Biochemistry and Medical Genetics

Page 1 of 30

Faculty of Medicine Biochemistry and Medical Genetics 

Annual Report 2007 

University of Manitoba, Bannatyne Campus, Winnipeg, Manitoba

Table of Contents Introduction ................................................................................................................................................................. 3 

Message from the Chair ............................................................................................................................................ 3 Strategic Priorities .................................................................................................................................................... 4 Organizational Chart ................................................................................................................................................. 5 Committees ............................................................................................................................................................... 6 

Academic & Administrative Staff.............................................................................................................................. 7 Research Academic Staff, Interests, and 2007 Publications ..................................................................................... 7 Research Academic Nil-Appointments .................................................................................................................. 13 Research Academic Adjunct Appointments ........................................................................................................... 13 Clinical Academic Staff, Interests, and Publications .............................................................................................. 14 Professors Emeriti ................................................................................................................................................... 17 Administrative Staff & Responsibilities ................................................................................................................. 17 Academic Awards and Honours ............................................................................................................................. 18 

Undergraduate students, Graduate Students, and Trainees ................................................................................. 18 Report from the BMG Students Association President .......................................................................................... 18 Undergraduate Honour’s Project Students ............................................................................................................. 20 Graduate Students ................................................................................................................................................... 20 Graduates ................................................................................................................................................................ 20 Trainees .................................................................................................................................................................. 22 Student Awards and Honours ................................................................................................................................. 22 

Seminar Series ........................................................................................................................................................... 24 Invited Speakers ..................................................................................................................................................... 24 BMG Seminar Series .............................................................................................................................................. 24 

Courses ....................................................................................................................................................................... 26 Undergraduate ........................................................................................................................................................ 26 Graduate .................................................................................................................................................................. 26 Workshops .............................................................................................................................................................. 27 

Review of Operations ................................................................................................................................................ 28 Operating Budget .................................................................................................................................................... 28 Research Funding ................................................................................................................................................... 28 Grant Support by Faculty Member, and Source ..................................................................................................... 29 

Page 2 of 30

Introduction Message from the Chair ********************* It gives me great pleasure to present you with the first of what is meant to be an “Annual Report” of the Department of Biochemistry and Medical Genetics’ (BMG) Achievements and Activities. 2007 was filled with many notable distinctions. We welcomed our newest faculty members Drs. Alison Elliott, Emma Frost, and Aaron Marshall as nil-appointments to our department. Congratulations Dr. David Merz for obtaining Tenure! This brought our ranks to 18 tenure-track and tenured faculty positions. Of these, Drs. Hao Ding, Geoff Hicks and Marek Los hold Tier 2 CRC Chairs, and Dr. Jim Davie a Tier 1 CRC Chair. Your hard work brought in over 4.5 million dollars in research funding and 40 articles were published in areas that span basic to translational research, as well as participation in an International Consortium. Notably, Dr. Elliott was appointed as the Director of Services for the Genetics and Metabolism Program; I am sure she will maintain strong research ties with our department. The award of the Dean of Medicine’s Strategic Recruitment Initiative for Biomedical Research to the “Regenerative Medicine” proposal, submitted by the Departments of Human Anatomy and Cell Science, Biochemistry and Medical Genetics, and Physiology represents a significant achievement and will be an important bonus to our ability to expand over the next few years. Dr. Francis Amara received the well-deserved University of Manitoba Presidential Outreach Award for his outreach activities. Most recently, Dr. Amara launched the Head Start Aboriginal Biomedical Youth Program for Grades 5 and 6 students, providing a platform for hands-on experimental opportunities in science and research. As we all know, recruiting the next generation of scientists begins very early in the educational process. Dr. Patrick Choy received this award in 2006. Dr. Jim Davie was presented with the Research Days 2007 Mentorship Award. This makes it 3 in a row for our department: Drs. Etienne Leygue and Jane Evans received this award in 2006 and 2005, respectively. Such awards speak volumes to our commitment to excellence in teaching and training. It goes without saying that the successes of our Faculty members depend upon the excellence of our graduate students. We awarded four Doctoral degrees (Kendra Cann, Tracy Cherlet, Katherine Dunn and Subba Reddy Maddika) and 5 Master’s (Nicolle Bristow, Alison Chatel, Jacqueline Ching, Melanie Durston and Jaganmohan Jangamreddy) in 2007. Notably, Dr. Katherine Dunn received the Governor General’s Gold Medal for Outstanding Achievement at the Graduate Level. A significant proportion of our students successfully competed for local, provincial and national studentships, and many received other important honours. Dr. Subba Reddy Maddika received the 2007 Research Day E.L. Drewry Memorial Award, as well as a Canadian Student Health Research Forum Award and the Merck Frosst Canada Inc. Award for excellence in Cell Biology. Dr. Kendra Cann was a recipient of a Canadian Student Health Research Forum Award as well as the Apotex Fermentation Inc. Award for Excellence in Molecular Biology. Starting even younger, Mr. Ted Paranjothy, a grade 12 student at Fort Richmond Collegiate, won 1st prize at the Sanofi-Aventis International BioGENEius Challenge held in Boston, MA. Mr. Yale Michaels, a grade 10 student of Grant Park High School, was awarded the American Dental Research Prize at the Intel International Science and Engineering Fair held in Albuquerque, New Mexico. Ted Paranjothy and Michael Yale were mentored by Drs. Marek Los and Geoff Hicks, respectively. These are only a few of the highlights, a full list is provided in this document. Finally, thank you to all our students for working together to produce the BMG “Survival Guide” – this represents an invaluable resource for all of our students.

