C953-04/00 TilE RAT - US EPA...Jun 27, 1995 · +ve 91ear 300 pci : pjlll date gest'n male young m litl'ered period nlmber day one (days) alive de'.!id : alive alive day 5 11 : young
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'
Li\C953-04/00
PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lN TilE RAT
FEMALE PAJ:IUN:; +VE S-1EAR PCI DATE GEST'N MALE YOUNG AT YOUNG YOUNG YOUNG YOUNG YOUNGNU1BER DATE DATE LITI'ERED PERIOD NU1BER DAY ONE ALIVE ALIVE ALIVE ALIVE ALIVE(DAYSl ALIVE DEAD DAY 5 DAY ll DAY 16 DAY 22 DAY 29
PERCHLOROETIIYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANIMAL DATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITTERS PER SYMPTOM) - F2A PUPS
The incidence is presented as the number of pups affected per litter.
Key:
E = extreme X = present L = left R = right B = bil atera1 M= male F = female
The findings do not include the observations during exposure.
CTL/P/4097 - 1178
(
LAC955-02/02
PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANJMi\L ll>\TA SUPPLEMENT
APPENDIX 2lA
GROUP 00: 3
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS
BODY SYSTEM:
MJTHER NJ, SEVERITY OF LITI'ER CODE
llEliTH
DAY 1
CLINICAL OBSERVATION: FOUND DFAD
DAY DAY DAY DAY DAY DAY DAY 2 3 4 5 6 11 16
(CANNIBIILISEDl
DAY DAY 22 29
1.33 X 2
C'"'l_, r -... -o ......._,. 0 ....,"'
....,-"'
LAC955-02/02
PERCHLORDETHYLENE: MOLTIGENERATION INHALATION STUDY IN TilE RAT
INDIVIDUAL ANlMAL DATA SUPPLJM:NT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITI'ERS PER S'il1Pm1) - F2A PUPS
GROUP ID: 4
BODY SYSIDJ: DEATH CLINICAL OBSERVATION: FOUND DEAD (C'.ANNIBALISED) MJl'HER m. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITI'ER CODE l 2 3 4 5 6 ll 16 22 29
182 X l
"-i.......,,
.......!»0\0....,
,_.,_.co0
-~
LAC955-02/02
PERCHLOROETHYLENE: MULTIGENERA:ITON lNHALATION STUDY IN TilE RAT
INDIVIIX!AL ANJMI\L ll'\TA SUPPLEMENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITI'ERS PER SY.Ml"'tMl - F2A PUPS
GROUP 00: l
BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEIID
M)THER 00. OF LITI'ER
SEVERITY CODE
Jl.\Y l
Jl.\Y 2
Jl.\Y 3
Jl.\Y 4
Jl.\Y 5
Jl.\Y 6
Jl.\Y ll
Jl.\Y 16
Jl.\Y 22
Jl.\Y 29
28 X l
32 X l
('").... r-"'0-~ 0 <.0.....,
.... .... co....
37
39
X
X
2
2
44 X l
47 X l
. -·" ------------··
LAC955-02/ 02
PERCHLOBDETilYLENE: M!JLTIGENERATION JNHAUTION STUDY IN THE RAT
INDIVIIX.lAL ANlMAL DATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS CLITI'ERS PER SYMPTCM) - F2A PUPS
GROUP N:l: 2
BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DE8D MJTHER N:J, OF LITI'ER
SEVERITY CODE
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
DAY 6
DAY 11
DAY 16
DAY 22
DAY 29
74 X 2
75 X 1
n...;
' ...... '"0 ......... 0 <.0 ......
,_. ,_. co N
95 X 3
IAC955-02/02
PERCHLORDE'I'HYLENE: MULTIGENERATION IN!IliLATION STUDY IN THE RAT
INDIVIDUAL .ANIMAL llAXA SUPPLEMENT
liPPENDIX 2JA
GROUP ID: 3
CLINICAL OBSERV.ATIONS (LITTERS PER SYMPTCM) - F2A PUPS
BODY SYSTEM: DEA1'H CLINICAL OBSERV.ATION: FOUND DEi\D
MJTHER ID. OF LITTER
SEVERITY CODE
JlliY 1
JlliY 2
JlliY 3
JlliY 4
Il'\Y 5
D!\Y 6
JlliY ll
JlliY 16
JlliY 22
JlliY 29
121 X 1
128 X 1
('") ..... r........., ........., 0 <0 ......
.... .... 0> w
129
130
133
136
137
X
X
X
X
X
2
1
2
3
2
2
143 X 3
LAC955-02/02
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
BODY SYSTEM: DEATII CLINICAL OBSERVATION: FOUND DF.!ID MYI'liER NO. SEVERITY' DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITTER CODE 1 2 3 4 5 6 11 16 22 29
169 X 1
170 X 2
171 X 2
172 X 1
173 X 1
176 X 1
177 X 2 2
180 X 3
181 X 1
182 X 3 1
187 X 3
189 X 3 1
190 X 1
191 X 2 1
("') -ir-....... "0.........,. 0\0.._,
,...,...Q:l ..,.
LAC955-02/02
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVI!XJAL ANIMAL ll'lTA SUPPLlliENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITTERS PER SYMP'ro1) - F2A PUPS
GROUP NO: 4
BODY SYSTEM: DEATH CLINICAL OBSERVATION: KILLED INVESTIGATION
MJT!IER NO. OF LITTER
SEVERITY CODE
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
DAY 6
DAY 11
DAY 16
D.A.Y 22
DAY 29
175 X 2
187 X 2
("") ......-... "0-.....,. 0
"" ......
..... ..... co U'1
LAC955-02/02
PERCHLORDEI'HYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT
INDIVllXIAL ANlMAL DATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS CLITIERS PER SYMP'JXM) - F2A PUPS GROUP NO: l
BODY SYSTEM: DEATH CLINICAL OBSERVATION: KILLED IN EliTREMIS MJTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITIER CODE l 2 3 4 5 6 ll 16 22 29
39 X 2
45 X l
('")-;
.......,r
......~lO......
..........co"'
l.AC955-02/02
PERCI:Il..ORDETHYLENE: MIJLTIGENERATION IN!lALATION STUDY IN THE RAT
INDIVIDUAL AN.IMAL Jl.\TA SUPPLEMENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS
GROUP 00: 2
BODY SYSTEM: llEA1'H CLINICAL OBSERVATION: KilLED IN EXTREMI:S
MJTHER 00. OF LITI'ER
SEVERITY CODE
DAY l
D.A.Y 2
DAY 3
D.A.Y 4
DAY 5
D.A.Y 6
DAY ll
DAY 16
DAY 22
DAY 29
83 X l
("") -1.... .......,...... ""' 0 0.0 ......
..... ...... o:> ......
I.
LAC955-02/02
PERC!lLORDETHYLENE: MIJLTIGENERATION INHAL/\TION STUDY IN THE RAT
INDIVI!JUAL .ANIMAL DATA SUPPLEMENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS GROUP NO: 3
BODY SYSTEM: DEATH CLINICAL OBSERVATION: KilLED IN EXTREMIS MJTBER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITTER CODE 1 2 3 0 4 ~ 6 11 16 22 29
130 X 2
133 X 1
137 X 1
144 X 2
("')
I'"' ...... ..,-i
.......,.0<0....,
..........cccc
I.<\C955-02/02
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIIXJAL ANIMAL DATA SUPPLEMENT
APPENDIX 2lA
GROUP NJ: 4
CLINICAL OBSERVATIONS (LITTERS PER SYMPTCMl - F2A PUPS
BODY SYSTEM:
MJTHER NJ. SEVERITY OF LITIER OODE
171 X
DEATH
JlA.Y 1
JlA.Y 2
JlA.Y 3
2
JlA.Y 4
JlA.Y 5
CLINICAL OBSERVATION:
JlA.Y JlA.Y 6 11
KILLED IN EXTREMIS
JlA.Y JlA.Y 16 22
JlA.Y 29
173 X 2
'"'-l r...... -o ......... 0
"' .....,
.... .... co "'
175
176
177
182
189
X
X
X
X
X
3
1
1
1
2
2
190 X 2
LAC955-02/02
PERCHLOROETHYLENE: MLlLTIGENERATION INHilllmON STUDY IN THE RAT
INDIVIlXlt\1 1INlMIIL DATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - F2A PUPS GROUP NO: 1
BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSING,PBEstM:D DEAD M:JTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5 6 11 16 22 29
32 X 2 34 X 1
36 X 137 X 4
39 X 4
40 X 5
41 X 1 43 X 1
45 X 4
("") .... r....... '"0....... 0""' 1.0 ......
--1.0 0
LAC955-02/02
PERCHLOROETHYLENE: MULTIGENERATION JN!lAL.<\TION STUDY IN TilE RA:r
INDIVIDUIIL AN1MAL IWrA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS
GROUP ID: 2
BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSJN:;.PRESU1ED DEAD
M:lTHER ID. OF LITTER
SEVERITY OODE
J:l.IU' 1
D.'\Y 2
D.'\Y 3
J:l.IU' 4
J:l.IU' 5
DAY 6
J:l.IU' ll
J:l.IU' 16
J:l.IU' 22
J:l.IU' 29
73 X 1
77 X 2
('"') -i r ....... -o ........., 0
"" .....,
--"" .....
81 X 2
87 X 2
88 X 1 2
89 X 1
91 X 3
93 X 1 1
95 X 6
96 X 1
LAC955-02/02
PERCHLOROET!:!YLENE: MDLTIGENERATION INHALIITION STUDY 1N THE RAT INDIVIDUAL .i\NIM8L DATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITTERS PER SYMP'I'Q1) - F2A PUPS GROUP NO: 3
BODY SYSTEM: DEAl'H CLINICAL OBSERVATION: MISSING,PRESLMED DEADMlTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY OF LIITER DAY CODE DAY DAY1 2 3 4 5 6 11 16 22 29
125 X 1 126 X 2 1 129 X 2130 X 2135 X 1 1138 X 2 143 X 3 144 X 3
(") .... ,... ....... "0....... ..,. 0....., ""
.......... ""N
'~
LIIC955-02/02
PERCHLORDETHYLENE: !1llLTIGENERATION INHALIITION STUDY IN THE RAT
INDIVIDUAL AlmlAL DATA SUPPLEMENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCMl - F2A PUPS
GROUP 00: 4
BODY SYSTEM: llEATil CLINICAL OBSERVATION: MISS:rn:;, PRESlliED DEAD
MJTHER 00. OF LIITER
SEVERITY OODE
DAY 1
DAY 2
DAY 3
DAY 4
Dl\l' 5
Di\.Y 6
DAY 11
DAY 16
DAY 22
]l.;.Y 29
169 X 1 1
171 X 6
(") -l........., ...... ""' 0
'""....,
...... ...... '"" w
172 X 1
173
174
X
X
2
5
175 X 3 1
176 X 1
180 X 8
182 X 1 1
185 X 2
186 X 1
187 X 6
189 X 1
LAC955-02/02
PERCHLOROETHYLENE: MIJLTIGE:NERATION INHAlATION STUDY IN THE RAT
INDIVIIXTAL .ANIMAL !lATA SUPPLEMENT
.APPENDIX 21A
CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - F2A PUPS GROUP NO: 3
BODY SYSTEM: EQUILIBRitM AND GAIT CLINICAL OBSERVATION: REW::ED HINDLIMB l'tiOCTION MlTHER NO. SEVERITY DKi DKi DKi DKi DKi DKi DKi DKi DKi DKiOF LITI'ER CODE 1 2 3 4 5 6 11 16 22 29
130 E 1
("')...........''"0.......1:>0
-1.0.....,
..... 1.0.1:>
~'
LAC955-02/02
PERCHLOROEI'!IYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANJ:M<\L DATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITTERS PER SYMP'l'CM) - F2A PUPS
GROUP NO: 2
BODY SYSTEM: EYES GENERAL CLINICAL OBSERVATION: CHRCMJll'ICRYORRHE'A
MJTilER NO. OF LITTER
SEVERITY CODE
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
no,y 6
DAY ll
DAY 16
DAY 22
DAY 29
91 L 1 1
n
........., ' -f
....... 0 ""' .....
.....
'""
..... 0"1 '""
,_
LAC955-02/02
PERCill.OROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANlMIIL lliiTA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS GROUP NO: 3
BODY SYSTEM: EYES GENERAL CLINICAL OBSERVATION: CHRJ:Mlll>\CiilRRHFAMlTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY OF LITI'ER DAY CODE DAY DAY1 2 3 4 5 6 11 16 22 29
126 L 1 1
132 B 1 1 1
n-ir-..."'0-... 0""'lO......
