BioSpine · Marianna A. Tryfonidou (Utrecht/NL) Scientific Programme • Thursday, April 9, 2015. 12 Scientific Programme • Thursday, April 9, 2015 08:50 Regeneration of impaired

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Table of Contents

Organisation and Imprint ........................................................................................... 4

Welcome Note of the Congress Chair ........................................................................ 5

Committees .............................................................................................................. 6

Invited Speakers ........................................................................................................ 7

Programme Overview Wednesday and Thursday, April 8 and 9, 2015 ............................ 8 Friday and Saturday, April 10 and 11, 2015 ................................. 9

Scientific Programme Wednesday, April 8, 2015 ............................................................ 10 Thursday, April 9, 2015 ............................................................... 11 Friday, April 10, 2015 ................................................................... 16 Saturday, April 11, 2015 .............................................................. 22

Poster Exhibition ....................................................................................................... 24

Sponsors, Exhibitors and Media Cooperation ............................................................. 26

Social Programme .................................................................................................... 29

General Information ................................................................................................... 30

General Hints for Authors and Presenters .................................................................. 33

Index of Authors and Chairs ...................................................................................... 34

City Map ................................................................................................................ 35

4

Organisation and Imprint

VenueLangenbeck-Virchow-HausLuisenstrasse 58/5910117 Berlin (DE)

DateApril 8–11, 2015

Organiser Regenerate Europe e. V.

Congress ChairProf. h. c. Dr. med. Hans Jörg MeiselBG Clinic BergmannstrostDepartment of NeurosurgeryMerseburger Strasse 16506112 Halle a. d. Saale (DE)

Congress SecretariesClaudia HoßbachYvonne Minkus

Congress Organisation Conventus Congressmanagement & Marketing GmbHNadia Al-Hamadi/Roxelane GörlsCarl-Pulfrich-Strasse 107745 Jena (DE)Phone +49 3641 31 16-315/-312Fax +49 3641 31 [email protected]

Design/LayoutLayout www.krea.tif–design.dePrint www.siblog.deCirculation 5,000Editorial Deadline February 19, 2015

mailto:[email protected]://www.conventus.de

5

Welcome Note of the Congress Chair

Dear colleagues and friends,

On behalf of the Organizing Committee and the Advisory Board, I am pleased to welcome you in Berlin from April 8–11, 2015 to participate in our 5th Biospine congress.

BioSpine has set itself the task to act as a catalyst between clinicians, scientists and in-dustrial partners, to support doctors’ curiosity and demand for new information, and at the same time to request that industrial partners elucidate product information with appropriate scientific scrutiny. Biomaterials in spine surgery have moved far beyond the role of “bone void fillers” like it used to be 10 years ago. That evolution has resulted in products that are now characterized as growth factors, cell products and combined products; each of which might follow various regulations to meet clinical use approval. BioSpine was initiated to give insights into technology development, has the aim to impart understanding and acceptance, but also wants to sharpen a critical view.

Nevertheless there are still noticeable differences regarding both the quality of academic support and the efficiency of introducing new products to the market. In particular, the clini-cal knowledge contribution from the medical point of view remains limited and will require ongoing support from the academics as well as from industry to sustain progress and improve therapeutic options.

BioSpine not only shows openness to the end-consumer, the surgeon, but further recognizes the importance of incorporating the scientist into a common dialogue in order to provide parallel direction for future industrial research.

Science subsists from the lively exchange of information. Join us for this fantastic opportunity, for fruitful conversations, for vigorous discussions and the mutual exchange of knowledge.

I cordially welcome you all to attend the BioSpine congress in Berlin.

Yours

Hans Jörg Meisel

6

Committees

Organizing Committee

Aldemar A. Hegewald (Mannheim/DE)

Christoph Josten (Leipzig/DE)

Jean-Charles Le Huec (Bordeaux/FR)

Michael Piccirillo (Zurich/CH)

Michael Rauschmann (Frankfurt a. M./DE)

Advisory Board

Kenneth Cheung (Hong Kong/CN)

Finn Bjarke Christensen (Aarhus/DK)

Lisa Ferrara (Southport, NC/US)

Jörg Franke (Dortmund/DE)

Timothy Ganey (Atlanta, GA/US)

Robert Gunzburg (Antwerp/BE)

Marco N. Helder (Amsterdam/NL)

Frank Kandziora (Frankfurt a. M./DE)

H. Michael Mayer (Munich/DE)

Björn P. Meij (Utrecht/NL)

Michael Ogon (Vienna/AT)

Jong-Beom Park (Uijeongbu/KR)

Theodoor H. Smit (Amsterdam/NL)

Petr Suchomel (Liberec/CZ)

Marek Szpalski (Brussels/BE)

Gianluca Vadalà (Rome/IT)

Péter P. Varga (Budapest/HU)

Jeffrey Wang (Los Angeles, CA/US)

Hans-Joachim Wilke (Ulm/DE)

Michael Winking (Osnabrück/DE)

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Invited Speakers

Mauro Alini (Davos/CH)

Lorin Michael Benneker (Bern/CH)

Ulrich Berlemann (Thun/CH)

Marike Broekman (Utrecht/NL)

