CAMPO PEARL EXTRACT Novel carbon-dioxide lypolized water soluble extract of sea-pearl for novel skin care & skin whitening cosmetics Novel functional ingredients for multi-purpose formulations CAMPO RESEARCH PTE LTD Level 30, 6 Battery Road, Singapore 049909 Tel: (65) 63833203 / 202 / 63833631 Direct Fax (65) 63833632 / 63834034 Email: [email protected]Website: http///www.campo-research.com Internet-Video-Phone Teleconferencing: [email protected] For Technical Assistance CAMPO® Multi-Purpose Cosmetic Base Chemicals & Active Ingredients CAMPO® Novel Functional Active Cosmetic Ingredient & Raw Materials
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CAMPO PEARL
EXTRACT
Novel carbon-dioxide lypolized water soluble extract of sea-pearl for novel skin care & skin whitening cosmetics
Novel functional ingredients for
multi-purpose formulations
CAMPO RESEARCH PTE LTD Level 30, 6 Battery Road, Singapore 049909
CAMPO SCIENCE BEHIND THE CAMPO PEARL EXTRACT (PWS) A Pictorial Efficiency of Skin Whitening and UV-Protection Effect
AFTER 2 weeks application of 10% Pearl Extract Crème all over the Body and facial skin, 2 times daily. A lightened skin becomes pronounced based on skin whitening and protection from sun and UV caused skin darkening.
CAMPO SCIENCE BEHIND THE CAMPO PEARL EXTRACT (PWS) A Pictorial Efficiency of Skin Whitening and UV-Protection Effect
AFTER 8 WEEKS Total lighten skins with 10% Pearl extract crème all over body and Facial skin, 2 times daily The protection effect form sun and UV Bronzing becomes very clearly effective.
SKIN WHITENING EFFECT OR CAMPO PEARL EXTRACT (PWS) AN UNIQUE NEW NOVEL BIOTECHNOLOGY ADAPTOGENIC MULTI-FUNCTIONAL COSMETIC INGREDIENT THAT DEFIES THE KNOWN PARAMETERS OF ALL SYNTHETIC SKIN WHITENING AND SUN & UV-PROTECTION AGENTS & CHEMICALS; WHITEN WITH ITS' (PWS) UNIQUE PROPERTIES AND CONFERS IRREVERSIBLE SKIN-TONED-WHITENING, AFFORDS A BIOLOGICAL SUN & UV-PROTECTION AND REVERSE UV-DAMAGED, AND REVERSE UV-DAMAGED IMMUNE SYSTEM TO FUNCTION AT ITS OPTIMAL AND NORMAL ACTIVATION LEVEL(S).
INTRODUCTION We need to refresh on the structure of the skin (see figures of skin) and understand the metabolism(s) of skin-whitening activity and its (skin-whitening) effect contrast to the UV-A induced skin darkening effect (i.e.: melanin synthesis) process at the Melanocytes cells (dentritic cell(s). Both processes (i.e.; skin whitening and UV-A induced skin darkening) begins at the Melanocytes and most current synthetic cosmetics materials used for skin-whitening address only one function primarily. Therefore, we begin at UV-protection effect and dwell into the Skin-Whitening effect, to reflect perfect understanding from our clients of our novel Campo Pearl Extract, (PWS) and the mechanisms involved for UV Protection, Skin-Whitening and Reversing of Damage to the Immune System by harmful UV-inducement. The pigment Melanin is synthesized at Melanocytes at the Basal layer level and this level is further also responsible for the re-generation of the Epidermis (including the Horny
layer or Stratum Corneum). This melanin production is increased by the level of UV-A light falling on the skin, this production and its (melanins') importance are of two-fold, (namely the first the melanin pigments affords a short-term protection of the deeper layers of dermis against immediate damage by ultra-violet B radiation and secondly, in the long term it affords protection against cancer (from UV-induced genetic damage to the normal cells which turn into malignant and cancerous growth). (1). The Melanin synthesis is synthesize in several stages, starting with the synthesis of pre-melansomes in the Golgi body of the Melanocytes (see figure of cell structure). The endoplasmic reticulum of the Melanocytes contains the amino-acid tyrosine, which oxidized by copper containing enzymes known as tyrosinase found in the pre-melanosomes, through a sequence of several steps to produce melanin as the final product (see summarized steps below, in this paragraph). The colorless pre-melanosomes are promoted further away from the cell-nucleus (as seen in figure of cell) by the dendrites (dentritic growth is analogous to a octopus tentacles moving far way