1 .E. Biotechnology, Department of Biotechnology, SIT, Tumkur, Karna SIDDAGANGA INSTITUTE OF TECHNOLOGY Department of Biotechnology B.E. Biotechnology roduction to Bioinformatic Mr. Vivek Chandramohan Asst. Professor Department of Biotechnology
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B.E. Biotechnology, Department of Biotechnology, SIT, Tumkur, Karnataka
SIDDAGANGA INSTITUTE OF TECHNOLOGY
Department of Biotechnology
B.E. Biotechnology
Introduction to Bioinformatics
Mr. Vivek ChandramohanAsst. Professor
Department of Biotechnology
Computer
Science
Statistics
BIOINFORMATICS
Molecular Biology
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B.E. Biotechnology, Department of Biotechnology, SIT, Tumkur, Karnataka
WHAT IS BIOINFORMATICS?
"Bioinformatics is the field of science in which biology, computer science, and information technology merge into a single discipline.”
-The National Center for Biotechnology Information(2001) , NCBI
DEFINITIONS
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YEAR DISCOVERY/INVENTION AND ITS SIGNIFICANCE
1953Watson and Crick proposed the DOUBLE HELIX structure of the genetic material
1965The first major bioinformatics project was undertaken by Margaret Dayhoff in1965, who developed a first protein sequence database called Atlas of Protein Sequence and Structure
1970Brookhaven National Laboratory established the Protein Data Bank for archiving three-dimensional protein structures
1970The first sequence alignment algorithm was developed by Needleman and Wunsch
1974The first protein structure prediction algorithm was developed by Chou and Fasman
1980GenBank and the development of fast database searching algorithms such as FASTA by William Pearson and BLAST by Stephen Altschul and coworkers.
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TIME LINE
B.E. Biotechnology, Department of Biotechnology, SIT, Tumkur, Karnataka
Analyze, Store and Collect Molecular Biological information from database
Main perspective of the field is the discovery of new biological approaches
Provides central, globally accessible databases that enable scientists to submit, search and analyze information
Offers analysis software for data studies and comparisons
Provides tools for modeling, visualizing, exploring and interpreting data
INTRODUCTION
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B.E. Biotechnology, Department of Biotechnology, SIT, Tumkur, Karnataka
GOALS
The ultimate goal of bioinformatics is to better understand
a living cell and how it functions at the molecular level
Analyzing raw molecular sequence and structural data,
bioinformatics research can generate new insights and
provide a “global” perspective of the cell.
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B.E. Biotechnology, Department of Biotechnology, SIT, Tumkur, Karnataka
WHY BIOINFORMATICS?
Number of researches increasing every day
Explosive growth in biological information
Need for a huge database to store, manage and retrieve
information
Regular updating
Available online to all
Without these most of the medical and biological field
would have been on standstill
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WHY BIOINFORMATICS?
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B.E. Biotechnology, Department of Biotechnology, SIT, Tumkur, Karnataka
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B.E. Biotechnology, Department of Biotechnology, SIT, Tumkur, Karnataka
WHY BIOINFORMATICS?
FIELDS RELATED TO BIOINFORMATICS
Systems biology
Proteomics
Genomics
Pharmacogenomics
Pharmacogenetics
Cheminformatics
In silico ADME-Tox Prediction
Computational biology
Structural bioinformatics
Evolutionary relationships
Next generation Sequencing
(NGS)
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APPLICATIONS
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B.E. Biotechnology, Department of Biotechnology, SIT, Tumkur, Karnataka
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Name of the Companies LocationOcimum Biosolutions Hyderabad
Strand Life Sciences Bangalore
Geschickten Bangalore
Top 3 Bioinformatics Companies by Revenue (2010-11)
Biospectrum, Thursday, June 09, 2011
http://biospectrumindia.ciol.com/content/BioServices/11106093.asp
2010-11 2009-10 2008-090
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Thank You
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