Page 3 of 30

In closing, congratulations to all, your hard work is very much appreciated. Your achievements have not gone unnoticed and have been posted on our web site. New initiatives will be pursued for 2008, and I look forward to reporting on these next year! Strategic Priorities ******************** Research: As a basic science department, research is one of our major priorities. Our research can be grouped under three umbrellas: Development, Human Pathologies and Animal models; Biochemistry, Metabolism, Apoptosis and Cancer; and Clinical Genetics and Genetic Epidemiology. Our ability to succeed in these areas necessitates strong ties between basic and clinical scientists. Enhanced collaborative efforts, and focused innovative and cutting edge strategies will be critical to future successes and for securing funding in the ever-increasing competitive environment. Education: Our second “raison d’être” is as educators. Our track record is one of “excellence”, but there is always room for improvement. A number of priorities come to mind and include the development of an innovative training program to prepare our students for the evolving job market, preparing a student guide as an addendum to our departmental sub-regulations, and continuing our outreach initiatives to put “science” on the radar of our youths’ career options. More challenging will be to enhance our ability to attract outstanding graduate students and trainees. Mechanisms to increase interactions between medical and graduate students would facilitate present and future ties between clinical and basic scientists. Revitalization: Increasing our numbers through recruitment is a key priority and the opportunity for this is possible through the Dean’s Strategic Initiative in Regenerative Medicine. This initiative was based on a proposal submitted by the Departments of Human Anatomy and Cell Science, Biochemistry and Medical Genetics, and Physiology. Consequently, our department is playing an active role in the recruitment process. A concerted effort will ensure that these new recruits enjoy natural ties with our faculty members and research interests. However, we must plan beyond this initiative as renewal will be very important in the coming years. Image: Increased visibility with our clinical colleagues, the Faculty of Medicine, the University of Manitoba, Canadian Universities and funding agencies will have an important impact on our ability to be competitive in research, education, retention and recruitment.

Dr. Louise R. Simard

Page 4 of 30

Professor and Head

Organizational Chart

Page 5 of 30

Dr. L. Simard Professor and Head

Clinical Academic Staff

___________________Chin, S. Chodirker, B. Chudley, A. Dalton, J. Dawson, A. Dembinski, T. Elliott, A. Greenberg, C.R. Leroux, M. Marles, S. Mhanni, A. Parry, D. Reed, M. Spriggs, B. Thorlacius, L. Williams, G.

Support Staff ___________________Burtniak, N. Cameron, L. Dyck, G. Middleton, J. Sarkar, T.

Academic

Research Academic Staff _____________________________________________________Amara, F. Gietz, R.D. Murphy, L.C. Arthur, G. Graham, M. Pind, S. Bhullar, R. Hatch, G. Rampitsch, C. Blanchaer, M. Hicks, G. Siow, Y.L. Choy, P.C. Jacobs, H. K. Stevens, F.C Civetta, A. Kashour, T.S. Szathmáry, E. Craig, D. Kupriyanov. V. Triggs-Raine, B. Dakshinamurti, K. Leygue, E. Valdimarsson, G. Davie, J. Los, M. Vanderwel, D. Ding, H. MacRae, A. Watson, P. Eisenstat, D. Mai, S. Wigle, J. Evans, J. Marshall, A. Wilkins, J Franck, J Merz, D. Wrogemann, K. Frost, E. Mesaeli, N. Yamada, E. Gibson, S Mowat, M. Ye, J. Zelinski, T.

Committees

Page 6 of 30

Nil Appointments

COUNCIL

Graduate Student Affairs Committee

_______________________ Dr. D. Gietz, Chair Dr. S. Pind, Chair in training Dr. M. Mowat Dr. G. Arthur Dr. R. Bhullar Dr. K. Wrogemann

Post Doctoral Representative

Graduate Student Awards Committee

_________________________ Dr. K. Wrogemann, Chair Dr. E. Leygue, Chair in training Dr. H. Ding Dr. L. Simard Dr. D. Merz Ms. N. Burtniak, finance Ms. T. Burton, student Rep.

Faculty

Graduate Student Admissions Committee

________________________ Dr. L. Murphy, Chair Dr. D. Merz, Chair in training Dr. S. Gibson Dr. D. Gietz Dr. B. Triggs-Raine

Special Academics Post Doctoral Fellows Residents

Grad Student Representative _________________________ Francisco Mendoza Evan Booy

Appointment, Promotions and Tenure Committee

________________________ Dr. J. Davie co-Chair Dr. B. Triggs-Raine, co-Chair Dr. G. Arthur Dr. L. Murphy Dr. K. Wrogemann Ms. T. Burton, student Rep. Alternates: Dr. J. Evans, Dr. E. Leygue

Graduate Students

Academic & Administrative Staff Research Academic Staff, Interests, and 2007 Publications

Page 7 of 30

Francis Amara

Associate Professor [email protected]

Research Interests: The association of Alzheimer pre-cursor protein and mitochondrial energy function in the cause of Alzheimer's Disease. Publications: • Salins P, Shawesh S, He Y, Dibrov A, Kashour T, Arthur G, Amara F.

Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett 412(3):211-6.

Gilbert Arthur

Professor [email protected]

Research Interests: Mechanism of action and development of lipid-based anticancer compounds: regulation of phosphotidylethanolamine biosynthesis Publications: • Salins P, Shawesh S, He Y, Dibrov A, Kashour T, Arthur G, Amara F. Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett 412(3):211-6. • Lin W. and Arthur G. Phospholipids are synthesized in the G2/M phase of the cell cycle. Int J Biochem Cell Biol 39, 597-605 • Bittman R. Li Z, Samadder P. and Arthur G. Anticancer activity of a ceramide analog containing a disulfide linkage. Cancer Lett 251, 53-58

Patrick Choy

Professor [email protected]

Research Interests: Lipids and lipoproteins in health and disease. Publications: • Au-Yeung KK, O K, Choy PC, Zhu DY, Siow YL. .Magnesium tanshinoate B protects endothelial cells against oxidized lipoprotein-induced apoptosis. Can J Physiol Pharmacol (11):1053-62. • Fan J, Li X, Li P, Li N, Wang T, Shen H, Siow Y, Choy P, Gong Y. Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury. Biochem Cell Biol 85(2):189-95. • Zu N, Li P, Li N, Choy P. Mechanism of saikosaponin-d in the regulation of rat mesangial cell proliferation and synthesis of extracellular matrix proteins. Biochem Cell Biol 85(2):169-74.

Jim Davie

Professor, CRC Chair [email protected]

Research Interests: Chromatin structure and function, eukaryotic gene expression, histone variants and modifications, sequence-specific DNA-binding proteins. Publications: • Sekhavat A, Sun JM, Davie JR. Competitive inhibition of histone

deacetylase activity by trichostatin A and butyrate. Biochem Cell Biol 85(6):751-8.

• Sun JM, Chen HY, Espino PS, Davie JR. Phosphorylated serine 28 of histone H3 is associated with destabilized nucleosomes in transcribed chromatin. Nucleic Acids Res 35(19):6640-7.

• Mandal S, Davie JR. An integrated analysis of genes and pathways exhibiting metabolic differences between estrogen receptor positive breast cancer cells.BMC Cancer 7:181.

• Sun JM, Chen HY, Davie JR. Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J Biol Chem 282(45):33227-36.

