Cancer: Principles and Practice of Oncology 6th edition (July 2001): by Vincent T. Devita (Editor), Samuel Hellman, Steven A. Rosenberg (Editor) By Lippincott Williams & Wilkins Publishers
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Cancer Principles & Practice of OncologyCancer: Principles and Practice of Oncology 6th edition (July 2001): by Vincent T. Devita (Editor), Samuel Hellman, Steven A. Rosenberg (Editor) By Lippincott Williams & Wilkins Publishers DeVita - Cancer: Principles and Practice of Oncology CONTENTS Editors Dedication PART 1 ESSENTIALS OF MODERN ONCOLOGIC SCIENCE Chapter 1 Essentials of Molecular Biology: Basic Principles LANCE A. LIOTTA EDISON T. LIU Chapter 2 Essentials of Molecular Biology: Genomics and Cancer LANCE A. LIOTTA EDISON T. LIU Chapter 3 Essentials of Signal Transduction CHRISTOPHER L. CARPENTER LEWIS C. CANTLEY Chapter 4 Essentials of Immunology NICHOLAS P. RESTIFO JOHN R. WUNDERLICH PART 2 PRINCIPLES OF ONCOLOGY Chapter 5 Molecular Biology of Cancer: Cytogenetics MAZIN B. QUMSIYEH PEINING LI Chapter 6 Molecular Biology of Cancer: The Cell Cycle MICHAEL B. KASTAN STEPHEN X. SKAPEK Chapter 7 Molecular Biology of Cancer: Apoptosis STANLEY J. KORSMEYER SANDRA S. ZINKEL Chapter 8 Molecular Biology of Cancer: Invasion and Metastases WILLIAM G. STETLER-STEVENSON DAVID E. KLEINER, JR. Chapter 9 Biology of Cancer: Angiogenesis ISAIAH J. FIDLER ROBERT S. KERBEL LEE M. ELLIS Chapter 10 Etiology of Cancer: Viruses Section 10.1 RNA Viruses ERIC M. POESCHLA GARY L. BUCHSCHACHER, JR. FLOSSIE WONG-STAAL Section 10.2 DNA Viruses PETER M. HOWLEY DON GANEM ELLIOTT KIEFF Chapter 11 Etiology of Cancer: Chemical Factors STUART H. YUSPA PETER G. SHIELDS Chapter 12 Etiology of Cancer: Physical Factors ROBERT L. ULLRICH Chapter 13 Etiology of Cancer: Cancer Genetics ALLEN E. BALE SUZANNE J. BROWN Chapter 14 Epidemiology of Cancer Section 14.1 Epidemiologic Methods MARGARET A. TUCKER Section 14.2 Descriptive Epidemiology: Cancer Statistics PHILIP COLE BRAD RODU Section 14.3 Analytic Epidemiology: Cancer Causes PHILIP COLE BRAD RODU Chapter 15 Principles of Cancer Management: Surgical Oncology STEVEN A. ROSENBERG Chapter 16 Principles of Cancer Management: Radiation Therapy SAMUEL HELLMAN Chapter 17 Principles of Cancer Management: Chemotherapy EDWARD CHU VINCENT T. DEVITA, JR. Chapter 18 Principles of Cancer Management: Biologic Therapy STEVEN A. ROSENBERG Chapter 19 Pharmacology of Cancer Chemotherapy Section 19.1 Pharmacokinetics and Pharmacodynamics MARK J. RATAIN Section 19.2 Cancer Drug Development Section 19.2.1 Cancer Drug Development: Identification and Screening of New Agents EDWARD CHU MICHAEL R. GREVER BRUCE A. CHABNER Section 19.2.2 Cancer Drug Development: Combinatorial Chemistry DAVID J. AUSTIN Section 19.3 Antitumor Alkylating Agents OLIVER MICHAEL COLVIN Section 19.4 Cisplatin and Its Analogues STEVEN W. JOHNSON JAMES P. STEVENSON PETER J. O'DWYER Section 19.5 Antimetabolites EDWARD CHU AUGUSTO C. MOTA MIKLOS C. FOGARASI Section 19.6 Topoisomerase Interactive Agents CLINTON F. STEWART MARK J. RATAIN Section 19.7 Antimicrotubule Agents ERIC K. ROWINSKY ANTHONY W. TOLCHER Section 19.8 Miscellaneous