Bio Matters A MichBio Publication Showcasing Michigan’s Biosciences Industry Michigan Incubators Boost State’s Bioscience Entrepreneurs SPRING 2009 Also Featured: Michigan Universities Pack a Powerful R&D Punch Governments Building Foundations for Regional Bioscience Growth In This Issue: 2009 Michigan Biosciences Directory and Resource Guide INNOVATION, TECHNOLOGY AND COMMERCIALIZATION
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BioMattersA MichBio Publication Showcasing Michigan’s Biosciences Industry
Governments Building Foundations for Regional Bioscience Growth
In This Issue:
2009 Michigan Biosciences Directory and Resource Guide
INNovatIoN, techNoloGy aNd coMMeRcIalIzatIoN
IN MICHIGAN, SOMETHING NEW IN HIGH-TECH INNOVATION IS HAPPENING EVERY DAY.
Working with our partners at MichBio, the Michigan Economic Development CorporationSM can connect high-tech companies and entrepreneurs to services, incentives, networking opportunities and venture capital through resources like the 21st Century Jobs Fund to help them grow and prosper.
Visit MichiganAdvantage.org and learn how Michigan can give your biotech company the Upper Hand.
MichiganAdvantage.org
1 BioMatters | Spring 2009
Dear Innovator,
Whether you are looking to launch a new company, expand, or relocate operations, I encourage you to consider the
advantages Michigan has to offer. With an abundance of high-tech talent, a legacy of technical know-how, proximity to 21st
century infrastructure, and strong state and local support, Michigan is the perfect place to take your life science enterprise
ments in life science research and development and our strong partnerships with educational institutions, entrepreneurs,
and commercial businesses position Michigan well as a world-class center of life science research and product development.
Over the past decade, Michigan has earned a well-deserved reputation for leadership in bioscience innovation. We have
made investments totaling more than a half billion dollars to support initiatives such as the Life Science and Technology
tricorridors, the 21st Century Jobs Fund, the Venture Michigan Fund, and the Bioscience Research and Commercialization
Center. And we are the #2 state in the nation for overall industrial research and one of the fastest growing life science
states with more than 125 new companies since 2000 and more than 540 life sciences companies overall.
Our aggressive strategy to grow and diversify Michigan’s economy, along with commercialization activities, healthy
sources of venture capital, and other growth opportunities created by our targeted initiatives, assure that Michigan will
continue to be an important life sciences center well into the future.
Sincerely,
Jennifer Granholm
Governor of Michigan
G O V E R N O R ’ S M E S S A G E
Wherever you are in the world, wherever you are in the R&D process, Michigan bioscience companies and organizations have the expertise, technologies and development understanding to give you the “Upper Hand” advantage.
Join us in the Michigan Pavilion #3147
HOSTED By:
WITH MICHIGAN ExHIBITORS:
Ann Arbor SPARK • Ash Stevens Beaumont BioBank • Genetics Squared LLCJasper Clinical R&D • Kalexsyn, Inc.MSU Technologies • Oakland County’s Medical Main St.Southwest Michigan First • The Right PlaceTSRL, Inc. • University of Michigan Technology Transfer Van Andel Institute • Velesco Pharmaceutical ServicesWayne County • Wayne State University • zuSyn, Inc.
yOUR COMPLETE BIOSCIENCES PACKAGETHAT’S THE MICHIGAN “UPPER HAND” ADVANTAGE
2BioMatters | Spring 2009
Nurturing an idea into a marketable product and growing it into a dynamic, self-sustaining bioscience company is a process. How do Michigan companies connect with the right people, learn what they need to know, find the resources to keep the pipeline flowing?
We know people.
In a state boasting the world’s longest freshwater coastline, with oceans of lakes, where water is a way of life and life is good; in an industry that studies life at its core, MichBio is there to propel Michigan’s bioscience people, products and prospects.
Join us.
MichBio brings the total continuum together. We know the players, the market; and what it takes to succeed. We give you access to a valuable network of people representing all facets of the biosciences community. We are your matchmaker, your guru and your standard bearer.
Ann Arbor, MichigAn 734.527.9150 www.Michbio.org
3 BioMatters | Spring 2009
Welcome to Michigan’s Biosciences Community! In this its second issue, BioMatters continues an up-front, inside look at
Michigan’s biosciences community today and the many exciting discoveries that
may lie ahead for tomorrow.
The biosciences are “big” business in the state and account for almost 96,000
direct and indirect jobs. Private bioscience R&D and academic research in Michigan
contributes $9.34 billion to the state’s GRP, including $2.5 billion in direct private
payroll. Michigan has an enviable bioscience infrastructure with an advantageous
business environment, strong commercialization resources and incentive programs,
an expert talent pool, and an exceptional quality of life.
The state is home to a myriad of bioscience companies involved in R&D,
manufacturing, and contract research/support services — “a complete package
for R&D”. Michigan has it all — from drugs and therapeutics, medical devices and
equipment, diagnostics and research tools, information technology systems and
software, clinical research and medical testing, as well as industrial biotechnology,
bio-agriculture, bio-defense, and bio-environmental. We are proud of our accomplish-
ments and growth, and are working hard to nurture today’s and tomorrow’s ventures,
and eager to give your business the “Upper Hand” Advantage.
The Michigan Biosciences Industry Association or MichBio, is a statewide,
BioMatters Next Issue: FALL 2009FEATURINGl Informatics: Where Technology Meets the Challenges of Sciencel Michigan Leading in High-Growth Generics Industryl And more stories chronicaling news, trends and issues affecting Michigan’s biosciences industry
4BioMatters | Spring 2009
CORPORATE SPONSORS
P L AT I N U M
G O L D
S I LV E R
B R O N Z E
O F F I C E R S , D I R E C TO R S A N D C O M M I T T E E S
PATRONAsh Stevens, Lumigen
FRIENDAdvantage Capital,
Wayne State University
SUPPORTERBiotechnology Business
Consultants, Caraco,sanofi-aventis U.S.,
West Michigan Science & Technology Initiative
M E D I A
ExECUTIVE OFFICERS Chairman Michael Kurek, Ph.D.Biotechnology Business ConsultantsPartner/President
Vice ChairmanStephen Munk, Ph.D.Ash Stevens, President and CEO
President and CEOStephen T. Rapundalo, Ph.D.MichBio, President and CEO
Secretary Christina DeHayesAsterand, Inc., General Counsel
Treasurer Matthew L. McCollErnst & Young LLP, Partner
Assistant TreasurerRyan Noel Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Administrator
DIRECTORSDan CalvoAssay Designs, Inc., President and CEO
Linda Chamberlain, Ph.D.West Michigan Science andTechnology InitiativeExecutive Director
David Felten, M.D., Ph.D.Beaumont Hospitals, Research InstituteVice President, Research and Medical Director
J. Patrick ElliotTerumo Cardiovascular Systems Corp.Vice President, Business Development
James Freeman, Ph.D.Pfizer Animal HealthVice President, Laboratory Sciences
Ricardo (Richard) Fuentes Jr.Dow Corporate Venture CapitalGlobal Life Science Investment Director
Teri GriebU of M Medical School, Office of ResearchDirector of Administration for ResearchOffice of Research and Graduate Studies
Mark KielbAltarum InstituteChief Financial Officer
Barry KlineGlaxoSmithKlineDirector, Market Development
Michael Kurek, Ph.D.Biotechnology Business ConsultantsPartner/President
Paul MorrisConsultant
Stephen Munk, Ph.D.Ash Stevens, President and CEO
Stephen T. Rapundalo, Ph.D.MichBio, President and CEO
John J.H. Schwarz, M.D.Family Health CenterPhysician,Former U.S. Representative
Eric StiefWayne State University — Technology CommercializationLicensing Manager Director of Venture Development
Karen Studer-RabelerCoy Manufacturing/Coy Laboratory ProductsGeneral ManagerVice President, Business Development
David ZimmermannKalexsyn, Inc.Chief Executive Officer
COMMITTEESFacilitiesIntellectual Properties and LegislationMarketing and CommunicationsMembership and ServicesProgramsPublic Policy
Where INNOVATION and OPPORTUNITY MeetOAKLAND UNIVERSITY
APPLIED RESEARCH
Office of Grants, Contracts and Sponsored Research544 O’Dowd Hall2200 North Squirrel RoadRochester, MI [email protected]/research
For further information, contact:
T.C.Yih,Vice Provost for Research • (248) 370-2552
Oakland is a known leader in many applied research
disciplines including biomedical research, manufacturing,
information technology, alternative energy/power train and
homeland defense.To foster emerging discoveries, the
university features several noted research centers, including:
BioMatters Ad 2.09:Biotech Life Science Ad 3/6/09 1:22 PM Page 1
7 BioMatters | Spring 2009
BioMattersT A B L E O F C O N T E N T S
A D V E R T I S E R SAnn Arbor Region CRO Network ........................9 Ash Stevens ....................................................... 43Asterand ............................................................ 42Bank of Ann Arbor ............................................ 17Beaumont Hospitals .......................................... 37Biotechnology Industry Organization (BIO) ........ 28The Brooks Industrial & Research Park ............ 18Business Review ................................................ 33CMU Research Corporation .............................. 46Cutting Edge Histology ..................................... 23DBA Analytical .................................................. 17Doeren Mayhew ................................................ 36Dykema ...............................................................6Great Lakes Entrepreneur’s Quest ..................... 40Hylant Group ..................................................... 18Karmanos Institute ........................................... 46Lake Superior State University .......................... 43
ProPharma Group ............................................. 43Quest Research Institute ................................... 22Rader, Fishman & Grauer PLLC ........................ 46RS Electronics ................................................... 23Smith Haughey Rice & Roegge .......................... 26Steve Raphael .................................................... 47Switchback ........................................................ 10TransPharm Preclinical Solutions ..................... 23Twin Bay Medical .............................................. 47University of MichiganTech Transfer ................ 29University of Michigan Department of Biomedical Engineering .......................... 26Varnum Riddering Schmidt Howlett ................ 17Warner Norcross and Judd ................................ 37Wayne County ................................................... 48Wayne State University ...................................... 23West Michigan Science & Technology Initiative ....40
Lumigen ............................................................ 26MichBio ...............................................................2Michigan Economic Development Corporation ................................................ IFCMichigan Small Business Technology Development Center ..................................... 42Midwest Cleanroom Associates ........................ 46MPI Research .................................................... 14Oakland County Planning and Economic Development .............................................OBCOakland University .............................................5P&M Corporate Finance, LLC .........................IBCPfizer ................................................................. 11Pharmacision .................................................... 18PhRMA .............................................................. 29Pinnacle Insurance ............................................ 42Prima Communications .................................... 47
4 MichBio Corporate Sponsors, Officers, Directors and Committees
21Williamston Inventor takes aim at airway Obstructions
30 eCONOMIC DeVeLOPMeNt: Governments Building Foundations for regional Bioscience Growth
Feature stories and sidebars by Steve Raphael.
The following MichBio members are featured in this issue of BioMatters:Accuri Cytometers, Ann Arbor SPARK, Asterand, Inc., Beaumont Hospitals, Center for Applied Research & Technology, Central Michigan University Research Corporation
Delphi Medical Systems, Dow Pharma, Esperion Therapeutics, Inc., Henry Ford Health System, Honigman Miller Schwartz and Cohn LLP, Housey Pharmaceutical Research Laboratories, LLC, Johnson & Johnson Co., Kalexsyn, Inc., Kellogg Co., Michigan Economic Development Corporation, Michigan State University, NanoBio Corp., NanoMed Pharmaceuticals, Inc., Oakland County
Planning and Economic Development, Oakland University, Pfizer, PharmOptima, LLC, Proteos, Inc., Southwest Michigan First, Southwest Michigan Innovation Center, TechTown, Tech Initiatives Inc., The Right Place, Inc., University of Michigan Life Science Institute, Venomix, Inc., Wayne State University, West Michigan Science & Technology Initiative
Subscribe to BioMatters:Visit www.michbio.org and click “Subscribe” or call 734.527.9150.
19reSearCH: Michigan universitiesPack a Powerful r&D Punch
34 Open Source approach Opens Markets for ann arbor SParK
35MeDC Shepherds State’s Biosciences
49 GueSt OPINION: Balancing Life Science efforts For Sustainable rOI
44 NeW FrONtIerS: Pint-Sized Nano- medicine Industry
38teCHNOLOGy: State expects to be Sitting on top
50DIreCtOry & reSOurCe GuIDe
8BioMatters | Spring 2009
That was the conclusion
of a recent study released by
industry advocate, the Phar-
maceutical Research and Manu-
facturers of America (PhRMA),
which concluded that “Michigan
has the assets to support and
grow bioscience, particularly in
the presence of its major research universities.”
The study points out that university biosciences
expenditurestotaled$897millioninfiscal2007
with industry payrolls reaching nearly $2.5 billion
for the same period.
Michigan is home to more than 540 biosciences
enterprises from pharmaceutical and medical
device companies to diagnostics, bio-agriculture
and nutriceuticals. The state’s contract research
industry alone has the depth to handle business
from across the globe at any stage of development.
Michigan’s SmartZones™ fuel a robust pipeline
of Michigan biosciences companies. SmartZones™
are distinct geographical areas where technology-
based businesses gain from collaborations between
local universities, industry, research organiza-
tions, government agencies and other community
resources. The business incubators (see Feature
story p. 12) located within many SmartZones™
nurture entrepreneurism with wet lab services,
SBIR and STTR assistance and access to business
planning and funding sources. From the tip of the
Upper Peninsula to the bustling Lower Peninsula,
Michigan’s “Upper Hand” Advantage is its Complete
Biosciences Package. Look no further.
The study points out that
bioscience expenditures totaled 897 million with industry payrolls reaching nearly $2.5 billion.
Bioscience is “Big Business” in Michigan
These days, access to viable, high quality CROs can mean the difference between success and failure in rapidly moving a pharmaceutical to market. That’s why so many life science leaders are looking to Southeastern Michigan as a source for CRO support in every phase of product development. Here, in the heart of Michigan’s Life Science Research Corridor, they’re finding a unique concentration of expertise and resources spanning the entire product development continuum.
Introducing the Ann Arbor Region CRO Network In this dynamic quadrant of the Great Lakes State you will find dozens of high-capability CROs specializing in pharmaceutical product development. The Ann Arbor region CROs have formed an alliance network with the following capabilities:
n Experienced life science researchers and consultants
n A full spectrum of CROs, many of them headed by former scientists and executives from Pfizer, Warner-Lambert, Upjohn, and other life science research giants
n Accessible, affordable pharmaceutical product development
n Demonstrated success with a diverse client-base from start-up to established companies in the US, Europe, Asia & Australia
Why Michigan should be your source for life science product development
n #2 state overall for R&D expenditures
n #3-ranked university for R&D funding
n Rated the 2nd most business-friendly state
n 4th largest high-tech workplace in the nation
n One of the fastest-growing life science states
n More than $2 billion invested annually in life science research
CART And Mid-MiChigAn PUll THEIR WEIGHT Dendritic Nanotechnologies Inc. (DNT)
in Mt. Pleasant, a company with origins
dating back to The Dow Chemical Co., is
a huge CART success story. CART helped
DNT secure funding, develop its intellectual
property and catch the eye of Starpharma
Holdings Ltd., a Melbourne, Australia com-
pany developing nanotechnology products
for the pharmaceutical industry that acquired
DNT in 2006.
Among other CART successes is Bauer
BioMedical whose genetic diagnostics tech-
From mid-town Detroit to downtown Grand Rapids and up north to the great outdoors of Houghton in the Upper Peninsula, innovation is emerging from Michigan business incubators. Incubatorsbringtogethertheknowledgeandresourcesoflocalgovernments,nonprofits,industryand
and business support services to help scientists and entrepreneurs translate their innovations and
technologies into commercial products.
nologies make possible the precise detection
of cancers and other disease conditions
through the analysis of peripheral blood
or body fluid specimens, all without the
need for invasive biopsy or excision of the
diseased tissues.
CART partners with other economic
development organizations throughout
the region, including Saginaw Valley State
University and the MidMichigan Innovation
Center. Together these organizations are
developing a regional business incubator
network to improve their collective efficiency
and effectiveness.
Just to the east in Midland, the four-
year-old MidMichigan Innovation Center
(MMIC) is making its presence felt too. Like
the other incubators across the state MMIC
provides a wealth of critical resources,
valuable services, flexible facilities, and
entrepreneurial training and education to
help support business ventures.
Our “role is to not only help our tenants
and virtual tenants by connecting them to
resources they wouldn’t otherwise be aware
of, but to inform and educate entrepreneurs
in our region and neighboring communi-
ties,” says Brent Case, executive director.
MMIC is a satellite of the Central
Michigan University Research Corporation
SmartZone™ in Mt. Pleasant and provides
services to all industrial sectors without
targeting specific technologies.
MMIC “is an emerging economic engine
for the region,” he adds. “It is home to 17 tenant
companies, employing 130 people and gener-
ating more than $5 million in new payroll.”
MMIC operates a 112,000-square-foot
business incubator with significant support
from The Dow Chemical Co., foundations
and area universities. MMIC was instru-
mental in starting Blue Water Angels and
connected Midland-based Gantec Advance
LLC to multiple resources, including
investment/funding, marketing and public
relations, website development and office
and lab space. Gantec manufactures and
sells all natural products in the Blossom
Springs Growing System, including a plant
health supplement spray concentrate that
eliminates the need for synthetic additives
or sprays in potting soils.
