C P F M C P F M Chemical Chemical Proteomics Proteomics Facility at Facility at Marquette Marquette The post- genomic challenge Exploring function across protein families using chemical probes The CPFM is in early stages of development Projects focus on studies of protein function (applied genomics) Participants from: - MCW - Marquette (Biology & Chemistry) - UW-Milwaukee (MFBSC) - UW-Madison (NMRFAM) Long term goal: “Science in Service to Society” Internet2: Enabling Post-Genomic Technology at Marquette Appli ed resea rch Basic resea rch
Internet2: Enabling Post-Genomic Technology at Marquette. C P F M Chemical Proteomics Facility at Marquette. The post-genomic challenge Exploring function across protein families using chemical probes. Basic research. Applied research. - PowerPoint PPT Presentation
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
C P F MC P F M
Chemical Chemical Proteomics Proteomics
Facility at Facility at MarquetteMarquette
The post-genomic challenge Exploring function across protein families using chemical probes
The CPFM is in early stages of development Projects focus on studies of protein function (applied genomics) Participants from:
Internet2: Enabling Post-Genomic Technology at Marquette
Applied research
Basicresearch
Internet2: Turning the CPFM into a Collaboratorium
Potential Benefits:
- Better understanding of biology - Pharmacogenomics & personalized medicine- Treatments for currently untreatable disease- Drugs with fewer side effects - Better understanding of toxicology of pollutants
The Promise of Genomics: not yet realized …
“The human genome is data not knowledge, and will be useless until we understand what it means.” attributed to Sydney Brenner
Genes => Proteins
C P F MC P F M
Chemical Chemical Proteomics Proteomics
Facility at Facility at MarquetteMarquette
The post-genomic challenge Exploring function across protein families using chemical probes
What is the Chemical Proteomics Facility at Marquette?Resources (equipment, software) and people
With a mission to: Enable Chemical Proteomic studies of protein-ligand interactions Facilitate collaboration across departments and institutions Provide a better understanding of basic biology Use science to address social needs Train scientists and entrepreneurs with social conscience
S3 = Biotechnology with social conscience: science, business, law and engineering
Beowulf/Linux cluster facility Modelling lab: remote access to NMRFAM
NMR spectrometer lab Fluorescence assay lab
CPFM Resources at Marquette:
Equipment
C P F MC P F M
Chemical Chemical Proteomics Proteomics
Facility at Facility at MarquetteMarquette
The post-genomic challenge Exploring function across protein families using chemical probes
Medical College of Wisconsin- Henry Miziorko: Enzymes in the mevalonate biosynthetic pathway: structural and mechanistic studies - Jung-Ja Kim: Structural characterization of molecular motion in NADPH-cytochrome P450 oxidoreducatase
Marquette: Chemistry- James Kincaid: Complementary use of NMR & Raman studies to probe substrate binding to cytochrome P450 - Dan Sem: Probing protein-ligand interactions in toxicology and chemical proteomics: methods and application
Marquette: Biology- Pinfen Yang: Mechanism of flagellar radial spoke: ligand binding and structural studies of radial spoke protein 2
- Rosemary Stuart: Role of Su e in oligomerizing the F1-F0 ATP synthase complex: structural and binding studies
Other collaborators and resources: UW-Milwaukee: Marine and Freshwater Biomedical Sciences Center UW-Madison: NMR Facility UT-Austin: Supercomputer Facility (NSF)