from the parent body) During this dendritic growth, the pre-melanosomes (in the dendrites) are converted to melanosomes and further darken into melanin form (contain in these dendrites) and these dendrites (with the new-formed melanins) are absorbed by the surrounding prickle layer (or Stratum Granulosum) Cells and the melanin passes into these cells from tips of the dentrites, thus pigmenting them. To summarize the biological pathway resulting in Melanogensis (i.e.; formation of Melanin as proposed by Mason & Raper (2), the key steps in this reaction process are the hydroxylation of Tyrosine to DOPA-(1,4, dihydroxyphenylalanine) and the oxidation of DOPA to dopaquinone by means of the catalytic action of the enzymes tyrosinase, a copper-containing oxidase (enzyme). At the stage above described, when PWS is absorbed thru the skin - a novel process take-place which is similar to the action of ordinary Pearls consumed orally (after ingestion & transmitting the gastro-intestinal organs, becomes deposited in cellular mechanisms of various organs including the skin - the largest of the organs). The germanium (3) ( a trace-element found ordinarily in Pearl, which is biologically soluble and readily bio-available in PWS) plays a novel multi-functional part both as an oxygen increasing and much more-uptaking - natural element during the oxidization process of the amino-acids tyrosine upon saturation point of the oxidation - a reverse-process of de-oxidizing mechanism then occurs ( osmosis )that return the darken melanin in to the colorless form (as colorless to almost colorless melanins-leuco-melanin) as it(melanin) exists (colorless) in pre-melanosomes and melanosomes stage, while another activity is spontaneously conducted - (by organic germanium) - that of protecting the cellular tissue from the highly reactive extra oxygen (free-radicals). These highly reactive molecules that can react with important substances in the human body, causing great damage (this control of free-radicals by germanium is also noted during the remedial reverse of UV-damaged immune system into a normal functioning immune system, and free-radicals are known to be released during regular or during reversed up & toned up-normal immune stimulation activity (also see the other paper on revitalization of Langerhans cells). Briefly to mention, organic germanium conduct and support cellular semi-conduction, and the cellular semi-conduction increases the UV –injury repair function in combination with the non-UV mutated p53s. p53s are also benefited by the presence of organic germanium in the cellular membrane to pump ions back and forth, and in and out of the skin cells, without being zapped and mutated ( p53 by the UV).
The PWS acted upon- colorless or almost colorless melanin pigments are channeled the same manner via dentritic (of Melanocytes) to the prickle layer and absorbed to be further keratinisation and desquamation when at the keratinisation and desquamation stage in skin surface layer (it should be briefly noted here that the ) PWS's nutrients in the enriched surface cells, enrich the epidermis & dermis for a few different separate but symbiotic functionalities such as:- A. enriching the "surface acid-mantle" of the skin (By Selenium (a trace element
in PWS) and its functions are enriching the nature of chemical debuffering, detoxifying & bacteriostatic action - of the acid mantle) and it derivatives are reflectors of UV rays;
B. - by the actions of PWS's (see below) functionalities; C. - the other actions is enrichment of the metal ions, amino acids (both
absorbed by the skin and released to the surface of epidermis thru the cells which after the desquamation process leaves a rich, TEWL protective barrier of water absorbing amino-acids'reservoir etc), which provides for smooth supple skin conditions.
D The PWS Strontium (another trace element) in its various forms function as a dekeratinisation substance of the desquamated skin cells to form a light protective lipid barrier that scatter the white light from the skin surface and reflects the respective color band of light at the deeper levels of the epidermis - dermis (see diagram on Light being reflected from skin).