“Almost all startups have a hard time thinking through and writing a good business plan. Virtually all have a particular challenge with the proformafinancials.Allhavefunding challenges.”
14BioMatters | Spring 2009
WEST MICHIGAN ROADMAP GUIDING COMMERCIALIZATION The West Michigan Science & Technology
Initiative (WSMTI) in Grand Rapids works
very closely with early stage inventors and
entrepreneurs, generally for pre-A round
funding to build a “commercialization” road-
map, says Linda Chamberlain, Ph.D., WMSTI
executive director. It operates a high-tech
incubator, chartered primarily for biosciences
companies.
Like other incubators, WMSTI’s relation-
ship with a nearby university, in this case
Grand Valley State, enables it to access and
leverage all university resources for its entre-
preneurs. Chamberlain says the university’s
support “is critical for sustainability.”
“The path to market is littered with more
obstacles than imagined. The costs are always
higher, things take longer than expected, and
the regulatory restraints can be challenging,”
Chamberlain says. “Success requires tenacity,
and you need to be absolutely passionate
about what you are developing.”
WMSTI has many success stories. It
helped procure a $66 million private equity
investment last year for Avalon Laboratories,
an international supplier of cardiopulmonary
vascular cannulae. In early January, Avalon
won approval from the FDA and its Canadian
counterpart to market three catheter devices
used in extracorporeal life support systems.
Last September, San Diego-based Sequenom
acquired the Center for Molecular Medicine
(CMM) – a clinical diagnostics lab in Grand
Rapids. Sequenom is fielding new genetic
tests that can detect disorders in the first
trimester of a pregnancy.
Prior to its acquisition, CMM had created
seven jobs in 18 months. With its new owner
20 more jobs will be added by mid-year and
500 more over the next five years. Sequenom
also announced collaboration with Spectrum
Health and the Van Andel Research Institute.
MLSIC BLUEPRINT FOR THE FUTURE The Michigan Life Science and Innova-
tion Center (MLSIC) provides entrepreneur-
ial support and incubator space in southeast
Michigan. Commenting when the new site
was announced last September, Roger
Newton, founder, president and CEO of
newly resurrected Esperion Therapeutics
Inc. said, “There will be a collective synergy
to having everyone together.”
FEATURE STORy
Like other incubators, WMSTI’s relationship with a nearby university, in this case Grand Valley State, enables it to access and leverage all university resources for its entrepreneurs.
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18BioMatters | Spring 2009
19 BioMatters | Spring 2009
Researchers at the three universities have
made dazzling discoveries and awe-inspiring
breakthroughs that are advancing human
health. For example:
l A Wayne State scientist developed the anti-
cancer, anti-viral drug, AZT. The drug failed
as a cancer fighter but was found to be the
first effective drug in the battle against AIDS.
l U-M scientists lay claim to Flu Mist
nasal spray, as well as the discovery of
the gene for cystic fibrosis.
l Michigan State scientists discovered for
the first time that leptin, a hormone
produced by fat cells, supports white
blood cell production in the body,
enhancing immune function.
According to the URC, from 2002 to 2005
U-M scientists received 353 patents, result-
ing in 43 start-up companies, generating
$63.6 million in revenue. Michigan State has
received 184 patents with 28 start ups and
$105.6 million in revenue; and Wayne State
has had 95 patents and eight start-up com-
panies that have resulted in $22.9 million.
According to National Science Foundation statistics, Michigan ranks fourth in the country in terms of R&D expenditures. In 2007,
the University of Michigan (U-M), Michigan State University (MSU) and Wayne State University (WSU)
received approximately $1.4 billion in total research dollars, according to the University Research
Corridor (URC), an alliance created by the three schools to advance their mutual interests. That amount
tops total research dollars reaped by North Carolina’s Research Triangle.
RESEARCH
Michigan Universities Pack a Powerful R&D Punch
the combined experience, depth and competence of michigan
academic inStitutionS provide huge economic impetuS for the State.
20BioMatters | Spring 2009
In 2007 alone, U-M had 329 disclosures,
signed 91 licensing agreements and was
issued 87 patents. Michigan State had 161
disclosures, 28 licensing agreements and 35
patents.Wayne State procured 16 licensing
agreements, 45 disclosures and 22 patents.
A disclosure is the written notice of an
invention to the tech transfer office.
U-M is the state’s – and one of the
nation’s – leading research universities. In
2007-08 university research spending hit
$875.8 million, an all-time high. The school
consistently ranks among the nation’s top
five research universities, based on the
NSF’s R&D expenditure statistics.
MSU’s Vice President of Research Ian
Gray, Ph.D., says in fiscal 2008 the school
received $288 million in research support
from six sources, of which $164.2 million,
came from the federal government. WSU
research expenditures in FY 2007 were
$235.2 million, a six percent increase from
$220.7 million in 2006, says Julie O’Connor,
director of research communications.
There’s a good reason why the three state
schools can attract significant funding.
“Our scientists and our universities (go)
toe-to-toe with anyone,” says Phil Torrence,
the managing partner of Honigman Miller
Schwartz and Cohn’s Kalamazoo office.
Torrence specializes in venture capital
and mergers. In his 10 years in the field
he has worked closely with the biggies –
Stanford, Harvard, Yale and MIT.
The world of funding, research and
commercialization are indispensable to one
another; to some degree you can’t have one
without the other.
In its simplest form, a scientist comes
upon a promising drug discovery in the lab
and then applies for a patent. Next it’s time
to pursue money from the government,
private investors and university. When the
research arrives at a point where it is ready
for commercialization the school’s tech
transfer office steps in, providing all sorts of
business support while hunting for private
companies or equity companies to buy the
product’s licensing rights.
The new owner could oversee clinical
trials, further develop and take the drug to
market. If the drug is a commercial success,
some of the dollars find their way back to the
university as licensing fees. These fees are then
reinvested into the university’s research units.
Its location in
mid-town De-
troit has been a
boom for Wayne
State’s research
endeavors.“Through
our cross-campus
collaborations and
our alliances with
other institutions
such as Children’s
Hospital of Michigan,
the Henry Ford
Health System,
and our University
Research Corridor,
to name a few, Wayne
State is actively
RESEARCH
Researchers at the three universities have made dazzling discoveries and awe-inspiring breakthroughs that are advancing human health.
involved on many research fronts,” O’Connor
says. The universities provide the opportu-
nity, resources and time, but the scientists are
the heroes.
Jerome Horwitz holds a Ph.D. in organic
chemistry and was an investigator at Wayne
State for nearly 40 years until he retired in
2005. In the 1960s, while in hot pursuit of
cancer killing drugs, he discovered anti-viral
AZT and two other AIDS drugs. The drugs
failed as cancer fighters and years later the
National Institutes of Health, working with
a predecessor to GlaxoSmithKline, turned
AZT into the AIDS drug.
At the time of his discovery Horwitz was
working for the Michigan Cancer Founda-
tion with a federal grant from the National
Institutes of Health.
Simon Ng holds a Ph.D. in chemical engi-
neering and is a chemical engineering profes-
sor in Wayne State’s College of Engineering. He
is deeply involved in solving the mysteries of
biodiesel fuel production, contemplating using
a variety of low-cost feedstock for continu-
ous biodiesel production. He is director of the
National Biofuels Energy Laboratory located at
TechTown in mid-town Detroit.
Robert Freedman holds a Ph.D. in psy-
chiatry in Wayne State’s School of Medicine.
His discoveries include development of a
sensor to pinpoint the frequency of difficult-
to-track hot flashes. The sensor is less than
2 inches in diameter, weighs about an ounce
and can collect and send data on changes in
skin moisture for up to a month. He also is
studying whether use of an anti-depressant
drug has an impact on hot flashes.
University of Michigan scientists Ivan
Maillard and Yi Zhang, M.D. are looking
for ways to make bone marrow transplants
safer and more widely available. Their
approach, considered revolutionary, is un-
proven thus far, they admit. But that didn’t
stop the Damon Runyon Cancer Research
“Our scientists and our universities (go) toe-to-toe with anyone.”
21 BioMatters | Spring 2009
John Schwartz, ph.d., developed the innovative airway rifl
you’d be surprised at the ideas you can come up with while
on vacation from work. In the case of brothers John and Rich-
ard Schwartz it was a new piece of equipment called the “Rigid
It snakes through the trachea, looking through the light, like in
(the movie) Fantastic Voyage. you’re slinking around and ‘whoa,’
there are the vocal chords, and you can slide the tube in.”
JohnSchwartz,whoholdsaPh.D.infisheriesandwildlife
and an undergraduate degree in engineering, recently retired
from Michigan State University. He and his brother, Richard,
the head of emergency medicine at the Medical School of
Georgia in Augusta, were sailing in the British Virgin Islands
in 2001, sipping pina coladas and bending the drinks’ straws.
Williamston Inventor Takes Aim at Airway Obstructions
The RIFL enables the medical practitioner to insert an endotracheal tube with ease, even when facing unanticipated complications, with minimal trauma to the patient.
Eureka! From that simple observation the idea of more
flexibleintubationequipmentemerged.
“(Richard) was in Special Forces at the time and told me
about the problems with intubation on patients with spinal
and helped with the original business plan. Economic develop-
ment organization, Ann Arbor SPARK gave us a $25,000 grant in
the early days and an acting CEO.”
Schwartz headquartered AI Medical Devices just outside
Lansing, in Williamston, MI, and raised about
$1,750,000. The company won a 21st Century
Jobs Fund grant of $400,000 from the Michigan
Economic Development Corp., and an individual
invested $500,000 in the company. The company
has seven Michigan employees.
AI Medical began marketing the RIFL two
years ago, and has sold the product, priced
at $6,500 each, to 60 hospitals from
Florida to Alaska. Schwartz expects
thecompanytoreachprofitabilitynext
year. Last October AI Medical intro-
duced a second generation RIFL
with video that uses a camera
and an LCD monitor on the back
of the scope.
Schwartz now holds three patents and 11 are pending.
21 BioMatters | Spring 2009
RESEARCH
22BioMatters | Spring 2009
MANUFACTURING
Foundation in New York City from awarding
the pair a $450,000 “Innovation Award” for
young scientists. They were two of just four
winners, selected from 198 applicants.
MSU’s Gray is reluctant to name names.
“We have many (scientists) who are nation-
ally and internationally recognized and
make major contributions to their fields,
whether it is education, environmental
sustainability, bioenergy, international
medicine, evolutionary biology, high energy
physics, and nuclear sciences,” he says.
Many of his stars work directly and
collaboratively with scientists from U-M
and Wayne State as the schools believe
strongly that working together is in their
best interests as well as those of Michigan.
The state’s other public universities
aren’t shrinking violets. Central Michigan,
Michigan Tech, Oakland University, Western
Michigan and Grand Valley State are deliver-
ing advances throughout the whole spectrum
of biosciences: health care, medicine, nano-
science, bioengineering and biotechnology,
including agriculture and energy.
And that’s just the universities. The Jay
and Betty Van Andel Research Institute
(VARI) in Grand Rapids and the Barbara
Ann Karmanos Cancer Institute in Detroit
are privately held academic research insti-
tutes highly regarded for their respective
and robust scientific programs.
Most recently, VARI announced the
appointment of Jeffrey Trent, Ph.D., as
its new Director of Research. He was
previously Scientific Director of the National
Human Genome Research Institute and on
faculty at the UM’s Comprehensive Cancer
Center. Dr. Trent will lead an expanding
VARI faculty focused on understanding the
genetics and molecular origins of cancer
and other diseases in a strategic partnership
with the Translational Genomic Research
Institute (TGen) where he also serves as
President and CSO.
Karmanos is one of 40 NCI-designated
comprehensive cancer centers in the U.S.
It cares for more than 6,000 new patients
annually and conducts more than 700
cancer-specific scientific programs and
clinical trials, second only to the M.D.
Anderson Cancer Center in Houston, TX.
Without a doubt, Michigan’s academic
research institutions generate innovation,
new technologies and commercialization
ventures, a huge economic force for the state
and much of it focused on the biosciences.
RESEARCH
“We have many (scientists) who are nationally and internationally recognized and make major contributions totheirfields...”
RESEARCH
31000 Telegraph Rd.
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248.644.7770
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We have senior physicians and staff with virtually no employee turnover.
We are top in the industry in study start-up cycle time.
We consistently meet or exceed enrollment targets with strong recruitment tactics and an 8,000 patient database.
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23 BioMatters | Spring 2009
Advancing life sciences through start-up companies since 1985.
http://www.techtransfer.wayne.edu
Toll Free 888.88.INFECT The Wellhoff Center Ph: 517.536.8210 7190 Brooklyn Rd. www.transpharmsite.com Jackson, MI 49201
“Working with us is CONTAGIOUS”
TransPharm Preclinical Solutions is a reliable single source provider of a complete array of studies in infectious disease
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We have vivarium and wet lab space available with monthly lease options.
• Negative pressure clean room bioBubbles® for animal housing • 1,700 sf laboratory with adjacent tissue culture room • State of the art surgical suite including Zeiss® surgical scope, gas
anesthesia and active scavenger system • Access to our in house IACUC for protocol review and approval • AAALAC accreditation in progress
Located in the heart of Michigan’s Biotechnology Corridor
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RS Electronics has been supplying electronic components and test & measurement instruments to the life sciencesand medical technology industry for more years than most other companies have been in existence. Withproducts and materials from the top manunfacturers inthe electronics industry, we can support your research, design, and manufacturing requirements whether youare a small start-up or a large well established business.
We have more sta� and more locally available inventoryto support the Michigan region than any other company.And, if you require support outside of Michigan, we haveadditional o�ces and sta� available in the United Statesand Mexico to meet your needs.
Let us show you how we can help you research, design,and build innovative, high quality, bioscience products.
doctors and scientists in the neurology area and has set up the
Primate Center in Puerto Rico to do monkey IVF. It is getting a NIH
grant to start making monkey-induced pluripotent stem cells for
clinical translational studies.
Morrison believes scientists at U-M,
Wayne State University and MSU will
more than carry their weight in the
field.“Itwilltakeeverybodytopush
thisfieldforward,andscientistsat
multiple institutions within the state are
capable of making breakthroughs.”
The easing of restrictions on stem
cell research makes it possible for UM
to develop its own new embryonic stem
cell lines to study, notably in the neuro-
degenerative diseases, such as Hunting-
ton’s disease.
Towards that goal, in mid-March
the U-M announced the formation of the
A. Alfred Taubman Medical Research
Institute Consortium for Stem Cell Ther-
apies. The Consortium will be among
thefirstgroupsinthecountrytoderive
new embryonic stem lines that are
linked to a database containing genetic
and medical history information about
donor embryos and families. This should
enable researchers to better understand
how disease genes have manifested
themselves over generations. Before
Obama lifted the ban, Michigan was one
of six exploratory centers funded by the National Institutes of
Health to conduct embryonic stem cell research.
PassageofProposal2hasalreadyhadasignificantimpact
on recruiting embryonic stem cell scientists to U-M. “Hiring new
faculty members takes months when you’re searching for the
best people in the world,” Morrison says. The LSI started the
recruiting process last September in anticipation of Proposal 2’s
passage, and there are now plenty of resumes to choose from.
For a long time it was rumored that Morrison could leave
the university because of the embryonic stem cell ban.
“I stayed here because Michigan is a spectacular place to do
research,” he says. “I would hope to have my cake and eat
it, too. I hope to be able to develop this environment into all
areas of stem cell research.”
Michigan shares this “can-do” attitude and is poised to
greatlyexpanditspresenceandimpactinthefieldofstem
cell research.
Thefirststepisgettingthebrain power here…“then the investment will trickle in”
“it will take everybody to push this field forward, and scientists at multiple institutions within the state are capable of making breakthroughs.”
embryonic Stem cellS provide a potentially renewable Source of replacement cellS and tiSSueS to treat diSeaSeS.
26BioMatters | Spring 2009
Realizing the Promise of Tomorrow’s Leaders
For more information go to: www.bme.umich.edu/industry
The University of Michigan Department of Biomedical Engineering (BME) works closely with industry and business to help improve products and techniques. We also provide several opportunities for you to support and build relationships with talented BME students who will be future leaders in the field. Find out how you can:
• Support our Design Program, sponsor a project, mentor students• Recruit BME students for internships and staff positions• Participate in our BME Career Fair and other events
Jonathan Song, PhDProf. Shuichi Takayama’s Micro/Nano/Molecular Biotechnology Lab
Traverse CityGrand RapidsAnn Arbor
www.shrr.com616-774-8000
When it comes to the
life sciences business,
many attorneys just
miss the point.
A good business law firm can help you
get your life sciences company up and
running, and secure legal protection for
your products and ideas. Smith Haughey
is certainly one of these firms.
But we bring something more to our
life sciences clients. As one of Michigan’s
premier health law firms, we understand
the practicalities of the healthcare
marketplace – the players involved, the
regulatory and reimbursement issues, and
the unique challenges and requirements
of various healthcare environments.
As a result, we can provide invaluable
insight that will help position your
product and business for maximum
success. And that really is the point,
isn’t it? To learn more, visit our web site
or call and ask for a member of our
Life Sciences Industry Team.