Finn Bjarke Christensen (Aarhus/DK)

Vincenzo Denaro (Rome/IT)

Jörg Franke (Dortmund/DE)

Timothy Ganey (Atlanta, GA/US)

Roger Härtl (New York, NY/US)

Aldemar A. Hegewald (Mannheim/DE)

Paul Heini (Bern/CH)

Marco N. Helder (Amsterdam/NL)

Christoph Josten (Leipzig/DE)

Jean-Charles Le Huec (Bordeaux/FR)

H. Michael Mayer (Munich/DE)

Björn P. Meij (Utrecht/NL)

Felix Michnacs (Reutlingen/DE)

Susanna Miettinen (Tampere/FI)

Susanne Müller (Leipzig/DE)

Michael Ogon (Vienna/AT)

Wilco C. Peul (Leiden/NL)

Kai Pinkernell (Bergisch Gladbach/DE)

Michael Rauschmann (Frankfurt a. M./DE)

Jens Reinhardt (Frankfurt a. M./DE)*

Rui L. Reis (Braga/PT)

Dino Samartzis (Hong Kong/CN)

Dariusz Śladowski (Warsaw/PL)Claudius Thomé (Innsbruck/AT)

Marianna A. Tryfonidou (Utrecht/NL)

Gianluca Vadalà (Rome/IT)

Hans-Joachim Wilke (Ulm/DE) * inquired

8

Programme Overview

Wednesday, April 8, 2015 Thursday, April 9, 2015

Lecture Hall Rudolf Virchow Lecture Hall

17:00–17:30 08:30–09:30

Congress Opening

17:30–19:00

p. 11

10:00–10:30

p. 10 Special Lecture p. 12

10:30–11:30

Welcome Reception p. 29

p. 12

12:00–13:30

p. 13

14:30–16:15

p. 14

16:30–17:45

p. 15

Quick Fire Session 1 Quick Fire Session 2

p. 11

10:30–11:30

The most important Bone Grafts & Biologics: New Approaches to Spinal

Surgeons and Scientists: A Symbiosis in Spine Research

Poster Exhibition

p. 24

19:00–20:00

Personalized Medicine: Integrating Patients Biology into Surgical Planning

Best Strategies for the Ageing Spine

Rudolf Virchow

08:30–09:30

Fusion: Part 1 p. 13

12:00–13:30

The most important Bone Grafts & Biologics: New Approaches to Spinal Fusion: Part 2

p. 13

14:30–16:15

Programme by International Study Groups for Bone and Disc Regeneration: Part 1

p. 15

16:30–17:45

Animal Models for IVDD

Programme by International Study Groups for Bone and Disc Regeneration: Part 2

p. 15

Reducing Operative Trauma: New Strategies in minimal invasive Spine Surgery

9

Programme Overview

Friday, April 10, 2015 Saturday, April 11, 2015

Lecture Hall Rudolf Virchow Lecture Hall

08:30–09:30 08:30–09:30 08:30–09:30

p. 16 p. 16 p. 22

10:00–11:00 10:00–11:00 10:00–11:00

p. 17 p. 18 p. 22

11:15–12:30

11:30–13:00 11:30–13:00

p. 23

p. 18 p. 18 12:30–13:00

Summary & Farewell

14:30–16:00 14:30–16:00 Key

Panel Discussion

Keynote BioSpine

Spine Session

Special Lecture

p. 20 p. 19 Workshop

BioSpine Session

International Study Groups

16:30–17:30 16:30–17:45 Quick Fire Session

Poster Exhibition

Social Programme

p. 20

p. 21

Social Evening p. 29

Nucleus Pulposus Implants

Treatment of Anulus Fibrosus Defects

Poster Exhibition

Imitating Nature: Innovative Biomaterials and Implants: Part 2

Quick Fire Session 4

Recent Cell Therapies for Intervertebral Disc Regeneration: Part 1

Fusion and Non-Fusion Techniques

Imitating Nature: Innovative Biomaterials and Implants: Part 1

Regulatory Aspects of Biological Therapeutics

Available Bone Cements: the Surgeons Expertise

Recent Cell Therapies for Intervertebral Disc Regeneration: Part 2

p. 24

from 19:30


What the patient should know: Chances & Risks associated with Biological Therapeutics


10

Scientific Programme • Wednesday, April 8, 2015

17:00–17:30 Congress OpeningLecture Hall Vincenzo Denaro (Rome/IT), Hans Jörg Meisel (Halle a. d. Saale/DE)

17:30–19:00 Panel DiscussionLecture Hall Surgeons and Scientists: A Symbiosis in Spine ResearchModerators Dino Samartzis (Hong Kong/CN), Jean-Charles Le Huec (Bordeaux/FR)

Roger Härtl (New York, NY/US) Björn P. Meij (Utrecht/NL) Wilco C. Peul (Leiden/NL) Rui L. Reis (Braga/PT)

19:00–20:00 Welcome Reception (see p. 29) Foyer

11

08:30–09:30 Quick Fire Session 1Lecture HallModerator Giovanni Barbanti Brodano (Bologna/IT)