..........lOC'l
~
("") -i, ....... ....... ""'..,. 0
..... ""
--..... ""
····- ·------ ----~--
LIIC955-0Z/OZ
PERCHLOBDETHYLENE: MULTIGENERATION IN!lALATION STUDY IN THE RAT
INDIVIIJUAL ANlMAL DATA SUPPLEMENT
APPENDIX Z1A
CLINICAL OBSERVATIONS (LIT!'ERS PER SYMPTCM) - F2A PUPS
GROUP NO: 4
BODY SYSTEM: EYES GENERAL CLINICAL OBSERVATION: CER!M)J:l.\CRYORRHE'A
M:lTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITI'ER OODE 1 z 3 4 5 6 11 16 zz 29
171 R 1 1
172 R 1
191 L 1
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIOOAL ANIMAL DIITA SUPPLEMENT
APPENDIX 2JA
CLINICAL OBSERYATIONS (LITTERS PER SYMI?TCM) - F2A PUPS GROUP NJ: 1
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD MlT!lER NJ. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LI'ITER CODE 1 2 3 4 5 6 11 16 22 29
28 X 1
32 X 1
37 X 2
39 X 11
40 X 1
43 X 1
45 X 7
46 X 4
"-1..........-c.........0.....,"'
.........."'CXl
LAC955-02/02
~.
l.AC955-02/02
PERCHLOROETHYLENE: MDLTIGENERATION INHAlATION STUDY IN THE RAT
INDIVIOOAL ANlMI\L DATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVI\TIONS (LITI'ERS PER SYMPTCMl - F2A PUPS
GROUP 00: 2
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD
MlTHER 00. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITI'ER CODE 1 2 3 4 5 6 11 16 22 29 73 X 2
76 X 2
77 X 2
81 X 1
88 X 1
91 X 13
94 X 2
95 X 11
(") -l,... ...... -o ...... ... 0 \0 ....,
..... ..... \0 \0
l'ERall..ORDETHYLENE: MllLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIOOAL ANJMAL OOA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS CLITI'ERS PER SYMP'l'a1) - F2A PUPS GROUP NO: 3
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD M:lTHER NO. SEVERITY TWI DAY DAY DAY DAY DAY DAY TWI DAY DAY OF LITI'ER CODE 1 2 3 4 5 6 11 16 22 29
126 X 1
130 X 2
131 X 1
133 X 1
143 X 8
144 X 12
LAC955-02/02
("") ....,......r .,...... -!'>0<.0 .....
N..... 00
~-',
LliC955-02/02
PERCHLOilDET!IYLENE: MULTIGENERATION lNHALIITION STUDY IN THE RAT
INDIVIDUAL ANIMAL J:li\11\ SUPPLEMENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'ICM) - F2A PUPS
GROUP 00: 4
BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: OOLD
MlTHER 00. SEVERITY DAY D."-¥ DAY DAY DAY DAY DAY DAY DAY DAY OF LITI'ER OODE 1 2 3 4 5 6 11 16 22 29 169 X 1
171 X 4
173 X 4
176 X 1
180 X 2
182 X 1
186 X 2
189 X 7
191 X 1
("") -i
....... '
....... '"" ..,. 0 <D
"
...... N 0 .....
LAC955-02/02
PERCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIOOAL ANlMAL DATA SUPPLEMEN'l'
APPENDIX 2JA
CLINICAL OBSERVATIONS (LITl'ERS PER SYMPTCM) - F2A PUPS GROUP NO: 2
BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: HIND LlMB J:li>MAGEDMJTHER NO. SEVERITY IlAY IlAY DAY IlAY IlAY IlAY IlAY IlAY DAY OF LITI'ER DAYOODE l 2 3 4 5 6 ll 16 22 29
93 L l
.........
., 0
("")............
...,"'
N..... 0N
.~
LAC955-02/02
PERCHLORDETHYLENE: MULTIGENERATION IN!l'Al.AITON STUDY IN THE RAT
INDIVIlXJAL AN:lMAL DATA SUPPLEMENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'ICM) - F2A PUPS
GROUP 00: 3
BODY sYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: IIDID LlMB DliMAGED
PERCHLOROErllYLENE: MULTIGENERATION INIWATION STUDY IN THE RAT
INDIVIDUAL .ANIMAL IliiTA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS GROUP NO: 4
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: HIND LIMB llliMAGED1-DTilER NO. SEVERITY D.'U' Dtcr Dtcr Dtcr Dtcr D.'<Y OF LITI'ER Dtcr Dtcr CODE Dtcr 1 Dtcr2 3 4 5 5 11 16 22 29
170 R 1
185 B 2
('"').....r......"0.........,.0....,'""
.......,.0N
LAC955-02/02
PERCHLOBDETI!YLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANIMAL IlATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITI'ERS PER SYMP1U1) - F2A PUPS
GROUP NO: 1
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: HIND LlMB 5\o!JLLEN
MJTHER NO. OF LITTER
SEVERITY CODE
DAY 1
DAY 2
Il.'>Y 3
DAY 4
DAY 5
DAY 6
DAY 11
DAY 16
DAY 22
DAY 29
28 L 1
47 B 1
("')
........,' -;
...... ""'0
..... ""
..... N 0 U"1
PERCHLOROETHYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT
INDIVJIIUAL ANlMAL DATA SUPPLEMENT
.APPENDIX 21A
CLINICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2A PUPS GROUP NO: 1
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: MJRIBUND MlTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITI'ER DAY CODE 1 2 3 4 5 6 11 16 22 29
37 X 1
. L
LAC955-02/02
r,-!r ......-c.........0
......
N.....
"'0
""
LAC955-02/02
PEllCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDJAL ANIMAL DllTA SUPPLEMENT
APPENDIX 2JA
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS
GROUP NO: 2
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: PALE
MJTHER NO. OF LITI'ER
SEVERITY OODE
JltiY 1
JltiY 2
JltiY 3
JltiY 4
Di\Y 5
Di\Y 6
JltiY 11
JltiY 16
Di\Y 22
JltiY 29
91 X 2
-i " r-.... -....'"" 0"" ...... ""
,_. N 0 ......
LAC955-02/02
PERCHLOROE'l.'l!YLENE: MULTIGENERATION INHALATION STUDY lN THE RAT
INDIVI!XTAL ANlMi\L DATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITIERS PER SYMPTCM) - F2A PUPS GROUP NO: 4
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: PALE M)'!'HER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITTER DAYOODE 1 2 3 4 5 6 11 16 22 29
173 X 2
n-ir.._-o......."""0<D....,
......N0C»
.~. \ \
18C955-02/02
PERCHLOROEI'l!YLENE: MULTIGENERATION INHALAl'ION STUDY IN THE RAT
INDIVIDl.lAL ANlMIIL DATA SUPPLEMENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS
GROUP NO: 1
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: ~
J1)THER NO. OF LITI'ER
SEVERITY CODE
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
DAY 6
DAY ll
DAY 16
DAY 22
DAY 29
26 X 1
37 X 1
47 X 2 (") -l.-.....,-... "" 0
"" ......
-N 0
""
PERCHLORDEI'IlYLENE: MIJLTIGENERATION 1NEALATION STUDY IN THE RAT
INOIVIIXli\L ANlMi\L DATA SUPPLEMENT
APPENDlX 21A
CLINICAL OBSERVATIONS (LI'l'rERS PER sYMP'ltM) - F2A PUPS GROUP NO: 2
BODY SYSTEM: GENERiiL CONDITION CLINICAL OBSERVATION: OMI\LL MlTBER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LI'ITER CODE 1 2 3 4 5 6 ll 16 22 29
76 X 1
86 X 1 1 1 1 90 X 1 1 1 1 1
- -~ -. -- ·- _J.
LAC955-02/02
("')
...._-ir "'0...._...0<.0......
....N
0....
LAC955-02/02
PERCHLO!lOET!lYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIIXIAL ANlMAL l:l!\TA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LITIERS PER SYMPTCM) - F2A PUPS
GROUP NO: 3
BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: SMALL
M)THER NO. OF LITI'ER
SEVERITY OODE
DAY 1
DAY 2
DAY 3
DAY 4
lltU' 5
DAY 6
DAY 11
DAY 16
DAY 22
DAY 29
124 X 3 1 1 1 1
134 X 1
"-i r....... -o .........,. 0 \0 ......
.... N ..... ....
135
137
140
X
X
X
1
1
1
1
1
1
1
1
1
1
1
'"
LAC955-02/02
PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY JN THE R<\T
INDIVIDllAL 1INlMAL lliiTA SUPPLEMENT
APPENDlX 2lA
CLJNICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2A PUPS GROUP ID: 4
PERCHLORDETHYLENE: MllLTIGENERliT.ION INHALATION STUDY lN THE RAT
INDIVIJX!AL ANIMAL D.-'ITA SUPPLEMENT
APPENDJX Z1A
CLINICAL OBSERVATIONS (LITTERS PER SYMI?TCMl - FZA PUPS
GROUP 00: l
BODY SYSm!: GENERAL CONDITION CLINICAL OBSERVATION: TAIL DAMAGED
MJTHER 00. OF LITTER
SEVERITY CODE
DAY l
DAY z
DAY 3
DAY 4
DAY 5
DAY 6
DAY ll
DAY 16
DAY zz
DAY 29
41 X 1
("") -l r ....... "0 ....... 0 """ u::>-..
...... N ...... w
PERCHLOROE'I'HYLENE: MULTIGENERATION INHALATION STIIDY IN THE RAT
INDIVI!XlAL ANIMAL DATA SUPPLEMENT
.APPENDIX 21A
CLINIC&. OBSERV.ATIONS (LITTERS PER SYMPTCM) - F2A PUPS
GROUP 00: 1
BODY SYSTEM: GENERAL OONDITION CLINIC&. OBSERV.ATION: SEE FREE TEXT MlTHER 00. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITI'ER OODE 1 2 3 4 5 6 11 16 22 29
44 X 1
-··--·-·---~·----- ---·--- ----
I..A£955-02/02
('")
......r-i
.,......""'0
"""
N..........""'
~,
LAC955-02/02
PERCHLORDETHYLENE: MIJLTIGENERATION lliHA!.ATION STUDY IN THE RAT
INDIVIWAL ANlMAL IliiTA SUPPLE!1ENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS
GROUP 00: 2
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SEE FREE TEXT
PERCHLORDETHYLENE: MULTIGENERATION INHAJ:.ATION STUDY lN THE RAT
lNOIVIIX.IAL liNlMAL DATA SUPPLEMENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LITI'ERS PER SYMI'TCM) - F2A PUPS GROUP NO: 3
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SEE FREE 1EXT M)THER. NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITl'ER DAYCODE 1 2 3 4 5 6 11 16 22 29
127 X 1
130 X 1
144 X 1("") ....-...,r-....,.0.....,""
.....N.....en
Ll\C955-02/02
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIIXIAL 1INJMAL DATA SUPPLEMENT
APPENDIX 2lA
CLINICAL OBSERVATIONS (LIITERS PER SYMPTCM) - F2A PUPS
GROUP NO: 1
BODY SYSTEM: CLlN OBS RELATING TO HEAD CLINICAL OBSERVATION: HEAD SIDLLEN
MlTilER NO. OF LITIER
SEVERITY CODE
DAY 1
llliY 2
llliY 3
llliY 4
llliY 5
llliY 6
llliY 11
llliY 16
llliY 22
llliY 29
26 X 1
('") ....; ;...... ...... ""' "" 0 <.0 ......
..... N ..... ......
LAC955-02/02
PEBCHLORDE'l'l!YLENE: MDLTIGENER/\TION INHAl.ATION STUDY IN 'l1lE RAT
INDIVIOOAL ANlMAL DATA SUPPLEMENT
APPENDIX 21A
CLINICAL OBSERVATIONS (LI1TERS PER SYMPTCM) - F2A PUPS
COMMENT PAGE
CCM1ENTS: MJTllER NO. DAY NO. CCM1ENT
26 16 M 19.0g KlLLED SICK - AFTER CLIN-OB (10:00AM)
26 22 1 PUP TERMlNA1'ED DAY 16.
26 29 1 PUP TERMlNA1'ED DAY 16.
28 5 ONE PUP SEZED WRONG DAY 1 SHOULD BE MALE NOT Fl!MALE.
29 11 ONE Fl!MALE WRONGLY SEZED, SHOULD BE 5 MALES, 8 Fl!MALES. DAY 11.
36 5 ONE PUP EXTRA DAY 5 (Fl!MALE) •
37 1 MALE 6. Og COLD AND MJRIBUND DIEO AFTER CLINICAL OBSERVATION.
39 1 2 PUPS (KlLLED SICK) MJRIBUND.
40 22 DAY 21 ONE PUP FOUND WITH lli\l1AGE TO HEAD.
41 5 One extra pup found day 5 ,
44 1 MALE 6 • 6 BRUISING ON CHIN
44 5 One extra pup found day 5. (Fatale).
45 1 F 5.5g (KlLLED SICK) - WJUND TO LEFT SIDE OF HEAD.
74 1 M 6.0g accidently dropped, appears OK. F 5.9g bruised head.
74 5 One male pup sexed wrongly day 1. Should be 8 males, 3 fatales.
78 5 ONE Fl!MALE PUP SEXED WRONG DAY 1 SHOULD BE MALE.
78 11 ONE PUP SEZED WRONG DAY 5 SHOULD BE 5 MALES 6 Fl!MALES.
90 5 ONE PUP SEXED WRONG DAY 1. EXTRA Fl!MALE INSTEAD OF MALE DAY 5.
-; (")
.......r., ....... "" 0 <0......
....N ..... ():)
~
LAC955-02/02
PERCHLOROETHYLENE: MULTIGENERATION lNHt\IATION STUDY IN THE RAT
INDIVIDUAL ANlMAL DATA SUPPLEMENT
APPENDIX 2lA
CLINIQ\L OBSERVATIONS (LITTERS PER SYMI?TCMl - F2A PUPS
COMMENT PAGE
CCM1ENTS: MJTHER NJ. DAY NJ. CCM1ENT
92 1 F s.og snout bruised.
126 5 ONE PUP SEXED WRONG DAY 1 FE1ALE SHOULD BE MilLE.
127 1 MilLE PUP 5.6g LEFT HIND LIMB MAI.:ROTATED.
132 11 DAY 11 ONE PUP SEXED w"RONG DAY 1 & 5 SHOULD BE 13M, SF.
137 1 M 5. Sg KILLED SICK - TAIL MISSING AND RIGHT HIND RXJT CANNIBALISED
144 1 SKIN TORN UNDER LEFT FOBELIMB.