• Zhang X, Soong R, Wang K, Li L, Davie JR, Guarcello V, Diasio RB. Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression. Biochem Cell Biol 85(3):337-46.

Hao Ding

Assistant Professor, CRC Chair [email protected]

Research Interests: Apply mouse embryonic stem (ES) cells mediated transgenesis to analyze a gene’s function and to create human disease models. We are focusing on several genes that have been implicated in cell proliferation, angiogenesis and tumorigenesis. Publications: • Wu X, Sandhu S, Ding H. Establishment of conditional alleles for the gene

encoding the regulator of telomere length (Rtel). Genesis 45:788-792 • Wu X, Ding H. Generation of conditional knockout alleles for PDGF-C.

Genesis 45:653-657.

Jane Evans

Professor [email protected]

Page 8 of 30

Research Interests: Epidemiology of congenital malformations, numerical classification of phenotypic variability, prenatal screening and identification of high risk populations Publications: • Evans JA. Diaphragmatic defects and limb deficiencies - taking sides. Am J Med Genet A 143(18):2106-12. • De Wals P, Tairou F, Van Allen MI, Uh SH, Lowry RB, Sibbald B, Evans JA, Van den Hof MC, Zimmer P, Crowley M, Fernandez B, Lee NS, Niyonsenga T. Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 357(2):135-42. • Elliott AM, Reed MH, Evans JA. Triphalangeal thumb in association with split hand/foot: a phenotypic marker for SHFM3? Birth Defects Res A Clin Mol Teratol (1):58-61.

Spencer Gibson

Associate Professor [email protected]

Research Interests: Understanding the regulation of signal transduction pathways leading to either cell survival or cell death in cancer cells. This research will be translated into the clinical setting for the effective treatment of cancer. Publications: • Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J Cell Sci 120(Pt 23):4155-66. • Kammouni W, Wong K, Ma G, Firestein GS, Gibson SB, El-Gabalawy HS. Regulation of apoptosis in fibroblast-like synoviocytes by the hypoxia-induced Bcl-2 family member Bcl-2/adenovirus E1B 19-kd protein-interacting protein 3. Arthritis Rheum 56(9):2854-63.

R. Dan Gietz

Associate Professor [email protected]

Page 9 of 30

Research Interests: Molecular genetics; Mechanisms of DNA repair in eukaryotes. Applications of the Yeast two hybrid system. Mechanisms of DNA transformation in yeast. The Gietz lab has its own home page describing the best techniques of transformation in yeast. Publications: • Gietz RD, Schiestl RH. Large-scale high-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc 2(1):38-41. • Gietz RD, Schiestl RH. Quick and easy yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc 2(1):35-7. • Gietz RD, Schiestl RH. High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc 2(1):31-4. • Gietz RD, Schiestl RH. Microtiter plate transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc 2(1):5-8. • Gietz RD, Schiestl RH. Frozen competent yeast cells that can be transformed with high efficiency using the LiAc/SS carrier DNA/PEG method. Nat Protoc 2(1):1-4.

Geoff Hicks

Associate Professor, CRC Chair [email protected]

Research Interests: Functional Analysis of the genetic determinants of cancer and human disease. Publications: • The International Knockout Mouse Consortium. A Mouse for all Reasons. Cell 128: 9-13. 2(1):38-41.

Page 10 of 30

Etienne Leygue

Associate Professor [email protected]

Research Interests: Differential gene expression during breast tumorigenesis and breast tumor progression. Actual focus: Small breast epithelial mucin (SBEM) and Steroid Receptor RNA Activator (SRA) genes. Publications: • Leygue E. Steroid receptor RNA activator (SRA1): unusual bifaceted gene products with suspected relevance to breast cancer. Nucl Recept Signal 3; 5:e006. • Blanchard A, Shiu R, Booth S, Sorensen G, DeCorby N, Nistor A, Wong P, Leygue E, Myal Y. Gene expression profiling of early involuting mammary gland reveals novel genes potentially relevant to human breast cancer. Front Biosci 12:2221-32

Marek Los

Associate Professor, CRC Chair

Research Interests: Molecular biology of cancer. Development of anticancer drugs those are selectively toxic against tumor cells. The stimulation of immune response against cancer antigens. "Real time" monitoring of cancer therapy. Publications: • Zuse A, Prinz H, Müller K, Schmidt P, Günther EG, Schweizer F, Prehn JH, Los M. 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity. Eur J Pharmacol 575(1-3):34-45. • Alexander HK, Booy EP, Xiao W, Ezzati P, Baust H, Los M. Selected technologies to control genes and their products for experimental and clinical purposes. Arch Immunol Ther Exp (Warsz) 55(3):139-49. • Maddika S, Ande SR, Panigrahi S, Paranjothy T, Weglarczyk K, Zuse A, Eshraghi M, Manda KD, Wiechec E, Los M. Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat 10(1-2):13-29.

David Merz

Assistant Professor [email protected]

Research Interests: Cell migrations and axon guidance, using the model organism C. elegans. Emphasis on forward genetics and molecular biology to study the regulation and guidance of cell migrations and to identify novel genes and interactions between signalling pathways in development Publications: • Zheng H, Coudiere L, Camia C, Colavita A, Culotti JG, Merz DC. C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues. Dev Biol 310(1):44-53.

Page 11 of 30

Nasrin Mesaeli

Associate Professor [email protected]

Research Interests: Understanding the molecular mechanism of regulation of vascular development and remodeling by calreticulin. Publications: • Wu M, Massaeli H, Durston M, Mesaeli N. Differential expression and activity of matrix metalloproteinase-2 and -9 in the calreticulin deficient cells. Matrix Biol 26(6):463-72.

Mike Mowat

Professor [email protected]

Research Interests: Molecular mechanisms of the p53 tumour suppressor in cell cycle control and apoptosis (programmed cell death). Identification of recessive apoptosis genes using a promoter trap retrovirus. Molecular genetics of lung tumour cell progression.

Leigh Murphy

Professor [email protected]

Research Interests: Mechanism of action of hormones and growth factors in human breast cancer. Molecular mechanisms of anti-estrogen and progestin resistance in human breast cancer Publications: • Cherlet T, Murphy LC. Estrogen receptors inhibit Smad3 transcriptional activity through Ap-1 transcription factors. Mol Cell Biochem 306(1-2):33-42. • Mandal S, Curtis L, Pind M, Murphy LC, Watson PH. S100A7 (psoriasin) influences immune response genes in human breast cancer. Exp Cell Res 313(14):3016-25

Steven Pind

Assistant Professor [email protected]

Research Interests: Identification and characterization of mutations in the gene encoding 3-phosphoglycerate dehydrogenase; role of serine metabolism in growth and development of the human central nervous system; protein synthesis, folding, and targeting; expression and targeting of hyaluronidase enzymes.

