Calcium score as a predictor of coronary artery disease severity in patients with acute coronary syndromes Coordinator Author Prof.Dr.Benedek Theodora.

CORE - 316 patients, with coronary stenosis > 50% • Sensitivity - 85%• Specificity - 90%

ACC/AHA guidelines, JACC, june 2010

ACCURACY - 245 patients, with coronary stenosis > 50% – Sensitivity - 95%

– Specificity - 82%

ROTTERDAM - 360 pacients, with coronary stenosis > 50% – Specificity - 99%

– Specificity - 64%

Cardio CT - accuracy for calculation of coronary artery calcium score

CORE - 316 patients, with coronary stenosis > 50% • Sensitivity - 85%• Specificity - 90%

ACC/AHA guidelines, JACC, june 2010

ACCURACY - 245 patients, with coronary stenosis > 50% – Sensitivity - 95%

– Specificity - 82%

ROTTERDAM - 360 pacients, with coronary stenosis > 50% – Specificity - 99%

– Specificity - 64%

• However, all these studies focused on features describing mainly the global coronary tree, while the association between calcium score and the severity of coronary lesions in acute coronary syndrome (ACS) has not been described yet.

AIM OF THE STUDY

Correlation between the accumulation of calcium within the vessel wall of a coronary artery and the severity of coronary artery stenoses in patients who developed an acute coronary event.

Material and methods

29 patients

Group 1

Ca score < 100

7 patients

Group 2

Ca score 100 - 400

12 patients

Group 3

Ca score > 400

11 patients

CT: 1. calculation of coronary

calcium scoring

1. complex plaque analysis

Group 1 Group 2 Group 3

Mean calcium score(p<0.0001)

gr.1 25.08+/-21.94

gr.2 203.97+/-76.68

gr.3 808.8+/-369.48

.

Results

0

100

200

300

400

500

600

700

800

900

gr.1

gr.2

gr3

Mean ageMean age gr.1 60 years gr.2 65 years gr.3 64 years .

57

58

59

60

61

62

63

64

65

66

gr.1

gr.2

gr3

Ejection Fraction

Ejection fraction ( p=0.03)

Gr.1 54,33%

Gr.2 53% Gr.3 48,09%

3 vessel disease

Gr.1 16,7%

Gr.2 3,3%

Gr.3 27,3%

One single artery diseaseGr.1 83,3%Gr .2 58,3% Gr.3 9,1%

(p=0.02)

Location of the culprit artery

Left anterior descending

Gr.1 66,7%

Gr.2 66,7%

Gr.3 72,7%

Calcium score is significantly associated with the severity of coronary artery disease and can be used as a useful

prediction tool to evaluate the prognostic significance of coronary lesions in a non-invasive way.

Conclusions