Addressing gaps in clinically useful evidence on drug- drug interactions Update to W3C HCLS September 10 th 2013 Richard Boyce, University of Pittsburgh Department of Biomedical Informatics
Addressing gaps in clinically useful evidence on drug-drug interactions
Update to W3C HCLSSeptember 10th 2013
Richard Boyce, University of Pittsburgh
Department of Biomedical Informatics
A new paradigm for drug-drug interaction knowledge representation
Product labeling
Scientific literature
A framework for representing PDDI assertions and evidence as interoperable Linked Data available for community annotation
Pharmacoepidemiology studies
Semantic annotation
High priority PDDIs for research
Semantic annotation
Reduced risk of a PDDI medication
error!
Clinical experience
Better synthesis of PDDI evidence, easier identification of gaps
Expected benefits:• More complete and accurate PDDI evidence• Better informed pharmacists and other
clinicians• More effective PDDI alerting and decisions
support systems
DailyMed Linked Structured Product Labels
• LinkedSPLs is a Linked Data version of SPLs– http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/
• >40,000 FDA-approved prescription and over-the-counter drugs present in DailyMed (09/2013)
• simplifies access to SPL content• interoperable with other important drug
terminologies and resources– RxNorm, NDF-RT, DrugBank, ChEBI
• Pharmacogenomics biomarker statements– http://www.youtube.com/watch?v=Te546vOiruo
PDDI information mashups
http://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/outfiles-poc-10252012/dikb-label-mashup-citalopram-001714c1-a292-40be-bfbd-0ff67193ace6.html
Open Data Annotation
http://www.openannotation.org/spec/core/
Semantic Annotation of potential drug-drug interactions (PDDIs)
Scientific Discourse modeling
Drug Interaction Knowledge Base (DIKB) Open Data Anotation + Scientific Discourse
• See • >300 evidence sources • >1500 links to ~1300
assertions
A production rule base for inferring pharmacokinetic PDDIs
DIKB: http://dbmi-icode-01.dbmi.pitt.edu/dikb/
Initial conversion (not ready for release):http://swat-4-med-safety.googlecode.com/svn/trunk/analyses/dikb-open-annotation/
Work in progress…A pipeline for the extraction PDDIs from SPLs and publishing them as semantically annotated Linked Data
Potential for PDDI semantic annotation dissemination
• As Linked Data, it automatically extends– DrugBank, ChEBI, RxNorm, NDF-RT
• A user friendly knowledge base portal– Currently testing Domeo: http://swan.mindinformatics.org/
– Enables community annotation and scientific discourse
• Other possibilities:– The FDAs SPL indexing initiative
• Could guide future requirements for SPL submissions• Complements our work on representing pharmacogenomics clinical
statements [18]
AcknowledgementsCollaborators: • Harry Hochheiser, Qian Zhu, Robert Freimuth, Carol
Collins, John Horn, Mathias Brochhausen, Serkan Ayvaz, Majid Rastegar-Mojarad, Anita DeWaard, Jodi Schneider, Maria Liakata, Oktie Hassanzadeh, Joanne Luciano, Michel Dumontier, and the W3C HCLS
Funding:• Agency for Healthcare Research and Quality
(K12HS019461). • NIH/NCATS (KL2TR000146),• NIH/NIGMS (U19 GM61388; the Pharmacogenomic
Research Network) • NIH/NLM (T15 LM007059-24)