Chemotherapeutic Agents BRUCE D. CHESON Chapter 20 Pharmacology of Cancer Biotherapeutics Section 20.1 Interferons JOHN M. KIRKWOOD Section 20.2 Interleukin-2 JAMES W. MIER MICHAEL B. ATKINS Section 20.3 Hormonal Therapies CHARLES ERLICHMAN CHARLES L. LOPRINZI Section 20.4 Differentiation Agents RAYMOND P. WARRELL, JR. Section 20.5 Therapeutic Monoclonal Antibodies: General Principles LOUIS M. WEINER GREGORY P. ADAMS MARGARET VON MEHREN Section 20.6 Antiangiogenesis Agents JUDAH FOLKMAN Chapter 21 Clinical Trials in Cancer Section 21.1 Design and Analysis of Clinical Trials RICHARD SIMON Section 21.2 Research Data Management DOUGLAS HAGEMAN DIANNE M. REEVES PART 3 Chapter 22 Cancer Prevention: Preventing Tobacco-Related Cancers HOWARD K. KOH CHRISTINE KANNLER ALAN C. GELLER Chapter 23 Cancer Prevention: Diet and Chemopreventive Agents Section 23.1 Fat WALTER C. WILLETT Section 23.2 Dietary Fibers PETER GREENWALD Section 23.3 Retinoids, Carotenoids, and Micronutrients SUSAN TAYLOR MAYNE SCOTT M. LIPPMAN Section 23.4 Naturally Occurring Dietary Anticarcinogens PETER GREENWALD Section 23.5 Dietary Carcinogens PETER GREENWALD Section 23.6 Aspirin and Other Nonsteroidal Antiinflammatory Drugs and the Risk of Cancer Development MICHAEL J. THUN CHARLES H. HENNEKENS Section 23.7 Physical Activity and Body Weight GRAHAM A. COLDITZ Chapter 24 Cancer Prevention: Role of Surgery in Cancer Prevention RICHARD M. SHERRY Chapter 25 Cancer Screening BARBARA K. RIMER JOELLEN SCHILDKRAUT ROBERT A. HIATT Chapter 26 Cancer Diagnosis: Molecular Pathology JOSÉ COSTA CARLOS CORDON-CARDO Chapter 27 Cancer Diagnosis: Imaging Section 27.1 Computed Tomography ELLIOT K. FISHMAN BRUCE A. URBAN Section 27.2 Magnetic Resonance Imaging ARTHUR E. LI DAVID A. BLUEMKE Section 27.3 Functional and Metabolic Imaging MARTIN G. POMPER Section 27.4 Interventional Radiology JEAN-FRANCOIS H. GESCHWIND Section 27.5 Ultrasound ULRIKE M. HAMPER Section 27.6 Radionuclide Imaging E. EDMUND KIM Chapter 28 Cancer Diagnosis: Endoscopy ROBERT C. KURTZ ROBERT J. GINSBERG Chapter 29 Specialized Techniques in Cancer Management Section 29.1 Laparoscopy ALAN T. LEFOR Section 29.2 Vascular Access and Specialized Techniques of Drug Delivery STEVEN K. LIBUTTI MCDONALD K. HORNE III Section 29.3 Isolation Perfusion H. RICHARD ALEXANDER Section 29.4 Intensity-Modulated Radiation Therapy C. CLIFTON LING CHEN CHUI THOMAS LOSASSO CHANDRA BURMAN MARGIE HUNT GIGAS MAGERAS HOWARD IRA AMOLS MICHAEL J. ZELEFSKY ZVI Y. FUKS STEVEN A. LEIBEL Chapter 30 Cancer of the Head and Neck Section 30.1 Molecular Biology of Head and Neck Tumors DAVID SIDRANSKY Section 30.2 Tumors of the Nasal Cavity and Paranasal Sinuses, Nasopharynx, Oral Cavity, and Oropharynx STIMSON P. SCHANTZ LOUIS B. HARRISON ARLENE A. FORASTIERE Section 30.3 Tumors of the Larynx and Hypopharynx ROY B. SESSIONS LOUIS B. HARRISON ARLENE A. FORASTIERE Section 30.4 Tumors of the Salivary Glands and Paragangliomas ROY B. SESSIONS LOUIS B. HARRISON ARLENE A. FORASTIERE Section 30.5 Rehabilitation after Treatment for Head and Neck Cancer SUSAN D. MILLER ROY B. SESSIONS Chapter 31 Cancer of the Lung Section 31.1 Molecular Biology of Lung Cancer YOSHITAKA