LIFE SCIENCES ATTORNEYS
27 BioMatters | Spring 2009
RESEARCH
Students Collaborate to Give the Gift of LifeRESEARCH
For the past four years 15 students at Michigan Tech
University in Houghton, MI, have been building a better
mousetrap to improve the quality of CPR administered
in hospitals.
Their majors are in engineering, technical communi-
cations,management,marketingandfinance,andtheir
finishedproductistheCPRMattress,afoammattressthat
deflatesquicklytoprovideafirmsurfacetomakeCPR
moreeffective.Thefirmerthesurfacethemoreefficient
the compression.
The current generation of foam mattresses, most
commonly used in hospitals, is activated by patient
pressure and uses air valves to diffuse the mattress.
“We could be in the market as close as the end
of this year,” says Laurilee Kroll, an MTU student and
directoroffinanceandmarketingforTechInitiatives,
the S corporation created to sell the CPRMattress.
The students are working with the help of MTU facul-
ty and the Houghton SmartZone™, one of 15 state-backed
locationswheretechnology-basedfirms,entrepreneurs
and researchers take advantage of commercialization
resources.
Medical research studies over the past eight years
have shown that the depth and rate of compressions
being performed are not meeting the standards set forth
by the American Heart Association. Thus, in 2005 the
Cardiopulmonary Division of Portage Health Hospital
in Hancock approached MTU’s biomedical engineering
department,askingthemtofindoutwhyCPRwas
proving ineffective in hospitals and led to a large number
of deaths.
The faculty and students found that the problem
rested with the quality of existing foam mattresses upon
which medical personnel administered CPR to patients.
The students found that when CPR is performed on
a patient lying on a foam mattress, the CPR provided 41
percent of the compression needed to resuscitate the
patient; when a CPR board was placed under the patient
theefficiencyincreasedto53percent.Theideabehind
the CPRMattress was born.
When the CPRMattress is activated a vacuum motor
removes the air in the upper half of the mattress, causing
the foam mattress to compress into a rigid surface. The
vacuum will cycle again to make sure the mattress retains
its rigidity. When the mattress is no longer needed it can
bere-inflatedbypushingandholdingtheactivationbut-
ton for 2 seconds. The mattress returns to full comfort
level within one minute. This technology is adaptable to
virtually any foam-based mattress.
“It’s a good concept,” says Luretta Pandya, an RN
and strategic clinical sourcing manager for the Detroit
Medical Center. DMC nurses have crash carts with boards
anddefibrillatorstoadministerCPRwhenapatientgoes
into cardiac arrest. “[With the CPRMattress], you press a
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Initsfirstthreeyearstheprojectwasfunded
completely by grants totaling $150,000, coming from
the state of Michigan and private
investors. “Our future plans are to
get the mattress into clinical trials
and entertain offers for licensing
agreements with current medical
mattress manufacturers,” Kroll says.
Currently the CPRMattress is in
itsfinaldesignphaseandisabout
to go through further testing by
Underwriters Laboratories Inc.
Currently the CPRMattress is initsfinaldesignphaseandis about to go through further testing by Underwriters Laboratries Inc.
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RESEARCH
29 BioMatters | Spring 2009
The Pharmaceutical Research and Manufacturers of America
PhRMA MEMBER COMPANIES ARE COMMITTED TO SUPPORTING ECONOMIC GROWTH & FURTHER RESEARCH
THAT LEADS TO GOOD JOBS & THRIVING COMMUNITIES.
ECONOMIC DEVELOPMENT
Governments Building Foundations for Regional Bioscience Growth
ECONOMIC DEVELOPMENT
30BioMatters | Spring 2009
31 BioMatters | Spring 2009
Local governments are aggressively establishing biosciences enclaves, as they view the sector’s growth potential amid challenging economic times. Partnerships have been created, resources commit-
ted and incentives provided to lure biotech companies to their areas or to nurture new and exisiting
companies.
BIOSCIENCE IS BIG BUSINESS IN WAyNE COUNTy Wayne County’s economic development
unit has created partnerships, granted
money and reached out to biosciences
professionals, all aimed at growing
biosciences’ presence in the area.
At the 2008 MichBio Expo last November,
county executives huddled with Michigan’s
biosciences professionals to learn first hand
about the industry’s challenges and opportu-
nities. This was one more county strategy
to further hone its life sciences business
attraction efforts, says Todd Fenton,
executive manager of the Wayne County
Land Bank Corp.
Last summer Wayne County, along with
the Michigan Economic Development Corp.
(MEDC), Ann Arbor SPARK (see story 34),
the Michigan Life Science and Innovation
Center (MLSIC) and others opened what it
considers to be a cutting edge wet lab incu-
bator in Plymouth Twp. on property vacated
by Pfizer Inc. It scored a major coup when
Roger Newton moved his second generation
Esperion Therapeutics into a portion of the
57,518 square foot building.
In addition to its MLSIC collaboration,
Wayne County has:
l Created a partnership with TechTown
in mid-town Detroit to create the Wayne
County Stem Cell Commercialization
Center. (See story page 24.)
Spanos rattled off numerous existing
ones, such as Somanetics, Delphi Medi-
cal Systems, Housey Pharmaceuticals and
Rockwell Medical Technologies. And
that’s not counting Beaumont Hospitals,
a research giant that is now flexing its
muscles in commercialization through its
Beaumont Commercialization Center.
None of the county’s goals would be
possible without a world-class workforce.
Officials work closely with local school
districts and area colleges/universities to
ensure students are learning 21st century
skills. Oakland Community College has a
promising bioscience-focused curriculum.
OAKLAND COUNTy SEES BRIGHT FUTURE FOR BIO JOBS The future belongs to high tech, and
Oakland County Planning and Economic
Development knows that that’s where its
future has to be.
In late 2004 the county created the
Emerging Sectors Strategy, identifying
10 emerging industries ripe for nurturing.
Biosciences and health care were two of the
10 and today are the fastest growing sec-
tors in Oakland County, says Irene Spanos,
the county’s senior business development
representative.
The county boasts 4,324 biosciences
and medical-related facilities, including
hospitals, nursing homes, pharmaceuticals,
medical devices and medical office building
clusters. Knowing a good idea when it sees
it the county recently launched Oakland
County Medical Main Street, an effort to
brand Oakland County as a “medical tour-
ism” destination.
“We want to brand southeast Michigan as
a biosciences hub,” Spanos says. The county is
projecting the sector will create 45,000 jobs by
2018. It employed about 10,500 people last year.
The county uses its existing trade mis-
sions as well as exhibiting at many technol-
ogy conferences regionally and throughout
North America, Europe and Asia, to hunt for
new partnerships.
Oakland County already has an impres-
sive line-up of biosciences companies.
“We want to brand southeast Michigan as a biosciences hub.”
an expanding liSt of reSearch facilitieS now reSide in the quadrant Known aS grand rapidS’ medical mile, where there haS been $1 billion worth of inveStment in recent yearS. it began with the founding of the van andel inStitute (above) by Jay and betty van andel in 1996 and haS Since Spread to include grand rapidS community college’S calKinS Science center, Spectrum health’S butterworth hoSpital complex, grand valley State univerSity’S cooK-devoS center for health ScienceS, and the michigan State univerSity Secchia center medical School, among otherS.
32BioMatters | Spring 2009
l Announced a $750,000 construction
grant to the TechTown business
incubator. This grant will enable
TechTown to build out 10,000 square
feet of office and laboratory space
on its third floor – enough for nine to
12 new tenants.
l Made available a pool of $250,000 of
grant money for start-up companies
located in the MLSIC Plymouth
Township building.
For all the activity, commitment and
energy throughout the state, life sciences
professionals know what Fenton knows,
“Life science is not a panacea to cure all our
woes; it is crucial because it’s high tech and
attracts highly educated people. Even if it was
something that we didn’t have to do we would
still do it.”
RIGHT PLACE IS RIGHT FOR GRAND RAPIDS The Right Place Inc. in Grand Rapids has
the right stuff for western Michigan. At 24
years old it is a leader in regional collabora-
tion, luring new biosciences companies into
western Michigan and bolstering existing
ones through a myriad of overlapping rela-
tionships.
For example, The Right Place formed
a partnership with the West Michigan
Science & Technology Initiative (WMSTI)
that, in turn collaborates with the Van
Andel Research Institute, Grand Valley
State University, the City of Grand Rapids
and Grand Rapids Community College.
The partnership has recently expanded
to include Spectrum Health, Saint Mary’s
Health Care, Mary Free Bed Rehabilitation
Hospital, the Grand Angels and Michigan
State University College of Human Medicine.
The relationships are complex, but
The Right Place’s vision is simple:
l Lead West Michigan business
development efforts.
l Identify and develop emerging growth
opportunities.
l Strengthen the global competitiveness
and innovation of existing regional
manufacturers.
One of The Right Place’s biggest accom-
plishments was recruiting Sequenom Inc. to
the region from San Diego in 2008. Seque-
nom provides genomic and genetic analysis
solutions for the research and molecular
diagnostic markets.
The Right Place played an “integral
and critical role” in the process of creating
the Medical Mile in downtown Grand
Rapids, says Tim Mroz, senior director of
communications. “We provided economic
development support to the city as well as
public and private developers.”
The Right Place and Kalamazoo
neighbor, Southwest Michigan First, often
work together. In 2007 the pair co-funded a
thorough study of the biosciences industry
in West Michigan. From there they devel-
oped “A 2007 Study on ‘Regaining Global
Prominence in the Life Sciences in Western
Michigan.’” The study focused on biotech,
medical devices and pharmaceuticals.
The results of this study and execution
of the plan helped fuel the existing West
Michigan’s Life Science corridor, Mroz says.
SOUTHWEST MICHIGAN PUTS BIOSCIENCE GROWTH FIRST The mission of Southwest Michigan First
(SWMF) “is to create jobs and wealth in the
Kalamazoo region,” says Heather Smith, vice
president. The nine year-old private, non-
profit organization has assisted more than
120 organizations with retention, expansion
and recruitment projects. It has overseen 26
bioscience company start-ups and funded 10
companies through its venture fund. It cre-
ated more than 5,000 jobs in 2008, according
to its website.
One of SWMF’s best tools is the South-
west Michigan First Life Science Fund.
SWMF established the $50 million fund in
2005 as a limited partnership venture fund
to invest in early-stage bioscience compa-
nies. Smith says the fund is believed to be
the largest sum of community-based private
capital ever to be raised and managed by an
economic development organization.
The fund only invests in companies that
already have a presence or are committed
to establishing a presence in Southwest
Michigan, Smith says, such as Redmond,
Washington-based Micronics Inc. Micronics
is setting up its headquarters and produc-
tion, distribution and customer support
operations in Kalamazoo for the medical
devices it is developing to speed up genetic
testing.
“We work with existing companies within
our region to expand their opportunities,”
Smith says. “For fund companies…we provide
assis-tance in helping them find partnership
opportunities, executive leadership and physi-
cal space.”
Working with The Right Place, SMF has
“forged a strong networking base with the
Officialsworkcloselywithlocal school districts and area colleges/universities to ensure students are learning 21st Century skills. Oakland Com-munity College has a promising bioscience-focused curriculum.
Wayne County’s economic development unit has created partnerships, granted money and reached out to biosciences professionals, all aimed at growing biosciences’ presence in the area.
ECONOMIC DEVELOPMENT
PR15
35
Keep a pulse on thebusiness of health careWeekly in Business Review, and bi-monthly in Health Michigan. Satisfy your need to know.
Michigan Business Review is the largest business news organization inthe state. We provide relevant business news in your local market andacross your region, with an exclusive statewide perspective.
Michigan Business Review follows Michigan's key economic drivers —health care, development and advanced manufacturing — and theindustries they influence.
BUILDING BUSINESS ACROSS MICHIGAN THROUGH ENGAGING AND RELEVANT NEWS.
talent initiatives have been a cornerstone of economic development efforts. Programs
like Hot Shots, that connects employees and employers in a fun “happy hour” format,
or Mingle & Match, a sort of “speed-dating” for start-ups and potential employees,
have been highly effective in supporting the retention of talent in our region and
placing high-value knowledge workers in growing companies.
A steady stream of entrepreneurs seeking ways to accelerate their business provides
impetus for regional economic development activities. Programs like Entrepreneur Boot
Camp are foundational resources for new businesses; BioArbor, a monthly education
and networking series, and the Annual Collaboration for Entrepreneurship showcase
the entrepreneurial success needed to support Michigan’s new economy. Leveraging
educational resources throughout the region is integral to economic development. Ann
Arbor SPARK’s partnerships with the University of Michigan, Eastern Michigan University,
Washtenaw Community College and the University Research Corridor have increased the
success of technology transfer and kept valuable knowledgeable workers here in the
community — creating, innovating and thriving.
Biosciences in total remains “big business” in Michigan, accounting for nearly 100,000 direct and indirect jobs. It generates $9.34 billion in economic impact.
The study concludes thatMichigan has abundant assets to support and grow the bio-sciences, particularly in the presence of its major research universities and associated ini-tiatives throughout the state.
michael finney (left) iS preSident & ceo of ann arbor SparK.
34BioMatters | Spring 2009
ECONOMIC DEVELOPMENT
35 BioMatters | Spring 2009
For example it partnered with economic development
organizations in Ann Arbor, Holland and Kalamazoo to
retainPfizertalentandassetsthroughtheCompanyFor-
mation and Growth Fund. The MEDC channeled $12 million
from Michigan’s 21st Century Jobs Fund to the three or-
Zones™ don’t pay personal property tax on their equipment.”
MEDC offers MEGA tax incentives based on job creation
and retention for all businesses. The state also has a
ECONOMIC DEVELOPMENT
MEDC Shepherds State’s BiosciencesThe MEDC has created many programs to grow the industry, but what it all boils down to
is relationship building and investment, says Kapila Viges, managing director of program
administration for MEDC.
MEDC offers MEGA tax incentives based on job creation and retention for all businesses.
36BioMatters | Spring 2009
technology commercialization credit for all 21st Century Jobs
Fund competitors, as well as an angel fund tax incentive.
Last year these tax incentive plans paid off. “We had
the busiest year we ever had in getting tax incentives,
which means companies are expanding,” Viges says.
MEDC also invests in the 21st Century Investment Fund,
and Venture Michigan Fund, both part of the 21st Century
Jobs Fund. These are funds of funds, investing in venture
capital funds that invest in Michigan companies.
Overall, since 1996 the state has invested more than
$45 million in venture funds that in turn funded biosciences
companies. A total of $35 million of that amount has come
since 2006, a sign that the state is serious about a multilat-
eral approach to supporting entrepreneurial ventures.
MEDC COMMITS $200 M TO EqUITy MARKETS Ann Arbor-based HealthMedia Inc., which designs web-
based software that helps people manage certain diseases,
behavioral problems or general wellness issues, is a good
example of how state investment works.
In 2003-04, the MEDC was one of many organiza-
tions that invested a total of $24 million in Arboretum
Ventures, an Ann Arbor venture capital fund, which in
turn invested an undisclosed sum in HealthMedia. Last
year Johnson & Johnson Co. bought HealthMedia, seeing
itasaperfectfittoitsexpandinghealthcareplatforms.
Despite the state’s current economic woes, the
MEDC knows a good investment when it sees one. In the
next few years the state and MEDC will invest a total of
$200 million in equity markets in Michigan. The money
will come from the state’s Venture Michigan Fund, as
well as the 21st Century Investment Fund. Douglas
expects that $75 million will be placed annually in the
21stCenturyJobsFundthroughfiscal2015.
MEDC is banking heavily on the future of biosciences
in Michigan.
ECONOMIC DEVELOPMENT
In the next few years the state and MEDC will invest a total of $200 million in equity markets in Michigan.
37 BioMatters | Spring 2009
BioMatters Tells Michigan’s Biosciences Story Tell us what you’d
like to seel Topics you’d like coveredl Companies that are on the leading edgel Collaborations that workl People making a differencel How-to Informationl Guest opinion topics
NExT ISSUE: November 2, 2009 CONTENT DEADLINE: August 3, 2009
Anyone who has ever had a good idea knows you can’t nurture it alone. It takes a hospital. One that can help turn your idea into a breakthrough. Introducing the Beaumont Commercialization Center, with the resources to handle everything from prototyping to clinical trials. And everything in between. Because at Beaumont, we live for good ideas. Where ideas go to get better.
BioscienceWarner’s Life Sciences Group has the diverse talent required to bring your product or idea all the way from patent stage to commercial market. To get started, call Amy Rinaldo at 248.784.5107.
school research and resources aimed at fostering connections with public and private sector
initiatives designed to expand Michigan’s bioeconomic sector.
the Great Lakes Bioenergy Research Center
(GLBRC). The GLBRC funds projects led by
dozens of MSU faculty members.
The MSU discovery of a plant protein
— trigalactosyldiacylglycerol 4, or TGD4 —
last summer by Christoph Benning, Ph.D., a
professor in the department of biochemistry
and molecular biology, holds great com-
mercial promise.
Benning identified TGD4 as a protein
necessary for chloroplast development.
Chloroplasts, in plant cells, convert sunlight,
carbon dioxide and water into sugars and
oxygen for the plant during photosynthe-
sis. Understanding how the protein works
could allow scientists to create plants that
would be tailored specifically to produce
biofuels, possibly making the process more
cost-effective.
