Building new blood vessels

Step Closer to Custom-Building New Blood Vessels

•The group of researchers used Induced pluripotent

stem cells, commonly abbreviated iPSCs, are a type

of pluripotent stem cell artificially derived from a non-

pluripotent cell by inducing a "forced" expression of

specific genes. Usually used as target an adult cell

differentiated (cell differentiation) from a tissue on

which is induces the expression of several foreign

genes. IPS cells are able to differentiate into cells of

tissues from the three germ layers of a human

embryogenesis.Mathematical Models Target Disease With Drugs Chosen by Your DNA

•Pharmacogenomics is the technology that analyses how

genetic makeup affects an individual's response to

drugs. It deals with the influence of genetic variation on

drug response in patients by correlating gene

expression with a drug's efficacy or toxicity. By doing

so, pharmacogenomics aims to develop rational means

to optimize drug therapy, with respect to the patients'

genotype, to ensure maximum efficacy with minimal

adverse effects.

As you can read in the article, even from the title, the construction of a capillary network from pluripotent

stem cells and synthetic material (hydrogel infusion), is a process that is not ready, tested and safe for

humans, yet. It is clear that I have not checked other experiments in this area of investigation; so I have no

points of comparison to say how advanced is this research. At least, they started experimenting with

animals and seems to have good results; I hope that they continue, to find significant results applicable to humans. Something that can be an advantage in this research is the use of new processes of growth, like,

start from induced pluripotent stem cells, and selection of specifics stem cells to the needs of the

investigation.

Information on pharmacological

targets

The framework characterizes a medicament's

Absorption

Distribution

Elimination properties

Yielding

Physiological pathways and,

disease systems in patients

Resulting in predictions of treatment effectiveness.

This is the beginning of a truly personalized medicine, at least as far as medicaments are concerned, since thanks to the collection of

statistical data and pharmacological studies, is being achieved eliminate the margin of error

that could have a treatment, to suit the needs specific of patients according to their genetic material, thus fulfilling, in practice, with de

phrase: "no hay enfermedades sino enfermos". Personally I find a great step in medicine, so

that is closer to be an exact science.

The general application of this research is the ability to rebuild a microvascular

bed in a clinically relevant manner, they have made an important step toward the construction of blood vessels for

therapeutic use more effective treatments for patients afflicted with

burns, diabetic complications and other conditions in which vasculature function

is compromised.  

One particularity in this case was the used of technics that made the process quicker, and

the use induced pluripotent stem cells as their starting point. Since this type of cell is made by reverse-engineering mature cells -- from

the skin or blood, for example -- using it means that the resulting blood vessels could

be tailor-made for specific patients.

The goal of this research is a future with more effective medications,

faster healing and fewer side effects, and to achieve it, they

studied at how an individual person responds to an individual drug by deriving and using sophisticated mathematical models, such as

differential equations. The team's equations also including information

about how the body processes a drug and how the drug acts in the

body.

The researchers created a statistical analysis framework of differential

equations that they expect will help doctors and pharmacists, by simulating such variables as

protein-protein and protein-DNA interactions a drug has in a patient,

it will facilitate the quantitative prediction of the responses of

individual subjects as well as the design of optimal drug treatments, by determine what drug and dose

might be best for that person.

· Johns Hopkins Medicine (2013, July 16). Step closer to custom-building new blood vessels. ScienceDaily, [online]. Retrieved July 19, 2013, from http://www.sciencedaily.com /releases/2013/07/130716161844.htm;  [consulta: 16 de julio de 2013].

· Penn State (2013, July 16). Mathematical models target disease with drugs chosen by your DNA. ScienceDaily, [online]. . Retrieved July 19, 2013, from http://www.sciencedaily.com /releases/2013/07/130716120030.htm; [consulta: 16 de julio de 2013].