08:30 Biomaterials: a good alternative to bone grafts for spine fusion12 Giovanni Barbanti Brodano (Bologna/IT)

08:40 Histological analysis of bone regeneration with different doses of62 rhBMP-2 in an ovine lumbar interbody fusion model Katharina Siegrist (Leipzig/DE)

08:50 Implant surface design regulates mesenchymal stem cell fate and 23 production of an osteogenic environment Barbara Boyan (Richmond, VA/US)

09:00 Is osteogenic differentiation of human intervertebral disc cells a45 possibility for spinal fusion? Sarah Turner (Oswestry/GB)

09:10 The impact of surface geometry at the bone interface for improving 53 screw fixation: a biomechanical evaluation of a novel screw design Bradley Segebarth (Charlotte, NC/US)

09:20 Using the RealSpine system: surgical simulation for training and 61 usability testing Werner Korb (Leipzig/DE)

08:30–09:30 Quick Fire Session 2Rudolf VirchowModerator Benjamin Gantenbein (Bern/CH)

08:30 An in vitro investigation into bone inhibition in non-unions caused by 21 intervertebral disc cells Benjamin Gantenbein (Bern/CH)

08:40 Intradiscal injection of BMP-7 does not have regenerative effects in a 40 canine spontaneous disc degeneration model Marianna A. Tryfonidou (Utrecht/NL)

Scientific Programme • Thursday, April 9, 2015

12


08:50 Regeneration of impaired intervertebral discs by a newly designed 2 hydrogel system in combination with AMSC in the ovine model Andrea Friedmann (Leipzig/DE)

09:00 Human umbilical cord blood cell administration reduces behavioral36 deficit after severe spinal cord injury Sergey I. Ryabov (Moscow/RU)

09:10 Biomimetic polyurethane scaffold for nucleus pulposus replacement7 Zhen Li (Davos/CH)

09:20 WNT signal pathway analysis in human adipose derived mesenchymal 65 stem cells – Is gender important? Alexandra Stolzing (Loughborough/GB)

09:30–10:00 Coffee break

10:00–10:30 Ethics of Innovation in Regenerative Medicine and Spinal SurgeryLecture Hall Marike Broekman (Utrecht/NL)

10:30–11:30 Best Strategies for the Ageing SpineLecture HallModerator Christoph Josten (Leipzig/DE)

10:30 Role and relevance of the disc in fractures of the elder people Christoph Josten (Leipzig/DE)

11:00 Preclinical intradiscal application of celecoxib loaded hydrogels in a 41 canine spontaneous intervertebral disc degeneration model Marianna A. Tryfonidou (Utrecht/NL)

11:15 Range of motion in segmental versus nonsegmental UHWMPE 20 sublaminar wire growth guidance type constructs for early onset scoliosis correction Alex Roth (Maastricht/NL)

13


10:30–11:30 The most important Bone Grafts & Biologics: Rudolf Virchow New Approaches to Spinal Fusion – Part 1Moderator Jean-Charles Le Huec (Bordeaux/FR)

10:30 Augmentation of pedicle screws with a self-curing elastomeric material64 Werner Schmölz (Innsbruck/AT)

10:50 BMPs: good or evil? Lorin Michael Benneker (Bern/CH)

11:10 From autologous iliac crest to last bone substitutes materials: what is proven today for daily practice Jean-Charles Le Huec (Bordeaux/FR)


12:00–13:30 The most important Bone Grafts & Biologics: Rudolf Virchow New Approaches to Spinal Fusion – Part 2Moderator Jean-Charles Le Huec (Bordeaux/FR)

12:00 Interbody cage biomechanics and its impact on biology Finn Bjarke Christensen (Aarhus/DK)

12:25 TM – a special metal in a specific shape for cages without the need of additional biologics or bone Jörg Franke (Dortmund/DE)

12:50 Bone reconstruction in tumor surgery Giovanni Barbanti Brodano (Bologna/IT)

13:15 Improved osteointegration by Titanium vacuum plasma spray (VPS) coating of carbon/PEEK implants Lorin Michael Benneker (Bern/CH)

12:00–13:30 Personalized Medicine – Integrating Patients Biology into Surgical Lecture Hall PlanningModerator Dino Samartzis (Hong Kong/CN)

12:00 Immunogenic properties of cultured human nucleus pulposus cells for regenerative treatment approaches Aldemar A. Hegewald (Mannheim/DE)

14


12:15 Novel diagnostic and prognostic methods for disc degeneration and low back pain Dino Samartzis (Hong Kong/CN)

12:45 The effect of scoliosis implant design parameters on whole spine 19 mechanical behavior Jacobus Arts (Maastricht/NL)

13:00 Biomechanical assessment of different surgical procedures in the15 lumbar spine by computer simulation Karin Gruber (Koblenz/DE)

13:15 Computer simulation and navigation in a novel concept for14 individualized dynamic stabilization of the spine Michael Kosterhon (Koblenz/DE)

13:30–14:30 Lunch break and poster exhibition (see p. 24)

14:30–16:15 Animal Models for IVDDLecture Hall Moderator Björn P. Meij (Utrecht/NL)

14:30 The dog as animal model for translating new regenerative treatments for intervertebral disc degeneration Björn P. Meij (Utrecht/NL)