Benning’s work was funded by the
Energy Department and the National
Science Foundation to the tune of nearly
$1 million over the course of three years.
Just below the Arctic Circle, Kris
Berglund, MSU biochemical processing
researcher, is collaborating with scientists
at the Luleå University of Technology in
Sweden on products and processes that may
play a crucial role in furthering Michigan’s
bioeconomy.
Berglund’s research has spawned enter-
prises in Michigan, Sweden and France, and
raised tantalizing possibilities for diversified
biorefineries that crank out bioproducts
ranging from fuels to chemicals.
Working Bugs, LLC, an East Lansing-based
company, and its Swedish counterpart, Work-
ing Bugs AB, were co-founded by Berglund.
The companies identify microbes that could
be used in fermentation processes to make
products from renewable resources, as well
as intermediate chemicals that are then used
to make other biobased products.
OBT’s mission is to identify, encourage and support research programs that will position the university as a worldwide standard-bearer for the bioeconomy.
Berglund’s research has spawned enterprises in Michigan, Sweden and France, and raised tantalizing possi-bilitiesfordiversifiedbio-refineriesthatcrankoutbioproducts ranging from fuels to chemicals.
mSu reSearcherS bruce dale and mariam SticKlen (above), have genetically engineered corn varietieS to produce the enzymeS needed to breaK down celluloSe and hemicelluloSe into Simple SugarS that can be fermented into ethanol.
40BioMatters | Spring 2009
TECHNOLOGy
PLANT GENETICS, CROP PROTECTION DOMINATE DOW RESEARCH For more than a decade Dow Chemical
Co., primarily through its subsidiary
Dow AgroSciences, has been working in
the field of plant genetics and sustainable
processing technologies for crop protection,
pest and vegetation management, seeds,
traits, and agricultural biotechnology. Dow
AgroSciences has a facility in Harbor Beach,
MI that employs 90 people devoted to
manufacturing spinosad and spinetoram that
are active ingredients in several insecticides
consisting of naturally derived substances
created through a fermentation process.
The EPA presented Dow AgroSciences
with its Presidential Green Chemistry
Challenge Award in 2007 for developing
spinetoram.
The company has joint ventures strung
out worldwide, as well as domestically. It
has a joint venture with a Brazil company to
manufacture polyethylene from sugar cane.
The resulting ethylene will create ethanol.
Working with the U.S. Department
of Energy’s National Renewable Energy
Laboratory, Dow is developing a process that
could convert biomass to ethanol and other
chemical building blocks.
Dow AgroSciences has developed and
received federal regulatory approval for the
world’s first plant-made vaccine, Concerta,
which contains no animal components and
offers important safety advantages over
conventional vaccines.
Future goals include improving crops,
enabling lower cost feed stocks; bio-based
routes to replace existing molecules; create
new molecules; and both biotech and ther-
mochemical conversion technology.
michigan’S plentiful natural reSourceS could Support the growth of dedicated biomaSS cropS.
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venomix iS currently developing three Spider-venom peptideS and will Sell theSe productS directly in Selected agricultural marKetS.
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41 BioMatters | Spring 2009
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“Michigan is on the leading edge but in an
unusual way,” says Baker, who is also director
of the Michigan Nanotechnology Institute for
Medicine and Biological Sciences, a multi-
disciplinary team of University of Michigan
scientists collaborating on nanoscience in
biology and medicine. “We certainly have a lot
of forefront research going on right now. What
we don’t have is the breadth of activity you find
on either coast. Our overall activity may be
less, but our quality is second to no one.”
An immunologist at the University of
Michigan, Baker is the executive chair of
NanoBio Corp. The nine-year-old company
develops and commercializes topical phar-
maceuticals to prevent and treat infectious
diseases, such as herpes and acne, as well as
mucosal vaccines for the flu and hepatitis B
administered through the nose.
NANOBIO LOOKS TO BIG RESULTS NanoBio is in good shape, Baker says,
pointing to “wonderful clinical data” in its
topical cold sores lotion that is as good as
any [existing] anti-viral oral drugs. “And all
you have to do is dab it on,” he says.
The company finished Phase II meetings
in April and is anticipating starting the final
pivotal trial Phase III within the next six
months, Baker says. He hopes to have the
product on the market by 2011. Baker thinks
Quality, not quantity characterizes nanomedicine research in Michigan, says Dr. James Baker Jr., who has been a world-renowned catalyst for growth in the sector.
NEW FRONTIERS
Pint-Sized nanomedicine industry Producing
Mega-Sized Results
Baker thinks that NanoBio’s lotion is so good it can domi-nate the market and be sold over the counter.
45 BioMatters | Spring 2009
the lotion is so good it can dominate the
market and be sold over the counter. “We may
need a marketing partner, but not necessarily
a drug company,” he adds.
For its vaccines NanoBio began Phase
I clinical trials in April 2008. Commercial-
ization of a vaccine can take a little longer
because you have to follow up longer on
patients as you’re looking for an immune
response, Baker says.
AVIDIMER DEVELOPING CANCER PRODUCTS DESPITE HARD ECONOMy Avidimer Therapeutics in Ann Arbor and
NanoMed Pharmaceuticals in Kalamazoo also
are on the shortlist of outstanding nanomedi-
cine companies operating in Michigan.
Five-year-old Avidimer focuses on thera-
peutics for cancer detection and treatment. Its
polymer avidimers are designed to maximize
damage to disease targets while minimizing
collateral damage to healthy tissue and cells.
Currently its drug candidate is in the pre-
clinical stage and needs from $3 million to
$5 million to go into Phase I clinical trials.
NANOMED SEES A SOLID MARKET FOR PRODUCTS NanoMed Pharmaceuticals is a specialty
pharmaceutical company dedicated to de-
veloping therapeutic products to treat cancer
and other serious diseases. Its core technol-
ogy, Nanotemplate Engineering, is used to
formulate small molecules, peptides, proteins,
plasmid DNA, and diagnostic agents. The
company is applying its technology to refor-
mulate FDA-approved drugs to make them
more effective at treating tumors that are,
or have become, resistant to chemotherapy.
NanoMed, was founded in 2000 by
scientists Russell Mumper and Michael
Jay, inventors of its advanced drug delivery
technologies. Both men hold Ph.D.s in phar-
maceutical sciences from the University of
Kentucky, which has licensed their inventions
to NanoMed.
The scientists met Stephen Benoit at a
venture capital forum sponsored by economic
development organization, Southwest Michi-
gan First in 2001. Benoit was recruited from
Connecticut to run a Kellogg Co. division. At
the venture capital forum he liked what he
heard and saw, and he agreed to become the
company’s CEO.
The company finished its first institu-
tional funding in 2006, raising $3.3 million.
It hopes to complete a $20 million Series B
financing by year’s end, Benoit says.
NanoMed intends to self-fund early clini-
cal development and out-license products at
Phase II or later. It plans to file an IND in the
first half of 2010, with Phase I trials starting
60 to 90 days after that. The $20 million will
cover the cost of the initial trials.
Benoit says he is unfazed about raising
more money. “Oncology is an area that is still
interesting from an investor perspective.”
DENDRIMER TECHNOLOGy PAyS OFF WITH ACqUISITION Dendritic Nanotechnologies Inc. (DNT)
was started in Mt. Pleasant in 2003, built on
technology developed 30 years ago by Dow
Chemical Co.’s Donald Tomalia, who holds
a Ph.D. in chemistry. Tomalia’s technology
focused on the application of dendrimers to
safely deliver anticancer drugs, create power-
ful MRI contrast agents, and help provide
scientists innovative materials for creating
new products in numerous markets.
Today DNT is a wholly owned subsidiary
of Melbourne, Australia-based Starpharma
Holdings Ltd. Starpharma, which purchased
DNT in 2006, and develops dendrimer
nanotechnology products for pharmaceutical
applications. Ken Van Der Wende, president
and CEO of the Center for Applied Research
and Technology in Mt. Pleasant (see story on
page XX), considers its purchase by a huge
international drug company “a success story.”
Tomalia, often referred to as the father of
dendrimers, helped start Dendritech in Mid-
land, as well as a dendrimer nanotechnology
program at the University of Michigan medi-
cal school. Today he is director of the National
Dendrimer & Nanotechnology Center at
Central Michigan University.
DNT, with an investment from Starpharma,
began by manufacturing and selling a wide
variety of dendrimers to scientists. In 2005
Dow moved the dendrimers intellectual property
portfolio into DNT for a stake in the growing
nanotechnology company. That same year DNT
announced a breakthrough technology called
Priostar, a new family of dendrimers designed
to greatly reduce the cost and manufacturing
complexity associated with dendrimers.
With these and other exciting nanotech-
nologies coming out of Michigan laboratories,
expect the state’s nanoworld to expand in
coming months and years.
Avidimer’s polymer avidim-ers are designed to maximize damage to disease targets while minimizing collateral damage to healthy tissue and cells.
avidimerS are “Smart drugS” deSigned to maximize damage to diSeaSe targetS while minimizing collateral damage to healthy tiSSue.
dendrimerS can be Selected to either retain the drug throughout itS lifetime or allow it to diSaSSociate from the dendrimer following delivery.
46BioMatters | Spring 2009
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My
Opi
nion
G U E S T O P I N I O N
Balancing Life Science EffortsFor Sustainable ROI By
Linda Chamberlain, Ph.D.
Today’s headlines are filled with various uses of the term “investment”. The assorted
stimulus packages are investments in the future of our economic vitality. The re-training of
workers is an investment in sustainable skills and our ability to compete, and on and on. Given
the challenges ahead, the hypothesis of investment is one that we in the life sciences must take
particularly seriously. Perhaps in no point in history has it been so critical for our community
to deliver a return on the investments being made, and do so in a manner that is strategic and
transparent.
It seems many have come to associate life science new product development with an
“all-or-nothing” financial model – discoveries and commercialization efforts that either go
multi-platinum or die slowly in a spiral of ever-shrinking grants and dilutive equity funding.
Of course, there are no sure things. But investing in life science can and should be done in a
manner similar to a sound financial portfolio, i.e., balanced between short-, medium- and
long-term investments across diverse markets. Michigan’s investments in life science can and
should be made in a well planned fashion.
In West Michigan, the West Michigan Science & Technology Initiative (the Initiative),
has developed an inclusive strategy built around strengths in life science research and clinical
expertise, as well as legacy leadership in advanced manufacturing and human factors in
design. We are mapping a combination of life science investments, from near- term medical
device, to mid-term new diagnostic capabilities to long-term development of new therapeutics
to treat and cure disease, working diligently to maintain the investment of regional assets,
from capital to incubator space.
At the Initiative, we have a good start in implementing a balanced portfolio strategy. The
Venture Center incubator residents reflect a diversified profile: Avalon Labs in medical device,
Sequenom Center for Molecular Medicine in diagnostics, and ClinXus, Grand Valley State
University, and Michigan State University, in research for new therapeutics. These organiza-
tions have drawn over $66M in equity investment, and are promising over 500 new jobs over
the next five years.
In 2008, seeking more strategic emphasis on a shorter return, the Initiative led the forma-
tion of the West Michigan Medical Device Consortium to internationally promote existing
regional capabilities and capacities, as well as to build new, profitable collaborations. As is the
case when managing any portfolio, delivering a good return on life science investments is a
blend of science and art. Success requires collaboration and communication among many
organizations working together for a shared vision. The Initiative has built several platforms
for strategic collaborative efforts, i.e., filling gaps in product development infrastructure, and
we will continue to seek opportunities to build a comprehensive asset base from which strong,
competitive life science endeavors can be launched.
These challenging economic times place more emphasis on coordinating our state-wide
assets for strategic diversification. The time is now for leadership, planning and effective asset
management. Our many shareholders deserve nothing less.
Linda Chamberlain, Ph.D., is executive director of the West Michigan Science & Technology Initiative, based at Grand Valley State University in Grand Rapids, Michigan.
50BioMatters | Spring 2009
MichBio is pleased to provide the 2009 Michigan Biosciences Directory and Resource Guide, the most comprehensive listing of information on the state’s biosciences companies and organizations and the many resources they have at their disposal.
The full directory, which includes everything you see here plus company contacts, email, profiles, listings by sector and county as well as sections on Michigan’s business advantages, incentives, workforce training and more is available on CD. The CD can be purchased online at www.michbio.org for $40 including tax and shipping.
Please Note: Information contained in the 2009 Michigan Biosciences Directory and Resource Guide is as current as possible. MichBio is not responsible for any missing or incomplete data. All attempts were made to validate information submitted by companies and update existing data in MichBio’s archives. Companies and organizations bear sole responsibility for their profiles.
Add your Company or Make CorrectionsIf your bioscience company, related organization or institution is not listed in this directory, and you believe it should be OR if your listing requires corrections, please contact MichBio at [email protected] or (734) 527-9150.
2009 DIRECTORy and RESOURCE GUIDE
BioMattersM A y 2 0 0 9
MichiganBiosciences
51 BioMatters | Spring 2009
Small Business association of Michigan
helps Michigan small businesses succeed by
promoting entrepreneurship, leveraging buy-
ing power and engaging in political advocacy.
www.sbam.org
(800) 362-5461
CENTERS FOR ExCELLENCEBiosciences research and Commer-cialization Center of Western Michigan
University is a commercially focused and sci-
ence driven translational research center that
dedicates its pharmaceutical expertise and
resources to the commercialization of promis-
ing bioscience discoveries and the growth of
Michigan’s bio-science business sector.
