Estimated IQ and mental functioning The Wechsler Abbreviated Scale of Intelligence ‐ WASI(19)
Working Memory Letter and Number Sequence ‐ Wechsler Adult Intelligence Scale III (21)
149
TABLE 3 Main Findings of Obsessive‐Compulsive Disorder (OCD) Patients versus Healthy Controls in
terms of Neuropsychological Performance
Group
OCD Patients Healthy Controls Total Neuropsychological Measure mean SE mean SE mean SE
p
Vocabulary 4692 1376 5029 2034 4831 1172 0164
Block Design 3852 1828 4189 2712 3991 1551 0231
Similarities 3358 0807 3514 0879 3422 0599 0382
Matrix Reasoning 2228 0984 2309 1510 2261 0845 0237
Verbal IQ (WASI) 8964 1852 9617 2549 9233 1543 0055
Performance IQ (WASI) 9388 2107 9897 3119 9598 1795 0103
Full IQ (WASI) 9182 1737 9740 2852 9412 1575 0076
CVLT ndash Trials 1 ‐ 5 Correct 5494 1603 5734 1591 5593 1149 0629
CVLT ndash total intrusions 116 0231 074 0202 099 0160 0192
CVLT ndash perseverative responses 670 0855 500 0705 600 0585 0226
CVLT ndash semantic clustering 1950 1581 1917 1849 1936 1194 0882
CVLT ndash recognition hits 1528 0192 1514 0469 1522 0222 0515
CVLT ndash false alarm 040 0128 049 0176 044 0104 0691
VST (part D) 1388 0553 1341 0465 1369 0377 0863
VST (part D) Errors 008 0049 035 0295 019 0124 0635
VST (part W) 1569 0503 1544 0531 1559 0366 0837
VST (part W) Errors 008 0040 015 0075 011 0038 0562
VST (part C) 2537 1003 2321 1062 2448 0740 0199
VST (part C) Errors 086 0180 088 0192 087 0131 0724
VST effect 1149 0926 979 0967 1080 0678 0385
Hayling Test Section A 340 0167 412 0157 373 0122 0002
Hayling Test Section B 408 0353 526 0217 462 0225 0025
Hayling Test Section C ndash Errors 605 0332 665 0321 632 0233 0210
Hayling Test Total Score 1358 0585 1603 0504 1470 0415 0003
Del Prette Factor 1 799 0603 949 0514 867 0410 0037
Del Prette Factor 2 811 0336 914 0311 858 0238 0014
Del Prette Factor 3 623 0354 760 0335 685 0257 0004
Del Prette Factor 4 257 0240 377 0208 312 0175 plt000
Del Prette Factor 5 087 0125 133 0113 108 0089 0010
WASI ndash Wechsler Adult Intelligence Scale CVLT‐ California Verbal Learning test VST ndash Victoria Stroop Test
150
TABLE 4 Psychopathological Features of OCD Patients by Treatment Group
Treatment
CBT Fluoxetine Total
Measure mean SE mean SE mean SE p
BDI 1954 2195 1754 1587 1850 1332 0546
BAI 1883 2758 1704 1864 1790 1628 0785
Age of onset of OCD 1467 1611 1160 1361 1310 1064 0190
DY‐BOCS Dimension I 575 0969 1467 0941 1160 0669 0766
DY‐BOCS Dimension II 1310 0866 575 1056 412 0693 0261
DY‐BOCS Dimension III 792 0851 865 0640 830 0524 0456
DY‐BOCS Dimension IV 608 1049 500 1033 552 0733 0572
DY‐BOCS Dimension V 238 0696 354 0671 298 0485 0137
DY‐BOCS Dimension VI 804 0821 977 0585 896 0505 0102
DY‐BOCS Global 2058 1030 2196 0824 2130 0655 0325
Y‐BOCS Obsessions 1267 0537 1223 0631 1244 0414 0867
Y‐BOCS Compulsions 1283 0667 1300 0451 1292 0393 0937
Y‐BOCS Global 2575 1150 2523 0919 2548 0724 0733
Reduction in Y‐BOCS 3611 6085 3362 6617 3477 4483 0799
Comorbidity freq freq freq p
Major Depressive Episode 8 333 11 423 19 380 0565
Dysthymic Disorder 5 208 4 154 9 180 0719
Bipolar Disorder 3 125 1 38 4 80 0325
Generalized Anxiety Disorder 9 375 11 423 20 400 0775
Social Phobia 9 375 10 385 19 380 1000
Specific Phobia 6 250 8 308 14 280 0764
Skin Picking 4 167 3 115 7 140 0692
Trichotillomania 1 42 2 77 3 60 1000
Body Dysmorphic Disorder 1 42 2 77 3 60 1000
Pain Disorder 2 83 1 38 3 60 0608
Tourette Disorder 1 42 1 38 2 40 1000
Compulsive Buying 1 42 2 77 3 60 1000
PTSD 0 00 3 115 3 60 0242
ADHD 1 42 3 115 4 80 0613
Intermittent Explosive 5 208 3 115 8 160 0461
DY‐BOCS Dimension I ndash aggression violence and natural disasters DY‐BOCS Dimension II ndash sexual and religious DY‐BOCS
Dimension III ndash symmetry ordering arranging DY‐BOCS Dimension IV ndash contamination and cleaning DY‐BOCS Dimension
V ndash hoarding DY‐BOCS Dimension VI ndash miscellaneous PTSD ndash post‐traumatic stress disorder ADHD ndash attention deficit
hyperactivity disorder
151
TABLE 5 Neuropsychological and Clinical Predictors of Treatment Response
Independent Variables Coefficient SE p value
FLUOXETINE minus9893 64937 0880
Verbal IQ (WASI) 2379 0809 0008
CVLT (Trials 1‐5 correct) 0216 0573 0710
CVLT Perseverative Responses minus2123 0602 0002
VST part D (Dots) Time minus5037 0847 lt 0001
VST part W (Words) Time 2685 1104 0025
VST part C (Colors) Errors minus39459 9087 lt0001
FLUOXETINEAge 2655 0492 lt0001
FLUOXETINEVerbal IQ ( WASI) minus2696 0920 0008
FLUOXETINE CVLT (Trials 1‐5 correct) 1988 0728 0013
FLUOXETINE CVLT Perseverative Responses 4183 1236 0003
FLUOXETINE VST part C (Colors) Errors 30820 10366 0007
Age minus0399 0395 0325
Y‐BOCS at baseline 3717 0614 lt 0001
BDI 0744 0383 0066
Linear Regression Dependent variable of response Independent or predictive
variables type of treatment (fluoxetine or CBT) age gender years of education age at
onset of OCD Y‐BOCS score BDI score BAI score and all neuropsychological measures