Case # 85154: Bone marrow impression from a lame dog Presenter: Katie Boes Authors: Laurie O’Rourke, Geoffrey Saunders, Natalie Durrett Crawford, Nic Lambrechts, Jonathan Miller, Kurt Zimmerman Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website
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Case # 85154: Bone marrow impression from a lame dog Presenter: Katie Boes Authors: Laurie O’Rourke, Geoffrey Saunders, Natalie Durrett Crawford, Nic Lambrechts,
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Case # 85154:Bone marrow impression from a lame dog
Presenter: Katie BoesAuthors: Laurie O’Rourke, Geoffrey Saunders, Natalie Durrett Crawford, Nic Lambrechts, Jonathan Miller, Kurt Zimmerman
Presented at SEVPAC 2008 – Permission granted for use on
SEVPAC website only
Signalment & History
Signalment– 2-year-old– Castrated male – Golden Retriever
History– Chronic weight loss– Progressive left thoracic leg lameness
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Physical Examination
BCS 3/9 Left front limb
– Grade 3/4 lameness– Muscle atrophy– Pain with shoulder flexion– Solid scapular mass
Enlarged liver Abdominal distension
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Imaging: Left Shoulder
Radiographs– Well-circumscribed area
of bony lysis at the scapular neck, surrounded by a soft tissue mass
Ultrasound– Cortical lysis
• Loss of echogenic interface
• Loss of thedistal acoustic shadowing
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– 48-57% Non-specific Excessive catecholamine production
– 23-43%– Signs associated with hypertension– Panting, dyspnea, coughing, weakness,
exercise intolerance
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Pheochromocytomas:Clinical Diagnosis Routine blood and urine analysis
– Variable and non-specific Measure catecholamines and their metabolites in
blood and urine– Low availability– High technical difficulty and expense– False negatives due to cyclical excretion
Catecholamine stimulation and suppression tests– Dangerous due to profound changes in blood pressure
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Pheochromocytomas:Treatment & Survival Surgery is the treatment of choice
– Mortality rates: 22-29%– Survival with complete removal: Up to 3.25 years
Survival– No correlation between prognosis and histologic
appearance in dogs– Neurologic disease, abdominal distension, and
weight loss associated with advanced tumor stages
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Acknowledgements
VMRCVM’s Department of Biomedical Sciences
Dr. Eric Schultze, Eli Lilly & Co. Dr. Christopher Ober, VMRCVM
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References
1. Barthez PY, Marks, SL, Woo J, Feldman EC, Matteucci M. Pheochromocytoma in dogs: 61 cases (1984-1995). J Vet Intern Med. 1997;11:272-278.
2. Bouayad H, Feeney DA, Caywood DD, Hayden DW. Pheochromocytoma in dogs: 13 cases (1980-1985). J Am Vet Med Assoc. 1987;191:1610-1615.
3. Capen CC. Tumors of the adrenal gland. In: Moulton JE, ed. Tumors in Domestic Animals. 3rd ed. Berkeley, CA: University of California Press; 1990:576-583.
4. Gilson SD, Withrow SJ, Wheeler SL, Twedt DC. Pheochromocytoma in 50 dogs. J Vet Intern Med. 1994;8:228-232.
5. Raskin RE, Meyer DJ. Atlas of Canine and Feline Cytology. Philadelphia, PA: W. B. Saunders; 2001: 31-32.
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Questions?
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