www.brcc.wmich.edu
(269) 544-1072
Grand river aseptic Pharmaceutical Packaging is a fully validated, FDA/cGMP
Arbor Research Collaborative for Health 315 West Huron Street, Suite 360 Ann Arbor, MI 48103 (734) 665-4108 www.arborresearch.org Contract R&D, Informatics
Akervall Technologies 5520 Stonevalley Drive Ann Arbor, MI 48105 (734) 485-2949 Medical Devices
Albemarle Corporation 1421 South Kalamazoo Street South Haven, MI 49090 (269) 637-8474 www.albemarle.com Contract R&D
Alivio Corporation 20429 Honor Highway Interlochen, MI 49643 (231) 275-1345 www.aliviocorp.com Medical Devices
Alluvium Biosciences Inc. 789 N. Dixboro Road Ann Arbor, MI 48105 (734) 276-4921 Contract R&D, Industrial & Environmental, Pharmaceuticals & Therapeutics
Caltech Industries, Inc.4520 East Ashman Road, Suite C Midland, MI 48642 (989) 496-3110 www.caltechind.com Industrial & Environmental, Agriculture & Food
CardiArc7444 Haggerty Road Canton, MI 48187 (734) 207-3440 www.cardiarc.com Medical Devices
Cascade Hemophilia Consortium210 East Huron, Suite D Ann Arbor, MI 48104 (734) 996-3300 www.hemoalliance.org Association/Non-profit
Cascade Life Solutions3710 Sysco Court, SE Grand Rapids, MI 49512 (616) 977-2515 Medical Devices
62BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
Cerise Nutraceuticals, Inc.1670 Barlow Street, Suite A Traverse City, MI 49686 (231) 933-3300 www.cherrylotion.com Pharmaceutical & Therapeutics, Agriculture & Food
CFI Medical Solutions (Contour Fabricators, Inc.) 14241 Fenton Road Fenton, MI 48430 (810) 750-5300 www.cfimedical.com Medical Devices, Contract R&D
Charles River 9801 Shaver Road Portage, MI 49002 (269) 327-4248 www.criver.com Contract R&D
Christian Roux Ltd. 561 Woodlawn Ypsilanti, MI 48197 (734) 732-6671 www.hurricanecrutch.com Medical Devices
Clean Air Technology 41105 Capital Canton, MI 48187 (734) 459-6320 www.cleanairtechnology.com Research Tools
Clinical Ligand Assay Society 3139 South Wayne Road Wayne, MI 48184 (734) 722-6290 www.clas.org Association/Non-profit
ClinSite, Inc. 24 Frank Lloyd Wright Drive, Lobby A Ann Arbor, MI 48106 (734) 930-3700 www.clinsite.com Contract R&D
ClinxusCook-DeVos Center for Health Sciences 301 Michigan Street NE, Suite 537 Grand Rapids, MI 49503 (616) 331-5854 www.clinxus.com Association/Non-profit
Cybernet Medical, Cybernet Systems Corporation 727 Airport Boulevard Ann Arbor, MI 48108 (800) 292-3763 www.cybernetmedical.com Informatics, Medical Devices
CVR Gobal, Inc.18186 Park Lane Grosse Ile, MI 48138 (734) 604-6023 www.cvrgloabl.com Medical Devices
D
Danmar Products Inc. 221 Jackson Industrial Drive Ann Arbor, MI 48103 (800) 783-1998 www.danmarproducts.com Medical Devices
data integrated Scientific Systems 8031 Main Street, Suite 301 Dexter, MI 48130 (734) 426-4995 www.dissdata.com Informatics, Research Tools
Davis Dental Labs 5830 Crossroad Commerce Parkway Wyoming, MI 49519 (616) 261-9191 www.dentalservices.net/davis Medical Devices
DavisMade, Inc 2511 Davison Road Flint, MI 48506 (810) 742-0581 www.standingdani.com Medical Devices
Dermanaut 702 Dwight Street Ypsilanti, MI 48198 (734) 604-8214 www.dermanaut.com Informatics
Detroit R & D, Inc. Metropolitan Center for High Technology (MCHT) 2727 Second Avenue, Suite 4113 Detroit, MI 48201 (313) 961-1606 www.detroitrandd.com Diagnostics, Research Tools
Detroit Technical Equipment Company 55 East Long Lake Road, PMB #433 Troy, MI 48085 (248) 232-8894 ext. 115 www.detroit-tech.com Lab Equipment • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
EADevices, Inc. 7752 Primrose Lane Portage, MI 49024 (412) 334-7045 Medical Devices
Early Warning Healthcare Institute 3100 Cross Creek Parkway, Suite 160 Auburn Hills, MI 48326 (248) 371-9000 www.earlywarninghealth.net Diagnostics, Informatics
ECO PHySICS, INC. 3915 Research Park, Suite A-3 Ann Arbor, MI 48108 (734) 998-1600 www.ecophysics-us.com Medical Devices, Research Tools
Ecology Health Products, Inc. 12941 East Townline Road Goetzville, MI 49736 (906) 297-8770 www.ecologyproducts.com Pharmaceuticals & Therapeutics, Agriculture & Food
Exponent, Inc.39100 Country Club Drive Farmington Hills, MI 48331 (248) 324-9135 www.exponent.com Medical Devices, Industrial & Environmental, Contract R&D
GeneVivo, LLC 800 Technology Drive Ann Arbor, MI 48108 (248) 231-4761 www.genevivo.com Contract R&D
Genomatix Software, Inc. 3025 Boardwalk, Suite 160 Ann Arbor, MI 48108 (877) 436-6628 www.genomatix-software.com Informatics, Contract R&D, Research Tools
Gerber Product Company, a Division of Nestlé Nutrition 445 State Street Fremont, MI 49413 (800) 284-9488 www.gerber.com Agriculture & Food
Gerontology Network 500 Cherry Street SE Grand Rapids, MI 49503 (616) 456-6135 www.michiganseniors.org Association/Non-profit
Global Clinical Connections MTEC at the Groves Kalamazoo Valley Community College 7107 Elm Valley Drive, Suite 2680 Kalamazoo, MI 49009 (269) 488-3277 www.globalclinicalconnections.com Contract R&D • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Global Remediation Technologies Incorporated 1102 Cass Street Traverse City, MI 49684 (800) 899-3703 www.grtusa.com Industrial & Environmental, Contract R&D
Grand River Aseptic Pharmaceutical Packaging, inc. - Center for Excellence140 Front Avenue SW, Suite 3 Grand Rapids, MI 49504 (616) 644-0555 www.GrandRiverAPP.com Contract R&D
Grand Valley State University 100CHS 301 Michigan NE Grand Rapids, MI 49503 (616) 331-7192 www.gvsu.edu University/Institution/Hospital • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
67 BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
Grant Manufacturing Corporation10957 Old 27 Highway N. Vanderbilt, MI 49795 (989) 983-3641 www.granthealingenvironment.com Medical Devices
Great Lakes Angels, Inc. 568 Woodway Court, Suite 1 Bloomfield Hills, MI 48302 (248) 540-3758 www.glangels.org Angel Group • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Implants International NA 220 East Huron Street, 3rd Floor Ann Arbor, MI 48104 (734) 645-8937 www.implantsinternational.com Medical Devices, Pharmaceuticals & Therapeutics, Research Tools
In the Groove, LLC 7600 Madeline Street Saginaw, MI 48609 (517) 781-6030 www.inthegroovebrace.com Medical Devices
Incept BioSystems 401 West Morgan Road Ann Arbor, MI 48108 (317) 508-6972 www.inceptbio.com Medical Devices, Research Tools
Inland Waters Pollution Control2021 South Schaefer Highway Detroit, MI 48217 (800) 992-9118 www.inlandwaters.com Industrial & Environmental, Contract R&D
Innovative Analytics Inc. 161 East Michigan Avenue Kalamazoo, MI 49007 (269) 488-3200 www.ianalytics.biz Contract R&D, Informatics
Innovative BioTherapies, Inc.401 West Morgan Road Ann Arbor, MI 48108 (734) 213-8350 ext. 301 www.innbio.com Pharmaceuticals & Therapeutics, Medical Devices
Innovative Cell Technology 30186 Walnut Court Farmington Hills, MI 48331 (313) 966-7324 Contract R&D
INRAD, Inc. 4375 Donker Court SE Kentwood, MI 49512 (616) 301-7800 www.inrad-inc.com Medical Devices
Institute for Health Care StudiesMichigan State University D 132 West Fee Hall East Lansing, MI 48824 (517) 432-4325 www.ihcs.msu.edu University/Institution/Hospital
Institute for Health Studies4084 Okemos Road Okemos, MI 48864 (877) 908-2273 www.instituteforhealthstudies.com Universities/Institutions/Hospitals
Institute for Preventive SportsMedicine P.O. Box 7032 Ann Arbor, MI 48107 (734) 572-4577 www.ipsm.org University/Institution/Hospital, Association/Non-profit
Integrated Nonclinical Development Solutions, Inc. 3005 Miller Avenue Ann Arbor, MI 48103 (734) 929-5392 www.INDS-Inc.com Contract R&D, Informatics
Integrated Sensing Systems (ISSyS)391 Airport Industrial Drive Ypsilanti, MI 48198 (734) 547-9896 www.mems-issys.com Medical Devices, Research Tools
Intermediary Biochemicals, LLC2529 Dustin Road Okemos, MI 48864 Agriculture & Food, Industrial & Environmental, Research Tools
International Partnership for Critical Markers of Disease (CMOD)828 West Grand River Avenue Brighton, MI 48116 (810) 494-7193 www.cmod.org Association/Non-profit
INVIA Medical Imaging Solutions3025 Boardwalk Street, Suite 200 Ann Arbor, MI 48108 (734) 205-1231 www.inviasolutions.com Informatics, Medical Devices
Invirion, Inc. 2350 Pilgrim Highway Frankfort, MI 49635 (866) 231-8378 www.invirion.com Diagnostics, Research Tools
J
J. Rettenmaier, USA 16369 US Highway 131 Schoolcraft, MI 49087 (269) 679-2340 www.jrs.usa.com Agriculture & Food, Industrial & Environmental
Jade Scientific 7855 Ronda Canton, MI 48187 (734) 207-3775 www.jadesci.com Research Tools
Juvenile Diabetes Research Foundation - Metro detroit & SE Michigan24359 Northwestern Highway, #225 Southfield, MI 48075 (248) 355-1133 www.jdrfdetroit.org
Juvenile Diabetes Research Foundation - West Michigan 5075 Cascade Road SE, Suite F Grand Rapids. MI 49546 (6160 957-1838 www.jdrf.org/westmichigan Association/Non-profit
JV Biolabs2245 South State Street Ann Arbor, MI 48104 (734) 395-7436 www.jvbiolabs.com Contract R&D, Research Tools
McClinchey Histology Lab, Inc.P.O. Box 421 100 Rice Street Stockbridge, MI 49285 (517) 851-9149 www.mhistolab.com Contract R&D
McKesson Pharmacy Systems 30881 Schoolcraft Livonia, MI 48150 (734) 779-8800 www.mckesson.com Informatics
Mead Johnson Nutritionals, a Division of Bristo Myers Squibb Co725 East Main Street Zeeland, MI 49464 (812) 429-7795 www.meadjohnson.com Agriculture & Food
MedArray Inc.3915 Research Park Drive, Suite A-4 Ann Arbor, MI 48108 (734) 769-1066 www.permselect.com Medical Devices, Research Tools
Michigan Agri-Business Association1501 North Shore Drive, Suite A East Lansing, MI 48823 (517) 332-8663 www.miagbiz.org Association/Non-profit
Michigan Animal Model Consortium - Center for Technology Excellence 333 Bostwick Avenue Grand Rapids, MI 49503 (616) 234-5684 www.ctaalliance.org/cta-cores/michigan-animal-model-consortium University/Institution/Hospital, Contract R&D
Michigan Antibody TechnologyCenter - Center of TechnologyExcellence333 Bostwick Avenue NE Grand Rapids, MI 49503 (616) 234-5342 www.vai.org/Research/Labs/Antibody Technology.aspx University/Institution/Hospital, Contract R&D, Research Tools
Michigan Association of Health Plans327 Seymour Avenue Lansing, MI 48933 (517) 371-3181 www.mahp.org Association/Non-profit
Michigan Biological Imaging Center - Center for Technology ExcellenceDepartment of Biological Sciences 3425 Woodhall, Western Michigan University Kalamazoo, MI 49008 (269) 387-5640 www.wmich.edu/bios/facilities/imaging-center/index.html University/Institution/Hospital, Contract R&D
Michigan Biomass Energy Program 611 West Ottawa, P.O. Box 30221 Lansing, MI 48909 (517) 241-6223 www.michigan.gov/biomass Government/Economic Development
MEDIA SPONSOR
Michigan Business Review800 Monroe, Suite 213 Grand Rapids, MI 49503 (616) 222-5784 www.mlive.com/mbusinessreview Media • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
72BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
Michigan Center for Biologicalinformation - Center for Technology Excellence3600 Green Court, Suite 700 Ann Arbor, MI 48105 (734) 615-5814 www.ctaalliance.org/MCBI University/Institution/Hospital
Michigan Chemistry Council 326 West Ottawa, Capitol Corners Lansing, MI 48933 (517) 372-8898 www.michiganchemistry.com Association/Non-profit
Michigan Citizens for Stem Cell Research and Cures (MCSCRC)27177 Lahser Road, Suite 102 Southfield, MI 48034 (248) 948-5555 www.StemCellResearchforMichigan.com Association/Non-profit
Michigan Corn Growers Association/Corn Marketing Program of Michigan 12800 Escanaba Drive, Suite B Dewitt, MI 48820 (517) 323-6600 www.micorn.org Association/Non-profit
Michigan Diagnostics LLC 2611 Parmenter Boulevard Royal Oak, MI 48073 (248) 435-4472 www.michdiag.com Contract R&D, Research Tools
Michigan Health & Hospital Association 6215 West St. Joseph Highway Lansing, MI 48917 (517) 323-3443 www.mha.org Association/Non-profit
Michigan Health Council 2410 Woodlake Drive, P.O. Box 30014 Okemos, MI 48864 (517) 347-3332 www.mhc.org Association/Non-profit
Michigan High Throughput Screening Center - Center of Technology ExcellenceKalamazoo Valley Community College 7107 Elm Valley Drive Kalamazoo, MI 49003 (269) 353-1582 www.mhtsc.kvcc.edu University/Institution/Hospital, Contract R&D
Michigan Instruments 717 Talon Court SE Grand Rapids, MI 49512 (616) 554-9696 ext. 305 www.michiganinstruments.com Medical Devices
Michigan Israel Business Bridge3520 Green Court, Suite 450 Ann Arbor, MI 48105 (734) 604-2479 www.michiganisrael.com Association/Non-profit • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Michigan Medical Dental Association325 West Lake Lansing Road, Suite C East Lansing, MI 48823 (517) 332-8663 www.smilemichigan.com Association/Non-profit
Michigan Molecular Institute 1910 West Saint Andrews Road Midland, MI 48640 (989) 832-5550 www.mmi.org University/Institution/Hospital, Industrial & Environmental
Michigan Nurses Association 2310 Jolly Oak Road Okemos, MI 48864 (517) 349-5818 www.minurses.org Association/Non-profit
Michigan Orthopedic Services13450 Farmington Road Livonia, MI 48150 (734) 513-8205 www.michortho.com Medical Devices
Michigan Osteopathic Association2445 Woodlake Circle Okemos, MI 48864 (517) 347-1555 www.mi-osteopathic.org/index.php Association/Non-profit
Michigan Primary Care Association7215 Westshire Drive Lansing, MI 48917 (517) 381-8000 www.mpca.net Association/Non-profit
Michigan Research Institute 401 West Morgan Road Ann Arbor, MI 48108 (734) 302-3200 Association/Non-profit • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Michigan Science Teachers Association 3300 Washtenaw Avenue, Suite 220 Ann Arbor, MI 48104 (734) 973-0433 www.msta-mich.org Association/Non-profit
Michigan Small Business & Technology Development Center, Grand Valley State UniversitySeidman College of Business 510 West Fulton Street Grand Rapids, MI 49504 (616) 331-7480 www.misbtdc.org Government/Economic Development • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Michigan Soybean Promotion Committee 140 West Tuscola Street, P.O. Box 287 Frankenmuth, MI 48734 (989) 652-3294 www.michigansoybean.org Association/Non-profit
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Michigan State Medical Society 120 West Saginaw East Lansing, MI 48826 (517) 337-1651 www.msms.org Association/Non-profit
Michigan State University - Michigan Center for Structural Biology - Center for Technology Excellence Department of Biochemistry 310 A Biochemistry East Lansing, MI 48824 (517) 355-0199 www.mcsb.bch.msu.edu University/Institution/Hospital
Michigan State University - MSU Technologies301 Administration Building East Lansing, MI 48824 (517) 355-5040 www.cga.msu.edu University/Institution/Hospital
SILVER SPONSOR
Michigan State University - Office of Research & graduate Studies120 West Saginaw East Lansing, MI 48826 (517) 337-1651 www.vprgs.msu.edu University/Institution/Hospital • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Michigan State University - Product Center for Agriculture and Natural Resources80 Agriculture Hall East Lansing, MI 48824 (517) 432-1676 www.productcenter.msu.edu University/Institution/Hospital • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Michigan Technological University Office of Technology and Economic Development1400 Townsend Drive, Harold Meese Building Houghton, MI 49931 (888) 688-1885 www.admin.mtu.edu/iptc University/Institution/Hospital • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Michigan Technology and Research Institute, LLC 2245 South State Street, Suite 1100 Ann Arbor, MI 48104 (734) 222-0013 www.MTRInstitute.com Contract R&D • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
MIR Preclinical Services a Charles River Company800 Technology Drive Ann Arbor, MI 48108 (734) 821-1063 www.molecularimaging.com Contract R&D, Diagnostics
MMS Holdings Inc. 6880 Commerce Boulevard Canton, MI 48187 (734) 245-0310 www.mmsholdings.com Contract R&D
NanoVir LLC 4717 Campus Drive, Suite 1300 Kalamazoo, MI 49008 (269) 372-3261 www.nanovirpharm.com Pharmaceuticals & Therapeutics
National Center for Manufacturing Sciences3025 Boardwalk Ann Arbor, MI 48108 (800) 222-6267 www.ncms.org Association/Non-profit • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
National Kidney Foundation of Michigan1169 Oak Valley Drive Ann Arbor, MI 48108 (734) 222-9800 www.nkfm.org Association/Non-profit
Natural Therapeutics, LLC401 West Morgan Road Ann Arbor, MI 48108 (734) 302-3200 www.fungalnailrelief.com/PrivacyPolicy.asp Pharmaceuticals & Therapeutics
