Breast disease MUDr. Petr Šafář, CSc.
Benign breast disease
• Fibrocystic breast disease
• Adenosis – glandular prolif.
• Ductal hyperplasia – intraductal papilloma
• Cystosarcoma phyllodes – 80% benign
• fibroadenoma
WHO classification
• Non-invasive carcinoma-ductal carcinoma in situ ( DCIS ) +lobular carcinoma in situ ( LCIS )
Invasive carcinoma - invasive ductal carcinoma (NST,NOS) invasive ductal carcinoma with dominant intraductal component, invasive lobular, carcinom mucinous, carcinom papillary, carcinom tubular, adenoid cystic carcinoma, carcinom sekretoric (juvenile) carcinoma apocrine, Paget´s carcinoma of breast nipple
Breast cancer treatment
• Surgery - radical mastectomy vs. Segmentectomy, TE+SLNB
• Adjuvant radiotherapy
• Adjuvantní chemotherapy
• Biologic therapy – herceptin
• Hormonal therapy