Data Visualization Example plots • Heat maps • Bayesian adaptive clinical trials • Kaplan-Meir survival curves • Mixture of multivariate normal distributions • ROC curves Services Provided biostatistics & informatics shared resource This work core is supported by an NIH grant from NCI awarded to The University of Kansas Cancer Center (The KUCC) #1 P30 CA168524. CORE Faculty Associate Director Shared Resources, KUCC and Chair of Biostatistics M. Mayo Observational Data & Survivorship Bioinformatics, ‘Omics, and Analysis/Design of Basic Science Experiments Therapeutic Investigator Initiated Trials (IITs) Clinical Trial Design and Analysis Methods Pharmacological Modeling, High Throughput Screening and Bioassays BISR Director: B. Gajewski Associate Director: D. Koestler J. He* J. Mahnken F. Diaz D. Koestler M. Phadnis D. Koestler* P. Chalise F. Diaz M. Phadnis* F. Diaz M. Mayo P. Chalise J. Mahnken J. Wick* B. Gajewski F. Diaz J. He M. Mayo J. Mahnken F. Diaz* M. Mayo Instrument Development/ Psychometrics B. Gajewski* J. Wick J. He IAB J. Chien (CB) A. Greiner (CCPH) J. Hamilton-Reeves (CPS) P. Sharma (D3ET) EAB M. Hardin (Samford U.) B. Pollock (UC Davis) D. Wallace (RTI International) H. Weiss (U. of Kentucky) S. Byers (KUCC EAB, Georgetown) Administrative Support Team W. Anderson, L. McElgunn, & M. Tremblay Informatics and Data Coordination D. Mudaranthakam & S. Chintala 1. Cancer Biology (CB) 2. Drug Discovery, Delivery and Experimental Therapeutics (D3ET) 3. Cancer Prevention & Survivorship (CPS) 4. Cancer Control and Population Health (CCPH) Provide Support and Guidance to KUCC Programs & Investigators Statistical Expertise Sub-Units Health Equity and Disparities B. Gajewski* J. Wick J. He M. Mayo D. Koestler Jo Wick, PhD Assistant Professor, Department of Biostatistics, University of Kansas Medical Center Associate Director of Graduate Education, Department of Biostatistics [email protected] • Study Design: BISR personnel aid in the design of experiments by KUCC investigators to ensure the research questions are testable using existing statistical methodology. • Statistical Analyses: BISR personnel oversee statistical analyses for research projects to ensure: appropriate statistical methodology is used and interpretations of study findings are correct. • Research Informatics & Data Management: KUCC research projects can utilize the clinical information management database system within Velos. • Electronic Data Collection: BISR collaborate with the principal investigator and data entry personnel in determining the information and timing of the data to be captured for the study. • Bioinformatics / Statistical Genomics: BISR provide support for the managing, visualizing, analyzing, and interpreting high-dimensional ' omic data produced from human or model organisms. In addition, the BISR has partnered with the KUMC Kansas INBRE Bioinformatics Core to provide researchers access to Ingenuity Pathway Analysis (IPA) and high-performance computing (HPC) at KU-Lawrence. • IITs and Clinical Trials: The BISR supports data management, study design and statistical analysis of clinical trials conducted by KUCC researchers. Byron Gajewski, PhD Professor, Department of Biostatistics, University of Kansas Medical Center Director, Biostatistics and Informatics Shared Resource, The University of Kansas Cancer Center [email protected] Devin Koestler, PhD Assistant Professor, Department of Biostatistics, University of Kansas Medical Center Associate Director, Biostatistics and Informatics Shared Resource, The University of Kansas Cancer Center [email protected] Dinesh Pal Mudaranthakam, MS Director of Research Information Technology [email protected] (913) 945-6922 Prabhakar Chalise, PhD Research Assistant Professor, Department of Biostatistics, University of Kansas Medical Center [email protected] Francisco Diaz, PhD Associate Professor, Department of Biostatistics, University of Kansas Medical Center [email protected] Jianghua He, PhD Associate Professor, Department of Biostatistics, University of Kansas Medical Center [email protected] Matthew Mayo, PhD, MBA Founding Chair and Professor, Department of Biostatistics, University of Kansas Medical Center [email protected] Jonathan Mahnken, PhD Associate Professor, Department of Biostatistics, University of Kansas Medical Center [email protected]u Millind Phadnis, PhD Assistant Professor, Department of Biostatistics, University of Kansas Medical Center [email protected]