15:00 Animal Model 2.0: the loaded disc culture system51 Kaj Emanuel (Amsterdam/NL)

15:15 A reproducible disc degeneration scale in a large animal model28 Gianluca Vadalà (Rome/IT)

15:30 The ovine mechanical far lateral disc herniation model66 Felix Göhre (Halle a. d. Saale/DE)

15:45 In vivo models for the spine: the VUmc goat models67 Pieter-Paul A. Vergroesen (Amsterdam/NL)

16:00 Why using bioreactors for whole organ cultures of intervertebral discs?68 Marianna Peroglio (Davos/CH)

15


14:30–16:15 Programme by International Study Groups for Bone and Disc Rudolf Virchow Regeneration – Part 1Moderator Dino Samartzis (Hong Kong/CN)

Consortium Marianna A. Tryfonidou (Utrecht/NL) Consortium Mauro Alini (Davos/CH) Consortium Timothey Ganey (Atlanta, GA/US) Consortium Susanna Miettinen (Tampere/FI)


16:30–17:45 Programme by International Study Groups for Bone and Disc Rudolf Virchow Regeneration – Part 2Moderator Dino Samartzis (Hong Kong/CN)

Consortium Marco N. Helder (Amsterdam/NL) Consortium Gianluca Vadalà (Rome/IT)

16:30–17:45 Reducing Operative Trauma: New Strategies in minimal invasive Lecture Hall Spine SurgeryModerator H. Michael Mayer (Munich/DE)

16:30 Reducing Operative Trauma: New Strategies in minimal invasive Spine Surgery* Wilco C. Peul (Leiden/NL)

17:00 Neuromonitorisation in prevention of motor-deficit during pediatric18 spine surgeries Mirza Biscevic (Sarajevo/BH)

17:15 Minimally invasive treatment strategies in degenerative lumbar spinal stenosis H. Michael Mayer (Munich/DE)

17:30 Minimally invasive tubular decompression avoids fusion surgery in patients with lumbar stenosis and spondylolisthesis Roger Härtl (New York, NY/US)

*title tbd

16

Scientific Programme • Friday, April 10, 2015

08:30–09:30 Quick Fire Session 3Lecture HallModerator Lisa Ferrara (Southport, NC/US)

08:30 Trabecular metal – How does it support bone ingrowth? 63 Claude Rieker (Winterthur/CH)

08:40 Repair of anulus fibrosus repair with genipin-enhanced fibrin hydrogel 24 and silk membrane-fleece Daniela A. Frauchiger (Bern/CH)

08:50 A new alternative to expandable screws: expandable peek shell29 Teyfik Demir (Ankara/TR)

09:00 In-situ photopolymerized composite-hydrogel for minimally-invasive 32 nucleus pulposus replacement Andreas Schmocker (Lausanne/CH)

09:10 A biodegradable glue for annulus repair: evaluation of strength and 43 endurance Pieter-Paul A. Vergroesen (Amsterdam/NL)

09:20 Titanium truss structures as conduits for bone healing through 52 multiplanar stress distribution Lisa Ferrara (Southport, NC/US)

08:30–09:30 Quick Fire Session 4Rudolf VirchowModerator Cornelia Neidlinger-Wilke (Ulm/DE)

08:30 Influence of disc degeneration on the efficacy of stem cell treatment:6 an ex-vivo study Marianna Peroglio (Davos/CH)

08:40 Intervertebral disc regeneration: the role of MSCs recruitment by 25 hyaluronan-based delivery of stromal cell-derived factor-1 in matrix production improvement Catarina Leite Pereira (Porto/PT)

17


08:50 Does mesenchymal stem cell therapy have the potential to control 27 inflammation in a pro-inflammatory intervertebral disc organ culture system? Cornelia Neidlinger-Wilke (Ulm/DE)

09:00 Local treatment of inflammation and degeneration of intervertebral16 Disc – ex vivo study of anti-inflammatory drug delivery system based on Chitosan/Poly-(γ-Glutamic acid) nanoparticles Graciosa Q. Teixeira (Porto/PT)

09:10 Bovine coccygeal intervertebral discs contain multipotent Tie2+ cells 22 which can differentiate into osteogenic and adipogenic lineages Adel Tekari (Bern/CH)

09:20 Riboflavin cross-linked collagen gel for the repair of annular defects in 50 intervertebral discs: an in vivo study Peter Grunert (Vienna/AT)


10:00–11:00 Available Bone Cements – the Surgeons ExpertiseLecture Hall Moderator Paul Heini (Bern/CH)

10:00 Bone cement in spinal surgery – A lost decade?70 Paul Heini (Bern/CH)

10:30 Is hyperosmosis a better environment to maintain Nucleus Pulposus 13 Progenitor Cells (NPPC)? Benjamin Gantenbein (Bern/CH)

10:45 Bone void fillers in vertebro- and kyphoplasties – a survey Michael Rauschmann (Frankfurt a. M./DE)

18


10:00–11:00 Recent Cell Therapies for Intervertebral Disc Regeneration – Part 1Rudolf VirchowModerator Marianna A. Tryfonidou (Utrecht/NL)