Louise Simard

Professor and Department Head [email protected]

Page 12 of 30

Research Interests: Molecular genetics and cellular biology of the SMN (survival motor neuron) gene implicated in spinal muscular atrophy (SMA). Genetics of the complex trait attention deficit/hyperactivity disorder (ADHD). Publications: • Robaey P, Amre D, Schachar R, Simard L. French Version of the Strengths and Weaknesses of ADHD Symptoms and Normal Behaviors (SWAN-F) Questionnaire. J Can Acad Child Adolesc Psychiatry 16(2):80-9. • Nadeau A, D'Anjou G, Debray G, Robitaille Y, Simard LR, Vanasse M. A newborn with spinal muscular atrophy type 0 presenting with a clinicopathological picture suggestive of myotubular myopathy. J Child Neurol (11):1301-4. • Swoboda KJ, Kissel JT, Crawford TO, Bromberg MB, Acsadi G, D'Anjou G, Krosschell KJ, Reyna SP, Schroth MK, Scott CB, Simard LR. Perspectives on clinical trials in spinal muscular atrophy. J Child Neurol 22(8):957-66.

Barb Triggs-Raine Professor

[email protected]

Research Interests: Lysosomal storage disorders including genetic, biochemical and animal models aimed at determining the function of hyaluronidases in health and disease; Identification and characterization of disease genes in unique populations. Publications: • Martin DC, Mark BL, Triggs-Raine BL, Natowicz MR. Evaluation of the risk for Tay-Sachs disease in individuals of French Canadian ancestry living in new England. Clin Chem 53(3):392-8.

Jeff Wigle

Assisstant Professor [email protected]

Research Interests: The homeobox transcription factors Mox1 and Mox2 and how these genes regulate cardiovascular growth in development and disease. Publications: • Hurtado C, Wigle JT, Dibrov E, Maddaford TG, Pierce GN. A comparison of adenovirally delivered molecular methods to inhibit Na+/Ca2+ exchange. J Mol Cell Cardiol (1):49-53. • Douville JM, Wigle JT. Regulation and function of homeodomain proteins in the embryonic and adult vascular systems. Can J Physiol Pharmacol 85(1):55-65. • Le TN, Du G, Fonseca M, Zhou QP, Wigle JT, Eisenstat DD. Dlx homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2. J Biol Chem 282(26):19071-81

Klaus Wrogemann

Professor & Associate Head [email protected]

Research Interests: Molecular basis of genetic diseases, with special emphasis on muscular dystrophies, cardiomyopathies and androgen resistance syndromes. The current focus is on limb girdle muscular dystrophies

Research Academic Nil-Appointments

Bhullar, R. Graham, M. Parry, D. Chin, S. Greenberg, C.R. Reed, M. Chodirker, B. Hatch, G. Spriggs, B. Chudley, A. Leroux, M. Szathmáry, E. Dalton, J. MacRae, A. Thorlacius, L. Dawson, A. Mai, S. Valdimarsson, G. Dembinski, T. Marles, S. Watson, P. Eisenstat, D. Marshall, A. Wilkins, J. Elliott, A. Mhanni, A. Williams, G.

Research Academic Adjunct Appointments

Page 13 of 30

Civetta, A. Frost, E. Rampitsch, C. Craig, D. Graham, M. Vanderwel, D. Franck, J Kupriyanov. V. Ye, J.

Clinical Academic Staff, Interests, and Publications

B.N. Chodirker

Professor, MD, FRCPC, FCCMG [email protected]

Research Interests: Clinical genetics, genetic epidemiology, prenatal diagnosis

A.E. Chudley

Professor, MD, FRCPC, FCCMG [email protected]

Page 14 of 30

Research Interests: Clinical genetics, dysmorphology, clinical teratogenesis, Fetal Alcohol Syndrome, clinical cytogenetics and genetics of mental retardation, X-linked mental retardation, autism spectrum disorders Publications: • Chudley AE, Kilgour AR, Cranston M, Edwards M. Challenges of diagnosis in fetal alcohol syndrome and fetal alcohol spectrum disorder in the adult. Am J Med Genet C Semin Med Genet 145C(3):261-72. Review. • Attanasio M, Uhlenhaut NH, Sousa VH, O'Toole JF, Otto E, Anlag K, Klugmann C, Treier AC, Helou J, Sayer JA, Seelow D, Nürnberg G, Becker C, Chudley AE, Nürnberg P, Hildebrandt F, Treier M. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat Genet 39(8):1018-24. • Li C, Marles SL, Greenberg CR, Chodirker BN, van de Kamp J, Slavotinek A, Chudley AE Manitoba Oculotrichoanal (MOTA) syndrome: report of eight new cases. Am J Med Genet A 143A(8):853-857.

C.R. Greenberg

Professor, MD, CM, FRCPC, FCCMG [email protected]

Research Interests: Clinical genetics, inborn errors of metabolism and application of recombinant DNA technology to the study of human genetic disorders especially neuromuscular disorders, glutaric acidemia, and carnitine palmitoyl transferase-1 deficiency.

A. Mhanni

Assistant Professor, Ph.D.MD, FRCPC, FCCMG, FACMG

[email protected]

Research Interests: Clinical Genetics and Inborn Errors of Metabolism. Research focus is in epigenetics and how it relates to human disorders and DNA methylation role in early developmental processes and its relationship to specific birth defects such as conotruncal anomalies of the heart.

2007-2008 ANNUAL REPORT WRHA Program in Genetics and Metabolism The Program in Genetics and Metabolism is a primary Program within the Winnipeg Regional Health Authority (WRHA). This status was achieved in September 2004. The Genetics and Metabolism University affiliations include the Departments of Pediatrics and Child Health, and Biochemistry and Medical Genetics.

The Genetics and Metabolism mandate of the program is the provision of exemplary clinical service to all patients and Programs of the WRHA. In the discharge of this mandate, the Program endeavours to establish a responsive system of service delivery. In 2007, approximately 5,300 patients were seen through the service. What is new in 2007-2008:

Page 15 of 30

• As of August 2007, we were pleased to appoint Dr. Alison Elliott, PhD. as the Director of Services for the Genetics and Metabolism Program. Dr. Elliott is a certified genetic counsellor and obtained her PhD in Medical Genetics from the University of Manitoba in 2005. She comes with an excellent background in genetics research and practice.

