BROOKLYN 2 RADIOTHERAPY Patries HERST Fri 30 th Aug 2013 Session 2 / Talk 5 11:40 – 12:00 ABSTRACT Purpose: Severe acute radiation-induced skin reactions occur in a significant proportion of women who receive radiation therapy for breast cancer. We previously showed that soft silicone dressings decreased the severity of severe skin reactions by 40% when applied from the onset of erythema. Here we report the effect of a transparent silicone film on the severity of skin reactions and the incidence of moist desquamation when used from the beginning of treatment in breast cancer patients. Methods and Material: A total of 80 women were recruited from Dunedin Hospital. The breast or chest wall was randomly divided into lateral and medial halves at the start of radiation therapy treatment; one half was treated with Mepitel Film, the other half with aqueous cream. Skin reactions were assessed using the Radiation-Induced Skin Reaction Assessment Scale. Results: Mepitel Film prevented the onset of moist desquamation in all patients and decreased the severity of skin reactions by more than 80%. Patients preferred the film and found it very comfortable to wear. Conclusions: Mepitel Film prevents moist desquamation when used prophylactically
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BROOKLYN 2
RADIOTHERAPY
Patries HERST
Fri 30th Aug 2013
Session 2 / Talk 5
11:40 – 12:00
ABSTRACTPurpose: Severe acute radiation-induced skin reactions occur in a significant proportion of
women who receive radiation therapy for breast cancer. We previously showed that soft silicone dressings decreased the severity of severe skin reactions by 40% when applied from the onset of erythema. Here we report the effect of a transparent silicone film on the severity of skin reactions and the incidence of moist desquamation when used from the beginning of treatment in breast cancer patients.
Methods and Material: A total of 80 women were recruited from Dunedin Hospital. The breast or chest wall was randomly divided into lateral and medial halves at the start of radiation therapy treatment; one half was treated with Mepitel Film, the other half with aqueous cream. Skin reactions were assessed using the Radiation-Induced Skin Reaction Assessment Scale.
Results: Mepitel Film prevented the onset of moist desquamation in all patients and decreased the severity of skin reactions by more than 80%. Patients preferred the film and found it very comfortable to wear.
Conclusions: Mepitel Film prevents moist desquamation when used prophylactically
Mepitel Film for Radiation-Induced Skin Reactions
Dean Paterson, Prashika Poonam, Noelle Bennett, Annie Sutherland, Ruth Peszynski, Meredith van Beekhuizen, Katie Diggelmann, Marieke Jasperse,
Patries Herst
NZIMRT, 2013
RationaleUnavoidable side effect of external beam RT
No standard treatment
Form protective barrier
Inert
Adhere to healthy skin but do not stick to open wounds
Decrease the severity of erythema by 30% in a pilot study of 30 breast cancer patients.
(Diggelmann et al. Br J Radiol 83, 2010)
4] time to healing
Mepilex
Standard dressings
Healing
Aqueous creamMepilex
In-Patient Randomization
Erythema• Post-mastectomy• No metastatic disease
• No previous RT to chest
• Able to attend follow up
• Good performance status
Eligibility
RISRAS• 3x a week during TMT• 1x a week for 4 weeks after TMT completion