Bmp sales presentation 306610811

BONE MARROW PROCESSING (BMP) PROTOCOL

SPECTRA OPTIA® APHERESIS SYSTEM

Presentation title, Month #, Year. Confidential1

Bone Marrow Processing (BMP) Protocol

ComparisonProtocol Compared Between Systems

Protocol ValueFeatures and Benefits

IntroductionAbout Terumo BCT, Protocol Overview, How it Works, Accessory Set

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ABOUT TERUMO BCT

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Terumo BCT, a global leader in

blood component, therapeutic apheresis

and cellular technologies.

We believe in the potential of blood to do

even more for patients than it does today.

This belief unites our organization, inspires

our innovation and strengthens our

collaboration with customers.

Terumo BCT

Unlocking the Potential of Blood

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Looking at Terumo BCT at a Glance

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Terumo Corporation

Blood Management Business

David Perez

Approaching $1B

David Perez

More than 2,700 globally

Medical Device Manufacturer

Blood Banking, Transfusion Medicine,

Cellular Therapies and Cell Processing

Blood Centers, Therapeutic Apheresis Centers

and Cell Processing

Lakewood, Colorado, United States

Brussels, Buenos Aires, Hong Kong, Tokyo

United States, China, India, Japan, Northern Ireland

Parent company:

Division:

Chairman:

Revenues:

President and CEO:

Associates:

Classification:

Industry:

Customer segments:

Global headquarters:

Regional headquarters:

Major manufacturing facilities:

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PROTOCOL OVERVIEW

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Protocol Overview

Bringing ease of use to BMP procedures

The Spectra Optia system simplifies BMP procedures with:

Helpful on-screen guidance

Single-bag approach

Minimal operator interaction needed throughout the procedure

Allows operators to perform other tasks

Processes bone marrow in under 90 minutes

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How it Works

Setting up the procedure

Bone marrow is transferred into

the BMP accessory set, either by:

Using a spike on the administration

line (includes 200 micron filter)

Using the luer connector assembly

The system is primed

The system guides operators through

connecting the single BMP bag

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How it Works

Entering procedure data

The system guides the operation

through setting various operating

parameters:

Amount of bone marrow processed

Number of processing cycles

Target plasma volume

With the parameters set, the system

processes bone marrow to:

Collect mononuclear cells

De-bulk and reduce the volume

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How it Works

Monitoring and adjusting the run

The system provides operators with

information to monitor the progress of

the run

Operators can adjust the collection

preference to control the

concentration of cells through the

collect port

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Continuously compares how the

system is collecting cells with the

target collection preference

Displays an image of the collect port throughout procedure

Gives the ability to adjust collection preference

Accessory Set

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Compact packaging Minimizes the space required for storage

Color-coded components Simplify setup and operation

Functionally closed set Helps prevent contamination

Accessory Set used with the IDL Set

BMP bagStreamlines operator interaction with a single-bag approach

Sample bulb assemblyAllows sampling before or during the procedure while maintaining a functionally closed system

Administration lineIncludes a 200-micron filter on the line with spikes for additional filtration if desired

Protocol Value

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Advanced technology

and operator choice

Streamlines operator

interaction with a single-bag approach

Guides operators

through the protocol with an intuitive

graphical user interface (GUI)

Allows operators to

perform other tasks as the

system continuously monitors and adjusts the

interface

Minimizes memorization and simplifies

training

Provides operators with control over

parameters to meet target processing outcomes

Protocol Value

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Procedure precision and safety

Produces consistent results through interface stability

Performs red cell reduction greater than 97 percent*

Provides volume reduction greater than 80 percent*

Produces a final product volume under 200 mL*

Helps prevent the contamination of harvested bone marrowwith a functionally closed procedure

Frees up space, because a clean room is not required

*Data on file.

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COMPARISON

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Comparison

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Spectra Optia System COBE® Spectra Apheresis System

Single-bag approach with a constant

flow, no clamping

Two product bags, operators required

to move clamps during procedure

Automated Interface Management

(AIM) system

Operator manages interface

Intuitive GUI with touch screen LED and touch pad

Plasma collection is optional and can

be configured depending on the other

collection parameters

Plasma is automatically collected

for most procedures

Collect valve opens automatically when

cells are detected by AIM

Operator manually opens collect valve

Data management (reports),

stores up to 100 procedures

No data or report capabilities