Biomedical images processing and analysis Biomedical images processing and analysis
Jan 06, 2016
Biomedical images processing and analysisBiomedical images processing and analysis
Group members
Massimo De LucaMassimo De Luca (2003-) Fellowship – PhD student
Marco ForacchiaMarco Foracchia (-2003) PhD student
Alfredo GianiAlfredo Giani (2003-) Post doc
Enrico GrisanEnrico Grisan PhD student – Post doc
Lorenzo MarafattoLorenzo Marafatto (2005-) Fellowship
Alfredo RuggeriAlfredo Ruggeri Associate professor
Biomedical images processing and analysis
Cooperations
J. JaroszewskiJ. Jaroszewski - Cornea Bank Berlin, Clinic of Ophthalmology, University School of Medicine, Berlin, Germany
A. NeubauerA. Neubauer - Dept. of Ophthalmology, Ludwig Maximilians University, Munich, Germany
S. PiermarocchiS. Piermarocchi – Dept. of Ophthalmology, University of Padova
D. PonzinD. Ponzin - Veneto Eye Bank Foundation, Venice, Italy
A. PocobelliA. Pocobelli - Eye Bank, S. Giovanni-Addolorata Hospital, Rome, Italy
P. GainP. Gain - Ophthalmology Department, Bellevue Hospital, Saint-Etienne, France
A. BezerianosA. Bezerianos - Dept. of Medical Physics, University of Patras, Greece
G. BarbaroG. Barbaro - Nidek Technologies, Padova, Italy
P. FavaroP. Favaro - Siemens Corporate Research, Princeton (NJ), USA
Biomedical images processing and analysis
Publications
Biomedical images processing and analysis
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International Journals
Conference Papers
Conference Abstracts
Funding
University of Padova: € 60.000 (shared)
University of Padova: € 15.000
Ministry of University: € 20.000
Nidek Technologies: € 25.000
CARIPARO Bank Foundation: € 40.000
Biomedical images processing and analysis
Biomedical images processing and analysis
1.Cell contour recognition for in-vivo microscopy of corneal endothelium
Statistical Correction
Band-Pass Filtering
ROI extraction
Skeletonization
Contour completion
Correction
Perimeter extraction
ANN contour extraction
Hole removal and Erosion
Cell contour recognition
Statistical Correction
Band-Pass Filtering
ROI extraction
Skeletonization
Contour completion
Correction
Perimeter extraction
ANN contour extraction
Hole removal and Erosion
Cell contour recognition
Statistical Correction
Band-Pass Filtering
ROI extraction
Skeletonization
Contour completion
Correction
Perimeter extraction
ANN contour extraction
Hole removal and Erosion
Cell contour recognition
Statistical Correction
Band-Pass Filtering
ROI extraction
Skeletonization
Contour completion
Correction
Perimeter extraction
ANN contour extraction
Hole removal and Erosion
Cell contour recognition
Statistical Correction
Band-Pass Filtering
ROI extraction
Skeletonization
Contour completion
Correction
Perimeter extraction
ANN contour extraction
Hole removal and Erosion
Cell contour recognition
Statistical Correction
Band-Pass Filtering
ROI extraction
Skeletonization
Contour completion
Correction
Perimeter extraction
ANN contour extraction
Hole removal and Erosion
Cell contour recognition
Statistical Correction
Band-Pass Filtering
ROI extraction
Skeletonization
Contour completion
Correction
Perimeter extraction
ANN contour extraction
Hole removal and Erosion
Cell contour recognition
Statistical Correction
Band-Pass Filtering
ROI extraction
Skeletonization
Contour completion
Correction
Perimeter extraction
ANN contour extraction
Hole removal and Erosion
Cell contour recognition
Statistical Correction
Band-Pass Filtering
ROI extraction
Skeletonization
Contour completion
Correction
Perimeter extraction
ANN contour extraction
Hole removal and Erosion
Cell contour recognition
• The ENDO software is a module of the system for ophthalmology.
Nidek Technologies NAVIS-ENDO system
A glimpse of tomorrow …
Biomedical images processing and analysis
2.Fourier analysis for the estimation of cell density on eye bank images of donor corneas
AIM:• to develop a fully automatic technique for cell density
estimation (no user intervention).
2250 cell/mm2
Fully automatic density estimation
• It must be without cell contour detection.
A repetitive pattern of cell borders is clearly visible.
Spatial frequency of this pattern is proportional to cell density.
Frequency information is available through Fourier analysis.
Information from Fourier analysis can provide an estimation of cell density.
Frequency-based density estimation
A circular band indicates that the endothelium image contains a repetitive pattern at a specific frequency.
Spatial frequency is the radius of the bandSpatial frequency is the radius of the band
Gray-scale image of 2D-DFT log-magnitude.
Radius of circular band can be used to estimate cell density.
Frequency-based density estimation
Position of second peak provides estimated frequency f of cell borders.
Frequency-based density estimation
1500
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2500
3000
3500
1500 2000 2500 3000 3500
Manual density (cell/mm2)
Auto
matic d
ensity (cell/
mm
2)
Frequency-based density estimation
(Ruggeri et al., Br J Ophthalmol, Mar 05)
• The EyeBank software is a module of the
system for ophthalmology.
Nidek Technologies NAVIS-EyeBank system
3. Tracking techniques for vessel-like structure
Biomedical images processing and analysis
Applications to:
• vessels in retina
• nerves in cornea
Clinical outcomes:• length• tortuosity• bifurcations• caliber course• optic disc detection
Tracking techniques in retina
Tracking techniques in retina
Tracking techniques in cornea
Biomedical images processing and analysis
4.Methodologies in eye fundus analysis for the diagnosis of retinopathy
Diabetic retinopathy characterized by fundus lesions
Automatic and objective tools:• wide screening • disease assessment &
monitoring in time• (new) drugs efficacy
Three steps:
1. Detection
2. Classification & measurement
3. Clinical assessment
Eye fundus analysis
Biomedical images processing and analysis
5.Design and realization of an adaptive optics fundus camera
Flashpath
Wavefrontsensor
RetinalImaging
Eye
Image Processing
Biomedical images processing and analysis
5.Design and realization of an adaptive optics fundus camera
Imageacquisition Coma Defocus Astigmatism
Imagecorrected
Image Analysis
Mirrorupdate
Biomedical images processing and analysis
6.Bio-inspired omni-directional vision
Omnidirectional mirror
Space variant sensorproviding with a foveated vision
Development ofbiomimeticalgorithmsfor vision