NextGen Sciences, Inc.4401 Varsity Drive, Suite E Ann Arbor, MI 48108 (734) 973-7914 ext. 214 www.nextgensciences.com Contract R&D, Diagnostics, Research Tools
Nitrate Elimination Company, Inc.334 Hecla Street Lake Linden, MI 49945 (906) 296-1000 www.nitrate.com Research Tools
Northern Biomedical Research, Inc.930 West Sherman Boulevard Muskegon, MI 49441 (231) 759-2333 Contract R&D
northwest Orthotics- Prosthetic, Inc. 39830 Grand River, Suite BLD Novi, MI 48375 (248) 477-1443 Medical Devices
norwind-Cortez 305 North Hewitt Ypsilanti, MI 48197 (734) 434-0575 Medical Devices
NuStep 5111 Venture Drive, Suite 1 Ann Arbor, MI 48108 (734) 769-3939 www.nustep.com Medical Devices
Nymirum 117 North First Street Ann Arbor, MI 48105 (734) 604-9597 Pharmaceuticals & Therapeutics
RTI Health Solutions 3005 Boardwalk Street, Suite 105 Ann Arbor, MI 48108 (734) 213-5372 www.rtihs.org Contract R&D
Rubicon Genomics, Inc. 4370 Varsity Drive, Suite G Ann Arbor, MI 48108 (734) 677-6210 www.rubicongenomics.com Diagnostics, Contract R&D, Research Tools
RxDispense, Inc. 2706 Cumberland Berkley, MI 48072 (734) 277-0668 www.rxdispense.com Medical Devices
S
S & J Laboratories 4669 Executive Drive Portage, MI 49002 (269) 324-7383 www.sandjlab.com/index.html Contract R&D
ScreenTrack 1603 Peach Street Ann Arbor, MI 48105 (734) 665-0701 Informatics
Secretory IgA Inc. 333 Parkland Plaza Drive Ann Arbor, MI 48104 (734) 994-0966 www.secretoryiga.com Pharmaceuticals & Therapeutics
Selective Technologies, Inc. 132 West First Street Flint, MI 48502 (810) 767-7530 Medical Devices
Sensound 221 Lewiston Road Grosse Pointe Farms, MI 48236 (313) 882-1065 www.sensound.com Medical Devices
Sentry Medical Technologies 1039 Olivia Avenue Ann Arbor, MI 48104 (734) 476-8502 Informatics
Sequenom Center for Molecular Medicine301 Michigan Street NE, Suite 580 Grand Rapids, MI 49503 (616) 391-4330 www.cmmdx.org Diagnostics, Research Tools
Sparton Medical Supply2400 East Ganson Street Jackson, MI 49202 (517) 787-8600 www.spartonmedicalsystems.com/index.htm Medical Devices, Contract R&D
SPI Pharma P.O. Box 226 Grand Haven, MI 49417 (231) 935-6900 www.spipharma.com Contract R&D
80BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
SSV Therapeutics, LLC2245 South State Street, Suite 1100 Ann Arbor, MI 48104 (734) 262-0673 Pharmaceuticals & Therapeutics
Sterling Diagnostics 36645 Metro Court Sterling Heights, MI 48312 (810) 979-9171 www.sterlingdiagnostics.com Research Tools, Diagnostics
Stryker Corporation 2825 Airview Boulevard Kalamazoo, MI 49002 (269) 385-2600 www.stryker.com Medical Devices
Stryker Instruments 4100 East Milham Avenue Kalamazoo, MI 49001 (269) 323-7700 www.stryker.com/instruments Medical Devices
Stryker Orthopaedics 44736 Helm Street Plymouth, MI 48170 (734) 454-0023 www.stryker.com/en-us/corporate/ContactUs/Orthopaedics/index.htm Medical Devices
SubTerra LLC P.O. Box 55 104 Wilcox Road White Pine, MI 49971 (906) 885-5953 www.subterrallc.com Agriculture & Food, Contract R&D
Surge Medical Solutions 3710 Sysco Court SE Grand Rapids, MI 49512 (616) 949-2392 www.surgemedical.com Medical Devices
Surgitel 77 Enterprise Drive Ann Arbor, MI 48103 (734) 996-9200 www.surgitel.com Medical Devices
The MRI Insititute for Biomedical Research Imaging 440 East Ferry Street, Unit 2 Detroit, MI 48202 (313) 758-0065 www.mrimaging.com University/Institution/Hospital
University of Michigan - Medical Innovation Center24 Frank Lloyd Wright Drive, Lobby M, Suite 2600 Ann Arbor, MI 48106 (734) 998-6994 www.med.umich.edu/ummic University/Institution/Hospital • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
University of Michigan - Michigan Center for Oral Health1011 North University, Room 3228 Ann Arbor, MI 48109 (734) 647-4622 www.dent.umich.edu/research/clinicalresearch University/Institution/Hospital
University of Michigan - Michigan Institute for Clinical Health Research24 Frank Lloyd Wright Drive, Lobby M Ann Arbor, MI 48106 (734) 998-7474 www.michr.umich.edu University/Institution/Hospital
University of Michigan - Michigan Nanotechnology Institute for Medicine and Biological Sciences1150 West Medical Center Drive, SPC 5648, 9220C MSRB III Ann Arbor, MI 48109 (734) 647-2777 www.nano.med.umich.edu University/Institution/Hospital
University of Michigan – Michigan Proteome Consortium - Center for Technology Excellence300 North Ingalls Building, 11th Floor, Room 1198 Ann Arbor MI, 48109 (734) 763-3130 www.proteomeconsortium.org University/Institution/Hospital, Contract R&D
SILVER SPONSOR
University of Michigan – Office of Vice President for Research4080 Fleming Building 503 Thompson Ann Arbor, MI 48109-1340 (734) 764-1185 www.research.umich.edu University/Institution/Hospital • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
University of Michigan - Technology Transfer Office 1214 South University, 2nd Floor Ann Arbor, MI 48104 (734) 763-0614 www.techtransfer.umich.edu University/Institution/Hospital • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Versus Technology, Incorporated2600 Miller Creek Drive Traverse City, MI 49684 (231) 946-5868 www.versustech.com Informatics
Vertellus Health and Specialty Products, LLC215 North Centennial Street Zeeland, MI 49464 (800) 223-0453 www.vertellus.com Contract R&D, Industrial & Environmental
VetGen, LLC 3728 Plaza Drive, Suite 1 Ann Arbor, MI 48108 (734) 669-8440 www.vetgen.com Contract R&D, Diagnostics
Vigor Equipment, Inc. 4915 Advance Way Stevenville, MI 49127 (269) 429-0191 www.vigorequipment.com Medical Devices
Virotech Co., Inc. 34279 Hazelwood Street Westland, MI 48186 (734) 620-0221 www.virotech-inc.com Pharmaceuticals & Therapeutics
Wayne State University Applied genomic Technologies - Center for Technology ExcellenceWSU-5197, Biological Science Building 5047 Gullen Mall Detroit, MI 48202 (313) 577-3555 www.bioinformatics.wayne.edu/MCGT University/Institution/Hospital, Association/Non-profit, Industrial & Environmental
Welch Laboratories, Inc. 4270 Sunnyside Drive Holland, MI 49424 (616) 399-2711 www.welchlaboratories.com Contract R&D
West Michigan Regional Laboratory1726 Knollcrest Circle SE Grand Rapids, MI 49546 (616) 526-8440 www.calvin.edu/admin/wmrl Contract R&D
SUPPORTER
West Michigan Science and Technology Initiative 301 Michigan Street NE, Suite 537 Cook - DeVos Center for Health Sciences Grand Valley State University Grand Rapids, MI 49503 (616) 331-5840 www.wmsti.org Government/Economic Development • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •
Western Slope Laboratory 1197 Rochester Road, Suite K Troy, MI 48083 (248) 307-1168 www.westernslopelabs.com/index.shtml Contract R&D
Williams Syndrome AssociationP.O. Box 297 Clawson, MI 48017 (248) 244-2229 www.williams-syndrome.org Association/Non-profit
Agriculture & Food - Feed StockBayer CropScienceDraths Industries, LLCJ. Rettenmaier, USAThe Dow Chemical CompanyUckele Health and Nutrition
Agriculture & Food - Food ProductsCerise Nutraceuticals, Inc.Gerber Product CompanyGraminex, LLCHealthtreat, IncKellogg CompanyMead Johnson NutritionalsThumb Oilseed ProducersUckele Health and Nutrition
Agriculture & Food - Food SafetyMicrobiological Associates, Inc.Microcide, Inc.Neogen CorporationThumb Oilseed ProducersUckele Health and Nutrition
Agriculture & Food - ForestryJ. Rettenmaier, USA
Agriculture & Food - nutrition & NutriceuticalsCerise Nutraceuticals, Inc.Diversified Natural ProductsEcology Health Products, Inc.Gerber Product CompanyGraminex, LLCHaviland EnterprisesHealthtreat, IncKellogg CompanyMead Johnson NutritionalsUckele Health and Nutrition
Agriculture & Food - Plant Based TherapeuticsSubTerra LLC
ArchitectsCRB Consulting EngineersiDesign Solutions, LLCMidwest Cleanroom Associates, Inc.
Association/non-Profit - EducationalAmerican Diabetes AssociationAmerican Society for MicrobiologyAmerican Society of EmployersCascade Hemophilia Consortium
Clinical Ligand Assay SocietyField Neuroscience InstituteGerontology NetworkGift of Life MichiganInstitute for Health StudiesInternational Partnership for Critical Markers of Disease (CMOD)Juvenile Diabetes Research Foundation - Metro Detroit & SE MichiganJuvenile Diabetes Research Foundation - West MichiganMichBioMichigan Agri-Business AssociationMichigan Association of Health PlansMichigan Chemistry CouncilMichigan Citizens for Stem Cell Research and Cures (MCSCRC)Michigan Corn Growers Association/Corn Marketing Program of MichiganMichigan Health & Hospital AssociationMichigan Health CouncilMichigan Israel Business BridgeMichigan Medical Dental AssociationMichigan Nurses AssociationMichigan Osteopathic AssociationMichigan Primary Care AssociationMichigan Science Teachers AssociationMichigan Soybean Promotion CommitteeMichigan State Medical SocietyMichigan Venture Capital AssociationNational Kidney Foundation of MichiganPhRMA (Pharmaceutical Research and Manufacturers of Americas)Williams Syndrome Association
Association/non-Profit - Government AffairsAmerican Society of EmployersCanadian Consulate GeneralMichBioMichigan Agri-Business AssociationMichigan Association of Health PlansMichigan Corn Growers Association/Corn Marketing Program of MichiganMichigan Health & Hospital AssociationMichigan Health CouncilMichigan Medical Dental AssociationMichigan Nurses AssociationMichigan Osteopathic AssociationMichigan Primary Care AssociationMichigan Soybean Promotion CommitteeMichigan State Medical SocietyMichigan Venture Capital AssociationPhRMA (Pharmaceutical Research and Manufacturers of America)
87 BioMatters | Spring 2009
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Associations/non-Profit - MedicalAmerican Diabetes AssociationCascade Hemophilia ConsortiumClinical Ligand Assay SocietyClinXusField Neuroscience InstituteGerontology NetworkGift of Life MichiganInstitute for Health StudiesInternational Partnership for Critical Markers of Disease (CMOD)Juvenile Diabetes Research Foundation - Metro Detroit & SE MichiganJuvenile Diabetes Research Foundation - West MichiganMichigan Association of Health PlansMichigan Health & Hospital AssociationMichigan Health CouncilMichigan Medical Dental AssociationMichigan Nurses AssociationMichigan Osteopathic AssociationMichigan Primary Care AssociationMichigan State Medical SocietyNational Kidney Foundation of MichiganPhRMA (Pharmaceutical Research and Manufacturers of America)Williams Syndrome Association
Business DevelopmentAP Bio-Consulting LLCApjohn Group, LLCAptuit Consulting, IncBiotechnology Business Consultants (BBC)Collet Consulting, LLC
Field Consulting Services, Inc.Global Strategic Connections, LLCMichigan Biomass Energy ProgramMichigan Life Ventures, LLCMichigan Small Business & Technology Development CenterSouthwest Michigan Innovation CenterTEDCo - Technology Enterprise Development Co., Inc.Wise BioStrategies LLC
Business FundingAnn Arbor SPARKAutomation AlleyBiosciences Research and Commercialization Center - Center for Technology ExcellenceGreat Lakes Entrepreneur’s QuestMichigan Economic Development CorporationSouthwest Michigan FirstSouthwest Michigan Innovation CenterTechTownWest Michigan Science and Technology Initiative
ConsultingAP Bio-Consulting LLCApjohn Group, LLCAptuit Consulting, IncBeaumont Services Company LLCBiotechnology Business Consultants (BBC)Caladium ConsultingCollet Consulting, LLCDer-Balian IncEliason ConsultingGlobal Strategic Connections, LLCNational Center for Manufacturing SciencesPharmaMed Resources, LLCProPharma GroupSOI HR SolutionsTEDCo - Technology Enterprise Development Co., Inc.Wise BioStrategies LLC
Contract R&d - Chemistry continued...Riverside OrganicsShrader Analytical and Consulting Laboratories, Inc.Vortech PharmaceuticalsWelch Laboratories, Inc.
Contract R&d - Clinical Trial DevelopmentAnn Arbor Clinical ResearchAzoRx, Inc.Beaumont HospitalsBioPharma Data ServicesBioSTAT Consultants, Inc.Borgess Research InstituteClinSite, Inc.ClinXusExponent, Inc.Ferndale Laboratories Inc.Fulcrum Pharma Developments, Inc.Henry Ford Health SystemGreat Lakes Drug Development, Inc.i3 STATPROBE, Inc.Innovative Analytics Inc.Institute for Health StudiesInternational Discovery Sourcing Consultants LLCJasper Clinical Research & Development, Inc.KAR Bioanalytical, Inc.Karmanos Cancer InstituteKendle InternationalKestrel Consultants, Inc.Maximax International Inc.MMS Holdings Inc.Quest Research InstituteRTI Health SolutionsTERRE Clinical Research Services, Inc.United BioSource CorporationUniversity of Michigan - Michigan Institute for Clinical Health Research
Contract R&d - Commercializa-tion/Business SupportBeaumont Commercialization CenterBiosciences Research of Commercialization Center - Center for Technology ExcellenceMC3, Inc.Medical Device LaunchpadPharmicision, LLCPharmMor Consulting, LLCSANDAB GroupTech Initiatives Inc.
Contract R&d - drug Development & FormulationAccess Business GroupADMETRxArbor Preclinical & Consulting, LLCAzoRx, Inc.BioSTAT Consultants, Inc.CeeTox, Inc.Charles RiverCorium International, Inc.Eurofins Avtech Laboratories, Inc.Fulcrum Pharma Developments, Inc.Global Clinical ConnectionsInnovative Analytics Inc.Innovative Cell TechnologyIntegrated Nonclinical Development Solutions, Inc.International Discovery Sourcing Consultants LLCJasper Clinical Research & Development, Inc.Kendle InternationalKomodo Pharmaceutical Services, LLCMcClinchey Histology Lab, Inc.Michigan Technology and Research Institute, LLCMMS Holdings Inc.MPI ResearchNanoMed Pharmaceuticals, Inc.Next Generation Therapeutics, Inc.Northern Biomedical Research, Inc.Perrigo CompanyPharmOptima, LLCS & J LaboratoriesShanghai Bio CorporationSPI PharmaTERRE Clinical Research Services, Inc.TSRL, Inc.Velesco Pharma Services
Contract R&d - informaticsAIS ConsultingAltarumArbor Research Collaborative for HealthArivium, Inc.BioPharm Data ServicesBlueWare, Inc.Compendia BioscienceCritech Research, Inc.DNA Software, Inc.Genomatix Software, Inc.Integrated Nonclinical Development Solutions, Inc.Toxicogenomic Informatics and Solutions, LLCXB TransMed Solutions, LLC
Contract R&d - Manufacturing/ProductionAccess Business GroupAEGIS EnvironmentsAlbemarle CorporationAlluvium Biosciences, Inc.Ash StevensATEK Medical ManufacturingAvalon Laboratories LLCBoro Pharm, LLCBridge Organics Co.CFI Medical Solutions (Contour Fabricators, Inc.)Corium International, Inc.Creative Technology ServicesDi-Coat CorpDoctor’s Orders, IncDraths Industries, LLCDuPeron Medical SystemsFerndale Laboratories Inc.Fraunhofer USA CCLGrand River Aseptic Pharmaceutical Packaging, Inc. - Center for Technology ExcellenceHart EnterprisesKalexsyn, Inc.Keystone Product DevelopmentKomodo Pharmaceutical Services, LLCMedbio, Inc.Michigan Animal Model Consortium - Center for Technology ExcellenceMicro Machine Co.Midbrook, Inc.Next Generation Therapeutics, Inc.Optical SupplyOrchard Unique Orchid Orthopedic Solutions, LLCOxford Biomedical Research, Inc.Perrigo CompanyPhillips Plastics CorporationPlas-Labs, Inc.Proteos, Inc.ProtomaticRiverside OrganicsRose TechnologiesRoush Life SciencesSaline Lectronics, Inc.Sparton Medical SystemsSPI PharmaSubTerra LLCTower Laboratories MontagueTroy PolymersUckele Health and NutritionVertellus Health and Specialty Products, LLCVortech PharmaceuticalsWelch Laboratories, Inc.Working Bugs, LLC
Toxicogenomic Informatics and Solutions, LLCTransPharm Preclinical Solutions, LLCWarde Medical LaboratoryWestern Slope Laboratory
Contract R&d - Structural Biology & Drug DesignAAPharmaSyn LLCDNA Software, Inc.Michigan Center for Structural Biology - Center for Technology Excellence
Creative ServicesGlobal Strategic Connections, LLCLindsay Exhibit Group, Inc.Teresa M. Arnold & Associates
diagnostics - genetic Testing & Index ArraysAntel BioSystems, Inc.AquaBiochip, LLCBauer BioMedical, LLCdeCODE geneticsGenemarkers LLCInvirion, Inc.Michigan Technology and Research Institute, LLCQuest Diagnostics IncorporatedRoche Biomedical LabsRubicon Genomics, Inc.Sequenom Center for Molecular MedicineVetGen, LLCWarde Medical Laboratory
diagnostics - imaging & ScansCutting Image Histology, LLCCVR Global, Inc.Diagnostic Instruments Inc.Early Warning Healthcare InstituteMIR Preclinical Services (a Charles River Company)OcuSciences, Inc.Xoran Technologies, Inc.
Financial ConsultantsBank of Ann ArborCornerstone Benefits, LLCDoren MayhewErnst & Young LLPHylant Group
Freezer & Refrigeration ServicesBruce Johnson Service Co.,Inc.
