BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are

1. Dr K’s office hours: In office Tuesdays 2:30 - 3:30 PM (In office: 3122A Pacific Hall) Group Fridays 11:00 AM - noon (Meeting room: 3501 Pacific Hall)

2. Dr K’s problem-solving session: Wed and Thurs 5-6 in 3500 Pacific Hall (same material).

3. Midterm exams: returned at around noon—have your ID in hand. 4. Grading errors?

1. Check the answer key on the web site (by mid-afternoon today). 2. Talk to the appropriate TA (see “# graded” below) by Wed, Nov. 11. 3. Turn in a written description of the error(s) to Dr. K, along with exam, by Fri. Nov. 13. ***Dr. K may regrade the whole ***

5. Pick up graded exams: If you signed the waiver, outside the elevator of the third floor of Pacific Hall. If you did not sign the waiver, from Dr. K after class or at office hours.

6. TA sections, office hours:      

BIPN100    Human  Physiology  1                Bill  Kristan,  Ph.D.  

. Section IA # graded Office Hour . Fri 11:00-11:50am SEQUO 148…..Winjet Chou……....(3)…..Wed 3-3:50 pm……...HSS 1145B Fri 12:00-12:50pm SEQUO 147…...Saatchi Patell…….(7)…..Wed 1-1:40 pm……...Muir Woods Fri 1:00-1:50pm WLH 2115 ….. Justine Liang….….(4)…..Tues 10-10:50 am…..Hi Thai Fri 2:00-2:50pm WLH 2206 …….Hao Shi……………(2)…...Fri 3-3:50 pm………...HSS 1128A Mon 9:00-9:50am WLH 2115……. Tim Macaulay....….(8)…...Tues 12:30-1:20 pm…Mandeville Cart Mon 4:00-4:50pm WLH 2208……. Mallorie Nguyen….(6).....Thurs 2-2:50 pm…….Goody's Market Mon 5:00-5:50pm WLH 2208……..Donel Purcella……(5)..…Mon 3:30-4:20 pm…..Price Center East, SR 2 Mon 6:00-6:50pm WLH 2115……...Kyra Rashid………(1)…..Thurs 10-10:40 am…Revelle Com. Lounge

Time course of twitches in fast (L.R.), slow (S.), and mixed (G.) muscles

L.R. = lateral rectus (eye muscle—pulls eye outward) G. = gastrocnemius (large calf muscle—extends ankle) S. = soleus (small calf extensor; parallel to gastocnemius)

Synergistic and antagonistic muscles in the lower leg that control ankle movements

Fatigue rates in slow twitch and fast twitch muscles

Fast vs. slow muscles

1. Skeletal muscle

Muscles are of 3 general sorts:

2. Smooth muscle

3. Cardiac muscle

Smooth  muscle  

Skeletal  (striated)  muscle  

Contrac;on  and  relaxa;on  rates  in  skeletal,  cardiac,  and  smooth  muscles  

Figure 12-11 Skeletal muscle contraction Figure 12-28 Smooth muscle contraction

(L-type)

(RyR)

Metabotropic receptor

G

IP3

Ligand (DHP)

Figure 12-28 Smooth muscle contraction Figure 12-9 How Ca++ causes skeletal muscle contraction

Figure 12-29 (Silverthorn 5th edition) Relaxation of smooth muscle

Functional anatomy of smooth muscle

Connec;ons  between  smooth  muscle  cells.  

Aka:  unitary  

Two types of smooth muscle

Control systems of smooth muscles

Relationships between membrane potential (Em) and force (F) in different types of smooth muscle

intestines

blood vessels blood vessels

intestines

     Strategy  #1.  As  per  the  course  outline:  average  of  top  5  grades  =  92  

     A    (90%  of  92)  =  83-­‐94  [36]        B    (75-­‐89%  of  92)    =  69-­‐82  [119]        C    (60-­‐74%  of  92)    =    55-­‐68  [92]        D    (50-­‐59%  of  92)    =  46-­‐54  [34]        F    (<50%  of  92)  =  30-­‐45  [28]  

305  students  took  midterm  1  High  score  =  94  Low  score  =    30  

Grade  distribu;on:  

       Strategy  #2.  Mean  (67%)  is  the  B-­‐C  cutoff,  other  cutoffs            are  +  1  standard  devia;on  (13%):    

     A  =  80-­‐94  [56]        B  =  67-­‐79  [117]        C  =  54-­‐66  [81]        D  =  40-­‐53  [41]        F    =  30-­‐39  [10]  

Mean  =  67  St.  dev.  =  13