144 3 BOTH PUPS HAVE YELLOW COLOUBATION OF SKIN.
169 5 EXTRA MilLE FOUND DAY 5, PUP LOST DAY 2 TO BE DELETED.
171 5 ONE PUP SEXED WRONG DAY SHOULD BE MilLE NOT FE1ALE.
177 2 1 extra female found day 2.
187 4 ONE FEMIILE FOUND DAY 4.
n -i ,.-.., -""'0 \0 .......
.... N .... \0
(
(
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANIMAL DATA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITTERS PER SYMPTOM) - F2B PUPS
The incidence is presented as the number of pups affected per litter.
Key:
X = present
CTL/P/4097 - 1220
I..AC955-02/02
PERCHLOROETHYLENE: MIJLTIGENERATION INHAI.ATION STUDY IN THE RAT
INDIVIJJUAL ANlMAL DATA SUPPLEMENT
.APPENDIX 2lB
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2B PUPS
GROUP NO: 1
BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEAD (CANNilll\LISEDl
MYI'BER NO. OF LITI'ER
SEVERITY CODE
Jl.\Y 1
Jl.\Y 2
Jl.\Y 3
Jl.\Y 4
Jl.\Y 5
34 X 1
41 X 1
('") -i r-"0 .........,. 0
'""....,
,_. N N,_.
---------. ----------------- -------- L.
L.'\C955-02/02
PERCHLOROETHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT
INDIVIDUAL .1\NIMi\L DATA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'ro1) - F2B PUPS GROUP NO: 3
BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEAD (C\NNIBALISED)MlTHER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5
143 X 1
"-!r......'"0...... 0""......""
....NNN
-.
I.M:955-02/02
PERCHLORDETHYLENE: MllLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIOOAL ANIMAL DATA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (Ll'ITERS PER SYMPTCM) - F2B PUPS
GROUP N:J: 4
BODY SYSTEM: llEA'IH CLINICAL OBSERVATION: FOUND DEAD (CANNIBALISED)
M)TilER N:J. OF LITI'ER
SEVERITY OODE
DAY 1
D.>\Y 2
DAY 3
DAY 4
DAY 5
174 X 2
179 X 2
182 X 2
185 X 1
192 X 2 1
('") -i r...._ ..,...._..,. 0 <0 ......
.... N N w
LAC955-02/02
PERCHLORDETI!Yl.ENE: MDLTIGENERATION INHAl..ATION STUDY lN THE RAT
INDIVIDUAL AN1MAL DATA SUPPLEMENT
APPENDIX 21l3
CLlNICAL OBSERVATIONS (LITI'ERS PER S'iMPTCM) - F2B PUPS GROUP NO: 1
BODY SYSTEM: DEATH CLlNICAL OBSERVATION: FOUND DEAD MlTHER NO. SEVERITY DAY DAY DAY DAY DAYOF LITTER CODE 1 2 3 4 5
29 X 1
30 X 2
34 X 1
41 X 6
47 X 1
"-i..-.......-c....... "" 0\0.....
,_. NN
""
LAC955-02/02
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIIJlli\L ANJMAL DATA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - F2B PUPS
GROUP 00: 3
BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEAD
M:lTHER 00. OF LITTER
SEVERITY CODE
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
121 X 1
130 X 1
136 X 1
144 X 2
('") -1........ "'0 ........,. 0
"'....,
..... N N U1
'
I.M:955-02/02
PERCHJ..ORDE'l'HYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT
INDIVIIJUAL .ANIMAL Th\TA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS CLITI'ERS PER SYMP'KM) - F2B PUPS GROUP N:J: 4
BODY SYSTEM: D&\TH CLINICAL OBSERVATION: FOUND IID\DMJTHER N:J, SEVERITY DAY Di\Y DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5
170 X 1 171 X 1
172 X 2
175 X 4 2
179 X 3
182 X 6 1
185 X 4
188 X 1
190 X 2
192 X 1
".......r-i
.,....... 0 ""' """
...... NN
"'
LAC955-02/02
PERCHLOROETilYLENE: MULTIGENERATION INHliiATION STUDY IN THE RAT
INDIVIOOAL 1INJMIIL DA:rA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITIERS PER SYMP'I'CM) - F2B PUPS
GROUP NO: 3
BODY SYSTEM: DEATH CLINICAL OBSERVATION: KILLED l'OR HtMIINE REASONS
MJTilER NO. OF LITTER
SEVERITY CODE
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
123 X 3
(""") -i r ........, ........, 0 ....., "'
...... N N.....,
LAC955•02/02
PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lN THE RAT
INDIVIDJAL 1lNlli\L Jl.\TA SUPPLEMENT
APPENDIX 2lB
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2B PUPS
GROUP NO: l
BODY SYSTEM: llFATll CLINICAL OBSERVATION: 1C!LLED lN EliTREMIS M:l'I'HER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE l 2 3 4 5
30 X l
n,...-i
......."'C........,.0\0....,
CX>-"'"'
--
LAC955-02/02
PERCHLOROEI'HYLENE: MULTIGENERATION INIIAUI1'ION STUDY IN THE Rl\1'
INDIVIDUAL ANIMAL DATA SUPPLEMENT
APPENDIX 21B
CLINIC8L OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2B PUPS
GRlJUP NO: 3
BODY SYSTEM: DEATH CLINIC8L OBSERVATION: Kil.J1lD IN EXrREMIS
MlTliER NO. SEVERITY DAY DAY DAY DAY DAY OF LITI'ER CODE 1 2 3 4 5
126 X 1
("")_, , -o --..,. 0
...... ""
...... N N
""
LAC955-02/02
PERCBLOROETHYLENE: MULTIGENERATION lNHAIATION STUDY IN THE RAT
INDIVIDUAL .I\NIMI\1 DATA SUPPLEMENT
APPENDIX 2lB
CLINICAL OBSERVATIONS (LIITERS PER SYMPTCM) - F2B PUPS
GROUP NO: 4
BODY SYSTEM: DEATH CLINICAL OBSERVATION: KILLED IN EliTREMIS MJTHER NO. OF LIITER
SEVERITY OODE
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
175 X 3
187 X 1
("') -l r...... -o ........, 0 1.0....,
..... N w 0
UIC955-02/02
PERCHLORDETIIYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIIXIAL ANIMAL JlliTA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITI'ERS PER sYMPTCM) - F2B PUPS
GROUP ID: 1
BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSm:;. PREStMED DEAD M:lTHER m. SEVERITY D.>\Y DAY DAY DAY DAYOF LITTER CODE 1 2 3 4 5
41 X 3
46 X 2
48 X 1".......--..-o--....,.
-0<0....,
Nw-
L!IC955-02/02
PERCHLOROETHYLENE: MULTIGENERATION IN!lAI.ATION STUDY JN THE RAT
JNDIVIlli18L ANJMliL DATA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'l'Cl1) - F2B PUPS
GROUP ID: 3
BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSING,PRES!.MED DEAD MJTl:!ER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE l 2 3 4 5
124 X l
126 X 2
128 X l
133 X l
137 X 2
144 X 4
.......r n-1
.,....... ... 0lO.....,
....NwN
~-----
LAC955-02/02
PEru::!!LOROE'IHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT
INDIVIOOAL ANIMAL DATA SUPPLEMENT
APPENDIX 2lB
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2B PUPS
GROUP N:l: 4
BODY SYSTEM: IJEA1'H CLINICAL OBSERVATION: MISSING,PRESLMED DEi\D
MJTHER N:l. OF LITI'ER
SEVERITY CODE
DAY 1
DAY 2
Il<\.Y 3
DAY 4
DAY5
169 X 1
171 X 2
172 X 9
176 X 1
179 X 4
180 X 6
185 X 1
186 X 1
188 X 2
191 X 1
192 X 1
" ..... r -. ., .........,. 0 \0 ....,
..... N w w
LAC955-02/02
PERCHLOROETHYLENE: MOLTIGENERATION INHAlATION STUDY IN THE RAT
INDIVIDUAL IINll1AL ll8TA SUPPLEMENT
.APPENDIX 2lB
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2B PUPS GROUP 00: l
BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: 0010 MlT!lER NO. SEVERITY I>\¥ I>\¥ I>\¥ I>\¥ I>\¥OF LITI'ER OODE l 2. 3 4 5
35 X l
38 X l
('")
.._-lr
.._.,...0lO....,
N..... w...
,~
LAC955-02/02
PERCHLORDETHYLENE: MULTIGENERATION lNHAI.ATION STUDY IN THE RAT
INDIVIDUAL liN1MAL DATA SUPPLEMENT
APPENDIX 2lB
CLINICAL OBSE!WATIONS (LITTERS PER SYMP'ICM) - F2B PUPS
GROUP NO: 3
BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: OOLD
MJTHER SEVERITY DAY DAY DAY DAY DAY OF LITI'ER OODE 1 2 3 4 5
137 X 2
m.
n -< r..... "'0 .......,. 0 .....,"'
-N w U1
-- -- ! -
LAC955-02/02
PERCHLOROE'l1lYLENE: MULTIGENERATION INHIIJ.ATION STUDY IN THE RAT
INDlVI!JUi\L ANIMAL DATA SllPP.LEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITTERS PER SYI1I'TCM) - F2B PUPS GROUP NO: 4
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD MJTHER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5
169 X 1
171 X 1
177 X 1
179 X 4
185 X 1
188 X 2
190 X 4
(""")
......r-!
"0...... 0"""1.0 ......
'....w""0'>
I.
J..J\C955-02/02
PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lli THE RAT
INDIVIIJUAL AN1WIL DATA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCMl - F2B PUPS
GROUP NJ: 1
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: PALE
M:lTHER NJ. OF LITIER
SEVERI1Y OODE
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
39 X 1
n -f....... "'0 ...... 0 """ ...., "'
..... N w....,
-------------------------~~---- -- ·--· "L
LAC955-02/02
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL 1INM\L DATA SUPPLEMENT
APPENDIX 2lB
CLINICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2B PUPS
GROUP I'D: l
BODY SYSTEM: GllNERAL CONDmON CLINICAL OBSERVATION: i:MALL M)T!lER I'D. OF LITI'ER
SEVERITY CODE
DAY l
DAY 2
DAY 3
DAY 4
D.'<Y5
39 X l l
47 X l
n -;
........, r
....... .... 0 1.0 ......
..... N w ():)
-~,
LAC955-02/02
illTHER NO. OF LITTER
SEVERITY CODE
DAY 1
DAY 2
DAY 3
DAY 4
DAY 5
128 X 1
140 X 1 1
(") ............ '"0 ........,. 0
""' "
..... N w ""'
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVI!XlAL iiNIMIIL DATA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPitMl - F2B PUPS
GROUP NO: 3
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SMAI.J..
I"
LAC955-02/02
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVlDUAL ANM\1 DATA SUPPLEMENT
APPENDIX 21B
CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'J'(M) - F2B PUPS
GROUP NO: 4
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: OMALL MlTHER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5
169 X 1
171 X 1
180 X 2
190 X 2
192 X 1
n -ir-...... "'0...... ""'0 <0....,
N..... ""'0
"~ ~---
l..AC955-02/02
PERCHLORDE:l'HYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT
INOIVIlXIAL ANlM.'\L DATA SUPPLEMENT
APPENDIX 2lB
CLINICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2B PUPS
GROUP l'Kl: 3
BODY sYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SEE FREE TEXT
MJTHER l'Kl. SEVERITY DAY DAY DAY DAY DAY OF LITTER CODE 1 2 3 4 5
142 X 1
(""')_, r ....... '"t:l ....... 0""' ..... '""
...... N
...... ""'
--
LAC955-02/02
PERCHLORDETilYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT
INDIVIDUAL ANIMAL DATA SUPPLEMENT
APPENDIX 21B
CLJNICAL OBSERVATIONS (LIITERS PER SYMPTCM) - F2B PUPS
COMMENT PAGE
CCM1ENTS: MlTHER NO. DAY NO. CCM1ENT
41 1 3 LIVE PUPS IXl NOT APPEAR TO HAVE BEEN FED.
123 1 PUPS KILLED DUE TO DAM KILLED DIFFICULT PARTURITION
142 1 FE1ALE 4. 8g BRUISING TO BACK OF HEAD.
175 1 THREE PUPS KILLED SICK AlL MlRIBUND.
182 1 LIVE PUP !XlES NOT APPEAR TO HAVE BEEN FED.
187 1 FE1ALE PUP 4.6g MlRIBUND.
189 5 1 m!ALE SEXED WRONGLY AT DAY 1.
190 1 LIVE PUPS APPEAR NOT TO HAVE BEEN FED.
"-! ...... ' "0 ......... 0 ...,"'
.... N... N
-~
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANIMAL DATA SUPPLEMENT
APPENDIX 21C
CLINICAL OBSERVATIONS (LITTERS PER SYMPTOM) - F2C PUPS
The incidence is presented as the number of pups affected per litter.
Key:
X = present F = female
CTL/P/4097 - 1243
LI\C955-02/02
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIllUAL AN1MAL DATA SUPPLEMENT
APPENDIX 21C
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCMl - F2C PUPS
GROUP NO: 1
BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEAD
MJTHER NO. OF LITI'ER
SEVERITY CODE
DAY 1
DAY 5
210 X 1
212 X 1
n ..... r ........, ......... 0 \0....,
..... 1'0......
