Mehran SHARIFI , Peter JOZA, Romulo LODEVICO, Bill RICKERT CAMBRIDGE FILTER PAD COLLECTION EFFICIENCY OF MENTHOL FROM E-CIGARETTE AEROSOLS – AN INVESTIGATIVE STUDY 70 th TOBACCO SCIENCE RESEARCH CONFERENCE September 18-21, 2016 Palm Beach Gardens, Florida, USA LABSTAT INTERNATIONAL ULC. 262 Manitou Drive Kitchener, Ontario, Canada N2C 1L3 Phone: (519) 748-5409 Fax: (519) 748-1654 www.labstat.com Presentation no 46 2016_TSRC46_Sharifi.pdf TSRC2016(70) - Document not peer-reviewed
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Mehran SHARIFI, Peter JOZA, Romulo LODEVICO, Bill RICKERT
CAMBRIDGE FILTER PAD COLLECTION EFFICIENCY OF MENTHOL FROM E-CIGARETTE AEROSOLS – AN
INVESTIGATIVE STUDY
70th TOBACCO SCIENCE RESEARCH CONFERENCESeptember 18-21, 2016
To evaluate the performance efficiency of Cambridge pad filter for collecting menthol in e-cigarette aerosols.
Objective
To identify the factors affecting both CFP collection efficiency and analyte transfer to aerosol.
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Typical collection methodologies used for trapping constituents in tobacco mainstream smoke are based on three approaches:
Adequacy of Current Methodologies for Exploration of E-cigarette Emissions?
Cambridge Filter Pad (CFP)
Direct Solvent Collection (Impinger)
Combined Filter Pad + Impinger
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Plan of the Presentation
I Cambridge Filter Pad Collection Efficiency: Cigarette Smoke vs E-Cigarette Aerosol
Suitability for collecting Menthol (breakthrough?) Suitability for other analytes in e-aerosols (i.e. humectants or degradation compounds Impact of puffing intensity on breakthrough rate
II Factors Affecting CFP Collection Efficiency and Analyte Transfer into Aerosol
PG/Glycerol composition ratio in e-liquid Water content in e-liquid
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Glycidol
Prop
ylen
e G
lyco
l
Menthol
Anethol(ISTD)
Nicotine
Inte
nsity
(mVo
lts)
Minutes
Ethy
lene
Gly
col
Glycerol
Menthol, Nicotine and Humectants
5
E-Cigarette Linear Smoking
Machine
Cambridge Filter Pad+
Impinger(Isopropanol)
Impinger Content
Extract CFP with Isopropanol
GC-FID Analysis
DB-WAX 15m, 0.53mm, 1µm
Injector: 220°C
Detector: 260°C
Temp. Program:
120°C for 2 min,15°C/min to 180°C,180°C for 4 min
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Investigative Study 1
• CFP efficiency for collecting menthol from aerosol?
• Puffing regimen (“aerosol load”) impact on CFP collection efficiency?
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Investigative Study 1 - Experimental
Test Products Puffing Regime(Volume/Duration/Frequency)
E-liq. Analyte Levels High Content Low Content Blank
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Summary (2nd investigative study)
• The results of the 2nd study did not confirm our previous observations with respect to menthol breakthrough (simply not observed)!?
This may be attributed to:
Differences between e-cigarette devices Power, resistance, wick material, etc… Refillable e-liquid tank system vs. Cigalike e-devices
Differences in e-liquid compositions Contribution of other compounds (i.e. flavoring agents) in the commercial
Cigalike products that would favor menthol breakthrough.
• A combination of high water/glycerol contents in e-liquid can increase (ca. 10-30 %) the transfer rates of Diethylene glycol, menthol, nicotine and ethylene glycol.
• Glycidol exhibited a significant amount of breakthrough under 80/3/30 puffing regimen. It was demonstrated that glycidol breakthrough increases with glycerol content in e-liquid/aerosol.
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Conclusion
It is recommended that an impinger be included when determining glycidol, ethylene glycol or menthol contents of e-aerosols regardless of the puffing regimen, e-liquid composition or vaporizer type (i.e. Cigalike or refillable tank).