As described above, the PWS's dual functions of UV-protection and Skin-Whitening effect are inseparable but yet a major separate but spontaneously Skin-Whitening effect is further being in process at the level to be discussed below. The biologically soluble amino-acid Gluthathione (in PWS) further also involves in the reverse of darken melanin to colorless or almost colorless (in simultaneous action to the action of Germanium) but as previously discussed above and again here these PWS actions are not "inhibition or inactivation of tyrosinase" from being formed into melanin (as conventional synthetic skin-whitening agents does & acts as a tyrosinase inactivating agent) but in PWS action - melanin is completely formed with less color or colorless, as natural melanin solvents like compounds are naturally enhanced within the skin and acts as thinner of these melanin pigment(s). More to this, Gluthathione found in ordinary Pearl can be absorbed only thru the oral ingestion and can’t be absorbed thru the skin, the bioactive concentration of gluthathione reaching the skin for to be any functionality is very negligible (experimental trials of pure biologically soluble gluthathione is directly absorbed thru the skin to where it is required to function in the most appropriate bioavailability is simply a novelty unique to PWS, but this is not the only case of PWS Skin-whitening effect, as the bioavailability soluble Bezoar Acid has a few separate functionality in the whitening regime of the skin. PWS's Bezoar acid stereoisomers- D-Bezoar acid &L-Bezoar acid, and the racemic mixture of DL-Bezoar acid had shown a strong skin-whitening effect and these PWS Bezoar acid derivatives are also further acts to enhanced the unsaturated fatty acids (USAF) with 12 -22 carbon chains found in the lipids of the skin cells to acts a skin- whitener as well (within epidermis level); while the functionality of these USAF are increased actions as "lipid moisture retainer - formed as a fatty film" at the surface layer of the epidermis. PWS's Bezoar acid's uniqueness is that of one of its derivative which acts similar to magnesium salts of Ascorbic acid’s - 3-phosphate acts (4) as an antioxidant stabilizer to the whitening effect actions (inhibits the browning again of the PWS whitened skin and mimic of the Vitamin C's regenerative actions to various stages in the cell-metabolism, including removing the accumulated cellulite and toxins in the cellular region to transported via the fatty acids to be broken down in the liver during the
conversion to Glycogen (animal starch), and discharged from the body thru the normal excretory means. There is an UV-A&B absorbance action further to be credited to the presence of Bezoar acid derivatives on the skin, which principal methodology of efficacy is out of context for this paper, as the above said implication "Mimic of Vitamin C esters by the PWS's Bezoar acid esters" as it (vitamin C) is not synthesis by mammals i.e.; human body) and as it is known that Bezoar Acid (from Bezoar Gail-stone/Nui Huang) and its esters can be produced by human body,; will required a full paper to elaborate the mechanism. This whole concept of understanding the PWS SKIN WHITENING-EFFECT has to be elaborated in the manner as discussed above, as there are more fifteen different actions and pathways spontaneously taking place when skin has absorbed PWS, which elaboration and discussions will be too lengthy with the nature of minute and esoterically complex mechanism(s) being taking and hypothesizes as such, involved etc, to be any other-wise manner of explanation in this summarized paper. As we have clearly defined else where that the PWS was a spin-off cosmetic ingredient that was reached Drug-Candidate status for Human Clinical Phase I for Anti-Melanoma and other types of Skin-Cancers, before being scrapped due to technical difficult of filing and in obtaining a full patent protection from generic drug manufacturers who simply can deliberate and copy in parameters of PWS production and its very excellent drug efficacy by various other scientific means in short possible time.
DISCLAIMER : The information contained herein is accurate to the best knowledge and belief of Campo Research Pte Ltd, and specification quoted may change without prior notice. Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company,Campo Research Pte Ltd, however, cannot assume any liabilities or risks involved in the use of its natural products or their derivatives or raw materials or ingredients, since the conditions of use are beyond Campo Research Pte Ltd’ s control. Statements concerning the possible use are not intended as recommendations to use our materials in the infringement of any patents or infringements of mandatory regulatory requirements or without any safety evaluations conducted when used in combination with materials of other suppliers.. We make no warranty of any kind, expressed or implied, other than that the material conforms to the applicable standard specifications. Campo Research Pte Ltd accepts no liabilities of whatsoever either expressed or as otherwise arising out of the information supplied, the application, adaptation or processing of the products described herein, or the use of other materials in lieu of the Campo materials or the use of Campo raw materials or ingredients in conjunction with any other products and raw materials. The use of Campo Research Pte Ltd's raw materials or ingredients in any formulations are to be compulsory tested and to be assayed for safety and toxicology profiles evaluations and according the mandatory regulations as required by the laws and regulations of the countries where the evaluation and use of Campo Research Pte Ltd's raw materials or ingredients has been formulated as single components in any carrier systems or as in multi-components formularies. The end-users, marketers; manufacturers, formulation laboratories or importers of Campo Research Pte Ltd' raw materials and ingredients which are incorporated into any formularies as formulated or re-sold or re-exported or assayed in accordance with any mandatory regulatory requirements of any country or infringement of any patents assume all liabilities as that may arise out of the use of Campo Research Pte Ltd's raw materials and ingredients in any formularies in combination with raw materials and ingredients of other suppliers or as single components in any carriers. The definition of users as mentioned in these instances are manufacturers, marketers, formulation laboratories, consultants, and importers assumed all liabilities arising as either personal injuries suits, infringements of patents suits, infringements of or failures to meet regulatory requirements suits of a formulary either as single components in any carrier systems or in as multi-components formularies in which are may consist of a Campo Research Pte Ltd's raw material or ingredients.
IMPORTANT NOTICE Specifications may change without prior notice. Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company, however, cannot assume any liability or risk involved in the use of its natural products or their derivatives, since the conditions of use are beyond our control. Statements concerning the possible use are not intended as recommendations to use our products in the infringement of any patent. We make no warranty of any kind; expressed or implied, other than that the material conforms to the applicable standard specifications.