-·--·-··-·---
LAC955-02/02
MJTilER N:). OF LITI'ER
SEVERITY CODE
DAY 1
DAY 5
225 X 1
227 X 1
231 X 2
242 X 1
246 X 1
247 X 2
n --l r-........, ........,. 0 <.0 ....,
...... N.,. <.TI
PERCHLOROEl'HYLENE: MULTIGENERATION INHALATION STUDY lli THE RAT
INDIVIIXJAL ilNJMI\L DATA SUPPLEMENT
APPENDIX 21C
CLINICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2C PUPS
GROUP N:l: 4
BODY SYSTEM: DFATH CLINICAL OBSERVATION: RJUND DEAD
LAC955-02/02
PERCHLORDEI'HYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIIXIAL ANIMAL DATA SUPPLEMENT
APPENDIX 21C
CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCMl - F2C PUPS
GROUP NO: 1
BODY SYSTEM: llEAXll CLINICAL OBSERVATION: MISSIN:;,PRESlMED DEAD
Ml'l'HER NO. OF LITI'ER
SEVERITY CODE
DAY 1
DAY 5
201 X 1
202 X 1
204 X 1
207 X 1
209 X 1
2ll X 1
212 X 1
2l3 X 2
217 X 1
218 X 2
219 X 1
220 X 1
224 X 8
('")
-<, .
"""
......, ...... 0
"' .....,
.... N
0"1 """
_L.
LAC955-02/02
PEru::Hl..ORDErHYLENE: MULTIGENERATION 1NHALATION STUDY IN THE RAT
INDIVIDJAL ANJMi\1 DATA SUPPLEMENT
APPENDIX 21C
CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'ICM) - F2C PUPS GROUP NO: 4
BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSING,PREStl1ED DEAD MJTHER NO. SEVERITY DAY DAYOF LITI'ER CODE 1 5
225 X 1
226 X 1
227 X 1
228 X 1
231 X 1
232 X 1
237 X 2
240 X 1
241 X 2
242 X 3
243 X 1
245 X 1
('"')
-....-fr "'C-.... ..,. 0
......
N
"'
-..,......,
LAC955-0Z/OZ
PEI<CHLOROET!!YLENE: MULTIGENERATION 1NHAI.JITION STUDY IN 'IHE RAT
INDIVIDUAL AN1M!IL Jl.\TA SUPPLEMENT
APPENDIX ZlC
CLINICAL OBSERVATIONS (Ll'ITERS PER SYMP'ID1l - F2C PUPS
GROUP NO: 1
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD
MlTHER NO. OF LITI'ER
SEVERI'lY CODE
D.'IY 1
DAY 5
Zll X 1
Zl5 X 1
ZZ4 X 2 n -i, .._ -o.._ ., 0 '-0.....,
N --<> ():)
-- - .l
LAC955-02/02
PERCHLORDETHYLENE: MULTIGENERATION :rnHALATION STUDY lN THE RA:r
lNDIVIDJAL ANIMAL IliiTA SlJPPLEl1ENT
APPENDIX 21C
CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - F2C PUPS
GROUP N:l: 4
BODY SYSTEM: GENERAL CONDITION CLJNICAL OBSERVATION: COLD MYl'HER N:). SEVERITY DAY DAYOF LI'ITER CODE 1 5
228 X 1
245 X 1
.,.-in
.......
........,.0
.....""
......,.""""
!JIC955-0Z/OZ
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY W THE RAT
INDIVIIJIJAL ANn1AL DATA SUPPLEMENT
APPENDIX 21C
CLINICAL OBSERVATIONS (LITTERS PER SYMI?TCM) - F2C PUPS
GROUP NO: 1
BODY SYSTEM: GENERAL CONDITION CLWICAL OBSERVATION: SWil.J..
MJTHER NO. OF LITI'ER
SEVERITY CODE
DAY 1
DAY 5
203 X 1
206 X 1
208 X 1
214 X 2
217 X 2
218 X 2 1
219 X 4
220 X 1
(")
-i
........., r
....... .,. 0
...... ""
..... N c.n 0
I..AC955-02/02
PEBCHLOROETHYLENE: MDLTIGENERATION 1Nl!/\LATION STUDY IN THE RAT
INDIVI!JUAL ANlli\1 DATA SUPPLEMENT
APPENDIX 21C
CLINICAL OBSERVATIONS (LIITERS PER SYMPTCM) - F2C PUPS GROUP NO: 4
BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SMALL MJTHER NO. SEVERITY DAY DAYOF LITTER CODE 1 5
228 X 2
231 X 4
236 X 1
237 X 1 3
238 X 1 1
240 X 1
242 X 1
246 X 1
("") ....,r-... -o-... 0""'1.0 ......
..... l1'lN
.....
LAC955-02/02
PERC!lLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVI!X.TAL ANIMAL DATA SUPPLEMENT
APPENDIX 21C
CLINICAL OBSERVATIONS (LITTERS PER SYMPTCMl - F2C PUPS
COMMENT PAGE
CCM1ENTS: M:>THER NO. UIIY NO. CCM1ENT
207 5 1 FEM\LE PUP SEXED \oiRDNGLY UIIY 1 NOW 8 M!ll..ES NOT 7.
219 1 F 4. 5G DISCOLOURED NOSE. (REDl
n ..... r ........., ........., 0 1.0
"
...... N (J1
N
(
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANIMAL DATA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTUM - F2A PUPS
Females 79, 141, 188 were dead prior to this litter.
Females 33, 80, 139, 178, 179, 183, 184, 188 did not litter.
Female 123 was killed due to difficult parturition.
Litter from female 129 day 11 was not weighed in error.
Key:
CNT = count (number of pups) WT = weight M = male F = female
CTL/P/4097 - 1253
(
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANIMAL DATA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTUM .. F2A PUPS
Females 79, 141, 188 were dead prior to this litter.
Females 33, 80, 139, 178, 179, 183, 184, 188 did not litter.
Female 123 was killed due to difficult parturition.
Litter from female 129 day 11 was not weighed in error.
Key:
CNT = count (number of pups) WT = weight M = male F = female
CTL/ PI 4097 - 125.3
(
l.IIC950-03/06
PERCHLOROETIIYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT
INDIVIOOAL ANn1IIL DA'l:A SUPPLEMENT
APPENDIX 22A
DAM NlMlER
PUP SEK 0 PJlll
EODYWEIGHTS (g) BY
INDIVIDUAL
LITTER TO DAY 29 rosT PARTt
WEIGHTS
M - F2A PUPS
DAY 00: 1 MALES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
25 M F
6.2 6.0
6.3 6.2
6.4 6.4
6.6 6.6 6.8 7.4 6.4 6.9
6.61 7 6.38 5
26 M F
6.2 6.1
6.4 6.3
6.6 6.4 6.5 6.5
6.40 3 6.36 5
27 M F
6.1 5.4
6.9 5.7
7.1 5.8
7.5 7.5 6.1 6.7 6.8 7.1
7.02 5 6.23 7
28 M F
5.1 4.7
5.1 5.3
5.5 5.5
5.5 5.6
5.8 6.0
5.8 5.9 6.3 5.63 8 5.42 5
29 M F
5.6 5.0
5.9 5.3
6.0 5.3
6.6 5.7 5.7 5.8 5.8 5.9 6.1
6.03 4 5.62 9
30 M F
5.4 5.2
5.6 5.3
5.7 5.5
6.0 6.2
6.2 6.3
6.4 6.5 6.7 6.06 8 5.70 5
31 M F
5.1 4.8
5.4 4.9
5.9 5.3
6.1 5.7
6.1 6.3
6.5 6.6 5.96 7 5.40 5
32 M F
5.4 6.3
5.9 6.7
6.1 6.5 5.98 4 6.50 2
34 M F
5.4 5.0
5.6 5.2
5.8 5.5
6.1 5.7
6.5 5.7
6.5 5.9
6.5 5.9 6.2
6.06 7 5.64 8
35 M F
4.9 5.2
5.0 5.2
5.2 5.3
5.4 5.4
5.5 5.5
6.5 5.5 6.0 6.3
5.42 6 5.55 8
36 M F
5.7 5.2
6.1 5.6
6.1 5.8
6.2 5.9
6.8 6.0
7.0 6.0
6.32 6 5.75 6
"--i r-... -o-.....,. 0 \0....,
..... N c.n..,.
I
!.8C950-03/06
PERalLOROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIWAL ANlMAL DATA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITTER TO Il!\Y 29 POST PART!.M - F2A PUPS MALES FEMALESll8M PUP INDIVIDUAL WEIGHTS Il!\Y 00: 1 MEAN CNT. MEAN CNT.NtMlER SEX 0 ppn wr. wr.
F 5.0 5.6 5.7 5.8 6.1 6.3 6.4 5.84 7 46 M 6.0 6.0 6.0 6.2 6.2 6.5 6.15 6
F 5.3 5.5 5.5 5.6 5.7 5.8 5.57 6 47 M 5.2 5.3 5.4 5.8 5.9 5.9 6.0 5.64 7
F 4.3 4.3 4.9 5.2 5.3 5.8 4.97 6
("'"') -<r-...... -c ...... 0 \0""' .....
......N t.11 t.11
~, ~,
LAC950-03/06
PERCffi..OROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT
INDIVI!JUAL ANIMAL DATA SUPPLEMENT
APPENDIX 22A
Jl.\M NU1BER
PUP SEX 0 Pfill
BODYWEIG!ITS (g) BY LITTER TO DAY 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY NJ: 1 MALES MEAN wr.
m1IILES CNT. MEAN CNT.
wr.
48 M F
6. 7 5.4
7.z 5.9 6.3 6.8
6.95 2 6.10 4
"-I ' ...... '"'0 ...... ""' 0
"".._,
-N CJ'l en
GROUP SlM1ARY MEAN
S.D.
COUNT
6. 07 140
0.47 0
23
5.67 124
0.46 0
23
---
-.L.
LAC9S0-03/06
PERCHLOROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIIlUAL ANIMAL DATA st1PPLEMENT
APPENDIX 22A
BODYWEIG!ITS (g) BY LITTER TO DAY 29 POST PART!M - F2A PUPS MALES lm1ALESDAM PUP INDIVIDUAL WEIGHTS DAY NO: s MEAN CNT. MEAN CNT.Ntl1BER SEX 0 ppn wr. wr.
PEBCHLOROEI'l!YLENE: !1LJLTIGENERATION INHALATION STUDY IN THE RAT
INDI.VIIXIAL .ANlMAL DATA SUPPLEMENT
APPENDIX 22A
BOIJYWEIGHTS (g) BY LITTER TO DAY 29 POST PAR:TIM - F2A PUPS
DAM NU1BER
PUP SEX 0 P!IIl
INDIVIDUAL WEIGHTS DAY NO: ll MALES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
GROUP stM1iiRY MEAN 18.38 128 18.26 ll4
S.D. 2.90 0 2.35 0
COUNT 23 22
n -1,......... -c ........,. 0
""....,
..... N
""N
------
···- ... -----~- .. !
LAC950-03/06
PERO:!LORDE'l'HYLENE: M!JLTIGENERATION INHA!.ATION STUDY IN THE RAT
INDIVIDUAL ANIMAL !lATA SUPPLEMENT
.APPENDIX 22A
DAM Nil18ER
PUP SEX 0 ppn
BODYWEIGHTS (g) BY LITTER '!'0 DAY 29 POST P.ART!M - F2A PUPS
INDIVIDUAL WEIGHTS DAY NO: 16 MALES MEAN wr.
FE1ALES 00. MEAN 00.
wr.
(') -i r ...... "C ........,. 0 1.0 .....,
..... N
"' w
25
26
27
28
29
30
31
32
34
M F
M F
M F
M F
M F
M F
M F
M F
M F
26.6 26.6
19.0 27.0
25.0 24.3
24.6 26.2
25.0 25.6
23.2 22.5
24.7 23.3
33.0 33.4
21.8 20.5
26.9 26.6
27.4 29.1
27.2 24.5
24.8 26.2
27.9 26.0
23.8 22.6
25.9 24.1
33.4 36.4
22.4 20.8
27.6 27.5
29.2 29.2
27.5 25.6
26.2 26.7
28.6 27.1
23.8 23.4
26.7 26.4
23.1 20.8
28.1 27.8
29.5
28.0 26.2
26.5 27.2
28.6 27.4
24.1 23.4
26.8 26.6
23.4 21.6
29.0 28.3
29.7
29.5 26.8
26.6
29.2 27.9
24.7 25.0
26.9 26.9
23.4 23.0
29.2
27.0
26.7
28.2
25.8
27.4
23.6 23.4
29.4
28.2
27.3
28.3
26.2
27.5
24.1 24.6
27.6
29.9
26.6
27.9
28.11
25.20
27.44
26.47
27.86
24.78
26.56
33.20
23.11
7
3
5
9
5
8
7
2
7
27.36
28.90
26.09
26.58
27.55
23.38
25.46
34.90
22.10
5
5
7
4
8
5
5
2
7
35 M F
20.5 21.9
21.9 22.1
24.4 22.4
25.0 23.6
25.7 23.8
28.2 23.8 24.3 24.6
24.28 6 23.31 8
36 M F
24.6 25.9
25.3 25.9
26.0 26.6
26.8 26.8
27.3 27.2
28.9 27.8
26.48 6 26.70 6
LAC950-03/06
PERC!!LOROEI'HYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIJJUliL ANIMAL DATA SUPPLEMENT
APPENDIX 22A
DAM NtMBER
PUP SEX 0 ppn
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PliRTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY 00: 16 MIILES MEAN wr.
FE111LES CNT. MEAN CNT.
wr.
37 M 17.9 17.90 1
38 M F
32.4 31.5
32.8 31.9
32.9 33.0
34.3 33.10 4 32.13 3
39 M F
34.5 31.3
36.0 34.5
36.1 35.1 37.8
35.53 3 34.68 4
n -i
' ....... -o .........,. 0 \0....,
.... N ~..,.