SEKIDO KWUN M. FONG JOHN D. MINNA Section 31.2 Non–Small Cell Lung Cancer ROBERT J. GINSBERG EVERETT E. VOKES KENNETH ROSENZWEIG Section 31.3 Small Cell Lung Cancer JOHN MURREN ELI GLATSTEIN HARVEY I. PASS Chapter 32 Neoplasms of the Mediastinum ROBERT B. CAMERON PATRICK J. LOEHRER CHARLES R. THOMAS, JR. Chapter 33 Cancers of the Gastrointestinal Tract Section 33.1 Molecular Biology of Gastrointestinal Cancers ERIC R. FEARON Section 33.2 Cancer of the Esophagus DAVID S. SCHRUMP NASSER K. ALTORKI ARLENE A. FORASTIERE BRUCE D. MINSKY Section 33.3 Cancer of the Stomach MARTIN S. KARPEH DAVID P. KELSEN JOEL E. TEPPER Section 33.4 Cancer of the Pancreas DOUGLAS B. EVANS JAMES L. ABBRUZZESE CHRISTOPHER G. WILLETT Section 33.5 Cancer of the Liver and Biliary Tree YUMAN FONG NANCY KEMENY THEODORE S. LAWRENCE Section 33.6 Cancer of the Small Intestine DANIEL G. COIT Section 33.7 Cancer of the Colon JOHN M. SKIBBER BRUCE D. MINSKY PAULO M. HOFF Section 33.8 Cancer of the Rectum JOHN M. SKIBBER PAULO M. HOFF BRUCE D. MINSKY Section 33.9 Cancer of the Anal Region BRUCE D. MINSKY JOHN P. HOFFMAN DAVID P. KELSEN Chapter 34 Cancers of the Genitourinary System Section 34.1 Molecular Biology of Genitourinary Cancers W. MARSTON LINEHAN BERTON ZBAR FREDRICK LEACH CARLOS CORDON-CARDO WILLIAM ISAACS Section 34.2 Cancer of the Kidney and Ureter W. MARSTON LINEHAN BERTON ZBAR SUSAN E. BATES MICHAEL J. ZELEFSKY JAMES C. YANG Section 34.3 Cancer of the Bladder HARRY W. HERR WILLIAM U. SHIPLEY DEAN F. BAJORIN Section 34.4 Cancer of the Prostate PETER R. CARROLL KEITH L. LEE ZVI Y. FUKS PHILIP W. KANTOFF Section 34.5 Cancer of the Urethra and Penis HARRY W. HERR GUIDO DALBAGNI DEAN F. BAJORIN WILLIAM U. SHIPLEY Chapter 35 Cancer of the Testis GEORGE J. BOSL DEAN F. BAJORIN JOEL SHEINFELD ROBERT J. MOTZER R. S. K. CHAGANTI Chapter 36 Gynecologic Cancers Section 36.1 Molecular Biology of Gynecologic Cancers SETSUKO KUKI CHAMBERS Section 36.2 Cancer of the Cervix, Vagina, and Vulva PATRICIA J. EIFEL JONATHAN S. BEREK JAMES T. THIGPEN Section 36.3 Cancers of the Uterine Body THOMAS W. BURKE PATRICIA J. EIFEL FRANCO M. MUGGIA Section 36.4 Gestational Trophoblastic Diseases FRANCO M. MUGGIA PATRICIA J. EIFEL THOMAS W. BURKE Section 36.5 Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma ROBERT F. OZOLS PETER E. SCHWARTZ PATRICIA J. EIFEL Chapter 37 Cancer of the Breast Section 37.1 Molecular Biology of Breast Cancer ROBERT B. DICKSON MARC E. LIPPMAN Section 37.2 Malignant Tumors of the Breast ERIC P. WINER MONICA MORROW C. KENT OSBORNE JAY R. HARRIS Section 37.3 Rehabilitation after Treatment for Cancer of the Breast JOSEPH J. DISA JEANNE A. PETREK Chapter 38 Cancer of the Endocrine System Section 38.1 Molecular Biology of Endocrine Tumors TERRY C. LAIRMORE SAMUEL A. WELLS, JR. JEFFREY F. MOLEY Section 38.2 Thyroid Tumors DOUGLAS L. FRAKER MONICA SKARULIS VIRGINIA LIVOLSI Section 38.3 Parathyroid Tumors DOUGLAS L. FRAKER Section 38.4 Adrenal Tumors JEFFREY A. NORTON HOP N. LE Section 38.5 Pancreatic Endocrine Tumors H. RICHARD ALEXANDER ROBERT T. JENSEN Section 38.6 Carcinoid Tumors and the Carcinoid Syndrome ROBERT T. JENSEN GERARD M. DOHERTY Section 38.7 Multiple