10:00 The evolution of cell based therapies for the treatment of intervertebral disc degeneration Marianna A. Tryfonidou (Utrecht/NL)

10:20 Cellular therapies for the intervertebral disc – Do we know enough?72 Marco N. Helder (Amsterdam/NL)

10:40 New approaches for stem cell mediated intervertebral disc regeneration Gianluca Vadalà (Rome/IT)


11:30–13:00 Recent Cell Therapies for Intervertebral Disc Regeneration – Part 2Rudolf VirchowModerator Marianna A. Tryfonidou (Utrecht/NL)

11:30 Intervertebral disc innovation; biologic and biogenic insights Timothy Ganey (Atlanta, GA/US)

12:00 Endogenous cell homing for intervertebral disc regeneration73 Mauro Alini (Davos/CH)

12:30 A combined phase I/II prospective randomized clinical trial using an in-situ polymerizable hydrogel seeded with autologous disc cells for IVD regeneration – study design – and phase I safety results Anja Tschugg (Innsbruck/AT)

11:30–13:00 Fusion and Non-Fusion TechniquesLecture HallModerator Michael Ogon (Vienna/AT)

11:30 Fusion and non-fusion technologies – literature review and personal experience Michael Ogon (Vienna/AT)

19


12:00 Efficacy of different grafts in anterior cervical discectomy and fusion 34 surgery (comparison regarding the rate of fusion, bone ingrowth and fusion speed) Matjaz Vorsic (Maribor/SI)

12:15 Four-year clinical and radiographic results of a semi-constrained total54 disc replacement Lubomir Jurák (Liberec/CZ)

12:30 Pedicle screw concept with shape memory components for improved 46 bone anchorage Mario Leimert (Dresden/DE)

12:45 Biomechanical analysis and histological evaluation of a new58 PEEK-silver zeolite composite biomaterial in spine Dan C. George (New Milford, CT/US)

13:00–14:30 Lunch break and poster exhibition (see p. 24)

14:30–16:00 Regulatory Aspects of Biological TherapeuticsRudolf VirchowModerator Kai Pinkernell (Bergisch Gladbach/DE)

14:30 ATMP the European perspective Dariusz Śladowski (Warsaw/PL)

15:00 Key regulatory aspects for commercialization of cellular therapeutics Kai Pinkernell (Bergisch Gladbach/DE)

15:15 TETEC AG – ATMP manufacturing in a regulated market71 Felix Michnacs (Reutlingen/DE)

15:30 Regulatory Aspects of Biological Therapeutics* Jens Reinhardt (Frankfurt a. M./DE)

15:45 The Translational Centre for Regenerative Medicine as an organism: development of an ATMP at the academic facility Susanne Müller (Leipzig/DE)

*title tbd

20


14:30–16:00 Imitating Nature – Innovative Biomaterials and Implants – Part 1Lecture HallModerator Hans-Joachim Wilke (Ulm/DE)

14:30 Observations of mechanical transduction and a biologic induction Lisa Ferrara (South Port, NC/US)

14:45 Prescriptive topology as a mimetic material enhancement Timothy Ganey (Atlanta, GA/US)

15:00 New responsive hydrogels for the regeneration of nucleus pulposus Rui L. Reis (Braga/PT)

15:30 Bimolecular based heparin and self-assembling hydrogel for cartilage 59 tissue engineering applications Carlos E. Semino (Barcelona/ES)


16:30–17:30 Imitating Nature – Innovative Biomaterials and Implants – Part 2Lecture HallModerator Hans-Joachim Wilke (Ulm/DE)

16:30 Imitating Nature – Innovative Biomaterials and Implants* Wilco C. Peul (Leiden/NL)

16:50 Philosophy of cementaugmentated pedicle screws – Indications, 74 technique, pearls and pitfalls Michael Rauschmann (Frankfurt a. M./DE)

17:10 Correction of adult scoliosis deformity using carbon fiber composite75 rod instrumentation in spinal fusion. Preliminary prospective results of an 84 patient series Paul Fayada (Saint-Pol-sur-Ternoise/FR)

*title tbd

21


16:30–17:45 What the patient should know – Chances & Risks associated with Rudolf Virchow Biological TherapeuticsModerator Claudius Thomé (Innsbruck/AT)

16:30 Informed consent for novel spinal therapies Claudius Thomé (Innsbruck/AT)

17:00 Balancing bone resorption and overzealous bone growth in Anterior 48 Lumbar Interbody Fusion (ALIF) with RhBMP-2 in the sheep model: A question of dose and/or concentration? Gerlinde S. Heil (Halle a. d. Saale/DE)

17:15 Long time follow up after posterior lumbar interbody fusion with bone 56 morphogenetic protein-2 Christian Hohaus (Halle a. d. Saale/DE)

17:30 Bone/PEEK implant contact zones – results of a large animal model Johannes Seeger (Leipzig/DE)

from 19:30 Social Evening (see p. 29)

22

Scientific Programme • Saturday, April 11, 2015

08:30–09:30 Quick Fire Session 5Lecture HallModerator Rahel D. May (Bern/CH)

