Inpatient & Outpatients Jan‐ Dec 2015 Susceptibilities shown in % susceptible Class↓ Carbapenem Furanes Glycopeptide Macrolide Streptogramin Oxazolidionone Rifamycines TMP/SMX Legend Organisms alphabetically↓ Number of Organisms Amikacin Gentamicin Gentamycin synergy Streptomycin synergy Tobramycin Ampicillin Ampicillin/ Sulbactam Benzylpenicillin (Penicillin G) Oxacillin Pip/Tazo Cefazolin (1st) Cefoxitin (2nd) Cefotaxime (3rd) Ceftriaxone (3rd) Ceftazidime (3rd) Cefepime (4th) Meropenem Nitrofurantoin Vancomycin Clindamycin Clindamycin Resistance Inducible Erythromycin Quinupristin/ Dalfopristin Linezolid Ciprofloxacin Levofloxacin Moxifloxacin Rifampin† Tetracycline Tigeccline SMX/TMP *: less than 30 isolates ‐ please exercise discretion when interpreting the susceptibility of these organisms because of the small sample size Susceptability Breakpoints 16 4 4 8 8 S pneumo meningitis= 0.0625 pneumonia = 2 Other= 0.25ẋ staph= 2 16ẋ pseudo =64 8 8 mening itis= 0.5 other= 1 8 8 8 4 32 S. aureus =2 Strep= 1 Staph 0.5 Strep 0.25 0.5 1 Staph 4 Other 2 1 2 Strep 1 other 2 1 4 Staph= 0.5 Entero coccus/ Strep= 40 Acinetobacter sp. 18* ~ 83 83 94 57 86 78 78 0 86 86 ~ ~ 72 Citrobacter sp. (All) 78 100 96 56 92 24 88 90 100 100 80 94 94 ~ ~ ~ 92 C. freundii 46 100 93 96 87 80 83 100 100 83 91 91 ~ ~ ~ 87 Enterobacter sp. (All) 95 100 95 96 82 86 87 98 98 20 93 93 ~ ~ ~ 93 E. aerogenes 27* 100 100 100 85 89 89 100 100 7 100 100 ~ ~ ~ 100 E. cloacae complex 57 100 95 96 82 86 86 98 98 25 91 91 ~ ~ ~ 89 Enterococcus sp. (All) 212 68 72 86 ~ 86 ~ ~ 93 92 15 8 100 58 59 ~ 20 100 E. faecalis 193 68 74 94 ~ 93 ~ ~ 99 97 17 0 100 62 64 ~ 21 100 E. faecium 18* 72 61 11 ~ 11 ~ 44 50 0 89 100 11 6 ~ 17 100 Escherichia coli 1365 100 93 95 57 65 97 90 87 96 96 97 100 94 80 80 ~ ~ ~ 77 ESBL + E. coli 57 100 81 72 0 46 95 9 37 18 21 23 100 81 14 14 ~ ~ ~ 47 Klebsiella sp. (All) 358 100 98 99 82 95 82 87 96 96 97 100 44 97 97 ~ ~ ~ 91 ESBL + Klebsiella sp. 14* 100 79 93 14 43 0 86 29 21 21 100 29 79 79 ~ ~ ~ 71 Morganella morganii 16* 100 69 75 0 94 25 94 81 100 100 63 63 ~ 56 Proteus sp. (All) 193 100 84 89 65 80 100 78 82 88 89 90 99 48 48 ~ 59 P. mirabilis 186 100 84 88 67 80 100 80 81 89 88 89 99 46 46 ~ 58 Providencia sp. 18* 100 6 6 0 89 89 100 89 89 100 50 50 ~ 78 Pseudomonas aeruginosa 124 98 86 95 100 88 86 88 69 63 ~ Serratia sp. 22* 100 86 82 18 32 86 95 95 95 73 73 ~ 95 Staphylococcus sp. (All) 621 ~ 97 ~ ~ ~ 10 56 ~ ~ ~ ~ ~ ~ ~ 99 98 69 88 39 100 100 64 65 81 100 87 100 93 ~ : not tested S. aureus (All) 469 ~ 98 ~ ~ ~ 10 55 ~ ~ ~ ~ ~ ~ ~ 99 98 71 89 40 100 100 61 62 81 100 88 100 97 $: less than $100 MRSA 215 ~ 97 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ 99 98 57 91 9 100 100 29 30 65 100 85 100 95 $$‐ $100‐$250 MSSA 263 ~ 99 ~ ~ ~ 18 100 ~ ~ ~ ~ ~ ~ ~ 100 98 81 87 65 100 100 86 87 94 100 91 100 98 $$$‐ $250‐$500 S. epidermidis 38 ~ 95 ~ ~ ~ 3 50 ~ ~ ~ ~ ~ ~ ~ 100 97 61 87 21 100 100 58 58 84 100 89 100 66 $$$$‐ >= $1000 S. haemolyticus 28* ~ 82 ~ ~ ~ 11 43 ~ ~ ~ ~ ~ ~ ~ 96 96 57 82 18 96 100 61 64 75 96 61 100 82 Stenotrophamonas maltophi 12* ~ ~ ~ 92 ~ ~ ~ 92 Streptococcus agalactiae 134 100 ~ 100 ~ ~ ~ ~ 67 100 ~ ~ ~ ~ 100 3 67 98 100 ~ 98 ~ 18 100 100 Streptococcus pneumoniae 10* ~ ~ meningi tis= 50 pneumo nia=100 ~ ~ ~ ~ meni ngitis =90 other mening itis=80 other=1 00 ~ ~ ~ ~ 100 50 50 100 ~ 90 ~ 80 ~ 80 Approx. drug charge/day ‡ $$ $$ $$ $$$ $$$ $$$ $$$ $$$ $$ $$$ $$ $$$ $$$ $$$$ $ $$ $$$ $$$$ $$$$ $ $$ $$$$ $$ $$$$ $ Tetracyclines Aminoglycosides (AMG) Cephalosporins (generation) Penicillins Fluoroquinolones (FQs) Lincosamide †: Do not use as monotherapy Black fields: bacteria is intrinsicly resistant to antibiotic or should not be used clinically Blue highlight: gram negative organism ‡: severe disease in 70kg patient without renal impairment or monitoring TMP/SMX: Trimethoprim/Sulfamethoxazole PIP/TAZO: Piperacillin/Tazobactam Shaded fields: test does not apply to organism Green highlight: non‐formulary medications Red highlight: gram positive organism Carbopenem resistant organisms # of isolates Amikacin Gentamicin Tobram y cin Cefe p im e Ceftazidime Ceftriaxone Ci p rofloxacin Levofloxacin TMP / SMX E. gergoviae 1S S S S. marcescens 1S S S S S S S S S