• As a WRHA Program, we report to senior management. Our VP was Mr. Mark Nescar, who left the

WRHA to work for a private company. We thank Mark for his short but effective time with us. We welcomed Mr. Milton Sussman as our WRHA Team leader.

Human Resources The Genetics and Metabolism Program is currently provided by medical staff, genetic counsellors, genetic assistants and administrative and secretarial support staff, who are primarily located at the HSC site.

Page 16 of 30

Management Team WRHA senior representative: Mr. Milton Sussman Medical Director: Dr. Albert Chudley Administrative Director: Mr. Ron VanDenakker Program Director: Dr Alison Elliott, PhD Medical Staff/Faculty: Bernie N. Chodirker, MD Albert E. Chudley, MD Cheryl R. Greenberg, MD Sandra Marles, MD Aziz Mhanni, MD., PhD Cross-Appointed Members: Angie Dawson, PhD Jane Evans, PhD Louise Simard, PhD Beth Spriggs, PhD Barbara Triggs-Raine, PhD Klaus Wrogemann, PhD Emeritus Member: James C. Haworth, MD Genetic Counsellors: Patricia Bocangel Linda Carter Karen MacDonald Judy Saltel-Olson Shannon Sanders Kim Serfas Genetic Counselling Assistants: Tatum Anderson Scarlett Drescher Nikki Lwiwski Medical Genetics Residents: Mariya Kozenko, MD PGY4 Julie Richer, MD PGY5 Alison Rusnak, MD PGY5+ Jagdeep Walia, MBBS PGY1

Professors Emeriti

M.C. Blanchaer

K. Dakshinamurti

F.C. Stevens

E.W. Yamada

Administrative Staff & Responsibilities

Front Row (left to right) Nadia Burtniak - Finance Officer; Gerhard Dyck - Office Manager Back Row (left to right) Tuntun Sarkar - Student Liaison; Jan Middleton - Communications and Media; Lil Cameron - Employee Records.

Page 17 of 30

Academic Awards and Honours Honours and Awards

Dr. Francis Amara - University of Manitoba Outreach Award - University of Manitoba, Faculty of Medicine: Nomination for a Teaching Excellence Award

Dr. James Davie - CRC in Chromatin Dynamics, Tier 1 - Research Days 2007 - Mentorship Award

Dr. Hao Ding - CRC in Genetic Modeling, Tier 2 - Boehringer Ingelheim Canadian Young Investigator Award in Biological Sciences

Dr. Jane Evans - Dr. John L Hamerton Distinguished Service Award, CCMG - Travel Award, MICH

Dr. Geoff Hicks - CRC in Cell Biology and Functional Genomics, Tier 2 Dr. Marek Los - CRC in New Cancer Therapy Development, Tier 2 Dr. Jeffrey Wigle - CIHR New Investigator Award Federal ‐ Canada Research Chair (CRC) ‐ Canadian Institutes of Health Research (CIHR) ‐ Canadian College of Medical Geneticists (CCMG)

Provincial

- Manitoba Institute of Child Health (MICH)

Undergraduate students, Graduate Students, and Trainees Report from the BMG Students Association President Francisco Mendoza- January to September Evan Booy - October to December Annual Report of the Biochemistry & Medical Genetics Students Association The 2007/2008 student council elections held in September resulted in the appointment of the following individuals to the Biochemistry and Medical Genetics student council: President: - Evan Booy Vice-President: - Bojan Drobic Secretary/Treasurer: - Pamela Miller GSA Representative: - Meghan Azad Academic Standards and Grad Students Awards Committee Rep: - Teralee Burton Sports Representatives: - Jimin Guo and Yongyao (Yoyo) Tan Social Representatives: - Ludivine Coudiere, Paula Espino and Francisco Mendoza Librarian: - Ludivine Coudiere

Page 18 of 30

Events: The BMG student association had a very active social program with well attended events. A year end wind-up party was held in the spring and was a great way to finish off the academic year. Activities began again in the fall when students from BMG and Immunology participated in a paintball outing. Additionally, a Halloween party was held that included a costume contest, pumpkin carving, games and food. The annual Christmas party was a great success and included gingerbread house decorating as well as a gift exchange. Survival Guide: This year marked the completion of the graduate students survival guide. This comprehensive guide was developed by the students to provide detailed information about the department and its graduate program. The goal of the guide is to make the transition to graduate school as easy as possible for new students. The guide includes information on university resources, research facilities, information on faculty, facility maps, registration procedures, events, awards, housing, utilities, transportation, etc. This is sure to be an asset to any new students entering the department. Report from the GSA Rep: Meghan Azad attended all of the monthly Health Sciences Graduate Students Association (HSGSA) meetings this year. She helped organize the GSA/HSGSA elections and the HSGSA social events: September Orientation, Holiday Wine & Cheese, Valentine's Wine & Cheese, Spring It Up event, etc. As an HSGSA councillor, she also served on the Mentorship Award committee and Distinguished Lectureship committee. Finally, she prepared and submitted the two Departmental Grant Applications to receive our semi-annual cash disbursements from the GSA. Report from the Treasurer: The BMG Graduate Students Association account opened with a balance of $840.19. After the various activities organized by the Social Committee, we retained a balance of $600.35. Report from the Graduate Student Awards & Academic Standards Student Representative: Teralee Burton met with this Committee to discuss student award applications to rank applications for University of Manitoba Graduate Fellowship, Manitoba Health Research Council, and the Health Sciences studentships. As the Academic Standards Student Representative, she met with the Academic Standards committee to discuss applications for tenure and/or promotion and cross-appointment to the department. Sports: This was a quiet year for our department. In the past we organized teams for a variety of sports including floor hockey, volleyball and soccer. We look forward to putting some teams together this coming fall.

Evan Booy President

Page 19 of 30

Undergraduate Honour’s Project Students

Solmaz Nafez Tamara Corkery Peyman Ezzati

Graduate Students Master of Science (MSc) Doctor of Philosophy (Ph.D.)