08:30 Bupivacaine induces death of rabbit intervertebral disc cells via 26 ROS-mediated lysosomal membrane permeabilization Xian-Yi Cai (Wuhan/CN)

08:40 Synthetic phytoestrogens and the native flax plant extract from Linum 31 usitatissimum effect human bone cells in vitro Victor Bügel (Rostock/DE)

08:50 Cost effectiveness of doubling the estimated sample size for medical products/33 devices in spine Clinical Investigation (CI) generates lower incremental costs Jacques Tshiang (Freiburg/DE)

09:00 Is bacterial infection connected to degenerative disc disease?37 Tomaz Velnar (Maribor/SI)

09:10 Non-viral gene delivery of Growth and Differentiation Factor 6 (GDF6)11 to whole bovine intervertebral disc Rahel D. May (Bern/CH)

09:20 Amniotic tissue in regenerative medical applications Thomas J. Koob (Atlanta, GA/US)


10:00–11:00 Nucleus Pulposus ImplantsLecture HallModerator Roger Härtl (New York, NY/US)

10:00 Nucleus augmentation with NuCore® Injectable Nucleus – previous 60 experience and long-term follow-up Ulrich Berlemann (Bern/CH)

10:20 Biological approaches for nucleus repair and regeneration Roger Härtl (New York, NY/US)

10:40 Ideas and mechanical requirements of nucleus implants Hans-Joachim Wilke (Ulm/DE)


23

Scientific Programme • Saturday, April 11, 2015

11:15–12:30 Treatment of Anulus Fibrosus DefectsLecture HallModerator Claudius Thomé (Innsbruck/AT)

11:15 Current and possible future options for anular closure Claudius Thomé (Innsbruck/AT)

11:45 Principles and biomechanical challenges of anulus sealing Hans-Joachim Wilke (Ulm/DE)

12:00 Autologous disc chondrocyte transplantation in lumbar spine disc 57 degeneration disease – a prospective, controlled, randomized study Florian Didrigkeit (Halle a. d. Saale/DE)

12:15 Tissue-engineered intervertebral discs – In vivo outcome in the rodent 49 spine Peter Grunert (Vienna/AT)

12:30–13:00 Summary and FarewellLecture Hall Dino Samartzis (Hong Kong/CN) Hans Jörg Meisel (Halle a. d. Saale/DE)

24

Poster Exhibition

The poster session will not be chaired. However, the presenting author gets the chance topresent his poster to an interested audience during the lunch breaks on Thursday, April 9 and Friday, April 10, 2015.

5 Outcome of posterior spinal fixation with pedicle screws and rods system in thoracolumbar spinal fractures Khan Kashif Mahmood (Karachi/PK)

9 An in vivo model for Intervertebral Disc Regeneration Carla Cunha, Sofia Lamas, Mário A. Barbosa (Porto/PT)

10 ACRON cage: A novel cage design and implantation technique for lumbar spinal fusion. Ronald J. Sabitzer (Vienna/AT)

30 Minimally Invasive Oblique Lumbar Interbody Fusion at L25: Benefits and Complications Jin Sung Kim, Kyeong Sik Ryu, Jung Woo Hur, Won Suh Choi (Seoul/KR)

39 The amount of organic phosphates (like DPG) existing in blood is determining factor of mammal’s bulk Ramin Amirmardfar (Tabriz/IR)

42 Could heavy degradable sutures replace metal wires in fixating unstable injuries of the cervical spine in the young pediatric population? Kamal Hamoud, Janan Abbas (Tiberias/IL)

76 Spinal fusion and a conflict of needs ovret time: carbon composite compared to traditional review. Robert Lange, Vittoria Brighenti (Zurich/CH), Paul Fayada (Saint-Pol-sur-Ternoise/FR) Steve Hansen (Fontaine lès-Dijon/FR)

Trabecular Metal Material is designed for bone in-growth and three-dimensional fusion.

Zimmer Spine+33 5 56 00 18 20

zimmer.com

© 2015 Zimmer Spine SASLit. N° 06.02726.012 - Ed. 01/2015

(Ref: ZS-SA0871)

F U S I O N I N 3 - D

Helps 3-D bone in-growth throughout the device as a result of its interconnected porous structure.

Trabecular Metal™ Material

Trabecular Metal MaterialThree-dimensional fusion

Bone in-growth through the device

Traditional Materialwith textured surface

No bone in-growth and boney on-growth on textured surface only

Traditional Material

No bone on-growth or in-growth

Bone in-growth through the Trabecular Metal Material (Artistic Representation)

TM-SCervical Fusion Device

TM Ardis®Interbody System

26

Bronze SponsorsBiomet Europe/LANX s.r.l. (Medolla/IT)

Depuy Synthes (Norderstedt/DE)

DiFUSIONTechnologies, Inc. (Georgetown, TX/US)

Zimmer Spine (Bordeaux/FR)

Sponsor of Congress Bags Ziehm Imaging GmbH (Nuremberg/DE)

Sponsor of Name Badges and LanyardsBiomet Europe/LANX s.r.l. (Medolla/IT)

Sponsor of Poster ExhibitionFehling Instruments GmbH & Co. KG (Karlstein/DE)