40
41
42
M F
M F
M F
23.2 25.9
22.2 19.9
29.4 29.3
23.7 26.2
23.4 24.6
29.7 29.6
24.8
23.9 24.9
30.3
24.9
24.2 24.9
30.5
25.1
25.6 25.8
31.6
25.4
26.5
31.8
26.1
26.7
26.6
27.2
26.8
27.7 27.7
25.18
25.51
30.55
9
10
6
26.05
24.02
29.45
2
5
2
43
44
M F
M F
25.5 23.1
25.9 25.9
26.1 25.3
27.9 26.3
26.3 25.8
28.0 26.4
26.8 27.2
28.3 27.1
27.4 27.2
29.7 27.5
27.6 27.3
27.6
28.3
27.7
26.62
27.96
6
5
26.31
26.93
7
7
45 M F
24.3 22.0
24.9 23.2
26.6 23.3
27.8 24.3 24.9 27.0
25.90 4 24.12 6
46 M F
24.5 22.2
25.3 25.6
25.5 25.7
26.3 25.8
27.2 26.0
28.4 26.6
26.20 6 25.32 6
47 M F
26.2 24.0
26.5 25.0
26.9 25.2
27.2 26.3
27.9 26.4
28.5 27.5
28.7 27.41 7 25.73 6
48 M F
39.5 34.1
39.8 36.1 36.2 38.5
39.65 2 36.23 4
LAC950-03/ 06
PEOC.llLOROErHYI.JlNE: MilLTIGENERATION !NHALATION STUDY IN THE RAT
INDIVliJUAL .ANIMAL DATA SUPPLEMENT
.1\PPENDIX 22A
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS MIILES DAM FEMALESPUP INDIVIDUAL WEIGHTS DAY ID: 16 MEAN CNT. MEAN CNT.NtMBER SEX 0 ppn wr. wr.
GROUP SlM1ARY MEAN 27. 61 128 27.42 114
S.D. 4.46 0 3.88 0
COUNT 2322
('"") -l
.......
.........,"" r
0....,'""
N.....
"'U'1
LI\C950-03/06
PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIIJUAL ANlMI\L ~ SUPPLEMENT
APPENDIX 22A
IW1 Nt:MBER
PUP SEX 0 Jllll1
BO!JYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTU1 - P2A PUPS
INDIVIDUAL WEIGHTS DAY NO: 22 11!\LES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
25 M F
39.2 40.8
43.3 40.9
43.4 41.4
43.9 42.8
44.0 42.9
44.0 45.0 43.26 7 41.76 5
26 M F
45.5 43.3
46.0 44.9 45.4 45.8 47.4
45.75 2 45.36 5
"-i,..-., -""' 0
"'....,
..... N
"' "'
27
28
29
M F
M F
M F
37.6 35.8
32.7 34.9
44.2 40.3
37.8 36.3
34.7 35.1
44.4 41.6
38.1 36.9
35.9 36.5
45.1 41.7
40.7 38.3
35.9 37.2
45.1 42.2
44.2 39.3
36.6
43.7
41.0
36.6
44.3
41.3
36.8
45.0
38.3
45.8
39.1
47.1
39.68
36.29
44.70
5
9
4
38.41
35.93
43.52
7
4
9
30 M F
37.3 37.1
38.4 37.3
38.8 37.6
39.9 39.5
40.3 40.3
41.9 42.4 43.1 40.26 8 38.36 5
31 M F
40.6 37.6
42.1 38.2
43.4 41.4
45.5 42.9
45.8 44.0
46.1 46.2 44.24 7 40.82 5
32 M F
49.2 48.9
50.5 53.9
49.85 2 51.40 2
34 M F
31.2 27.5
31.7 27.9
31.8 29.7
32.3 31.7
32.5 32.8
33.6 33.8
34.6 34.0
32.53 7 31.06 7
35 M F
32.3 34.8
33.9 35.6
37.6 36.3
37.6 36.7
38.9 36.7
41.7 37.8 37.9 38.2
37.00 6 36.75 8
36 M F
36.9 40.0
39.1 40.4
39.7 40.8
42.1 41.1
42.5 41.2
44.9 41.7
40.87 6 40.87 6
"-1.......,r..........0....,""
.....Ncr.....,
LAC950-03/06
PERCHLOROEI'HYLENE: 11ULTIGENERATION INHALATION STUDY IN THE RAT
INOIVIDtli\L IINJMAL DATA stlPPLEMJ!NT
APPENDIX 22A
BOIJYWEIGHTS (g) BY LITrER '10 DAY 29 POST PARTIM - F2A PUPS MALES FEMALESDAM PUP INDIVIDUAL WEIGHTS DAY NO: 22 MEAN CNT. MEAN CNT.NlMlER SEX 0 P!lll wr. wr.
PEBCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY ill THE RAT
OOlVIIJUAL AN1MAL DATA SUPf'I..EMENT
APPENDlX 22A
DAM NCMBER
PUP SEX 0 ppn
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY 00: 22 MALES MEAN wr.
FEMALES CNT. MEAN CNT. wr.
n ...;,.... ....... "'C ....... ""' 0 <0....,
...... N
"'OJ
GROUP StM1IIRY MEAN
S.D.
COUNT
42.15 126
6.87 0
23
41.04 115
6.28 0
22
LAC950-03/06
PERCHLORDETHYLENE: MDLTIGENERATION INHAlATION STUDY lN THE RAT
lNDIVIDUAL ANlMI\L DATA SUPPUMENT
APPENDIX 22A
DAM NtMBER
PUP SEX 0 ppn
BODYWEIGHTS (g) BY LI'ITER ro DAY 29 POST P.ARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY N:l: 29 MALES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
r, ~ r ...... "C ........,. 0 \0....,
..... N
"' \0
25
26
27
28
29
M F
M F
M F
M F
M F
71.3 71.4
81.6 75.4
73.1 68.4
73.0 70.7
79.0 73.0
80.7 73.4
82.9 78.1
75.1 68.8
74.9 72.1
80.0 75.2
82.4 74.8
79.2
78.4 71.0
75.1 73.9
81.2 75.3
82.9 76.1
79.5
80.5 72.8
75.7 76.1
83.5 77.3
83.0 76.1
80.4
85.5 73.5
76.6
77.8
83.7
75.4
76.7
78.3
84.5
77.1
78.2
80.0
79.8
81.4
81.3
85.5
81.21
82.25
78.52
76.81
80.93
7
2
5
9
4
74.36
78.52
72.43
73.20
78.20
5
5
7
4
9 30
31
M F
M F
70.9 68.2
76.1 67.0
73.5 68.6
82.7 67.7
74.5 69.1
84.0 74.7
75.2 72.8
85.0 76.4
76.8 73.6
87.6 78.0
77.2
88.9
77.3
89.1
78.4 75.48
84.77
8
7
70.46
72.76
5
5 32 M
F 86.9 81.7
92.7 89.4
89.80 2 85.55 2
34 M F
59.4 54.5
64.9 58.2
65.3 58.4
66.9 62.0
67.3 62.8
68.4 69.1
68.8 69.5
65.86 7 62.07 7
35 M F
67.0 66.5
67.9 66.8
72.0 68.4
73.4 69.5
74.2 70.1
80.8 71.5 71.7 74.6
72.55 6 69.89 8
36 M F
70.2 73.1
73.0 73.1
73.2 74.5
76.3 75.3
77.9 76.5
82.4 76.5
75.50 6 74.83 6
L\C950-03/06
PEru::HLORDETHYLENE: MtlLTIGENERATION INHAlATION STUDY IN TllE RAT
INDIVJJ:UAL AN1W<L lliiTA SUPPLEMENT
APPENDIX 22A
M1 NU1BER
PUP SEX 0 ppn
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY NO: 29 MALES MEAN wr.
rn1ALES CNT. MEAN CNT.
wr.
37 M 57.1 57.10 1 38 M
F 84.6 80.9
88.5 86.5
89.8 86.7
95.8 89.68 4 84.70 3
("") ..... r-.... "0-......,. 0
"' .....
..... N ..... 0
39
40
41
42
M F
M F
M F
M F
94.8 82.4
62.9 55.5
62.2 55.5
80.5 80.4
96.3 84.1
66.2 72.5
62.8 59.0
82.0 83.4
97.1 92.1
68.9
64.8 62.1
82.5
97.1
70.3
67.5 66.6
86.0
71.0
70.9 69.1
86.2
71.3
71.7
92.2
73.3
74.3
73.5
74.5
73.7
76.2 77.9
96.07
70.12
70.28
84.90
3
9
10
6
88.93
64.00
62.46
81.90
4
2
5
2 43
44
M F
M F
76.1 71.2
76.7 73.6
80.7 72.8
77.7 74.6
81.0 73.7
79.6 75.6
81.5 77.6
82.1 76.1
82.7 78.0
83.0 76.9
84.2 79.3
77.2
79.6
78.4
81.03
79.82
6
5
76.03
76.06
7
7
45 M F
75.1 64.0
77.9 64.0
85.1 68.2 68.6 68.8 73.6
79.37 3 67.87 6
46 M F
69.1 63.7
72.4 69.9
73.7 70.1
75.4 70.4
78.6 72.2
79.9 72.8
74.85 6 69.85 6
47 M F
73.5 65.0
73.7 67.3
74.9 67.9
76.4 71.1
78.1 72.7
80.2 73.6
83.6 77.20 7 69.60 6
48 M F
101.0 107.o 88.6 90.4 93.0 93.8
104.00 2 91.45 4
l.AC950-03/ 06
PERCELORDETHYLENE: MDLTIGENERATION :INEAI.ATION STUDY IN TilE RAT
INDIVIOOAL AliD1AL DATA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITrER TO DAY 29 POST PARTtM - F2A PUPS MALES FEMALESDi\M PUP INDIVIDUAL WEIGHTS DAY NO: 29 MEAN CNT. MEAN CNT.NU1BER SEX 0 ppn wr. wr.
GROUP stM1IIRY MEAN 79.48 125 74.78 ill
S.D. 9.85 0 8.03 0
COUNT 2322
(") -i
......-o' .........0<.0......
.....N...........
LAC950-03/06
PERCHLOROEI'HYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT . INOIVID.TAL ANIMAL DATA SUPPLEMENT
APPENDIX 22A
DAM NCMBER
PUP SEl( 100 ppn
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY!>Kl: 1 MALES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
73 M F
5.5 5.5
5.6 5.6
6.3 6.4
6.3 6.4 6.5 6.6 6.7 6.24 a 5.83 3
74 M F
5.8 5.3
6.0 5.3
6.1 5.7
6.1 5.9
6.1 6.4 6.7 6.17 7 5.55 4
("') -i r..._ -c..._..,. 0.., ......
...... N ...... N
75
76
77
M F
M F
M F
5.8 6.0
6.1 5.5
5.8 4.9
5.9 6.3
6.2 5.6
5.8 5.6
6.0
6.3 5.7
6.6 5.6
6.1
6.4 6.0
6.8 5.7
6.2
6.4
6.9 5.7
6.2
5.8
6.3
5.8
6.4
6.3
6.8
6.5
7.4 6.31
6.28
6.38
10
5
5
6.15
5.70
5.77
2
4
9
78 M F
4.8 4.8
5.1 5.0
5.6 5.2
5.7 5.6
5.8 5.8 5.8
5.40 5 5.37 6
81 M F
5.8 5.2
5.8 5.3
7.2 5.7 5.7 5.8 5.9 6.0 6.3 6,6
6.27 3 5.83 9
82 M F
6.1 5.1
6.2 5.2
6.2 5.8
6.4 6.1
7.1 6.40 5 5.55 4
83 M F
5.6 5.5
5.7 5.6
5.8 5.8
6.2 5.8
6.5 6.6 7.6 6.29 7 5.68 4
84 M F
4.8 5.3
5.7 5.4
5.7 5.7
5.9 5.9
6.1 5.9
6.1 5.9 6.3
5.72 6 5.77 7
85 M F
6.2 5.4
6.3 5.7
6.4 6.1
6.4 6.5
6.6 6.7
6.6 6.7 6.46 7 6.08 5
(")-!r......"C...... 0""'<0....,
.....N....,w
.----,
LAC950-03/06
PERCHLOROETHYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT
INDIVIDUI\L ANJMAL Jl.\TA SUPPLEMENT
l\PPENDIX 22A
EODYWEIGHTS (g) BY LITIER TO ll<\Y 29 POST PAR.TIM - F2A PUPS MALES FEMALESIW1 PUP INDIVIDUAL WEIGHTS ll<\Y ID: 1 MEAN CNT. MEAN CNT.NU1BER SEX 100 ppn wr. wr.
PERCHLORDETHYLENE: 11ULTIGENERATION IN!W..ATION SWDY IN THE RAT
INDIVIOOAL 11N1MAL DATA SUPPLEMENT
.APPENDIX 22A
DAM NtMBER
PUP SEX 100 ppn
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 PJST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY NO: 1 M!\LES MEAN WT.
CNT. miALES MEAN CNT. WT.
n ..... '-....,-...., 0
"" .....,
,_. N ........,
GROUP StM1ARY MEAN
S.D.
COUNT
6. 08 134
0.35 0
22
5.71122
0.34 0
22
"-ir......"0......""00.0......
.....N......tJ1
-~
LAC950-03/06
PERCHUlRDETHYLENE: MULTIGENERATION !NHAJ...ImON STUDY IN THE JlAT
INDlVIlltiAL ANlMAL Jl.\TA SUPPLEMENT
.APPENDIX 22A
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS MALES FEMALESDl!M PUP INDIVIDUAL WEIGHTS DAY ID: 5 MEAN CNT. MEAN CNT.NU1BER SEX 100 Jl!l1l wr. wr.