Diana (Joy) Armistead – Supervisor: Dr. Barb Triggs-Raine Vasantha Atmuri – Supervisor: Dr. Barb Triggs-Raine Ludivine Coudiere – Supervisor: Dr. David Merz Meghan Azad – Supervisor: Dr. Spencer Gibson Scarlett Drescher – Supervisor: Dr. Jane Evans Shannon Baxter - Supervisor: Dr. Jeff Wigle Mehdi Eshraghi – Supervisor: Dr. Jeff Wigle Sara Beiggi – Supervisor: Dr. Spencer Gibson Jimin Guo – Supervisor: Dr. Etienne Leygue Evan Booy – Supervisor: Dr. Spencer Gibson Ravikumar Jayachandran – Supervisor: Dr. Louise Simard Teralee Burton - Supervisor: Dr. Spencer Gibson Dilshad Khan – Supervisor: Dr. Jim Davie Shilpa Chooniedass - Supervisor: Dr. Etienne Leygue Anthony Lewis – Supervisor: Dr. Leigh Murphy Josette Douville – Supervisor: Dr. Jeff Wigle Lisa Levesque – Supervisor: Dr. Alberto Civetta Bojan Drobic – Supervisor: Dr. Jim Davie Pamela Miller – Supervisor: Dr. Hao Ding Paula Espino – Supervisor: Dr. Jim Davie Meenal Moudgil – Supervisor: Dr. Mike Mowat Dhimankrishna Ghosh – Supervisor: Dr. John Wilkins Md Zinnatun Nabi,. – Supervisor: Dr. Hao Ding Trung Le – Supervisor: Dr. David Eisenstat Vanessa Pinto – Supervisor: Dr. David Eisenstat Lin Li – Supervisor: Dr. Jim Davie Iran Rashedi – Supervisor: Dr. Phillip Gardiner Jaswinder Mangat – Dr. Desiree Vanderwel Sumit Sandhu – Supervisor: Dr. Hao Ding Dianna Martin – Dr. Barb Triggs-Raine Caroline Shields – Supervisor: Dr. Mike Mowat Francisco Mendoza – Supervisor: Dr. Spencer Gibson Yongyao (Yoyo) Tan – Supervisor: Dr. David Eisenstat Ellert Nichols – Supervisor: Dr. Doug Craig Duy Truong – Supervisor: Dr. Dan Gietz Carl Olson – Supervisor: Dr. Louise Simard Yi Yan – Supervisor: Dr. Etienne Leygue Anton Uvarov – Supervisor: Dr. Nasrin Mesaeli Hongmei Zeng – Supervisor: Dr. Geoff Hicks Yanmin Yang – Supervisor: Dr. Valery Kupriyanov Yueqin (Jane) Zhou – Supervisor: Dr. Geoff Hicks Behzad Yeganeh – Supervisor: Dr. Nasrin Mesaeli

Graduates

Kendra Cann, Ph.D. Supervisor: Dr. Geoff Hicks 2007 CSHRF Major Award Winner of the Apotex Fermentation Inc. Award for Excellence in Research in Molecular Biology Thesis Title: Analysis of the Function of TLS/FUS in DNA Repair and Genome Maintenance Tracy Cherlet, Ph.D. Supervisor: Dr. Leigh Murphy Thesis Title: Cross-talk between ER and TGFβ Signaling Pathways in Human Breast Cancer.

Page 20 of 30

Katherine Leslie Ruth Dunn, Ph.D. Supervisor: Dr. Jim Davie Governor General’s Gold Medal for outstanding achievement at the graduate level Thesis Title: Characterization of Distinct Populations of Histone H3 Phosphorylated in Response to Mitogen Stimulation Before and After Oncogene-Mediated Cellular Transformation Subba Reddy Maddika, Ph.D. Supervisor: Dr. Marek Los 2007 CSHRF Major Awards Winner - The E. L. Drewry Memorial Award and Merck Frosst Canada Inc. Award for excellence in Cell Biology; and winner of the Dean of Medicine poster award Thesis Title: Molecular dissection of the role of cell survival and apoptotic signaling in normal and cancer cells.

Nicolle Bristow, M.Sc. Supervisor: Dr. Spencer Gibson CSHRF Manitoba Medical College Foundation 2007 poster award recipient Thesis Title: BNIP3 Mutations in Breast Cancer

Alison Chatel, M.Sc. Supervisor: Dr. David Merz Thesis Title: The Characterization of HYA-1, A Hyaluronidase Family Member in C.Elegans

No pictures available for: Jacqueline Ching, M.Sc. Supervisor: Dr. Christof Rampitsch Thesis Title: Pyrenophora tritici-repentis ToxA requires Senescence Signals for the Induction of Necrotic Symptoms in Triticum aestivum Melanie Durston, M.Sc. Supervisor: Dr. Nasrin Mesaeli Thesis Title: Calreticulin Overexpression: A Mouse Model of Human Hemangioendothelioma Jaganmohan Jangamreddy, M.Sc. Supervisor: Dr. Jeff Wigle Thesis Title: Activation of Vascular endothelial growth factor receptor-3 expression by homeobox transcription factor, Prox1

Page 21 of 30

Trainees Post Doc Fellows:

Sudharsana Rao Ande – Supervisor: Dr. Jim Davie Arunkumar Arumugam – Supervisor: Dr. Leigh Murphy Yongqiang (Paul) Chen – Supervisor: Dr. Spencer Gibson Gamchimeg Ishdorj – Supervisor: Dr. Spencer Gibson Sumin Lu – Supervisor: Dr. Jim Davie Soma Mandal – Supervisor: Dr. Jim Davie Elizabeth McLachlan – Supervisor: Dr. Leigh Murphy Arzu Ozturk – Supervisor: Dr. Geoff Hicks Beatriz Perez-Cadahia – Supervisor: Dr. Jim Davie Mohammed G. Sabbir – Supervisor: Dr. Mike Mowat Ashok Kumar Sekar – Supervisor: Dr. Spencer Gibson Wineeta Weebadda – Supervisor: Leigh Murphy Anne Zuse – Supervisor: Leigh Murphy

Medical Genetic Residents*: *all supervised by Dr. Bernie Chodirker MarIya Kozenko, MD PGY4 Julie Richer, MD PGY5 Alison Rusnak, MD PGY5+ Jagdeep Walia, MBBS PGY1

Student Awards and Honours

CIHR NCIC NSERC MHRC Other

Behzad Yeganeh Teralee Burton Shilpa Chooniedass Jimin Guo Hongmei Zeng (CCMB) Josette Douville Meghan Webb Azad Yanmin Yang Caroline Shields (CCMB)

