Canary Foundation Luncheon Presentation

Welcome

Canary Foundation Luncheon

Progress to Patients:

Canary’s 10 year journey from

tests to clinical trial

March 26, 2015

Strategy

Strategy – 10 years later

# 1 Most cancers take decades to develop

1p

IT

F01

INd

dtq1p = (IN + IT)-q1p x F01

IN + IT

(1-e-F01t)q1p =F01

ln(2)t1/2marker

qsts=[IN(mass/time) + IT(mass/time)]

Steady state can be calculated as:

# 2 Cancer generates measurable items in blood

# 3 But old technology can’t find it until too large

# 4 New nano-technology can find it 1000 times

smaller and 1000 times cheaper!

# 5 Models show we will save lots of lives

# 6 Tests will be cost-effective for high-risk patients

# 7 Finding new blood tests has been elusive

# 8 Molecular imaging is progressing at a rapid pace

# 9 World’s finest leadership

# 10 An unprecedented partnership with Stanford

# 11 And we have inspired global investment

CRUK

# 12 New tests and companies are coming to market

Cyrcadia health – Detected Movie Trailer

Scientific Panel

Sanjiv Sam Gambhir, MD, PhD – Chair, Department of Radiology,

Stanford University

Jim Brooks, MD - Chief, Urologic Oncology, Stanford University

Utkan Demirci, PhD - Associate Professor, Stanford University

Heidi Auman, PhD – Scientific Program Manager,

Canary Foundation

New

Ideas

$50K

Individual

1 year

New

IdeasClinical

Research

$10M

Team

10 years

$50K

Individual

1 year

New

IdeasClinical

Research

$20M

COE

7 years

$10M

Team

10 years

$50K

Individual

1 year

Science

New

IdeasClinical

Research

$20M

COE

7 years

$10M

Team

10 years

$50K

Individual

1 year

Facilities

Faculty

Associates

Science

Technology

$50M

Center

10 years

Science

New

IdeasClinical

Research

$20M

COE

7 years

$10M

Team

10 years

$50K

Individual

1 year

Facilities

Faculty

Associates

Science

Technology

$50M

Center

10 years

Science

Spin-outs

Medical device

Imaging tech

New

IdeasClinical

Research

Clinical

Trials

$20M

COE

7 years

$10M

Team

10 years

$50K

Individual

1 year

Facilities

Faculty

Associates

Science

Technology

$50M

Center

10 years

Science

Spin-outs

Medical device

Imaging tech

New

IdeasClinical

Research

Clinical

Trials

$20M

COE

7 years

$10M

Team

10 years

$50K

Individual

1 year

Facilities

Faculty

Associates

Diagnostic

Companies

Science

Technology

$50M

Center

10 years

Science

Spin-outs

Medical device

Imaging tech

Diagnostic test

Lung Cancer Breast Cancer

Molecular Imaging

Measuring densities of cells in real-time down to a single-cell level

31

Lab on a chip

Development of a Clinical Test Clinical Trials for CT + Biomarkers

CT + Biomarker Trial

initiated by MD Anderson

10,000 in US &

International

participation in China,

Germany, Brazil

Multiple techniques to analyze a

common set of samples

Integrate data and discover biomarkers

Smokers vs. Never Smokers

Cell Lines Tumors Blood

Pro-Surfactant Protein B (pro-SFTPB)

Validation

Lung cancer research & clinical trial

Novel strategy

Ovarian cancer clinical trial

PASS Clinical Trial

1,000+ Men

5 Year

Follow-upNo Progression

Suspected

Central

Bio-Repository

Progression Suspected

Option for Treatment

Tissue Resources for Validation

Tissue of 1,000+

men who have

had radical

treatment

500+ Non-recurrent cancer

500+ Recurrent cancer

1,000s of prostate cancer

tissues arrayed to maximize

rapid and efficient analysis

Prostate cancer clinical trial

Pancreas Blood test

Targeted Microbubble Ultrasound

Pancreas microbubble in mice

Ovarian microbubble

42

Motivation for TRUSPA Imaging of Prostate

TRUS guided prostate biopsy Sagittal Ultrasound Transverse Ultrasound

Photoacoustic imaging

Sagittal array

Transverse array

45

Pilot Clinical Trial: TRUSPA Imaging of Prostate

Prostate Capsule

Clinical Trials

Prostate Ovary Pancreas

$1,500 to sponsor 1 person

$3,000 to sponsor 2 people

$4,500 to sponsor 3 people

Thank You

Canary Luncheon Committee

Dear Pixels

Lobird

Laure Woods

Avaya

Union Bank

Village Doctors

William K Bowes Jr. Foundation

Franklin and Cathryn Johnson Family Foundation

Debbi Spungen in memory of Florence Spungen

Canary Challenge

Canary Challenge – September 26, 2015