76 M 19.5 19.6 19.7 19.60 3 F 14.6 17.0 18.0 18.5 17.03 4
77 M F
18.8 17.3
18.9 17.8
19.9 18.1
20.7 18.4
20.7 18.4 18.7 19.1
19.80 5 18.26 7
78 M 16.5 17.6 17.7 17.8 18.4 17.60 5 F 16.6 17.3 17.4 17.5 18.0 18.3 17.52 6
81 M F
15.4 12.2
17.3 14.5 14.8 14.9 15.1 16.6 17.0 17.7
16.35 2 15.35 8
82 M 17.0 17.6 20.0 20.0 20.5 19.02 5 F 15.9 16.8 16.9 19.8 17.35 4
83 M F
18.5 17.6
18.5 17.8
18.5 18.5
19.0 18.9
19.1 19.6 19.7 18.99 7 18.20 4
84 M F
13.5 14.6
14.9 15.0
15.0 15.5
15.2 15.6
16.1 16.4
16.4 16.5 16.8
15.18 6 15.77 7
85 M F
17.3 17.0
18.1 17.4
18.8 17.6
18.9 17.9
18.9 19.2
19.6 19.6 18.74 7 17.82 5
("')-<......""C.........r
0lO.....
N..........lO
/-',
~ --------. . - .
LAC950-03/06
PERC!lLORDETHYLENE: MIJLTIGENERATION !NHALATION STUDY IN THE RAT
INDIVJU!AL ANIMAL MTA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITIER 'IO DAY 29 POST PAR.TtM - F2A PUPS MALES FEMALESDAM PUP INDIVIDUAL WEIGHTS DAY N:l: 11 MEAN CNT. MEAN NlWIER CNT.SEX 100 ppn wr. wr.
l'ERC!lLOllllE'l1!YLENE:: MULTIGENERATION INHALATION STUDY IN TEE RAT
INDIVIOOAL ANlMAL DATA stlPPLEl1ENT
APPENDIX 22.11
EODYVIEIGHTS (g) BY LITI'ER TO DliY Z9 POST PARTIM - F2A PUPS
DAM NU1BER
PUP SEX 100 ppn
INDIVIDUAL WEIGHTS DliY NO: 11 MALES MEAN wr.
FEMIILES CNT. MEAN CNT.
wr.
GllllUP SlM1ARY MEAN 18.88 124 17.60 107
S.D. 1.81 0 1.81 0
COUNT ZZ zz
(""') -i r ........, .........,. 0 <0 ......
..... N co 0
UIC950-03/06
PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDlVIIXJAL ANIMAL DATA SUPPLEMENT
APPENDIX 22A
DAM NlMBER
PUP SEX 100 ppn
BODYWEIGHTS (g) BY LI'l'l'ER ro DAY 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY 00: 16 MALES 1:1&\N wr.
FEMALES CNT. 1:1&\N CNT.
wr.
"--!,....... -o .........,. 0 <0 .....,
..... N 0> .....
~
73
74
75
76
77
78
81
82
M F
M F
M F
M F
M F
M F
M F
M F
26.4 25.2
24.8 23.6
27.7 28.3
29.8 24.3
26.7 25.4
23.1 24.1
21.4 19.5
26.6 24.8
27.1 26.9
24.9 24.1
29.3 30.5
30.5 26.6
27.8 25.7
24.6 24.8
23.4 19.8
26.9 25.7
27.5 27.1
25.3 24.9
29.9
31.8 27.7
28.3 26.8
26.1 25.1
20.4
29.4 25.9
27.6
25.6
30.1
28.3
28.4 26.8
27.0 25.6
20.8
29.7 29.2
27.8
25.8
30.1
29.0 26.8
27.0 25.6
21.5
29.9
27.9
25.9
30.1
26.9
26.1
22.9
28.8
26.0
30.3
27.0
23.4
26.5
30.3
23.7
30.8 31.5
27.59
25.60
30.01
30.70
28.04
25.56
22.40
28.50
7
8
10
3
5
5
2
5
26.40
24.20
29.40
26.73
26.49
25.22
21.50
26.40
3
3
2
4
7
6
8
4
83 M F
29.5 27.8
30.1 28.3
30.3 28.4
30.4 29.5
30.5 30.9 30.9 30.37 7 28.50 4
84 M F
20.7 22.1
21.6 22.1
21.8 22.1
22.7 22.4
23.0 23.2
24.5 23.6 23.8
22.38 6 22.76 7
85 M F
25.3 24.5
26.7 25.8
27.5 26.0
27.8 26.5
28.0 27.2
28.3 28.6 27.46 7 26.00 5
LAC950-03/06
PERCHLOROE:l'HYLENE: MlLTIGENERli:I.'ION INI!ALATION STUDY IN THE RAT
INDIVIllUAL ANIMAL DATA SUPPLEMENT
APPENDIX 22A
Jl.'M NU1BER
PUP SEX 100 PJl11
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY 00: 16 M!ILES ME'.AN wr.
FEMALES CNT. ME'.AN CNT.
wr.
86 M F
21.4 17.2
24.1 19.8
24.5 21.0
24.7 22.2
25.8 22.5
25.9 24.1
26.8 24.4
24.74 7 21.60 7
87 M F
30.3 32.6
31.7 33.6
32.0 33.7
32.8 34.0 36.3 32.85 6 33.30 3
n .....-'""' -..,. 0
""......
.... N co N
88
89
90
M F
M F
M F
28.4 26.9
25.8 24.7
28.2 18.4
30.7 27.1
26.7 26.2
28.4 25.7
31.5 27.9
26.9 26.5
28.6 25.9
32.6 28.6
27.2 26.9
26.4
29.5
27.7 27.8
26.5
27.9 28.2
26.8
28.3
27.0 27.1 27.9
30.80
27.21
28.40
4
7
3
28.00
26.72
25.74
5
6
9
91 M F
29.2 27.1
29.2 27.7
30.0 28.6
31.8 29.0 29.6 30.7
30.05 4 28.78 6
92 M F
29.0 24.5
32.4 29.1
33.4 33.9 35.6 32.86 5 26.80 2
93 M F
22.1 19.8
23.0 22.5
23.3 24.1
23.7 24.4
24.2 24.4
25.2 25.4
25.3 25.6 24.05 8 23.43 6
94 M F
25.7 27.0
26.5 27.6
27.9 28.0
28.3 28.3
29.0 27.48 5 27.73 4
95 M F
31.0 25.7
31.6 28.5
33.0 33.8 32.35 4 27.10 2
96 M F
26.2 25.2
26.2 27.1
27.9 27.7
27.9 28.3
27.9 28.5 27.43 6 27.08 4
LAC950-03/06
PERCHLOROETHYLENE: 11DLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANIMAL Th\TA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITIER TO Jl.\.Y 29 POST P.ARTIM - F2A PUPS MALES FEMALESDliM PUP INDIVIDUAL WEIGHTS Jl.\.Y NO: 16 MEAN CNT. MEAN CNT.NU1IlER SEX 100 ppn wr. wr.
GROUP stM1ARY MEAN 28.04 124 26.36 107
S.D. 3.07 0 2.66 0
COUNT 2222
("') -i r .._ "'0..........0lO......
....Ncow
LAC950-03/06
PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY IN TilE RAT
INDIVIDUAL ANIMI\L DATA SUPPLEMENT
APPENDIX 22A
IW1 NlMBER
PUP SEX 100 P!Ill
BODYWEIGHTS (g) BY LITl'ER TO JlliY 29 POST PARTlM- F2A PUPS
INDIVIDUAL WEIGHTS DAY 00: 22 MALES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
73 M F
38.4 37.5
38.5 38.2
38.9 40.9
39.2 40.5 42.2 43.5 40.17 7 38.87 3
74 M F
40.2 38.3
40.3 40.2
41.6 41.0
42.3 42.5 43.0 44.0 44.2 42.26 8 39.83 3
('") ..... ' ........, ....... ""' 0
""' ......
..... N OJ
""'
75
76
77
M F
M F
M F
40.3 43.6
44.7 35.1
40.5 36.9
44.2 44.1
45.2 39.5
40.9 37.7
44.2
45.7 41.2
41.0 37.7
45.2
42.7
42.8 39.0
45.6
43.2 39.1
45.8
39.1
46.1
39.4
46.2 47.0 49.1 45.37
45.20
41.68
10
3
5
43.85
39.63
38.41
2
4
7
78 M F
38.9 38.7
42.3 39.0
43.4 39.3
43.4 39.5
44.0 40.5 42.4
42.40 5 39.90 6
81 M F
34.0 31.6
35.6 32.9 33.2 33.9 35.7 36.6 37.6 38.3
34.80 2 34.98 8
82 M F
40.1 37.8
41.6 38.9
43.8 39.1
44.7 44.3
45.7 43.18 5 40.03 4
83 M F
44.8 40.5
45.3 44.8
46.2 44.9
47.3 46.5
48.5 49.3 49.8 47.31 7 44.18 4
84 M F
33.6 35.7
35.3 37.3
36.3 37.8
36.9 38.0
37.8 38.7
38.9 40.3 41.6
36.47 6 38.49 7
85 M F
38.2 35.8
39.6 36.8
41.2 39.7
42.3 40.1
42.5 40.6
42.6 43.9 41.47 7 38.60 5
LAC950-03/06
PERCHLOROETHYLENE: MilLTIGENERATION INHALATION STUDY IN THE RAT
lNDIVIOOAL .ANIMAL DATA SUPPLEMENT
APPENDIX 22A
Ili\M NlMBER
PUP SEX 100 ppn
BODYWEIGl:!TS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY NO: 22 MALES MFAN wr.
FE1ALES CNT. MFAN CNT.
wr.
86
87
M F
M F
33.4 25.7
44.6 48.5
35.5 28.9
49.5 50.5
35.7 32.4
49.5 51.9
35.8 32.8
49.7
36.0 34.5
52.2
37.4 35.3
54.9
40.6 36.3
36.34
50.07
7
6
32.27
50.30
7
3
("') -i r-"0 -"""0 >.0.....,
...... N co c.n
88
89
90
M F
M F
M F
42.8 40.3
38.3 36.9
43.2 28.1
46.2 41.4
39.7 38.7
44.1 39.0
47.0 42.3
40.4 39.0
45.2 40.2
48.3 43.3
41.2 39,6
40.9
44.9
41.3 41.6
40.9
43.8 42.4
41.2
43.9
41.3 43.1 43.5
46.08
41.23
44.17
4
7
3
42.44
39.70
39.80
5
6
9 91
92
93
M F
M F
M F
43.2 40.1
49.8 39.8
32.5 27.9
43.6 41.7
52.4 47.4
33.6 32.4
43.7 42.2
54.9
35.3 33.9
47.9 42.5
55.0
35.9 36.1
43.5
56.3
36.4 36.1
44.1
36.4 36.9
37.5 37.7
44.60
53.68
35.66
4
5
8
42.35
43.60
33.88
6
2
6
94 M F
39.8 41.3
40.0 43.1
42.5 43.2
42.9 44.4
44.0 41.84 5 43.00 4
95 M F
46.3 41.9
46.5 42.5
49.4 50.1 48.08 4 42.20 2
96 M F
42.2 42.0
43.9 44.4
44.5 45.2
45.7 46.1
46.1 46.2 44.77 6 '44.43 4
L<\C950-03/06
("') --{ r ....... ""0 ....... -"' 0
"'......
,_. N 0>
""
PERCH!.OllDETHYLENE: MULTIGENERATION IN!W.ATION STUDY IN THE RAT
INDIVIIXIAL 11NIMAL DATA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITrER TO U\Y 29 POST PARTtM - F2A PUPS
JlAM NlliBER
PUP SEX 100 ppn
INDIVIDUAL WEIGHTS U\Y 00: 22 MALES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
GROUP SlM1ARY MEAN 43 •04 124 40.49 107
S.D. 4.68 0 3.91 0
OOUNT 22 22
LAC950-03/06
PERCHLORDET!!YLENE: MJLTIGENERATION INHAlATION STUD\:' IN TEE RAT
INDIVIDUAL liNlMAL DA:rA SllPPLEMENT
APPENDIX 22A
DAM Ntl1BER
PUP SEX 100 ppn
BODYWEIGHTS (g) BY LI'l'I'ER TO DAY 29 POST PART!M - F2A PUPS
INDIVIDUAL WEIGHTS DAY NO: 29 MALES ME'.i\N wr.
FEMALES CNT. ME'.i\N CNT.
wr.
