Kevin S.Hughes, MD, FACS Co-Director, Avon Comprehensive Breast Evaluation Center Massachusetts General Hospital Harvard Medical School Date 06/01/2007 Breast Cancer in the Older Woman - Is Radiation Necessary? American Society of Breast Surgeons Phoenix, Arizona 2012
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Breast Cancer in the Older Woman - Is Radiation Necessary?
Breast Cancer in the Older Woman - Is Radiation Necessary?. Kevin S.Hughes, MD, FACS Co-Director, Avon Comprehensive Breast Evaluation Center Massachusetts General Hospital Harvard Medical School. American Society of Breast Surgeons Phoenix, Arizona 2012. Date 06/01/2007. - PowerPoint PPT Presentation
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Kevin S.Hughes, MD, FACSCo-Director, Avon Comprehensive Breast Evaluation Center
Massachusetts General HospitalHarvard Medical School
Date 06/01/2007
Breast Cancer in the Older Woman - Is Radiation
Necessary?
American Society of Breast SurgeonsPhoenix, Arizona
2012
1.9 cm, ER+, clinical N0 Cancer1.9 cm, ER+, clinical N0 Cancer
Lumpectomy
Plus
Radiation/Boost
Tamoxifen
Sentinel Node
Chemotherapy
BRCA testing
1.9 cm, ER+, clinical N0 Cancer1.9 cm, ER+, clinical N0 Cancer
Lumpectomy
Plus
Radiation/Boost
Tamoxifen
Sentinel Node
Chemotherapy
BRCA testing
Lumpectomy
Plus
Radiation/Boost
Tamoxifen/AI
Sentinel Node
Chemotherapy
BRCA testing
Can we Vs should we?
CALGB 9343Comparison of Lumpectomy Plus Tamoxifen With and Without Irradiation in Women 70 or Older with
Clinical Stage I, ER+ Breast Carcinoma
Kevin S. Hughes, Lauren A. Schnaper, Constance Cirrincione, Donald Berry, Barbara L. Smith, Beryl McCormick, Hyman B.
Muss, Clifford Hudis, Eric Winer
Cancer and Leukemia Group BRadiation Therapy Oncology Group
Eastern Cooperative Oncology Group
Concerns regarding this study
• Patients randomized to no radiation would be inappropriately under-treated
Concerns regarding this study
• Patients randomized to receive no radiation would be inappropriately under-treated
• Patients randomized to radiation therapy would be inappropriately over-treated