Endocrine Neoplasias GERARD M. DOHERTY ROBERT T. JENSEN Chapter 39 Sarcomas of the Soft Tissue and Bone Section 39.1 Soft Tissue Sarcoma MURRAY F. BRENNAN KALED M. ALEKTIAR ROBERT G. MAKI Section 39.2 Sarcomas of Bone MARTIN M. MALAWER MICHAEL P. LINK SARAH S. DONALDSON Chapter 40 Benign and Malignant Mesothelioma Section 40.1 Molecular Biology of Mesothelioma JOSEPH R. TESTA HARVEY I. PASS MICHELE CARBONE Section 40.2 Management of Mesothelioma KAREN H. ANTMAN HARVEY I. PASS PETER B. SCHIFF Chapter 41 Cancer of the Skin Section 41.1 Molecular Biology of Skin Cancer DOUGLAS E. BRASH ALLEN E. BALE Section 41.2 Management of Skin Cancer DAVID J. LEFFELL JOHN A. CARUCCI Section 41.3 Skin Cancer Atlas DAVID J. LEFFELL Chapter 42 Melanoma Section 42.1 Molecular Biology of Cutaneous Melanoma MEENHARD HERLYN KAPAETTU SATYAMOORTHY Section 42.2 Cutaneous Melanoma MICHAEL T. LOTZE RAMSEY M. DALLAL JOHN M. KIRKWOOD JOHN C. FLICKINGER Section 42.3 Intraocular Melanoma JOSÉ A. SAHEL ARTHUR S. POLANS MINESH P. MEHTA RICHARD M. AUCHTER DANIEL M. ALBERT Chapter 43 Neoplasms of the Central Nervous System Section 43.1 Molecular Biology of Central Nervous System Neoplasms DAVID N. LOUIS WEBSTER K. CAVENEE Section 43.2 Neoplasms of the Central Nervous System VICTOR A. LEVIN STEVEN A. LEIBEL PHILIP H. GUTIN Chapter 44 Cancers of Childhood Section 44.1 Molecular Biology of Childhood Cancers LEE J. HELMAN DAVID MALKIN Section 44.2 Solid Tumors of Childhood DAVID H. EBB DANIEL M. GREEN ROBERT C. SHAMBERGER NANCY J. TARBELL Chapter 45 Lymphomas Section 45.1 Molecular Biology of Lymphomas RICCARDO DALLA-FAVERA GIANLUCA GAIDANO Section 45.2 Leukemias and Lymphomas of Childhood HOWARD J. WEINSTEIN NANCY J. TARBELL Section 45.3 Non-Hodgkin’s Lymphomas JAMES O. ARMITAGE PETER M. MAUCH NANCY LEE HARRIS PHILIP BIERMAN Section 45.4 Cutaneous T-Cell Lymphomas LYNN D. WILSON GLENN W. JONES BARRY M. KACINSKI RICHARD L. EDELSON PETER W. HEALD Section 45.5 Primary Central Nervous System Lymphoma LISA M. DEANGELIS JOACHIM YAHALOM Section 45.6 Hodgkin’s Disease VOLKER DIEHL PETER M. MAUCH NANCY LEE HARRIS Chapter 46 Leukemias Section 46.1 Molecular Biology of Leukemias CLARA D. BLOOMFIELD MICHAEL A. CALIGIURI Section 46.2 Acute Leukemias DAVID A. SCHEINBERG PETER MASLAK MARK WEISS Section 46.3 Chronic Leukemias Section 46.3.2 Chronic Leukemias: The Chronic Lymphocytic Leukemias BRUCE D. CHESON Section 46.4 Plasma Cell Neoplasms NIKHIL C. MUNSHI GUIDO TRICOT BART BARLOGIE Section 46.5 Myelodysplastic Syndromes HAGOP M. KANTARJIAN ELIHU ESTEY Chapter 47 Paraneoplastic Syndromes SUSANNE M. ARNOLD ROY PATCHELL ANDREW M. LOWY KENNETH A. FOON Chapter 48 Cancer of Unknown Primary Site FRANK A. GRECO JOHN D. HAINSWORTH Chapter 49 Peritoneal Carcinomatosis DAVID L. BARTLETT Chapter 50 Immunosuppression-Related Malignancies Section 50.2 Transplantation-Related Malignancies STANLEY R. RIDDELL Chapter 51 Oncologic Emergencies Section 51.1 Superior Vena Cava Syndrome JOACHIM YAHALOM Section 51.2 Spinal Cord Compression BRIAN G. FULLER JOHN D. HEISS EDWARD H. OLDFIELD Section 51.3 Metabolic Emergencies RAYMOND P. WARRELL, JR. Section 51.4 Urologic Emergencies McCLELLAN M. WALTHER Chapter 