73 M F
72.2 73.9
78.4 77.2
78.5 77.3
79.6 80.4 84.2 84.2 79.64 7 76.13 3
74 M F
73.6 73.1
75.5 73.9
78.2 78.2
78.8 80.1 80.4 83.8 84.1 79.31 8 75.07 3
...,
..... r ......., ...... ""' 0
""....,
..... N co....,
"
75
76
77
M F
M F
M F
76.0 76.4
83.3 66.1
76.9 67.4
82.0 78.7
84.4 73.0
77.9 68.8
82.7
85.5 74.7
78.1 70.1
83.5
77.5
80.9 70.2
85.0
81.4 71.7
85.1
71.7
86.7
73.3
86.7 86.8 89.5 84.40
84.40
79.04
10
3
5
77.55
72.83
70.46
2
4
7
78 M F
72.1 68.8
79.0 71.3
80.6 71.8
81.8 72.1
82.7 73.3 74.6
79.24 5 71.98 6
81 M F
65.9 58.2
65.9 58.4 60.0 63.3 66.7 66.8 70.2 70.9
65.90 2 64.31 8
82 M F
77.9 68.8
80.0 72.2
80.5 73.2
85.0 79.8
85.0 81.68 5 73.50 4
83 M F
86.6 80.2
87.0 81.1
90.1 81.7
91.0 82.1
91.9 93.3 95.0 90.70 7 81.28 4
84 M F
65.1 64.5
68.5 68.7
68.6 70.1
70.7 71.1
70.9 71.2
71.8 72.4 73.5
69.27 6 70.21 7
85 M F
71.9 66.9
79.1 67.7
79.1 72.0
79.2 72.2
79.8 73.6
80.8 84.6 79.21 7 70.48 5
LAC950-03/06
PERCHLOROETIIYLENE: MJLTIGENERATION 1NHALATION STUDY Til THE RAT
INDIVIDUAL ANn1AL DATA SUPPLEMENT
.IIPPENDIX 22A
IW1 NU1BER
PUP SEX 100 PJIIl
BOIJYWEIGHTS (g) BY LITI'ER TO !l'.Y 29 POST PARTU1 - F2A PUPS
INDIVIDUAL WEIGHTS !l'.Y ro: 29 MALES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
86 M F
65.2 52.7
68.9 59.4
69.5 60.8
69.5 62.0
70.2 63.4
73.2 64.6
78.0 68.9
70.64 7 61.69 7
87 M F
81.8 82.3
86.8 84.0
87.3 86.1
87.4 92.7 95.8 88.63 6 84.13 3
n ..... r........, .......,. 0
"" ....,
..... N co co
88
89
90
M F
M F
M F
80.7 74.5
77.0 70.1
79.5 57.0
88.1 76.0
77.8 70.4
80.5 71.0
90.6 78.8
78.2 72.8
84.8 71.5
91.3 80.7
81.4 73.5
71.7
88.3
82.8 77.4
72.2
83.3 78.5
73.6
84.1
74.0 75.4 76.0
87.68
80.66
81.60
4
7
3
79.66
73.78
71.38
5
6
9
91 M F
80.1 72.9
82.1 74.7
84.3 75.0
90.9 79.7 81.9 82.2
84.35 4 77.73 6
92
93
M F
M F
87.4 69.9
67.7 56.4
92.7 81.7
68.0 61.6
97.2
71.4 65.6
98.4 100.9
71.7 72.0 67.1 69.4
72.5 69.7
73.3 77.5
95.32
71.76
5
8
75.80
64.97
2
6
94 M F
75.7 76.8
77.6 78.4
79.9 78.5
80.3 80.7
87.3 80.16 5 78.60 4
95 M F
86.7 78.5
88.9 80.2
90.0 91.9 89.38 4 79.35 2
96 M F
77.4 75.2
80.6 78.9
82.6 80.5
82.7 82.1
83.1 87.3 82.28 6 79.18 4
---~ --. --·-·--·
LAC950-03/06
PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY Dl THE RAT
INDIVIDUAL ANlMAL DATA S1JllPl..ruENT
APPENDIX 22A
BODYWEIGHTS {g) BY LITTER TO D& 29 EOST PliRTIM - F2A PUPS
!lAM NU1llER
PUP SEJ( 100 ppn
INDIVIDUAL WEIGHTS D& NO: 29 MALES MEAN wr.
FE1ALES CNT. MEAN CNT.
wr.
GROUP SlM1ARY MEAN 81.15 124
S.D. 7.18 0 74.09 107
5.68 0 OOUNT 22
22
('") -! r ...... "0 ...... ""' 0 <.0 ......
..... S5 <.0
I.JIC950-03/06
l?ERC!lLORDEl'HYLENE: MULTIGENERATION INHAlATION STUDY IN THE llAT
INDIVIIXJAL ANIMAL DATA SUPPLEMENT
APPENDIX 22A
JlAl1 NU1BER
PUP SEX 300 ppn
EODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTtM - F2A PUPS
INDIVIDUAL WEIGHTS DAY NO: 1 MALES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
l2l M F
5.8 5.3
5.9 5.5
6.2 5.7
6.2 5.8
6.3 5.8
6.3 6.0
6.4 6.2
6.16 7 5.76 7
l22 M F
6.4 6.0
6.6 6.1
6.7 6.2
6.7 6.3
7.1 6.5
6.70 5 6.22 5
"-1 r........., .......... 0
""....,
.... N
""0
124
l25
126
M F
M F
M F
5.2 4.2
4.1 5.2
5.2 4.8
6.0 5.6
6.0 5.9
5.3 4.9
6.2 6.1
6.0 6.0
5.4 5.3
6.3 6.1
6.0
5.4 5.3
6.4 6.3
6.2
5.6 5.6
6.5
6.4
6.1 5.9
6.8
6.1
6.9 6.29
5.78
5.59
8
6
7
5.66
5.70
5.30
5
3
6
127
128
M F
M F
5.4 5.4
5.1 4.9
5.4 5.7
5.1 5.7
5.5 5.8
5.4 6.0
5.5 6.1
5.5
5.6
5.7
5.7
5.7
5.7
6.0
5.8
6.4 6.7
5.58
5.73
8
9
5.75
5.53
4
3
129 M F
5.5 5.2
6.2 5.4
6.2 5.9
6.3 5.9
6.4 6.12 5 5.60 4
130 M F
6.0 5.0 5.3 5.4 5.6 5.7 5.7 5.7 6.1
6.00 1 5.56 8
131 M F
5.3 5.6
5.7 5.7
5.8 5.9
5.9 6.1 6.1 6.2 6.2 6.5 6.5 6.03 10 5.73 3
132 M F
5.2 5.2
5.4 5.4
5.8 5.5
5.8 5.6
5.9 5.6
6.1 6.3
6.1 5.76 7 5.60 6
LAC950-03/06
PERCBLOBDETiiYLENE: MlJLTIGENERA:riON INHALATION STUDY IN THE RAT
INDIVIJXTAL llNJMAL DATA SUPPLEMENT
APPENDIX 22A
Jli\M NU1BER
PUP SEX 300 P!Il1
BODYWEIGHTS (g) BY LITTER TO MY 29 POST PARTU1 - F2A PUPS
INDIVIDUAL WEIGHTS MY NO: 1 MALES MEAN wr.
FJ;MALES CNT. MEAN CNT.
wr.
133 M F
4.6 4.9
5.0 4.9
6.3 5.30 3 4.90 2
134 M F
6.3 6.1
6.4 6.1
6.9 6.4
7.0 7.2 6.76 5 6.20 3
....., -I...._.,..._.., 0 \0....,
..... N \0 .....
,-_
135
136
137
138
140
M F
M F
M F
M F
M F
5.6 3.9
5.0 4.7
4.1 5.0
6.3 4.9
5.9 5.8
5.7 4.2
5.0
5.6 5.3
6.3 5.0
6.1 6.0
5.9 4.8
5.9
5.9 5.9
5.6
6.4 6.3
5.9 5.1
6.0
5.9
6.6 6.3
5.2
6.1
6.0
6.6 6.5
5.5
6.6
7.1 6.7
5.5
6.8
5.6 6.2 5.78
5.30
5.54
6.30
6.45
4
3
5
2
6
5.11
4.70
5.40
5.67
6.34
9
1
3
6
7
142 M F
5.9 5.4
6.4 5.9 6.2 6.5 7.0
6.15 2 6.20 5
143 M F
5.2 5.5
5.8 5.7
6.7 5.8 6.1 6.2
5.90 3 5.86 5
144 M F
6.1 5.5
6.3 5.8
6.3 6.0
6.5 6.1
6.5 6.3
6.7 6.4
6.40 6 6.02 6
LAC950-03 I06
PERCHLORDETHYLENE: MDLTIGENERATION JNHALATION STUDY IN THE RAT
INDIVIIXJ8L 1IN.IM!<L DATA SUPPLEMENT
APPENDIX 22A
DAM NtMBER
PUP SEX 300 PJill
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY 00: 1 MALES MEAN wr.
Fl'MALES CNT. MEAN CNT.
wr.
GROUP SlM1ARY MEAN
S.D.
COUNT 21
5. 98 ll2
0.41 0 5.66 101
0.42 0
21 (") -i r -""' -.., 0
"" ......
,_. N
""N
LAC950-03/06
PERCHLOROET!lYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDlVIIJUAL ANlMAL DATA SUPPLEMENT
APPENDIX 22A
Il8M NU1BER
PUP SEX 300 ppn
BOIJYWEIG!ITS (g) BY LITIER 'IO Il!\Y 29 POST P.ARTIM - F2A PUPS
INDIVIDUAL WEIGHTS Il!\Y NO: 5 MALES MEAN wr.
FEMALES CNT. MEAN em.
wr.
121 M F
8.1 7.5
8.5 7.7
9.0 7.9
9.3 8.2
9.4 8.3
9.7 8.8
9.9 9.2.
9.13 7 8.2.3 7
12.2. M F
8.8 8.4
8.9 8.6
9.7 8.7
9.7 9.0
9.7 9.6
9.36 5 8.86 5
("")....,,... ....... -o .......
"""0 \0 .....,
..... N \0 w
'~
12.4
12.5
12.6
M F
M F
M F
6.6 7.0
9.3 9.1
6.1 6.2
8.1 8.5
9.7 9.6
6.6 6.7
9.1 10.1
9.7 9.8
6.6 7.5
9.3 10.3
9.8
7.2
9.5 11.2
10.2
7.2
10.5
7.2
10.8
7.7
11.3
7.8
9.40
9.74
7.05
8
5
8
9.42
9.50
6.80
5
3
3
12.7 M F
7.6 7.9
8.7 8.3
8.7 8.6
8.7 8.8
8.7 9.0 9.2. 9.3 8.74 8 8.40 4
12.8 M F
7.6 8.0
8.3 8.2
8.4 8.4
8.5 9.1 9.2 9.5 9.6 10.2 8.93 9 8.20 3
12.9 M F
9.2 8.5
9.3 8.7
9.8 9.3
10.1 9.60 4 8.83 3
130 F 7.7 8.2 8.3 8.3 8.4 9.0 8.32 6
131 M F
7.3 6.5
7.3 7.4
7.4 8.1
7.5 7.6 7.6 7.8 8.1 8.2 8.3 7.71 10 7.33 3
132 M F
8.5 8.0
8.6 8.9
8.6 9.3
8.7 9.6
9.3 9.6
9.6 9.9
10.7 9.14 7 9.22 6
134 M F
7.0 5.1
7.4 6.6
7.7 7.4
7.9 8.1 7.62 5 6.37 3
UC950-03/06
PERCHLORDETHYLENE: MIJLTIGENERATION JNHl\LATION STUDY IN THE RAT
INDIVIIXJAL ANIMAL DATA SUPl'LEl1ENT
APPENDIX 22A
lliiM NlMBER
pUp SEl( 300 P!lll
BODYWEIGHTS (g) BY LITI'ER TO Jl.\Y 29 POST P.i\RTIM - F2A PVPS
INDIVIDUAL WEIGHTS Jl.\Y 00: 5 MALES MEAN wr.
FE1ALES CNT. MEAN CNT.
wr.
135 M F
7.4 5.0
7.8 6.0
7.9 6.9
8.1 7.2 7.2 7.4 7.5 7.8
7.80 4 6.88 8
136 M F
6.2 5.4
6.9 7.7 6.93 3 5.40 1
n ...;....... "0 ........,. 0 140
"
..... N 140..,.
137
138
140
M F
M F
M F
5.4 7.8
8.8 6.6
8.7 7.8
9.5 8.7
8.8 7.4
8.8 8.5
9.6 9.7
8.8
9.1 8.5
10.5
9.0
9.1 8.8
11.3
9.3 8.9
10.3 9.0 9.8
9.26
8.80
9.22
5
2
6
8.73
7.95
8.76
3
4
7
142 M F
8.9 7.6
9.1 9.0 9.6 9.8 10.3
9.00 2 9.26 5
143
144
M F
M F
7.1 8.1
6.8 6.2
8.8 8.3
6.8 6.8
8.9
7.6 7.0
7.9
7.95
7.28
2
4
8.43
6.67
3
3
----------------------GROUP SlM1!<RY MEAN
S.D.
OOUNT
8.56 104
0.91 0
19
8.08
1.14
20
85
0
----------------------
("").....r..._ "C..._.l>o0<0....,
N..... <0<.11
~~
LAC950-03/06
PERCHLORDETHYLENE: MIJLTIGENERA:J.'ION INI!ALATION STUDY IN THE RAT
INDIVIOOl\L ANlMAL IlA.TA SUPPLEMENT
APPENDIX 22A
BODYWEIG!ITS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS MALES F.EMALESDAM PUP INDIVIDUAL WEIGHTS DAY 00: 11 MFAN CNT. MFAN CNT.NU1llER SEX 300 ppn wr. wr.
PERCHLORDETHYLENE: MDLTIGENERATION INHIILATION STUDY IN THE RAT
INDIVIIXJAL ANlMAL DATA SUPPLEMENT
APPENDIX 22A
ll'IM NlMlER
PUP SEX 300 PJlll
BODYWEIGHTS (g) BY LITrER 1D ll'IY 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY 00: 16 MALES MEAN wr.
FEMALES 00. MEAN CNT.
wr.
135 M F
23.4 16.7
23.8 19.9
26.1 21.9 22.4 22.8 22.9 23.3 23.4
24.43 3 21.66 8
136 M F
24.4 27.1
27.7 28.9 27.00 3 27.10 1
n --i r-.. ""0 ...... ""' 0 <.0.....,
..... N <.0 ():)
137
138
140
M F
M F
M F
21.7 26.8
31.2 25.5
25.3 21.4
29.6 27.0
31.3 27.0
26.5 24.4
29.7 29.8
30.3
26.5 25.3
29.9
32.2
27.1 25.7
32.2
27.2 26.5
28.3 27.0 27.5
28.62
31.25
26.82
5
2
6
27.87
28.75
25.40
3
4
7
142 M F
29.5 24.4
29.8 28.9 29.0 29.5 29.8
29.65 2 28.32 5
143
144
M F
M F
22.8 26.8
25.4 23.9
27.1 28.7
26.4 26.5
30.6
28.4 26.7
29.3
24.95
27.38
2
4
28.70
25.70
3
3
----------------------GROUP SlM1ARY MEAN
S.D.
