This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
(1)(1) T type: T type: Mibefradil Mibefradil (咪拉地尔) (咪拉地尔) (2)(2) N type: N type: Conotoxin Conotoxin (竽螺毒素)(竽螺毒素)(3)(3) P type: P type: Spider toxin Spider toxin (蜘蛛毒(蜘蛛毒
素)素)
(1)(1) T type: T type: Mibefradil Mibefradil (咪拉地尔) (咪拉地尔) (2)(2) N type: N type: Conotoxin Conotoxin (竽螺毒素)(竽螺毒素)(3)(3) P type: P type: Spider toxin Spider toxin (蜘蛛毒(蜘蛛毒
素)素)
Ⅱ Ⅱ Selective effects on other voltage-deSelective effects on other voltage-dependent calcium channelspendent calcium channels ::
Third Third :: PranidipinePranidipine 普拉地平,普拉地平, AmlodipineAmlodipine 氨氯地平氨氯地平
L and T type are the main types in cL and T type are the main types in c
ardiovascular systemardiovascular system, , and and L typeL type is the is the
most important one, which involves maimost important one, which involves mai
nly in the nly in the contraction ofcontraction of cardiac and smcardiac and sm
ooth muscleooth muscle, , sinuatrial node pacingsinuatrial node pacing 窦窦房结率房结率 , and , and atrioventricular conductionatrioventricular conduction
房室间传导房室间传导 . .
Extracellular
III IV
II IIVIII
56
56
Out
In
I II III IV
The The 1C subunit of the L-type Ca1C subunit of the L-type Ca2+2+ channel channel is the pore-forming subunit is the pore-forming subunit
The expression and function of the The expression and function of the 1C 1C subunit is modulated by other smaller subunit is modulated by other smaller subunitssubunits
NH3+
NH3+
COO-
COO-
1C
NH3+
COO-
2
I II III IV
COO-
NH3+
Action ModeAction ModeResting State Open Resting State Open
Cardiac cells rely on L-type CaCardiac cells rely on L-type Ca2+2+ channels for channels for the upstroke of the AP in slow response cellsthe upstroke of the AP in slow response cells
L-Type
Slow Response Cells(SA node, AV node)
Ca2+
Ca2+
40
3
Calcium Channel Blockers
ActionsActions
HeartHeart
negative inotropic effectnegative inotropic effect 负性肌力作用负性肌力作用 negativenegative frequencyfrequency 负性频率 负性频率 and and
negativenegative conductionconduction 负性传导作用负性传导作用::obvious in obvious in sino-atrial node and atrioventricular nsino-atrial node and atrioventricular n
odeode
--rationale for treating supraventricular arrhythmiarationale for treating supraventricular arrhythmia
ActionsActions
HeartHeart
negative inotropic effectnegative inotropic effect 负性肌力作用负性肌力作用 negativenegative frequencyfrequency 负性频率 负性频率 and and
negativenegative conductionconduction 负性传导作用负性传导作用::obvious in obvious in sino-atrial node and atrioventricular nsino-atrial node and atrioventricular n
odeode
--rationale for treating supraventricular arrhythmiarationale for treating supraventricular arrhythmia
smooth musclesmooth muscle
blood vesselblood vessel :: dilate Adilate A>>V; obvious for V; obvious for spasmodic spasmodic