1 Biol321 Molecular Genetics Handout 3 Transcription generates two units PlacI LacI Plac O DNA LacZ LacY LacA mRNA Unit 1 Unit 2 Repressor -Galactosidase Permease Trans- acetylase Molecular Genetics & Genomics CT CT NT NT recA lexA CT CT NT NT SOS genes CT CT NT NT CT NT OFF low expression OFF low expression OFF low expression Dr. Fahd M. Nasr Sixth Edition September 2006 Department of Biology Faculty of Sciences Lebanese University Hadath-Beirut Lebanon
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Biol321 Molecular Genetics - WordPress.com · 2016-11-01 · Molecular acetylase Genetics & Genomics CT CT NT NT recA lexA CT CT NT NT SOS genes CT CT NT NT CT NT OFF low expression
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Department of Biology Faculty of SciencesLebanese University Hadath-Beirut Lebanon
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Structure of eukaryotic genes and chromosomesStructure of eukaryotic genes and chromosomes
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11nm fiber
Solenoid model for packaging of nucleosomes into the 30-nm chromatin fiber
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Organization of 30-nm chromatin fiber into looped domains
H3/H4 tetramer
H2A/H2B dimer
H2A/H2B dimer
H2A/H2B dimer
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Electron micrograph of a metaphase chromosome depleted of histonesThe chromosome maintains its general shape by a nonhistoneprotein scaffold from which loops of DNA protrude
Sizes of eukaryotic genomes
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The mountain grasshopper Podisma pedestris
The fruit flyDrosophila melanogaster
18,000 Mb 180 Mb
C-value paradox
C-value paradox: complexity does not correlate with genome size
3.4 x 109 bpHomo sapiens
6.7 x 1011 bpAmoeba dubia
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N-value paradox: complexity does not correlate with gene number