COUNT
26.66 104
2.56 0
19
25.91
2. 73
20
83
0
----------------------
n-;r.....-o..... 0""'1.0....,
....N1.01.0
LAC950-03/06
PERCBLOBDETHYLENE: MDLTIGENERATION INffALIITION STUDY IN THE RAT
INDIVIIXIAL ANlMAL DATA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTIM - F2A PUPS MALES FEMALES1lllM PUP INDIVIDUAL WEIGHTS DAY NO: 22 ME'AN CNT. ME'AN CNT.NU1BER SEX 300 wn wr. wr.
PERCHLOROETHYLENE: MULTIGENERAl'!ON INHALATION STUDY ru THE RAT
INDI.VmlAL ANIM.'IL DATA SUPPLEMENT
APPENDIX 22A
DIIM NU1BER
PUP SEX 300 ppn
BODYWEIGHTS (g) BY LI'ITER TO DAY 29 POST PiiRTtM • F2A PUPS
INDIVIDUAL WEIGHTS DAY N:l: 29 11<\LES MEAN wr.
Fl:MALES CNT. MEAN CNT.
wr.
135 M F
69.3 51.7
70.9 60.1
78.0 63.9 65.6 66.4 66.8 68.7 69.2
72.73 3 64.05 8
136 M F
72.1 70.1
78.3 78.5 76.30 3 70.10 1
<"> -1 r-.. """-....,. 0 <.0.....,
...... w 0 N
137
138
140
M F
M F
M F
65.3 75.5
79.8 67.5
71.5 54.8
81.8 77.3
84.5 71.5
72.2 63.2
84.9 82.7
78.1
72.5 63.7
87.5
81.6
73.8 66.9
89.1
74.0 71.1
75.1 71.3 71.8
81.72
82.15
73.18
5
2
6
78.50
74.68
66.ll
3
4
7
142 M F
82.7 66.9
84.9 77.8 80.5 81.4 83.6
83.80 2 78.04 5
143
144
M F
M F
73.7 76.5
72.3 65.9
85.2 82.0
74.9 70.0
83.5
78.2 72.5
81.3
79.45
76.68
2
4
80.67
69.47
3
3
----------------------GBDUP stM1II.RY MEAN
S.D.
COUNT
76.18 104
6.88 0
19
71.13
6.50
20
83
0
c-j\:
)'''
.-...
!'., '· :~ ...,, •., >.:,,
----------------------
LAC950-03/06
PERCHLORDETHYLENE: MOLTIGENERATION INHALATION STUDY IN THE RAT
INDIVIIX!AL ANIMAL DATA SUPPI..EMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS MIILES ffi1ALESDAM PUP INDIVIDUAL WEIGHTS DAY NO: 1 MEliN 00. MEliN 00.Nll1BER SEX 1000 ppn wr. wr.
PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT INDIVI!XTAL ANIMAL DATA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITTER !0 DAY 29 POST PARTIM - F2A PUPS MALES !lAM PUP FJ!M!ILESINDIVIDUAL WEIGHTS DAY ID: 22 NtMBER MEAN SEX CNT. MEAN 1000 CNT.PJlll wr. wr.
169 M 42.5 43.0 43.2 44.8 45.1 45.1 43.95 F 6 38.3 38.5 41.0 41.1 39.73 4170 M 48.0 51.3 53.0 50.77 F 328.5 47.5 48.2 41.40 3171 M 40.7 45.1 46.0 48.2 45.00 4 F 43.8 43.80 1172 M 33.8 35.4 39.3 36.17 3 F 35.0 35.1 35.7 36.1 35.48 4174 M 41.1 43.2 43.3 43.9 45.4 48.6 44.25 6F 39.3 41.6 40.45 2176 M 33.3 34.0 37.1 37.2 35.40 4 F 30.9 34.5 35.1 38.7 34.80 4181 M 38.5 39.1 39.7 42.0 43.4 43.7 47.0 41.91 7F 31.7 39.8 40.4 41.1 41.7 38.94 5185 M 43.3 45.3 46.1 49.2 50.4 46.86 5F 43.7 45.3 44.50 2186 M 36.9 39.5 40.5 41.6 42.0 40.10 5F 35.3 36.7 36.8 37.8 38.5 40.3 37.57 6187 F 45.5 45.50 1189 M 49.8 49.80 1F 43.1 46.7 46.9 47.4 47.7 46.36 5 191 M 40.2 43.3 44.1 44.7 43.08 4F 38.1 41.3 42.0 43.0 44.3 44.6 42.22 6
PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT
OOIVIOOAL ANlMAL DATA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS Jli\M MALES PUP FEMALESINDIVIDUAL WEIGHTS DAY N:>: 22 MFiiN NU1BER CNT. MFiiN SEX 1000 CNT.ppn wr. wr.
PERCHLOROETHYLENE: MULTIGENERATION INHAU\TION STUDY IN THE RAT
INDlVIJJUAL l\NlMAL DATA SUPPLEMENT
APPENDIX 22A
BODYWEIGHTS (g) BY LITrER TO DAY 29 POST P.i\RTtM - F2A PUPS MALES FE1ALESruM PUP INDIVIDUAL WEIGHTS DAY NO: 29 MEAN CNT. MEAN CNT.NU1llER SEX 1000 ppn wr. wr.
PERCHLOROETHYLENE: 11IJLTIGENERATION INHA!liTION STUDY IN THE RAT
INDIVIIXIAL .ANIMAL DATA SUPPLEMENT
APPENDIX 22A
Dl!M NlMBER
PUP SEX 1000 ppn
BODYWEIGHTS (g) BY LITTER TO !liT 29 POST PARTIM - F2A PUPS
INDIVIDUAL WEIGHTS DAY NO: 29 MIILES MEAN wr.
FEMALES CNT. MEAN CNT.
wr.
192 M F
78.8 73.0
79.9 74.4
82.6 78.8
82.9 83.0 83.7 84.2 82.16 7 75.40 3
----------------------GROUP Sl.M1IIRY MEAN
S.D.
COUNT
79.16
6.99
12
55
0 72.52
4.75
13
46
0
n -! r..._ -o..._.,. 0
"'....,
..... w ......,.
(
PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT
INDIVIDUAL ANIMAL DATA SUPPLEMENT
APPENDIX 228
BODYWEIGHTS (g) BY LITTER TO DAY 5 POST PARTUM
- F2B PUPS
Females 25, 33, 122, 131, 173, 178 did not litter.
Pups from female 123 were all dead.
Females 141, 183, 184 were dead prior to this litter.
The litter from dam 29 was weighed on day 4 post partum and not on day 5
post oartum.
Key:
CNT = count (number of pups)
WT = weight
M = male
F = female
CTL/P/4097 - 1315
(
LAC950-03/06
PERCHLORDETHYLENE: MULTIGENERATION INHAUITION STUDY IN THE RAT
INDIVIOOAL ANJMIIL 11'\TA SUPPLEMENT
APPENDIX 22B
JlliM NU1BER
PUP SEX 0 Jlllll
BODYWEIGHTS (g) BY LITI'ER 10 DIIY 5 EIJST PARTIM - F2B PUPS
INDIVIDUAL WEIGHTS DIIY N:l: 1 MALES MEliN wr.
CNT. rn-w.ES MEliN CNT. wr.
26 M F
5.2 4.8
5.4 5.0
5.8 5.1
5.8 5.4
5.8 5.5
6.0 5.6 5.7 5.8 5.9
5.67 6 5.42 9
27 M F
7.3 5.8
7.6 6.4 6.9 6.9 7.0
7.45 2 6.60 5
n --i.--.. -o-....,. 0
"" ......
..... w ..... 01
28
29
30
M F
M F
M F
5.4 5.3
6.4 6.5
6.5 5.9
5.5 6.1
6.8 6.5
6.1
5.9 6.1
7.1
6.2
6.0 6.1
7.2
6.2 6.2
7.3
6.4
7.4
6.5
7.7
5.99
7.13
6.50
7
7
1
5.96
6.50
6.07
5
2
3
31 M F
6.2 6.2
7.2 6.6 6.7 7.5
6.70 2 6.75 4
32 M F
6.2 5.7
6.2 5.9
6.3 6.0
6.4 6.1 6.2 6.4
6.28 4 6.05 6
34 M F
5.3 5.0
5.5 5.1
5.7 5.1
5.8 5.3
5.9 5.4
6.0 5.6
6.1 6.3 6.3
5.76 7 5.51 8
35 M F
5.5 5.4
5.7 5.6
5.9 5.8
6.0 5.8
6.2 5.8
6.7 6.1
6.8 6.11 7 5.75 6
36 M F
5.0 4.9
5.6 5.1
5.7 5.1
5.7 5.2
5.7 5.3
5.9 5.4
6.1 5.5
6.2 5.5
5.74 8 5.25 8
37 M F
7.4 6.6
8.1 7.4 7.4
7.75 2 7.13 3
('")_,........"1::>....... 0""'\0.....,
.....w..........,
.~
.. I
LAC950-03 I06
PERCHLOROETHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT
INDIVIIXIAL ANlMAL MTA SUPPLEMENT
APPENDIX 22B
BODYWEIGHTS (g) BY LITI'ER ID DAY 5 POST PARTtM - F2B PUPS MALES FEMALESJlAM PUP INDIVIDUAL WEIGHTS DAY NO: 1 MEAN CNT. MEAN CNT.NU1BER SEX 0 ppn wr. wr.
PERCHLOROETHYLENE: 11ULTIGENERATION INHALATION STI!OY IN THE RAT
INDIVIru\L ANlli\L D.t<rA SUPPLEMENT
.APPENDIX 22C
BODYWEIG!ITS (g) BY LITI'ER TO DAY 5 POST PAR11M - F2C PUPS MIILES DAM FEMM.:ESPUP INDIVIDUAL WEIGHTS ll!IY NO: 1 MEANNU1BER em. MEAN SEX em.1000 ppn wr. wr.
PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT INDIVIllUAL ANlMAL rnTA SUPPLEMENT
APPENDIX 24 ORC.-'lN WEIGHTS (g) - E2A PUPS
FEMALES GROUP: 1 lXlSE LEVEL: 0 PEM
PARENT FEMALE N:l. PUPID TERM KIDB LIV TESB
25 A 82.9 0.893 4.204 26 B 75.4 0.994 4.232 32 E 90.7 1.231 4.934 35 A 66.8 0.794 3.656 36 B 85.2 0.969 4.338 39 I 84.1 1.054 4.564 44 B 77.2 0.946 4.317 45 G 72.5 0.975 4.402 47 B 71.1 0.875 3.704 48 A 89.9 1.261 4.767
("") -! r-....,-... ""'0
"'.....
..... w "' ""'
- L
PERCHLOROE'l'l!YLENE: !10LTIGENERATION INHALATION STUDY IN THE RATINDIVIIJUAL ANIMAL DATA SUPPLEMENT
APPENDIX 24ORGAN WEIGHTS (g) - F2A PUPSFEMALES
GROUP: 2 IXlSE LEVEL: 100 PEM PARENT FEMALE NO. PUPID TERM KIDB LIV TESB
77 c 82.4 0.974 4.37578 A 73.5 0.925 4.24781 c 74.3 0.840 3.94982 A 79.8 0.994 4.91283 B 78.5 0.967 4.88684 A 72.4 0.952 4.08089 c 78.6 1.044 4.68890 A 81.2 0.906 4.24593 c 67.1 0.919 3.64794 A 81.8 0.966 4.337r.--!.............""-1'>0....,"'
......
tn"'w
~ ~
--
PERCHLOROEI'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT INDIVIDJAL ANIMAL JliiTA SUPPLEMENT
APPENDIX 24
ID1ALES ORGAN WEIGHTS (g) - F2A PUPS
GROUP: 3 IXlSE LEVEL: 300 PEM
PARENT FEMALE 00. PUPID TERM KIDB LIV TESB
121 c 78.4 1.105 4.033 122 A 78.6 1.000 4.493 125 c 78.8 1.076 4.128 129 E 76.6 0.989 3.645 130 G 81.6 1.020 4.693 137 E 85.0 0.981 4.958 138 c 81.6 0.986 4.522 140 A 71.8 . 3.711 142 A 87.8 1.037 4.473 143 G 78.8 0.896 4.252
-i " ' -o --.,. 0
....."'
..... w "' "'
PERCH!..OROETHYLENE: !1llLTIGENERATION INHAIATION STUDY lli THE RAT lliDIIIIIXTAL l\NIMAL DATA SUPPLEMENT
APPENDIX 24
l!'EMALES OBGAN WEIGHTS {g) - F2A PUPS
GROUP: 4 OOSE LEVEL: 1000 PEM
ARENT 1!'EMALE NO. PUPID TERM KIDB LIV TESB
169 170 174 176 181 185
K D G F c D
69.8 92.1 80.2 57.5 84.3 86.1
0.945 1.383 1.057 0.800 0.951 0.976
3.635 5.132 4.057 2.737 4.387 4.860
186 c 68.5 0.860 3.309 187 K 88.1 1.010 4.354 189 H 75.6 0.972 4.054 191 E 84.7 1.029 4.640 192 B 85.1 1.072 4.152