BioSC ™ Lab BIOSC™ system product range BIOPROCESS CHROMATOGRAPHY SOLUTIONS Adaptability: operations from 1 up to 6 columns in batch, parallel batch, continuous chromatography or continuous process Easy switch from batch to continuous, optimizing process parameters with BioSC™ Predict software Reduction of media and buffer consumption by up to 75% Increased productivity by 2 to 6-fold
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BioSC™ Lab
BIOSC™ system product range
BIOPROCESS CHROMATOGRAPHY SOLUTIONS
� Adaptability: operations from 1 up to 6 columns in batch, parallel batch, continuous chromatography or continuous process
� Easy switch from batch to continuous, optimizing
process parameters with BioSC™ Predict software
� Reduction of media and buffer consumption by up to 75%
� Increased productivity by 2 to 6-fold
• Continuous processes (perfusion) and high titer
feed (fed-batch) are more and more developed
in USP. DSP is now becoming the bottleneck
of biopharmaceutical processes,
• Large volumes of buffer and high priced media required,
long process times, target protein degradation,
Batch chromatography
• Single column
• Each portion of the resin is working for a very short period of time
Continuous chromatography
• Multiple columns in series
• Media is used at its maximum capacity
• Target molecule is not lost
• Load more and faster
A Market in Continuous Evolution
Fully loadedNot working anymore for capture
Ready to be eluted1. Washing2. Elution3. Regeneration4. Equilibration5. Recycling
Column undergoes:
LOADING
LOA
DIN
G
And is put back in the lineto continue capturing
Partially loadedReady to be fully loaded
Not loadedReady to be loaded
• Process intensification, flexibility of
equipment, CAPEX reduction, smaller
footprint,
• Time-to-market with lower costs at the
same quality (biosimilars),
• Environmental challenges (buffer reduction,
waste treatment…),
• High value blood proteins…
MAbs, insulin, blood fractionation, recombinant proteins, vaccines and viral vectors demand innovative technologies and bring new challenges:
For decades, Novasep has worked on continuous chromatography and has built the largest FDA-audited continuous chromatography platform at commercial scale. To adapt to the current biopharma challenges, Novasep is committed to delivering expertise in continuous
chromatography, know-how by developing the state-of-the-art BioSC™ Sequential Chromatography platform.
A Precursor in Continuous Process Improvement
Continuous chromatographyBatch chromatography
Predict your future!
BioSC™ Predict is the unique simulation and optimization software for the development of continuous chromatography processes dedicated for the purification of biopharmaceuticals.
It is a process development accelerator enabling any scientist to start developing continuous chromatography processes even without prior knowledge. With a few clicks, the user can switch from batch chromatography to an optimized continuous chromatography process, ready to be tested on the BioSC™ Lab equipment.
Great power, small footprint!
Possibility to work with different process modes:
21CFR Part 11 & GAMP 5 ready control software
BioSC™ control software enables user-friendly, secure and traceable production compliant with FDA recommendations for PAT approach implementation:
• Multi-level access control • Recipe editor • Real-time monitoring of all process parameters
Upon request, the operating software can be connected to other databases or Distributed Control Systems (DCS) (Delta V).
Batch process Parallel Batch Continuous chromatography from 2 to 6 columns
Continuous Process
The Only All-In-One Equipment on the Market
• Wide range of process scenario screening: Possibility to work from 1 to 6 columns or membrane to adapt all customer objectives (productivity, media and buffer savings…)
• Whatever your process strategy (with or without elution gradient), BioSC™ allows you to develop or process in accordance with equipment specifications.
BioSC™ Predict Software
BioSC™ Control Software
In addition to the standard chromatography sensors (pH, UV, conductivity), BioSC™ also features extra sensors (flowmeter, pressure, temperature) for PAT approach.
Capitalized on Novasep’s know-how to become an expert on Novasep technologies with our wide range of training offering (equipment, process, maintenance, software).
Through our process development team, we have the possibility to develop, optimize and industrialize your valuable molecules.
Stay up to date with our software upgrade services package.
Maximize your up time by managing your OPEX with different levels of maintenance contracts.
Based on your needs, you have the best of Novasep readily on your site, 24 hours a day, 7 days a week, to respond to any urgency.
Try Novasep technologies with your molecule at site before adopting them with our rental offering.
Proven Continuous Scaling-Up
Fast and Continuous Global Support
BioSC™ Lab
BioSC™ Pilot
Industrial Scale Continuous Chromatography
Whatever your scale, Novasep can provide the right continuous solution:
Services and technologies for the life science industries Contact our experts at