ExhibitorsAureus Medical GmbH (Munich/DE)Biomet Europe/LANX s.r.l. (Medolla/IT) Depuy Synthes (Norderstedt/DE)DiFUSION Technologies, Inc. (Georgetown, TX/US)Intrinsic Therapeutics (Woburn, MA/US)Königsee Implantate GmbH (Allendorf/DE)Medtronic GmbH (Meerbusch/DE)Ranier Technology Ltd. (Cambridge/GB)RTI Surgical/Tutogen Medical GmbH (Neukirchen a. Brand/DE)Titan Spine Europe (Laichingen/DE)Zimmer Spine (Bordeaux/FR)

Media CooperationBIBA Medicals LDT (London/GB) • “Spinal News”Biermann Verlag (Cologne/DE) • “Orthopädische Nachrichten”Deutscher Ärzte-Verlag GmbH (Cologne/DE)“OUP - Zeitschrift für die orthopädische und unfallchirurgische Praxis”Reflex Verlag GmbH (Berlin/DE) • “Wirbelsäule & Rücken”Thieme Publishers (New York, NY/US) • “Global Spine Journal“Trillium GmbH (Grafrath/DE) • “Trillium Diagnostik”

State at printing

Sponsors, Exhibitors and Media Cooperation

27

17/02/2015 11:04

29

Social Programme

Welcome Reception Right after the exciting panel discussion we would like to invite you to our Welcome Reception with some drinks and snacks within the industrial exhibition.Chatting, relaxing, amusing – Enjoy a networking evening in a relaxed atmosphere!

Date Wednesday, April 8, 2015Time from 19:00 hrs © 41761122 l CandyBox Images l Fotolia.comLocation Industrial exhibition (venue)Fee included for participants, accompanying person 15 EUR

Social Evening The social evening will take place in the Soho House Berlin that has a long and versatile history. Join us for a memorable evening in the former Politisches Büro, where the GDR Central Committee used to meet. Follow the tracks from former GDR presidents Wilhelm Pieck and Walter Ulbricht and savour delicious meals, have a drink at the circular bar and enjoy the view from the balcony over the Berlin Mitte district. © Soho House Berlin

Date Friday, April 10, 2015Time from 19:30 hrsLocation Soho House Berlin Torstrasse 1 10119 Berlin (DE)Fee 75 EUR

Individual arrival Taxi no. +49 30 20 20 20

General Information

30

Registration Registration for the congress is required. Please register online at www.biospine.org. Registration can also be made via fax or mail.

Registration Fees from January 5, 2015Regular 600 EURPostgraduate Student* 450 EURUndergraduate Student* 250 EUR

Welcome Reception, April 8, 2015Participant includedAccompanying Person 15 EUR

Social Evening, April 10, 2015 75 EUR* Please send a confirmation of your status either to [email protected], Fax +49 3641 31 16-244 or by mail to Conventus GmbH indicating the keyword: BioSpine 2015 • Carl-Pulfrich-Strasse 1 • 07745 Jena (DE).

Payment and Confirmation of PaymentAn invoice or confirmation of registration will be sent to you via postal or electronic mail within 14 days. This invoice is a valid invoice which may be submitted to the local tax and revenue office. All fees are due upon receipt of invoice/registration confirmation. Payment transfers must include participant’s name and invoice number. Payment is also accepted by credit card (Master-/Eurocard, American Express, VISA).

General Terms and ConditionsPlease find our General Terms and Conditions at www.biospine.org.

AccommodationWe reserved a contingent of rooms at special rates in different categories. Further information on accommodation is provided at www.biospine.org.

http://www.biospine.orgmailto:[email protected]://www.biospine.orghttp://www.biospine.org

General Information

31

Travel to Berlin Lufthansa Group Ticket Partner Airlines offer a comprehensive global route network linking major cities around the world. We offer special prices and condi-tions to participants, visitors, exhibitors, invited guests as well as employees of the contracting partner and their travel companions.

To make a reservation, please go to www.lufthansa.com/event-booking_en and enter the access code DEZEMGD in the “Access to Your Special Lufthansa Offer” area. This will open an online booking platform that will automatically calculate the discount offered or provide you with an even better offer if another promotional fare is available.NOTE: Pop-ups must be enabled otherwise the booking platform window will not open.

These promotional fares are also available through your IATA/ARC travel agent. Travel agents can obtain ticketing instructions by sending an email to [email protected] and pro-viding the access code as a reference.

DB German Rail Event Ticket In cooperation with DB German Rail and Conventus you travel safely and conveniently to the BioSpine 2015.

The price for your event ticket of a return trip* to Berlin is: 2nd class 99 EUR (for a defined train connection)1st class 159 EUR (for a defined train connection)

2nd class 139 EUR (for all trains)1st class 199 EUR (for all trains)

* Changes and reimbursement before the first day of validity are 15 EUR excluded from the first day of validity onwards. Passengers restrict themselves to a particular train and travel times.