52 Treatment of Metastatic Cancer Section 52.1 Metastatic Brain Cancer PATRICK Y. WEN PETER MCLAREN BLACK JAY S. LOEFFLER Section 52.2 Metastatic Cancer to the Lung JOE B. PUTNAM, JR. Section 52.3 Metastatic Cancer to the Liver H. RICHARD ALEXANDER CARMEN J. ALLEGRA THEODORE S. LAWRENCE Section 52.4 Metastatic Cancer to the Bone HOLLY K. BROWN JOHN H. HEALEY Section 52.5 Malignant Pleural and Pericardial Effusions DAO M. NGUYEN DAVID S. SCHRUMP Section 52.6 Malignant Ascites FRANCESCO M. MARINCOLA DOUGLAS J. SCHWARTZENTRUBER Chapter 53 Hematopoietic Therapy Section 53.1 Transfusion Therapy PETER L. PERROTTA EDWARD L. SNYDER Section 53.2 Autologous Stem Cell Transplantation DENNIS L. COOPER STUART SEROPIAN Section 53.3 Allogeneic Stem Cell Transplantation RICHARD W. CHILDS Section 53.4 Hematopoietic Growth Factors JAMES D. GRIFFIN Chapter 54 Infections in the Cancer Patient BRAHM H. SEGAL THOMAS J. WALSH STEVEN M. HOLLAND Chapter 55 Adverse Effects of Treatment Section 55.1 Nausea and Vomiting ANN M. BERGER REBECCA A. CLARK-SNOW Section 55.2 Oral Complications ANN M. BERGER THOMAS J. KILROY Section 55.3 Pulmonary Toxicity DIANE E. STOVER ROBERT J. KANER Section 55.4 Cardiac Toxicity LAUREL J. STEINHERZ JOACHIM YAHALOM Section 55.5 Hair Loss CLAUDIA A. SEIPP Section 55.6 Gonadal Dysfunction MARVIN L. MEISTRICH RENA VASSILOPOULOU-SELLIN LARRY I. LIPSHULTZ Section 55.7 Second Cancers FLORA E. VAN LEEUWEN LOIS B. TRAVIS Section 55.8 Miscellaneous Toxicities RAYMOND B. WEISS Chapter 56 Supportive Care and Quality of Life Section 56.1 Management of Cancer Pain KATHLEEN M. FOLEY Section 56.2 Nutritional Support J. STANLEY SMITH WILEY W. SOUBA Section 56.3 Sexual Problems PATRICIA A. GANZ MARK S. LITWIN BETH E. MEYEROWITZ Section 56.4 Genetic Counseling ELLEN T. MATLOFF ALLEN E. BALE Section 56.5 Psychological Issues MARY JANE MASSIE LISA CHERTKOV ANDREW J. ROTH Section 56.6 Community Resources BONNIE A. INDECK PHYLLIS M. SMITH Section 56.7 Specialized Care of the Terminally Ill FREDERICK A. FLATOW SCOTT LONG Chapter 57 Rehabilitation of the Cancer Patient LYNN GERBER JEANNE HICKS JAY SHAH Chapter 58 Advanced Practice Nurses and Physician Assistants in Oncology Care M. TISH KNOBF SUSAN ANDERSON Chapter 59 Ethical Issues in Oncology and Clinical Trials CHRISTOPHER DAUGHERTY MARK SIEGLER Chapter 60 Information Systems in Oncology SUSAN MOLLOY HUBBARD Chapter 61 Complementary, Alternative, and Unproven Methods of Cancer Treatment JEFFREY D. WHITE PART 4 Chapter 62 Genetic Therapy Section 62.1 Gene Therapy PATRICK HWU Section 62.2 Molecular Therapy ALBERT B. DEISSEROTH AMANDA PSYRRI DAVID J. AUSTIN Chapter 63 Cancer Vaccines Section 63.1 Preventive Cancer Vaccines DOUGLAS R. LOWY JOHN T. SCHILLER Section 63.2 Therapeutic Cancer Vaccines NICHOLAS P. RESTIFO MARIO SZNOL WILLEM W. OVERWIJK Chapter 64 Image-Guided Surgery NICK BRYAN STEVEN K. LIBUTTI Chapter 65 Proton Beam Radiation Therapy IRA J. SPIRO ALFRED R. SMITH ANTHONY LOMAX JAY S. LOEFFLER CONTRIBUTING AUTHORS Annie Laurie Howard Research Distinguished Professor Department of Gastrointestinal Medical Oncology The University of Texas M. D. Anderson Cancer Center Houston, Texas Gregory P. Adams, PhD