Biomedical science 2nd year immunology course introduction

8/11/2019 Biomedical science 2nd year immunology course introduction

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Immunology


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Immunology


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Immunology


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Inflammation and pathogenesis of type 1 diabetes: Discuss the current knowledge of

the contribution of cellular and molecular components of the immune system to the

pathology of type 1 diabetes

- What is Type1 diabetes?

- What are the molecular and cellular components of the immune system involved in the

initiation and development of Type 1 diabetes?

Review

Object of the exercise

- Test your capacity to process and synthesise large amounts

of information

- Test your critical thinking


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- You need to start searching and reading information for your essay





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1. Search and read the available information





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Bibliographic/Literature databasesSearching for the information

Some bibliographic databases of relevance for Life Sciences and Biomedicine

http://www.cell.com/

http://www.nature.com/siteindex/index.html

http://www.sciencemag.org/

http://www.biomedcentral.com/browse/journals/http://www.sciencedirect.com

http://www.ncbi.nlm.nih.gov/

(the database of databases: pubmed for bibliography)

http://apps.isiknowledge.com (also to find journals IF)

Highest impact scientific journals

To search for the latest high impact scientific work in Biomedical Sciences

Bibliographic databases


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How to handle largeamounts of information?


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2. Process and summarise read information





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-Use BULLET LISTS: most relevant points that I will addressin my essay (review)

a) Bullet list with the information you have read in each source

(E.g. In each review article)

Example: Structure of review by Naidoo et al.s bullets points and sections


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Example: Structure of review by Naidoo et al.s bullets points and sections:

- HGP

- Architecture and function of the human genome

- Development of the genome-wide association studies (GWAS) approach to complex diseases

and traits

- High-throughput sequencing technologies and their impact on genomic studies

- Personalised genomic medicine


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b) Bullet list with the points I will be addressing in my essay


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- You need to start searching and reading information for your essay

- I will give you more directions about how to write your essay in week 4.





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QUESTIONS?


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Immunology


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Introduction to Immunology

Basic concepts


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Definition by Oxford Dictionary


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The organs, cellsand processesof the body that provide

resistance to infection, toxinsand cancer:

- Organsinclude the thymus, bone marrow, and lymphnodes.

- Cells: Leukocytes (circulating and tissue resident)

- Soluble factors:

- Antibodies

- Complement- Proteins (cytokines and chemokines) and lipid

intermediates: signalling proteins.

Immune System


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Cells of the blood: Haematopoiesis


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- Soluble factors:

- Antibodies



Immune System


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Antibodies

Globular proteins produced by B-cells that recognise and bind antigens


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Immunology: Basic concepts

Antigen: Any substance that can specifically bind to an antibody

or T cell receptor

- Examples: proteins, LPS, DNA, lipids

Immunogen: Antigen able to induce an immune response

Epitope (Antigenic determinant): Specific site in an Ag, which is

recognised by the immune system (site of antibody binding)


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- Soluble factors:

- Antibodies



Immune System


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P t i ( t ki d h ki ) d li id


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Proteins (cytokines and chemokines) and lipid

intermediates: signalling proteins

Function: Cell communication and signalling:

-Activation and modulation of the immune response

(proinflammatory vs regulatory signalling)

- Chemotaxis: Leukocyte trafficking

C t ki t k


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Cytokine networks


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QUESTIONS?

Biomedical science 2nd year immunology course introduction

Documents