Paula Espino Francisco Mendoza Shannon Baxter Sumit Sandhu (MGS) Evan Booy Iran Rashedi Ravikumar Ramachandran (MGS)

Yeuqin Zhou Lisa Renee Leveque Zinnatun Nabi (UMGF) Sara Beiggi Dilshad H. Khan (IGSS) Diana Joy Armistead Anton Uvarov

Federal Agencies ‐ Canadian Institutes of Health Research (CIHR) ‐ National Cancer Institute of Canada (NCIC) ‐ Natural Sciences and Engineering Research Council of Canada (NSERC)

Page 22 of 30

Provincial Agencies ‐ Manitoba Health Research Council (MHRC) ‐ Manitoba Graduate Scholarship (MGS)

Other Agencies ‐ CancerCare Manitoba (CCMB) ‐ International Graduate Student Scholarship (IGSS) ‐ Manitoba Institute of Child Health (MICH) ‐ University of Manitoba Graduate Fellowships (UMGF)

Katherine Dunn was the winner of the Governor General Gold Medal for Outstanding Achievement at the Graduate Level for the spring 2007 convocation. Canadian Student Health Research Forum - 2007 Research Days

Subba Reddy Maddika ‐ The E. L. Drewry Memorial Award ‐ Merck Frosst Canada Inc. Award for excellence in Cell Biology

Kendra Cann ‐ Apotex Fermentation Inc. Award for excellence in Molecular Biology Shilpa Chooniedass ‐ Dean of Graduate Studies Poster Award (Manitoba Competition)

‐ SILVER in the International CIHR poster competition. Meghan Webb Azad ‐ The Dean of Medicine Poster Award (Manitoba Competition) Shannon Baxter ‐ Graduate Students' Association Health Sciences Caucus Poster Award

(Manitoba Competition) George Skliris ‐ Manitoba Health Research Council Post Doctorate Fellow Award

(Manitoba Competition) Evan Booy and Teralee Burton ‐ Manitoba Poster Competition Honourable Mentions

Page 23 of 30

Seminar Series Invited Speakers Date Speaker Topic Thursday, December 6, 2007 Balwant S. Tuana, Ph.D.

Professor Department of Cellular & Molecular Medicine University of Ottawa

"Deregulated expression of the tail-anchored membrane protein SLMAP leads to defective muscle and neuronal development"

Thursday, April 26, 2007

The Fifth Irene Uchida Lecture Charles R. Scriver, MDCM, FRS. Alva Professor Emeritus of Human Genetics McGill University, Montreal Children’s Hospital Research Institute, Montreal, Quebec

Pediatric Grand Rounds “PKU: A Paradigm Shift in Medical Thinking” and Pediatric Research Rounds “The PAH locus is full of surprises”

BMG Seminar Series

Date Speaker Title/Topic of Presentation

Page 24 of 30

Jan. 10/07 Anton Uvarov Activation of Endoplasmic Reticulum Associated Degradation pathway in calreticulin deficient cells

Jan. 17/07 Shauna Loewen Dlc-1 and Dlc-2, Studies of RhoGAP Genes and Etoposide Resistance

Jan. 24/07 Jacqueline Ching Pyrenophora tritici-repentis ToxA on the chloroplast proteome

Jan. 24/07 Duy Truong Genes Affecting Transformation Efficiency in Saccharomyces cerevisiae

Jan. 31/07 Iran Rashedi DNase-X Jan. 31/07 Anoushe Sekhavat The mechanism of Histone deacetylase inhibition by different HDAC

inhibitors Feb. 7/07 Shannon Baxter Mechanisms of Prox1 mediated target gene regulation

Feb. 7/07 Yongyao Tan Dlx and Pax genes in forebrain development. Feb. 14/07 Josette Douville Meox1 and Meox2 in vascular cells Feb. 14/07 Melanie Durston eNOS and Calreticulin

Feb. 21/07 Nicolle Bristow BNIP3 mutations in breast cancer Feb. 21/07 Jimin Guo (Alex) Shifting the balance between coding and non-coding Steroid Receptor RNA

Activator isoforms in T5 cells Feb. 28/07 Allison Chatel Hyaluronidase in C. elegans March 7/07 Ellert Nichols single molecule enzymology March 14/07 Evan Booy Bystander Effect March 21/07 Meghan Webb Hypoxia-Induced Autophagy March 28/07 Yanmin Yang (Victor) Characterization of cardiac ischemia and myocardial infarction with near

infrared light April 4/07 Ludivine Coudiere genetics with worms (C. elegans)

April 4/07 Yi Heng (Henry) The role of TRIM32 in limb-girdle muscular dystrophy type 2H (LGMD2H)/ sarcotubular myopathy(STM)

April 11/07 Hongmei Zeng the function of TLS April 11/07 Sumit Sandhu April 18/07 Lisa Levesque Genetics of Canspecific Sperm Precedence

April 18/07 Caroline Shields The role of Dlc-2 in ceramide signalling to PGP synthase April 25/07 Mehdi Eshraghi Apoptosis April 25/07 Yi Yan (Ethan) How SRA/SRAP regulate the expression of ER beta

May 2/07 Shilpa Chooniedass The role of steroid receptor RNA activator protein ( SRAP) in the estrogen signaling pathway

May 9/07 Vasantha Atmuri Hyaluronidase 3 Knockout Mice Sept. 19/07 Dr. Alison Elliott

Sept. 26/07 Jaswinder Mangat "Mechanism of the mating-induced decline in the level of sex pheromone in the female yellow mealworm beetle, Tenebrio molitor (Coleoptera: Tenebrionidae)"

Oct. 3/07 Dr. Aaron Marshall Oct 17/07 Sara Beiggi "BNIP3 in breast and GBM tumors" Oct. 24/07 Anton Uvarov "Role of Calreticulin in Regulation of ERAD"

Oct. 31/07 Behzad Yageneh "Characterization of Transgenic Mice Over-experiencing Calreticulin"

Nov. 14/07 Paula Espino "H3 Variants and Phosphorylation"

Nov. 21/07 Bojan Drobic "MSK Function" Nov. 28/07 Francisco Mendoza "Mekk1 Regulates Apoptosis Through the Action of DR4" Dec. 5/07 Teralee Burton "Nuclear BNIP3 Down-regulates A1F Expression in Glioma Cells"

Page 25 of 30

Courses Undergraduate

Course Description Co-ordinator BGEN 3020

Introduction to Human Genetics Principles necessary to understand and study genetically controlled malformations and diseases and variation in individuals and in populations. Two terms. Lectures, tutorials and assignments. Held at Fort Garry Campus.