Assistant Member Department of Medical Oncology Fox Chase Cancer Center Philadelphia, Pennsylvania Daniel M. Albert, MD, MS F. A. Davis Professor and Chair; Lorenz E. Zimmerman Professor Department of Ophthalmology and Visual Sciences University of Wisconsin Center for Health Sciences Madison, Wisconsin Kaled M. Alektiar, MD H. Richard Alexander, MD Carmen J. Allegra, MD Chief, Medicine Branch National Cancer Institute, National Institutes of Health Bethesda, Maryland Nasser K. Altorki, BCh, MB Professor of Cardiothoracic Surgery Weill Medical College of Cornell University New York, New York Howard Ira Amols, PhD Professor of Physics in Radiology Weill Medical College of Cornell University Memorial Sloan-Kettering Cancer Center New York, New York Susan Anderson, BSN, MFA Director, Clinical Trials Office Yale Cancer Center Yale University School of Medicine New Haven, Connecticut Karen H. Antman, MD Wu Professor of Medicine and Pharmacology Herbert Irving Comprehensive Cancer Center Columbia University College of Physicians and Surgeons New York, New York James O. Armitage, MD Professor of Medicine Dean of the College of Medicine University of Nebraska Medical Center Omaha, Nebraska Susanne M. Arnold, MD Assistant Professor of Medicine Department of Hematology and Oncology Lucille P. Markey Cancer Center University of Kentucky Chandler Medical Center Lexington, Kentucky Michael B. Atkins, MD Richard M. Auchter, MD Clinical Assistant Professor of Human Oncology University of Wisconsin Medical School Madison, Wisconsin David J. Austin, PhD Assistant Professor of Chemistry Yale University School of Medicine New Haven, Connecticut Dean F. Bajorin, MD Professor of Medicine Weill Medical College of Cornell University Attending Physician Memorial Sloan-Kettering Cancer Center New York, New York Allen E. Bale, MD Associate Professor of Genetics Yale University School of Medicine New Haven, Connecticut Bart Barlogie, MD, PhD Professor of Medicine and Pathology Director, Arkansas Cancer Research Center University of Arkansas for Medical Sciences Little Rock, Arkansas David L. Bartlett, MD Susan E. Bates, MD Jonathan S. Berek, MD Professor and Chair of Applied Anatomy Vice Chair and Chief, Division of Gynecologic Oncology University of California, Los Angeles, UCLA School of Medicine Los Angeles, California Ann M. Berger, RN, MSN, MD Chief of Pain and Palliative Care Service National Institutes of Health Bethesda, Maryland Philip Bierman, MD Associate Professor of Medicine Department of Internal Medicine Section of Oncology/Hematology University of Nebraska Medical Center Omaha, Nebraska Peter McLaren Black, MD, PhD Franc D. Ingraham Professor of Neurosurgery Harvard Medical School Brigham and Women’s Hospital Children’s Hospital Boston, Massachusetts Clara D. Bloomfield, MD Professor of Medicine Ohio State University College of Medicine and Public Health Department of Internal Medicine Division of Hematology/Oncology The Comprehensive Cancer Center Columbus, Ohio David A. Bluemke, MD, PhD, MSB Associate Professor of Radiology Johns Hopkins University School of Medicine Baltimore, Maryland George J. Bosl, MD Chair, Department of Medicine Memorial