Government AffairsBrooks KushmanButzel LongDykema LLCMiller, Canfield, Paddock & Stone, PLC
Government/Economic DevelopmentAnn Arbor SPARKAutomation AlleyCanadian Consulate GeneralCity of Marshall Economic DevelopmentGoteborgBio - BRGMichBioMichigan Biomass Energy ProgramMichigan Economic Development CorporationMichigan Israel Business BridgeMichigan Small Business & Technology Development CenterOakland County Planning & Economic DevelopmentSouthwest Michigan FirstSouthwest Michigan Innovation CenterTechTownThe Right Place, Inc.West Michigan Science and Technology Initiative
Government/Economic development - Business Development & PlanningAnn Arbor SPARKAutomation AlleyCanadian Consulate GeneralOakland County Planning & Economic DevelopmentSouthwest Michigan FirstThe Right Place
Government/Economic development - incubatorsAnn Arbor SPARKAutomation AlleyCentral Michigan University - Center for Applied Research & TechnologyGoteborgBio - BRGMichigan Life Science and Innovation CenterMichigan Research InstituteMidMichigan Innovation CenterMTEC
92BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
L IST ING By CATEGORy
government/Economic development - Incubators continued...OUInc.Southwest Michigan FirstSouthwest Michigan Innovation CenterTechTownUniversity Corporate Research ParkWest Michigan Science and Technology Initiative
Government/Economic development - Small Business AssistanceAnn Arbor SPARKAutomation AlleyGreat Lakes Entrepreneur’s QuestMichigan Biomass Energy ProgramMichigan Economic Development CorporationMichigan Small Business & Technology Development CenterMidMichigan Innovation CenterOakland County Planning & Economic DevelopmentSouthwest Michigan FirstSouthwest Michigan Innovation CenterTechTownThe Right Place, Inc.West Michigan Science and Technology Initiative
Human ResourcesAmerican Society of EmployersSOI HR Solutions
informatics - data Capture & ManagementAgfa CorporationAIS ConsultingArbor Research Collaborative for HealthAvicenna Medical Systems, Inc.BioMedware Inc.BioPharma Data ServicesCompendia BioscienceCritech Research, Inc.Data Integrated Scientific SystemsDdots, Inc.DermanautGE Medical Systems Information TechnologyGene CodesGenomatix Software, Inc.HealthCure, LLCInnovative Analytics Inc.Integrated Nonclinical Development Solutions, Inc.INVIA Medical Imaging SolutionsKestral Consultants, Inc.McKesson Pharmacy SystemsMedImage, Inc.OcuSciences, Inc.POLY BioinformaticsRADAR Medical Systems LLCSentry Medical TechnologiesThomson HealthcareToxicogenomic Informatics and Solutions, LLCUnival, Inc.Versus Technology, IncorporatedXB TransMed Solutions, LLC
93 BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
informatics - developmentArivium, Inc.BioPharma Data ServicesCompendia BioscienceDdots, Inc.GE Medical Systems Information TechnologyThomson HealthcareXB TransMed Solutions, LLC
informatics - Enterprise ManagementAgfa CorporationBlueWare, Inc.Centromine, Inc.Cielo MedSolutionsContented Hearts, Inc.Cybernet MedicalDdots, Inc.DermanautGE Medical Systems Information TechnologyMcKesson Pharmacy SystemsMedImage, Inc.OptimRADAR Medical Systems LLCScreenTrackSentry Medical TechnologiesThomson HealthcareUnival, Inc.
informatics - healthcare & WellnessArbor Research Collaborative for HealthAvicenna Medical Systems, Inc.Better Rehab, LLCBioMedware Inc.BlueWare, Inc.Centromine, Inc.Cielo MedSolutionsContented Hearts, Inc.Critech Research, Inc.Cybernet MedicalDdots, Inc.Early Warning Healthcare InstituteGE Medical Systems Information TechnologyLinde LLCHealthMedia, Inc.Johnson & JohnsonMcKesson Pharmacy SystemsPOLY BioinformaticsRADAR Medical Systems LLCThomson HealthcareUnival, Inc.Versus Technology, IncorporatedYourSurgery.com
informatics - liMSData Integrated Scientific SystemsINVIA Medical Imaging SolutionsScreenTrackThomson Healthcare
informatics - ResearchArbor Research Collaborative for HealthBioMedPharmIS, Ltd.BioMedware Inc.BioSTAT Consultants, Inc.Compendia BioscienceCritech Research, Inc.Data Integrated Scientific SystemsDdots, Inc.GE Medical Systems Information TechnologyGene CodesGeneGo, Inc.Genetics Squared, Inc.Genomatix Software, Inc.Innovative Analytics Inc.Michigan Center for Biological Information - Center for ExcellencePOLY BioinformaticsThomson HealthcareTorrey Path LLCToxicogenomic Informatics and Solutions, LLCXB TransMed Solutions, LLC
Information Services ProviderBioMedPharmIS, Ltd.Nature Publishing Co.PharmacisionScience Direct
Insurance ProvidersBrown & Brown of DetroitChubb Group of Insurance CompaniesCornerstone Benefits, LLCHylant GroupMonitor Liability Managers Inc.Pinnacle Insurance Partners
Lab EquipmentBruce Johnson Service Co.,Inc.Calibrate, Inc. - The Pipet PeopleDetroit Technical Equipment CompanyFarnell Equipment CompanyMarketLabO’Mara ProductsVWR International
Manufacturing SupportBeaumont Services Company LLCCalibrate, Inc. - The Pipet PeopleField Consulting Services, Inc.Global Strategic Connections, LLCNational Center for Manufacturing SciencesPlex SystemsPTI Engineered Plastics, Inc.
Marketing ConsultantsAP Bio-Consulting LLCBiotechnology Business Consultants (BBC)Global Strategic Connections, LLCLindsay Exhibit Group, Inc.Teresa M. Arnold & AssociatesWise BioStrategies LLC
MediaMichigan Business ReviewPR Newswire
Medical devices - dentalAir Force Inc.Akervall TechnologiesAmerican Dental Technologies, Inc.Axenic Dental, Inc.Bio-Coat Inc.Davis Dental LabsGarrison Dental SolutionsSurgitel
Medical devices - diagnosticsAgfa CorporationAngott Medical Products, LLCCritical Signal TechnologiesDNADNB LLCIncept BioSystemsINRAD, Inc.Life Science Systems, Inc.MedArray Inc.MedtronicNorwind-CortezRG Medical DiagnosticsRJL Systems, Inc.RxDispense, Inc.SensoundSiemens Ultrasound Division
94BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
L IST ING By CATEGORy
Medical devices - diagnostics continued...Somanetics CorporationSonetics Ultrasound, Inc.Terumo Heart, Inc.Xoran Technologies, Inc.
Medical devices - hospital Equipment & FurnishingsAmigo Mobility InternationalBiotronic Neural Monitoring SpecialistsCascade Life SolutionsCFI Medical Solutions (Contour Fabricators, Inc.)Creative Technology ServicesCritical Signal TechnologiesCustom Biogenic SystemsCybernet MedicalDelphi Medical SystemsEnnew Medical Devices, LLCFlowTech CorporationGrant Manufacturing CorporationJohnson & JohnsonLake Erie Medical and SurgicalLynn Medical InstrumentsMedical Imaging Resources, Inc.Medi-Nuclear Corp.MedtronicMichigan InstrumentsMidbrook, Inc.NEXT MobilityNuStepRG Medical DiagnosticsRJL Systems, Inc.Rockwell Medical Technologies, Inc.SkytronStryker CorporationSurge Medical SolutionsSurgitelTech Initiatives Inc.Terumo Cardiovascular Systems Corp.Twin Bay Medical, Inc.Vigor Equipment, Inc.
Cascade Life SolutionsCovalent Medical, Inc.Coy Laboratory Products Inc.Critical Signal TechnologiesCustom Biogenic SystemsCybernet MedicalDiagnostic Instruments Inc.DNADNB LLCEADevices, Inc.Essen InstrumentsFlowTech CorporationGrant Manufacturing CorporationHart EnterprisesIncept BioSystemsIntegrated Sensing Systems (ISSYS)Johnson & JohnsonKeystone Product DevelopmentKOA OrthopedicsLake Erie Medical and SurgicalLife Science Systems, Inc.Lynn Medical InstrumentsMager Scientific Inc.MC3, Inc.MedArray Inc.Medical Accessories & Research CorporationMedtronicNephrion, Inc.NeuroNexus TechnologiesOmega Surgical Instruments, Inc.Pall Corporation - Life SciencesPlas-Labs, Inc.Precision Edge Surgical ProductsProtomaticRG Medical DiagnosticsRoush Life SciencesSlaughter Instrument Co.SoloHill Engineering, Inc.Stryker CorporationStryker InstrumentsSurge Medical SolutionsSurgitelTerumo Cardiovascular Systems Corp.Terumo Heart, Inc.Twin Bay Medical, Inc.
Medical devices - Medical ImagingAdvanced Photonix Inc.Advanced X-Ray Technology, Inc.Agfa CorporationAngott Medical Products, LLCAxsys Technologies, Inc.CardiArcCVR Global, Inc. Diagnostic Instruments Inc.
INVIA Medical Imaging SolutionsMager Scientific Inc.Medical Imaging Resources, Inc.MedImage, Inc.M-VisionOcuSciences, Inc.Pixel Velocity Inc.Rigaku Innovative TechnologiesSensoundSiemens Ultrasound DivisionSonetics Ultrasound, Inc.SurgitelUltrasound Medical Devices, Inc.Xoran Technologies, Inc.
Medical devices - Prosthetics & OrthoticsBecker OrthopedicBioProBremer Prosthetics, Inc.Brenner Orthotic and Prosthetic LabsCFI Medical Solutions (Contour Fabricators, Inc.)Christian Roux Ltd.College Park IndustriesDavisMade, Inc.Elkins Innovations, Inc.Freeman Manufacturing CompanyHanger Prosthetics & OrthodicsLake Erie Medical and SurgicalMichigan Orthopedic ServicesMotion Resources, Styker OrthopedicMt. Clemens Orthopaedic Appliances, Inc.Northwest Orthotics-Prosthetic, Inc.Progressive Dynamics MedicalPros-TechProsthetic Center, Inc.Signal Medical CorporationUltralight Prosthetics, Inc.
Medical devices - SafetyAEGIS EnvironmentsAteq CorporationCreative Technology ServicesCritical Signal TechnologiesDanmar Products Inc.Ennew Medical Devices, LLCFreeman Manufacturing CompanyGrant Manufacturing CorporationLake Erie Medical and SurgicalLynn Medical InstrumentsMedi-Nuclear Corp.Michigan InstrumentsMichigan Orthopedic ServicesPlas-Labs, Inc.
95 BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
Signal Medical CorporationStryker CorporationSurge Medical SolutionsSurgitel
Medical devices - SensorsAdvanced Sensor Technologies, Inc.Bio-Nano Power LLCBiotronic Neural Monitoring SpecialistsCritical Signal TechnologiesCVR Global, Inc.Delphi Medical SystemsECO PHYSICS, INC.Integrated Sensing Systems (ISSYS)Life Science Systems, Inc.MC3, Inc.MedtronicMemsTechMichigan InstrumentsNeuroNexus TechnologiesNext Generation Therapeutics, Inc.Optical DimensionsRapid BioSenseSelective Technologies, Inc.SensoundSomanetics CorporationSonetics Ultrasound, Inc.Terumo Cardiovascular Systems Corp.Ultrasound Medical Devices, Inc.
Medical devices - SurgicalAccord Biomaterials, Inc.Accumed Systems Inc.AI Medical Devices, Inc.Aspen Surgical Products, Inc.ATEK Medical ManufacturingAutocam MedicalAvalon Laboratories LLCBio-Coat Inc.BioProCascade Life SolutionsCovalent Medical, Inc.Di-Coat CorpDoctor’s Orders, Inc.EADevices, Inc.Exponent, Inc.Ferndale Laboratories Inc.Hart EnterprisesHistoSonics, LLCImplants International N.A.INRAD, Inc.Johnson & JohnsonKeystone Product DevelopmentKOA Orthopedics
Technical WritingAptuit Consulting, IncBiotechnology Business Consultants (BBC)ProPharma Group
98BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
University/Institution/Hospital – Academic/EducationCentral Michigan University - Office of Research and Sponsored ProgramsCentral Michigan University - Research CorporationGrand Valley State UniversityInstitute for Preventive Sports MedicineLenawee Intermediate School DistrictMichigan Molecular InstituteMichigan State University - Institute for Health Care StudiesMichigan State University - MSU TechnologiesMichigan State University – Office of Research & Graduate Studies Michigan State University - Product Center for Agriculture and Natural ResourcesMichigan Technological University - Office of Technology and Economic DevelopmentOakland UniversityThe MRI Institute for Biomedical Research ImagingUniversity of Michigan - Biomedical EngineeringUniversity of Michigan - Coulter Translational Research Partnership ProgramUniversity of Michigan - Life Sciences InstituteUniversity of Michigan - Medical Innovation CenterUniversity of Michigan - Michigan Center for Oral HealthUniversity of Michigan - Michigan Institute for Clinical Health ResearchUniversity of Michigan - Michigan Nanotech-nology Institute for Medicine and Biological SciencesUniversity of Michigan – Office of Vice- President for Research University of Michigan - Technology Transfer OfficeWayne State University - Technology CommercializationWayne State University Applied Genomic Technologies - Center for Technology Excellence
University/institution/hospital - Clinical/HospitalBeaumont HospitalsBorgess Research InstituteHenry Ford Health SystemInstitute for Health Care StudiesInstitute for Health StudiesInstitute for Preventive Sports MedicineKarmanos Cancer Institute
The MRI Insititute for Biomedical Research ImagingUniversity of Michigan - Medical Innovation CenterUniversity of Michigan - Michigan Center for Oral Health University of Michigan - Michigan Institute for Clinical Health ResearchUniversity of Michigan - Michigan Nanotechnology Institute for Medicine and Biological SciencesWayne State University Applied Genomic Technologies - Center for Technology Excellence
University/institution/hospital - Contract WorkAltarum InstituteBeaumont HospitalsBiosciences Research & Commercialization Center - Center for Technology ExcellenceBorgess Research InstituteInstitute for Health StudiesMBI InternationalMichigan Animal Model Consortium - Center for Technology ExcellenceMichigan Biological Imaging Center - Center for Technology ExcellenceMichigan Center for Biological Information - Center for Technology ExcellenceMichigan Molecular InstituteMichigan State University - Michigan Center for Structural Biology - Center for Technology ExcellenceUniversity of Michigan - Michigan Institute for Clinical Health ResearchUniversity of Michigan - Michigan Proteome Consortium - Center for Technology ExcellenceWayne State University Applied Genomic Technologies - Center for Technology Excellence
University/institution/hospital - PrivateAltarum InstituteBeaumont HospitalsBorgess Research InstituteHenry Ford Health SystemInstitute for Health StudiesKarmanos Cancer InstituteMichigan Animal Model Consortium - Center for Technology ExcellenceMichigan Antibody Technologies Center - Center For Technology ExcellenceMichigan Molecular InstituteThe MRI Institute for Biomedical Research ImagingVan Andel Institute
University/institution/hospital - PublicBiosciences Research & Commercialization Center - Center for Technology ExcellenceCentral Michigan University - Office of Re-search and Sponsored ProgramsCentral Michigan University - Research CorporationGrand Valley State UniversityMichigan Biological Imaging Center - Center for Technology ExcellenceMichigan Center for Biological Information - Center for Technology ExcellenceMichigan High Throughput Screening Center - Center for Technology ExcellenceMichigan State University - Michigan Center for Structural Biology - Center for Technology ExcellenceMichigan State University - MSU TechnologiesMichigan State University – Office of Research & Graduate Studies Michigan State University - Product Center for Agriculture and Natural ResourcesMichigan Technological University Office of Technology and Economic DevelopmentMichigan Universities Commercialization Initiative (MUCI)Oakland UniversityUniversity of Michigan - Biomedical EngineeringUniversity of Michigan - Coulter Translational Research Partnership ProgramUniversity of Michigan - Life Sciences InstituteUniversity of Michigan - Medical Innovation CenterUniversity of Michigan - Michigan Center for Oral HealthUniversity of Michigan - Michigan Institute for Clinical Health ResearchUniversity of Michigan - Michigan Nanotechnology Institute for Medicine and Biological SciencesUniversity of Michigan - Michigan Proteome Consortium - Center for Technology ExcellenceUniversity of Michigan – Office of Vice- President for Research University of Michigan - Technology Transfer OfficeWayne State University - Technology CommercializationWayne State University Applied Genomic Technologies - Center for Technology Excellence
L IST ING By CATEGORy
99 BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
University/institution/hospital - ResearchAltarum InstituteBeaumont HospitalsBiosciences Research & Commercialization Center - Center for Technology ExcellenceBorgess Research InstituteCentral Michigan University - Office of Research and Sponsored ProgramsCentral Michigan University - Research CorporationGrand Valley State UniversityHenry Ford Health SystemInstitute for Health StudiesInstitute for Preventive Sports MedicineKarmanos Cancer InstituteMBI InternationalMichigan Animal Model Consortium - Center for Technology ExcellenceMichigan Biological Imaging Center - Center for Technology ExcellenceMichigan Center for Biological Information - Center for Technology ExcellenceMichigan Molecular InstituteMichigan State University - Michigan Center for Structural Biology - Center for Technology ExcellenceMichigan State University - MSU TechnologiesMichigan State University – Office of Research & Graduate Studies Michigan State University - Product Center for Agriculture and Natural ResourcesMichigan Technological University - Office of Technology and Economic DevelopmentMichigan Universities Commercialization Initiative (MUCI)Oakland UniversityQuantum LaboratoriesThe MRI Institute for Biomedical Research ImagingUniversity of Michigan - Biomedical EngineeringUniversity of Michigan - Coulter Translational Research Partnership ProgramUniversity of Michigan - Life Sciences InstituteUniversity of Michigan - Medical Innovation CenterUniversity of Michigan - Michigan Center for Oral HealthUniversity of Michigan - Michigan Institute for Clinical Health ResearchUniversity of Michigan - Michigan Nanotechnology Institute for Medicine and Biological SciencesUniversity of Michigan - Michigan Proteome Consortium - Center for Technology Excellence
University of Michigan - Office of Vice President for Research University of Michigan - Technology Transfer OfficeVan Andel InstituteWayne State University - Technology CommercializationWayne State University Applied Genomic Technologies - Center for Technology Excellence
University/institution/hospital-Tech TransferBeaumont Commercialization CenterBiosciences Research & Commercialization Center - Center for Technology ExcellenceBorgess Research InstituteCentral Michigan University - Office of Research and Sponsored ProgramsCentral Michigan University - Research CorporationGrand Valley State UniversityGreat Lakes Drug Development, Inc.Michigan Technological University Office of Technology and Economic DevelopmentMichigan Universities Commercialization Initiative (MUCI)Michigan State University - MSU TechnologiesMichigan State University - Product Center for Agriculture and Natural ResourcesOakland UniversityUniversity of Michigan - Medical Innovation CenterUniversity of Michigan - Technology Transfer OfficeVan Andel InstituteWayne State University - Technology Commercialization
Venture & Angel CapitalApjohn Group, LLCArboretum VenturesArdesta, LLCCapital Advisors Group, Inc. Great Lakes Angels, Inc.Michigan Life Ventures, LLCMicroDose Life Sciences, LLC
100BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
AlleganDrug & Laboratory Disposal, Inc.Perrigo CompanyTeam Pharmaceutical Inc.