Dr. D. Merz

BGEN 4010

Project Course in Human Genetics A research project chosen in consultation with and supervised by a Faculty member. A written report is required. The course is available primarily to final year Honors student in the Honors Genetics program

Dr. D. Gietz

Graduate

Course Description Co-ordinator BGEN 7000 (M.Sc.) BGEN 8000 (Ph.D.)

Research Seminar A one credit pass/fail course. Consists of the presentation on the student's current research. All registered graduate students in Biochemistry & Medical Genetics MUST present (“writing” is no longer an exemption) 1 Credit Hour

Dr. E. Leygue

BGEN 7020 Proteins Three hours per week held in one term. Course includes purification, bioinformatics, characterization, expression, structure, folding and engineering of proteins. 3Credit Hours

Dr. S. Pind

BGEN7090 Principles and Practice of Human Genetics Lectures, tutorials and assignments designed to review major topics in human genetics and give practical experience in the analysis and interpretation of human genetics data and critical review of published work. 3 Credit Hours

Dr. B. Chodirker

BGEN 7210 Topics in Biochemistry 2 Advanced study and reading on two topics chosen by the course director in consultation with the student's supervisor. Topics include but are not limited to Neurochemistry, Lipids, Carbohydrates, Biomembranes, Inborn Errors, Cystoskeleton Proteins. 3 Credit Hours

Dr. G. Arthur

BGEN 7260 Cellular and Molecular Biochemistry Three hours per week, one term. Recent research advances on the study of cellular components, assembly and organization of plasma membrane components, cell signaling, and cell cycle. 3 Credit Hours

Dr. G. Arthur

IMED 7090 Cell Biology Comprehensive introduction to the structure and function of cells. Prerequisite: consent of instructor. 6 Credit Hours

Dr. R. Shiu

IMED 7200 Cancer Biology One hour per week on the basic (cellular and molecular) and clinical (diagnostic and treatment) aspects of cancer. Students will give one seminar and submit an essay on an assigned topic. Prerequisite: consent of instructor. 3 Credit Hours

Dr. M.Mowat

Page 26 of 30

Workshops

Course Description Co-ordinator BGEN 7070 Principles of Microscopy and Imaging

A one credit pass/fail course. Consists of the presentation on the student's current research. All registered graduate students in Biochemistry & Medical Genetics MUST present (“writing” is no longer an exemption) 3 Credit Hours

Dr. Sabine Mai

IMED 7180 Molecular Approaches in Medical Research Three hours per week held in one term. Course includes purification, bioinformatics, characterization, expression, structure, folding and engineering of proteins. *Student has to register for PHYG 7190 (L04 advance lecture session offered by the Dept. of Physiology) when they register for IMED 718 0. On successful completion of the workshop course, the student gets 6 Credit Hours (3 Cr. Hrs. for IMED 7180 & 3 Cr. Hrs. for PHYG 7190).

Dr. Sabine Mai

Page 27 of 30

Review of Operations Operating Budget

Research Funding

Page 28 of 30

Grant Support by Faculty Member, and Source PRINCIPAL INVESTIGATOR: 

CIHR        (not incl. CRC) 

CRC  NCIC  NRC  NSERC  GC  Other*   

TOTAL PER P.I. 

AMARA                   10,000  (UMSPD)  10,000ARTHUR  98,403          8,750    57,230  (URGC, EUPF)  164,383CHOY  58,352                116,534  (CP,AP,HE,MFS,HSFM) 174,886DAVIE  124,406  200,000  118,059 183,021       87,500  (CBCF, CCMB)  712,986DING  36,986  100,000  95,308          33,041  (MHRC, BI)  265,335GIBSON  182,667                127,871  (LLSC, LLSA)  310,538GIETZ             30,000          30,000HICKS  456,039  100,000  139,983       564,816       1,260,838LEYGUE  80,414                7,000  (MHRC)  87,414LOS  92,740  100,000              13,570  (MHRC)  206,310MERZ  64,516                22,333  (MHRC)  86,849MESAELI                   43,500  (MHRC, HSFM)  43,500MOWAT       131,200                131,200MURPHY  130,161    128,277                258,438SIMARD  30,088                114,266  (MDC, ALS, FSMA)  144,354TRIGGS‐RAINE  256,768                      256,768WIGLE  143,233    51,648          45,900  (MHRC, HSFM)  240,781WROGEMANN  131,451                      131,451

Total per Agency: 1,886,224  500,000  664,475 183,021 38,750 564,816 678,745  0  4,516,031

Federal:       CIHR  Canadian Institute of Health Research     CRC  Canada Research Chair     NCIC  National Cancer Institute of Canada     NSERC  Natural Sciences and Engineering Research Council of Canada     GC  Genome Canada    

*Other:       ALS  Amyotrophic Lateral Sclerosis Society of Canada     AP  Astra Pharma     BI  Boehringer Ingelheiim     CBCF  Canadian Breast Cancer Foundation     CCMB  Cancer Care Manitoba     CP  Cronus Pharma     EUPF  Elsa U. Pardee Foundation     FSMA  Families of Spinal Muscular Atrophy     HE  Husky Energy     HSFM  Heart and Stroke Foundation of Manitoba     LLSA  Leukemia and Lymphoma Society of America     LLSC  Leukemia and Lymphoma Society of Canada     MDC  Muscular Dystrophy of Canada     MFS  Merck‐Frosst‐Schering     MHRC  Manitoba Health Research Council     UMSPD  University of Manitoba Strategic Program Development 

Page 29 of 30

    URGC  University Research Grants Committee 

Page 30 of 30

Mission Statement The department’s fundamen-tal mission is to provide schol-arship in teaching, innovative research, and best practices in patient care. This mission includes advancing the fron-tiers of knowledge in bio-molecular research, dedica-tion to research underpinning the prevention and treatment of genetic and other diseases, and disseminating our knowl-edge, discoveries, and inven-tions. Our activities are pur-sued in a respectful and col-laborative learning environ-ment with the aim to better the health of Manitobans, Canadians and individuals worldwide.

Biochemistry and Medical Genetics 336 Basic Medical Sciences Building 730 William Avenue Winnipeg, Manitoba R3E 0W3 Canada Telephone: (204) 789-3593 Fax: (204) 789-3900 WEB: http://www.umanitoba.ca/faculties/medicine/biochem