / 54

Page 31: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Cell-Matrix Interactions

Elements of the model:

cell modelled as flat hemispherical object

I base radius : 15µmI height : 2.6µm

extracellular matrix fibres modelled as rigid cylinders

I length ∼N(75µm, 5µm)I width 200nmI uniformly distributed in 2D space

Cell-Fibre Interaction:

cell polarisation and migration

contact inhibition of locomotion

matrix remodelling

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 29 / 54

Page 32: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Cell-Matrix InteractionsMatrix Remodelling - fibre realignment due to adhesion and forcegeneration

a polarised cell pulls fibres towards itself whereby:

fibre is lever that is rotated about the moment of force

end of fibre that is furthest away from cell acts as fulcrum

realignment of fibre dependent on integrin expression and matrixstiffness

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 30 / 54

Page 33: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Summary

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 31 / 54

Page 34: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Single Cell Simulation

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Page 35: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Multicell Simulation

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 33 / 54

Page 36: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Further Single Cell Simulations

Investigation of changes in:

fibre length

fibre density

matrix stiffness

matrix architecture

and the effect on:

cell speed

persistence time

Results:

matrix stiffness has a large influence on cell speed and persistence→ matrix reorientation seems to be a very important process in cellmigration

decrease in matrix isotropy leads to increase in persistence

nonlinear relationships between persistence times and fibre length anddensity

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 34 / 54

Page 37: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Further Single Cell Simulations

Investigation of changes in:

fibre length

fibre density

matrix stiffness

matrix architecture

and the effect on:

cell speed

persistence time

Results:

matrix stiffness has a large influence on cell speed and persistence→ matrix reorientation seems to be a very important process in cellmigration

decrease in matrix isotropy leads to increase in persistence

nonlinear relationships between persistence times and fibre length anddensity

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 34 / 54

Page 38: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Metastasis

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Page 39: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment Modelling

hybrid cellular automaton - PDE approach

individual cancer cells

cell-cycle

blood vessels

oxygen, chemotherapy drug

radiation

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 36 / 54

Page 40: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment Modelling

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 37 / 54

Page 41: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment Modelling

Cell-cycle - ODEs in each cancer cell

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 38 / 54

Page 42: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment Modelling

Blood vessel distribution - 2D cross-section of tissue

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 39 / 54

Page 43: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment Modelling

Oxygen and chemotherapy drug:

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 40 / 54

Page 44: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment Modelling

Radiation:

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 41 / 54

Page 45: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment Modelling

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 42 / 54

Page 46: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment Modelling

Radiation:

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 43 / 54

Page 47: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment Modelling

Radiation:

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 44 / 54

Page 48: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Chemotherapy and Radiotherapy Treatment ModellingRadiation:

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 45 / 54

Page 49: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Cancer Invasion Modelling

Thursday 10th December:15:30 - 16:15 Pia Domschke (Technische Universitat Darmstadt)Mathematical Modelling of cancer invasion: The role of cell adhesionvariability

Friday 11th December11:30 - 12:30 Alf Gerisch (Technische Universitat Darmstadt)Nonlocal models for interaction drive cell movement

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 46 / 54

Page 50: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Cancer Invasion Modelling

Thursday 10th December:15:30 - 16:15 Pia Domschke (Technische Universitat Darmstadt)Mathematical Modelling of cancer invasion: The role of cell adhesionvariability

Friday 11th December11:30 - 12:30 Alf Gerisch (Technische Universitat Darmstadt)Nonlocal models for interaction drive cell movement

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 46 / 54

Page 51: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Cancer Invasion Modelling

Thursday 10th December:15:30 - 16:15 Pia Domschke (Technische Universitat Darmstadt)Mathematical Modelling of cancer invasion: The role of cell adhesionvariability

Friday 11th December11:30 - 12:30 Alf Gerisch (Technische Universitat Darmstadt)Nonlocal models for interaction drive cell movement

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 46 / 54

Page 52: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Applications and Impact

“The REF”

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 47 / 54

Page 53: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Applications and Impact

“The REF”

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 47 / 54

Page 54: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Applications and Impact

“The REF”(Unfortunately NOT) “The Last Judgement”

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 48 / 54

Page 55: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Applications and Impact

“The REF”(Unfortunately NOT) “The Last Judgement”

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 48 / 54

Page 56: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Applications and Impacthttp://www.ref.ac.uk

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 49 / 54

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Applications and Impact

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 50 / 54

Page 58: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Applications and Impact

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 51 / 54

Page 59: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Applications and Impact

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Page 60: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Summary

Mathematical models of cancer growth/treatment at multiple scales

Quantitative, predictive

Applications to clinical practice, patient-specific therapy

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 53 / 54

Page 61: Case Studies in Cancer Modelling: Connecting with …Case Studies in Cancer Modelling: Connecting with the Clinic Mark Chaplain School of Mathematics and Statistics Mark Chaplain Multiscale

Collaborators

Marc Sturrock (ICL)

Ignacio Ramis-Conde (UCLM, Spain), Daniela Schluter (Lancaster)

Gibin Powathil (Swansea)

Mark Chaplain Multiscale cancer modelling INI 9th December 2015 54 / 54