Biomol

PRESCRIBING SPLICING AND NEW STUDY EXAMINES THE METHYLOME

OF TRIPLE-NEGATIVE BREAST CANCER

MARY LUZ BOHORQUEZ TORRES

medicine student

3RD SEMESTER

INTRODUCTION

Approach any form of diseases should be first preventing it , for this in the field of research have developed models for the prevention of some diseases.

accordingly studies mentioned today are the ability to prevent disease through molecular biology . the first shows that using mathematical machinery and equipment can be discovered variations in the RNA splicing that generates genetic variations in the drawn order at this develop pathologies . The second study is to sort and display the methylation of DNA in breast cancer to recoating time the disease and is a breakthrough for the next prevention for future babies who may suffer this disease.

INTRODUCTION

In This presentation will show two studies that linking the importance about the molecular biology in the medicine such in practice as in the research.

The first studie it´s about a prescribing splicing and how Xiong et al realized a advance to predicts the variations caused in the RNA splicing keeping in mind features which be able to predicts the pathologies according individual genomic sequence.

The second studie it is about new searching of methylome (ADN methylated) of triple-negative breast cancer which was compared with healthy DNA to reveals distinct Methylation patterns in breast cancer cells indicating better or worse prognosis.

splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined. This process realized for obtain a RNAm mature who can keep moving with the DNA translate and transcription.

PRESCRIBING SPLICING9 january, 2015

when there is a variation in the DNA sequence can be generated for many reasons including variation in the sequence of mRNA splicing, when this occurs a mutation is generated in the code for the production of proteins

PRESCRIBING SPLICING

DNA sequences variations can influence wrong translation and generate non functional proteins; It is beacuse of this that Xiong et al in silico predicted the effects in variation sequence on pre-RNAm splicing. Xiong et al in the mechanical model took into account differents features for find out with accuracy the individual proteins encode through determination of wrong Exon inlcusion and the introns mutations. This causes can affecting health but with this Project the people may be able know some disease.

Student observation

This Project will can be a society tool to foresee and prevent pathologies related gene expression and its alterations is also the first step to continue searching on these modification and prevent serious diseases , heritable and mutagenic

PRESCRIBING SPLICING9 january, 2015

the mutagenic RNA expression mostly often produces pathologies, an example is spinal muscular atrophy and autism.

through this study can be viewed

and prevent these diseases

PRESCRIBING SPLICING9 january, 2015

obtaining the results of this studies was made through algebra and using sophisticated machine-learning approach that generate a mathematical model to predict the number of exons including considering the tissue in which it is located. The intron mutation also accurately predict individually for some diseases

PRESCRIBING SPLICING9 january, 2015

Student observation

This Project will can be a society tool to foresee and prevent pathologies related

gene expression and its alterations is also the first step to continue searching on these modification and prevent serious

diseases, heritable and mutagenic

PRESCRIBING SPLICING9 january, 2015

New study examines the methylome of triple-negative breast cancer

3 february,2015

DNA methylation is given by the inclusion of a methyl into cytosine level that allows modifying the sequence and generate group alteration of some processes.

the methylation of DNA can be visualized in breast cancer which could indicate a better or worse diagnosis , so can be associated with states of cancer and if you can find on time advancing cancer is prevented

New study examines the methylome of triple-negative breast cancer

3 february,2015

The term epigenetics refers to heritable changes

in gene expression (active versus inactive genes)

that does not involve changes to the

underlying DNA sequence; a change

in phenotype without a change in genotype.

the methylome is classified in epigenetics and in this studie

developed the methodology to sequence the methylome using DNA

extracted from the archived tissue blocks which was comparate with

healthy samples

New study examines the methylome of triple-negative breast cancer

3 february,2015

researchers of this study believe that in the future could determine changes ( methylation ) in the DNA sequence according to the specific cancer and this allows genetic studies relate to diseases that are the future to prevent cancer in future generations

New study examines the methylome of triple-negative breast cancer

3 february,2015NEW STUDY EXAMINES THE METHYLOME OF TRIPLE-NEGATIVE BREAST CANCER

Triple negative breast cancers is when in the three receptors translation(oestrogen, progesterone or HER2) are added in the ADN sequence a Methyl group that would make them responsive to targeted drugs.Researchers Professor Susan Clark, Dr Clare Stirzaker and Dr Elena Zotenko established this study in order to classify the triple-negative breast cancer and provide a breakthrough in epigenetics.

Student observation

for each disease is necessary to know the cause to treat the disease , symptoms and eventually cure , so it is essential to conduct genetic studies as methylome of breast cancer not only for research but also to treat and heal.

for each disease is necessary to know the cause to treat the disease , symptoms and eventually cure , so it is essential to conduct genetic studies as methylome of breast cancer not only for research but also to treat and health

New study examines the methylome of triple-negative breast cancer

3 february,2015

Student observation

MEDICAL UTILITY

Learn and apply in the medical practice how the splicing process can generate a pathological conditions and as from this predicts the effects of sequence variations in the genome code.

Learn about the process denominated splicing and know using this knowledge in the medicine practice for the pathologies relative directly with the funcionality of RNA splicing.

MEDICAL UTILITY

Learn to manage breast cancer from the genetic variations such as methylation of the receptors and produce a treatment given these variables.

MEDICAL UTILITY

The era of molecular biology and genetics with developments, studies and researching have facilited the medical practice because contributed to knowledge about disease and allows the diagnostic of pathologics for prompt treatment .

MEDICAL UTILITY

REFERENCES

· MARTINEZ SÁNCHEZ, LINA MARÍA. Biología molecular. septima ed. Medellín: UPB. Fac. de Medicina, 2012. 78-101 pp.

  · GUIOGO, RODERIC; VALCÁRCEL, JUAN. Prescribing Splicing.

Journal science, vol 347 issue 6218, Barcelona, Spain.2015. 124-125 pp

  · CLARK,SUSAN;STIRZAKER ,CLARE; ZOTENKO, ELENA. Sydney's

Garvan Institute of Medical Research. New study examines the methylome of triple-negative breast cancer. “www.news-medical.net/news/20150203/New-study-examines-the-methylome-of-triple-negative-breast-cancer.aspx”