Biophysics of Metalloenzymes Topics and Themes: 1) (Metallo-) Proteins and Enzymes in the Cell 2) Some Principles of Coordination Chemistry 3) Methods for Investigation at Molecular Level 4) Overview on Metal Cofactors in Biology 5) Cofactor Assembly and Maturation 6) Excitation-Energy and Electron Transfer 7) Proton Transfer 8) Metal centers in Photosynthesis and Water Oxidation 9) Biological Hydrogen Catalysis 10) Metal Cofactors in Nitrogen Fixation 11) Carbon Oxide Conversion at Metal Sites 12) Molybdenum Enzymes 13) Oxygen Reactions 14) Metal Centers in Human Diseases 15) Bioinspired Materials
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Biophysics of Metalloenzymes
Topics and Themes:
1) (Metallo-) Proteins and Enzymes in the Cell
2) Some Principles of Coordination Chemistry
3) Methods for Investigation at Molecular Level
4) Overview on Metal Cofactors in Biology
5) Cofactor Assembly and Maturation
6) Excitation-Energy and Electron Transfer
7) Proton Transfer
8) Metal centers in Photosynthesis and Water Oxidation
9) Biological Hydrogen Catalysis
10) Metal Cofactors in Nitrogen Fixation
11) Carbon Oxide Conversion at Metal Sites
12) Molybdenum Enzymes
13) Oxygen Reactions
14) Metal Centers in Human Diseases
15) Bioinspired Materials
Nitrogenase protein x107
x108
Fe3O4 catalyst (ferrit)
300 bar
500 °C
~20 % Ausbeute
Turnover 10 s-1 => 150 Mt / 50t(enzyme) year
Ammonia-plant (Haber-Bosch) x10-3
150 Mt / year
Nitrogen for Industry
Prof. Gerhard Ertl (78)
Fritz-Haber Institut Berlin
Chemie Nobelpreis 2007
Fritz Haber Nobelpreis 1918, Carl Bosch Nobelpreis 1931
Detailed mechanism of N2 catalysis at catalyst surface
Ertl hat die Grundlage der modernen Oberflächenchemie geschaffen, die so unterschiedlichen Vorgängen wie
dem Rosten von Eisen oder der Wirkung eines Katalysators im Auto nachgeht. Ertl wurde 1936 in Stuttgart
geboren. Er promovierte 1965 in physikalischer Chemie an der Technischen Universität München und arbeitete
nach verschiedenen Stationen - auch in den USA - seit 1986 am Fritz-Haber-Institut in Berlin.