Sloan-Kettering Cancer Center New York, New York Douglas E. Brash, PhD Professor of Therapeutic Radiology and Genetics Yale University School of Medicine New Haven, Connecticut Murray F. Brennan, MD Chair, Department of Surgery Memorial Sloan-Kettering Cancer Center New York, New York Holly K. Brown, MD Suzanne J. Brown, MD Fellow in Oncology Yale Comprehensive Cancer Center Yale University School of Medicine New Haven, Connecticut Nick Bryan, MD, PhD Gary L. Buchschacher, Jr., MD, PhD Department of Medicine Division of Hematology/Oncology University of California, San Diego, School of Medicine La Jolla, California Thomas W. Burke, MD Professor of Gynecologic Oncology The University of Texas M. D. Anderson Cancer Center Houston, Texas Chandra Burman, PhD Michael A. Caligiuri, MD Professor of Medicine Ohio State University College of Medicine and Public Health Arthur James Cancer Hospital and Research Institute Columbus, Ohio Robert B. Cameron, MD Assistant Professor of Surgery University of California, Los Angeles, UCLA School of Medicine Los Angeles, California Lewis C. Cantley, PhD Professor of Cell Biology Harvard Medical School Beth Israel Deaconess Medical Center Boston, Massachusetts Michele Carbone, MD, PhD Christopher L. Carpenter, MD, PhD Assistant Professor of Medicine Harvard Medical School Beth Israel Deaconess Medical Center Boston, Massachusetts Peter R. Carroll, MD Professor and Chair, Department of Urology University of California, San Francisco, School of Medicine San Francisco, California John A. Carucci, MD, PhD Clinical Instructor of Dermatology Yale University School of Medicine New Haven, Connecticut Webster K. Cavenee, PhD Professor of Medicine University of California, San Diego, School of Medicine Director, Ludwig Institute for Cancer Research Center for Molecular Genetics; University of California Laboratory of Tumor Biology La Jolla, California Bruce A. Chabner, MD R. S. K. Chaganti, PhD Member and William E. Snee Chair Human Genetics Memorial Sloan-Kettering Cancer Center New York, New York Setsuko Kuki Chambers, MD Professor of Obstetrics and Gynecology Division of Gynecologic Oncology Yale University School of Medicine New Haven, Connecticut Lisa Chertkov, MD Bruce D. Cheson, MD Clinical Professor of Medicine Georgetown University School of Medicine Vincent T. Lombardi Cancer Research Center Washington, DC Head, Medicine Section Cancer Therapy Evaluation Program National Cancer Institute, National Institutes of Health Bethesda, Maryland Richard W. Childs, MD Senior Investigator Hematology Branch National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland Edward Chu, MD Chen Chui, PhD Rebecca A. Clark-Snow, RN, BSN, OCN Director of Clinical Services Oncology and Hematology Associates of Kansas City Kansas City, Missouri Daniel G. Coit, MD Chief of Gastric and Mixed Tumor Service Department of Surgery Memorial Sloan-Kettering Cancer Center New York, New York Graham A. Colditz, MD, DrPH Professor of Medicine Harvard Medical School Brigham and Women’s Hospital Boston, Massachusetts Philip Cole, MD, PhD Professor Emeritus Department of Epidemiology University of Alabama School of Medicine Birmingham,…