BenzieAlivio CorporationInvirion, Inc.Thorn Smith Laboratories
BerrienGeneGo, Inc.Horseshoe HerbalsPhycoTechSlaughter Instrument Co.Vigor Equipment, Inc.
CalhounCity of Marshall Economic DevelopmentKellogg CompanyProgressive Dynamics Medical
ChippewaEcology Health Products, Inc.Precision Edge Surgical Products
ClintonMichigan Corn Growers Association/Corn Marketing Program of Michigan
Eaton Michigan Primary Care Association
GeneseeBremer Prosthetics, Inc.CFI Medical Solutions (Contour Fabricators, Inc.)DavisMade, Inc.Motion Resources, Styker OrthopedicOmega Surgical Instruments, Inc.Selective Technologies, Inc.TEDCo - Technology Enterprise Development Co., Inc.
Grand TraverseCerise Nutraceuticals, Inc.Global Remediation Technologies IncorporatedThe Point ServicesThompson Surgical InstrumentsTwin Bay Medical, Inc.Versus Technology, Incorporated
HillsdaleW.F. Valentine & Co.
HoughtonKeweenaw Nanoscience CenterMichigan Technological University Office of Technology and Economic DevelopmentNitrate Elimination Company, Inc.Tech Initiatives Inc.
HuronThumb Oilseed Producers
InghamAFID Therapeutics Inc.AI Medical Devices, Inc.Antel BioSystems, Inc.AquaBiochip, LLCBiophotonic Solutions, Inc.Biopolymer InnovationsDraths Industries, LLCEcoSynthetixEmerald BioAgriculture Corporation / Auxein CorporationEmergent BioSolutionsFraunhofer USA CCLGEMA, LLCInstitute for Health StudiesIntermediary Biochemicals, LLCLEC Tech, Inc.MBI InternationalMcClinchey Histology Lab, Inc.Merit Laboratories, Inc.MetagenX, LLCMichigan Agri-Business AssociationMichigan Association of Health PlansMichigan Biomass Energy ProgramMichigan Center for Structural Biology - Center for Technology ExcellenceMichigan Chemistry CouncilMichigan Economic Development CorporationMichigan Health & Hospital AssociationMichigan Health CouncilMichigan Medical Dental AssociationMichigan Nurses AssociationMichigan Osteopathic AssociationMichigan State Medical SocietyMichigan State University, Office of Research and Graduate StudiesMSU Technologies, Michigan State UniversityNeogen CorporationOrchid Orthopedic Solutions, LLCPBS BiotechPlas-Labs, Inc.Product Center for Agriculture and Natural Resources, Michigan State UniversityProsthetic Center, Inc.Rapid BioSense
Symmetry JetToxicogenomic Informatics and Solutions, LLCWorking Bugs, LLCXG Sciences, Inc.
IoniaConceivex
IsabellaBauer BioMedical, LLCBio-Nano Power LLCCentral Michigan University - Office of Research and Sponsored ProgramsCentral Michigan University - Research CorporationDendritic Nanotechnologies, Inc.
JacksonCoy Laboratory Products Inc.Midbrook, Inc.Sparton Medical Systems TransPharm Preclinical Solutions, LLC
KalamazooADMETRxApjohn Group, LLCArmune BioScience, Inc.AureoGen Biosciences, Inc.Aursos, Inc.Axenic Dental, Inc.AzoRx, Inc.BioMedPharmIS, Ltd.Biosciences Research & Commercialization Center - Center for Technology ExcellenceBiosciences Research and Commercialization Center at Western Michigan UniversityBioSTAT Consultants, Inc.Borgess Research InstituteBridge Organics Co.CeeTox, Inc.Charles RiverContented Hearts, Inc.CRB Consulting EngineersCSM GroupEADevices, Inc.EmiliemEnnew Medical Devices, LLCEurofins Avtech Laboratories, Inc.FlowTech CorporationGenemarkers LLCGlobal Clinical ConnectionsHAC of America, Inc.Hanger Prosthetics & OrthodicsHistoSonics, LLC”Honigman Miller Schwartz and Cohn LLP
L IST ING By COUNTIES
101 BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
Innovative Analytics Inc.J. Rettenmaier, USAJasper Clinical Research & Development, Inc.Kalexsyn, Inc.KAR Bioanalytical, Inc.Keystone Product DevelopmentKomodo Pharmaceutical Services, LLCMedElute, Inc.Metabolic Solutions Development CompanyMichigan Biological Imaging Center - Center for Technology ExcellenceMichigan Business ReviewMichigan High Throughput Screening Center - Center of Technology ExcellenceMicro Machine Co.Micromyx, LLCMonteris Medical, Inc.MuciMed, Inc.NanoMed Pharmaceuticals, Inc.NanoVir LLC NephRx CorporationOrthopedic Development, Inc.OtoMedicine, Inc.Pfizer Inc.Phadia USPharmMor Consulting, LLCPharmOptima, LLCProNAi Therapeutics, Inc.ProPharma GroupProteos, Inc.Richard-Allan ScientificS & J LaboratoriesSingle Source Procurement, LLCSouthwest Michigan FirstSouthwest Michigan Innovation CenterStryker CorporationStryker InstrumentsTolera Therapeutics, Inc.Trilithon Pharma, LLCVenOmix, Inc.zuSyn
KentAccess Business GroupArivium, Inc.Aspen Surgical Products, Inc.ATEK Medical ManufacturingAutocam MedicalAvalon Laboratories LLCBio-Chem Laboratories, Inc.Cascade Life SolutionsClinXusCorium International, Inc.Davis Dental LabsElkins Innovations, Inc.Ernst & Young LLP
Gerontology NetworkGrand River Aseptic Pharmaceutical Packaging, Inc.Grand Valley State UniversityHart EnterprisesHaviland EnterprisesINRAD, Inc.Juvenile Diabetes Research Foundation - West MichiganMarketLabMedbio, Inc.MedtronicMichigan Animal Model Consortium - Center for Technology ExcellenceMichigan Antibody Technology Center - Center of Technology ExcellenceMichigan InstrumentsMichigan Small Business & Technology Development CenterMidwest Cleanroom Associates, Inc.O’Mara ProductsOptical SupplyPinnacle Insurance PartnersPrice, Heneveld, Cooper, DeWitt & LittonRose TechnologiesSequenom Center for Molecular MedicineSkytronSurge Medical SolutionsThe Right Place, Inc.Van Andel InstituteVarnum, Riddering, Schmidt & HowlettWarner Norcross & Judd LLPWest Michigan Regional LaboratoryWest Michigan Science and Technology InitiativeXB TransMed Solutions, LLC
LenaweeBio-lab, Inc., A Chemtura CompanyLenawee Intermediate School DistrictUckele Health and NutritionWacker Chemical Corporation
LivingstonAcuity Medical, Inc.BioFlow Technology, IncBruce Johnson Service Co., Inc.deCODE geneticsGreat Lakes Drug Development, Inc.International Partnership for Critical Markers of Disease (CMOD)
Macomb21st Century Therapeutics, Inc.ASI Instruments, Inc.
Birchbrook Technologies L.L.C.College Park Industries Custom Biogenic Systems Mt. Clemens Orthopaedic Appliances, Inc.PTI Engineered Plastics, Inc.RJL Systems, Inc.Sterling Diagnostics
OttawaAir Force Inc.Doctor’s Orders, Inc.Garrison Dental SolutionsMead Johnson NutritionalsMedical Accessories & Research CorporationSPI PharmaVertellus Health and Specialty Products, LLCWelch Laboratories, Inc.
SaginawAgriumAmigo Mobility InternationalDuPeron Medical SystemsField Neuroscience Institute
St. JosephAbbott LaboratoriesFreeman Manufacturing Company
Van BurenAlbemarle CorporationMPI Research
Washtenaw3D BiomatrixAAPharmaSyn LLCAastrom Biosciences, Inc.Accord Biomaterials, Inc.Accumed Systems Inc.Accuri Cytometers Adeona PharmaceuticalsAdvanced Photonix Inc.AIS ConsultingAkervall TechnologiesAlluvium Biosciences Inc.AlphaCore PharmaAltarum InstituteAmerican Society for MicrobiologyAnn Arbor Clinical ResearchAnn Arbor SPARKArbor Preclinical & Consulting, LLCArbor Research Collaborative for HealthArboretum VenturesArdesta, LLCAssay Designs, Inc.Atodyne Technologies LLCAVAcore TechnologiesAvicenna Medical Systems, Inc.Avidimer Therapeutics, Inc.Bank of Ann ArborBerry & Associates, Inc.Better Rehab, LLCBio Logic Engineering, Inc.Biodiscovery, LLCBioLumix, IncBiomedical Diagnostics, LLCBioMedware Inc.BioPharma Data Services Biosol, Ltd.Biotechnology Business Consultants (BBC)
103 BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
BiotectixBiotronic Neural Monitoring SpecialistsBluestone Realty AdvisorsBrinks, Hofer, Gilson & LioneBrown & Brown of DetroitButzel LongCaladium ConsultingCalibrate, Inc.Cascade Hemophilia ConsortiumCayman Chemical CompanyCentromine, Inc.Cerenis Therapeutics Inc.Christian Roux Ltd.Cielo MedSolutionsClinSite, Inc.Collet Consulting, LLCCompendia BioscienceCoulter Translational Research Partnership Program, University of MichiganCovalent Medical, Inc.Critech Research, Inc.Cutting Image Histology, LLCCybernet MedicalDanmar Products Inc.Data Integrated Scientific SystemsDBA Analytical (an NSF International Com-pany)Ddots, Inc.DermanautDigilab Genomic SolutionsDNA Software, Inc.ECO PHYSICS, INC.Essen InstrumentsEyeLab GroupField Consulting Services, Inc.Fulcrum Pharma Developments, Inc.GE Medical Systems Information TechnologyGene Codes Genetics Squared, Inc.GeneVivo, LLCGenomatix Software, Inc.Gift of Life MichiganGoteborgBio - BRGGreat Lakes Entrepreneur’s QuestHamztec LLCHandy Lab, Inc.HealthMedia, Inc.Hygieia, Inc.Hylant Groupi3 STATPROBE, Inc.Implants International N.A.Incept BioSystems Innovative BioTherapies, IncorporatedInstitute for Preventive Sports Medicine
Integrated Nonclinical Development Solutions, Inc.Integrated Sensing Systems (ISSYS)International Discovery Sourcing Consultants LLCINVIA Medical Imaging SolutionsJiva Pharma, Inc.JV BiolabsKendle InternationalKestrel Consultants, Inc.Koppert Biological Systems, Inc.Lead Biopharma Consulting, LLCLindsay Exhibit Group, Inc.Luminos LLCMager Scientific Inc.Mainline Technologies International MayaterialsMC3, Inc.MedArray Inc.Medical Imaging Resources, Inc.Medical Innovation Center, University of MichiganMedImage, Inc.Meditrina Pharmaceuticals, Inc.MERS, LLCMichBioMichigan Center for Biological Information - Center for Technology Excellence Michigan Center for Oral HealthMichigan Institute for Clinical Health ResearchMichigan Israel Business BridgeMichigan Life Ventures, LLCMichigan Nanotechnology Institute for Medi-cine and Biological SciencesMichigan Proteome Consortium - Center for Technology ExcellenceMichigan Research InstituteMichigan Science Teachers AssociationMichigan Technology and Research Institute, LLCMichigan Universities Commercialization Initiative (MUCI)Michigan Venture Capital AssociationMIR Preclinical Services (Molecular Imaging Research)Molecular Therapeutics, Inc.NanoBio CorporationNanoderm Therapeutics, Inc.National Center for Manufacturing SciencesNational Kidney Foundation of MichiganNatural Therapeutics, LLCNephrion, Inc.NeuroNexus TechnologiesNext Generation Therapeutics, Inc.NextGen Sciences, Inc.
Norwind-CortezNuStepNymirumOcuSciences, Inc.Ophthigenics LLCOriginus, Inc.Pall Corporation - Life SciencesPhrixus Pharmaceuticals, Inc.Pixel Velocity Inc.POLY BioinformaticsProtomaticQuatRx PharmaceuticalsRTI Health SolutionsRubicon Genomics, Inc.Saline Lectronics, Inc.ScarPrev PharmaceuticalsScreenTrack Secretory IgA Inc.Sentry Medical TechnologiesSiemens Ultrasound DivisionSmith Haughey Rice & RoeggeSOI HR SolutionsSoloHill Engineering, Inc.Sonetics Ultrasound, Inc.SSV Therapeutics, LLCSurgitelSwitchbackTCF National BankTCH Pharmaceuticals, Inc.TERRE Clinical Research Services, Inc.Terumo Cardiovascular Systems Corp.Terumo Heart, Inc.Thomson HealthcareThreefold Sensors, LLCThromgenTopspins, Inc.Torrey Path LLCTSRL, Inc.Ultrasound Medical Devices, Inc.United BioSource CorporationUniversity of Michigan - Biomedical EngineeringUniversity of Michigan - Life Sciences InstituteUniversity of Michigan - Office of Vice President for ResearchUniversity of Michigan - Technology Transfer OfficeVelcura Therapeutics, Inc.Velesco Pharma ServicesVetGen, LLCVWR InternationalWarde Medical LaboratoryWise BioStrategies LLCXoran Technologies, Inc.
104BioMatters | Spring 2009
D I R E C TO Ry & R E S O U R C E G U I D E
WayneAdvanced Sensor Technologies, Inc.ApoLife, Inc.Ash StevensAsterand, Inc.Ateq CorporationBecton Dickinson - Difco LaboratoriesBiomideBrenner Orthotic and Prosthetic LabsCanadian Consulate GeneralCaraco Pharmaceutical Laboratories, Ltd.CardiArcClean Air TechnologyClinical Ligand Assay SocietyCreative Technology ServicesCVR Global, Inc.Detroit R & D, Inc.Dykema, PLLCEliason ConsultingEsperion Therapeutics, Inc.Fullscope, Inc.Grant Manufacturing CorporationHarvard Drug CompanyHenry Ford Health SystemInland Waters Pollution ControlJade ScientificKarmanos Cancer InstituteLaw Offices of Gary Kendra, PCLVAD Technology, Inc.Lycera CorporationMcKesson Pharmacy SystemsMemsTechMichigan Orthopedic ServicesMMS Holdings Inc.M-VisionNeocutisNEXT MobilityPainex CorporationParagon Laboratories, Inc.Pharmacision LLCPointe Scientific, Inc.PVS Chemicals, Inc.Riverside OrganicsRoche Biomedical LabsRoush Life SciencesSciTech DevelopmentSensoundShanghai Bio CorporationShrader Analytical and Consulting Laboratories, Inc.Stryker OrthopedicsTechTown
The MRI Insititute for Biomedical Research ImagingUltralight Prosthetics, Inc.Virotech Co., Inc.Vortech PharmaceuticalsWayne State University - Technology CommercializationWayne State University Applied Genomic Technologies - Center for Technology Excellence
L IST ING By COUNTIES
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PMCF Life Sciences 8.75x11.25 Color bleed.qxp 3/11/2009 9:06 AM Page 1
Me Grow My business.wouLD HeLPits educated and innovative people would give companies like mine the resources to create and discover new medicines to treat life-threatening human diseases. its county would initiate economic development programs to help companies like ours attract and retain outstanding research scientists to keep our businesses growing. My ideal City would keep me connected to a network of more than 2,000 other high-tech research and development facilities in the same county. but my ideal City is not just ideal, it’s real, and can be found in oakland County, Michigan.
Find out more about your Ideal City at globaloakland.comGerard M. Housey, M.D., Ph.D.President and CEO Housey Pharmaceutical Research Laboratories Southfield, Michigan