Please find more detailed information on conditions and booking at www.biospine.org.

http://www.lufthansa.com/event-booking_enmailto:[email protected]://www.biospine.org

32

General Information

CertificationThe 5th International Congress on Biotechnologies for Spinal Surgery (BioSpine) is accredited by the European Accreditation Council for Continuing Medical Education (EACCME).The congress is being granted with 15 European CME credits (ECMEC).

Additionally an application has been made to the Medical Chamber of Berlin.

Please remember to sign the list of attendants (with barcode, if required or applicable) at the Check-In.

Internet Corner & WIFI AccessVouchers for WIFI can be purchased at the Check-In for 4,95 EUR/24 hrs.

Congress Language The congress language is English.

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General Hints for Authors and Presenters

Submitting your Presentation/Technical InformationPlease prepare your presentation in 4:3 aspect ratio. A presentation notebook with a PDF reader and MS Office PowerPoint 2007 will be provided. The use of personal notebooks is possible upon agreement. However, it may interrupt the flow of the programme in the lecture hall. Please provide an adapter for VGA if necessary. A notebook, presenter and laser pointer are available at the speaker’s podium in the lecture hall. A technical supervisor will help you.

Speakers’ PreparationPlease submit your presentation to our technical staff in the room where you will have you talk, no later than 90 minutes before the presentation begins. You may view and/or edit your presentation. For submission, please use a USB flash drive.

Poster ExhibitionPosters should be no larger than DIN A0 portrait format (84.1 cm x 118.9 cm). Poster boards are 120 cm x 150 cm (portrait format). They are only to be used with the designated pins. Poster boards will be numbered. All posters have to be mounted on Thursday, April 9, 2015 until 13:00 hrs and have to be removed by Friday, April 10, 2015 until 17:00 hrs.

Biomechanik biologischer Gewebe (Knochen, Knorpel, Bänder, Meniskus, Organe) Biomaterialien, Implantate, Prothesen Tribologie (Prothetik, Knorpel, Meniskus) Biomechanik des Bewegungsapparates und weitere

© 16579085 l yetishooter l Fotolia.com

6.–8. Mai 2015 • Bonn

9. Jahrestagung der Deutschen Gesellschaft für Biomechanik (DGfB)

Informationen, Anmeldung und Programm:

www.biomechanik-kongress.de

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Index of Authors and Chairs

AAbbas, J. 24Alini, M. 15, 18Amirmardfar, R. 24Arts, J. 14

BBarbanti Brodano, G. 11, 13Barbosa, M. 24Benneker, L. M. 13Berlemann, U. 22Biscevic, M. 15Bjarke, F. 13Boyan, B. 11Brighenti, V. 24Broekman, M. 12Bügel, V. 22

CCai, X.-Y. 22Choi, W. S. 24Cunha, C. 24

DDemir, T. 16Denaro, V. 10Didrigkeit, F. 23

EEmanuel, K. 14

FFayada, P. 20, 24Ferrara, L. 16, 20Franke, J. 13Frauchiger, D. A. 16Friedmann, A. 12

GGaney, T. 15, 18, 20Gantenbein, B. 11, 17George, D. C. 19, 26Göhre, F. 14Gruber, K. 14Grunert, P. 17, 23

HHamoud, K. 24Hansen, S. 24Härtl, R. 10, 15, 22Hegewald, A. A. 13Heil, G. S. 21Heini, P. 17Helder, M. N. 15, 18Hohaus, C. 21Hur, J. W. 24

JJosten, C. 12Jurák, L. 19

KKhan, K. M. 24Kim, J. S. 24Koob, T. J. 22Korb, W. 11Kosterhon, M. 14

LLamas, S. 24Lange, R. 24Le Huec, J.-C. 10, 13Leimert, M. 19Leite Pereira, C. 16Li, Z. 12

MMayer, H. M. 15Meij, B. P. 10, 14Meisel, H. J. 10, 23Michnacs, F. 19Miettinen, S. 15Müller, S. 19

NNeidlinger-Wilke, C. 16, 17

OOgon, M. 18

PPeroglio, M. 14, 16Peul, W. C. 10, 15, 20Pinkernell, K. 19

RRauschmann, M. 17, 20Reinhardt, J. 19Reis, R. L. 10, 20Rieker, C. 16Roth, A. 12Ryabov, S. I. 12Ryu, K. S. 24

SSabitzer, R. J. 24Samartzis, D. 10, 13, 14 15, 23Schmocker, A. 16Schmölz, W. 13Seeger, J. 21Segebarth, B. 11Siegrist, K. 11Śladowski, D. 19Stolzing, A. 12

TTeixeira, G. Q. 17Tekari, A. 17Thomé, C. 21, 23Tryfonidou, M. A. 11, 12 15, 18Tschugg, A. 18Tshiang, J. 22Turner, S. 11

VVadalà, G. 14, 15, 18Velnar, T. 22Vergroesen, P.-P. A. 14, 16Vorsic, M. 19

WWilke, H.-J. 17, 20, 22, 23

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© Bezirksamt Mitte von Berlin, Stadtentwicklungsamt – Kataster und Vermessung

BioSpine · Marianna A. Tryfonidou (Utrecht/NL) Scientific Programme • Thursday, April 9, 2015. 12 Scientific Programme • Thursday, April 9, 2015 08:50 Regeneration of impaired

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