Biochemical Mechanism of Magnesium Mark H. Whitney, Jeffrey S. Knott, and Jayne L. Kalbfleisch
Biochemical Mechanism of Magnesium Mark H. Whitney, Jeffrey S. Knott, and Jayne L. Kalbfleisch.
Dec 24, 2015
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Biochemical Mechanism of Magnesium
Mark H. Whitney, Jeffrey S. Knott, and Jayne L. Kalbfleisch
Central Nervous SystemSTRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic HormoneAdapted from Classen and Porta, 1996.
Hypothalamus
CRF
Pituitary
Central Nervous SystemSTRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic HormoneAdapted from Classen and Porta, 1996.
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Central Nervous SystemSTRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic HormoneAdapted from Classen and Porta, 1996.
ACTH
Adrenal Cortex
ACTH
cAMP Concentrations
Adrenal Cortex
ACTH
cAMP Concentrations
20, 22 Lyase Activation
Adrenal Cortex
ACTH
cAMP Concentrations
20, 22 Lyase Activation
Cortisol Synthesis
Adrenal Cortex
ACTH
cAMP Concentrations
20, 22 Lyase Activation
Cortisol Synthesis Glycogen Release
Adrenal Cortex
Liver
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Central Nervous System
Cortisol Liver
Glycogen
STRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic HormoneAdapted from Classen and Porta, 1996.
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Central Nervous System
Cortisol Liver
Glycogen
Muscle
Glycogen
STRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic HormoneAdapted from Classen and Porta, 1996.
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Adrenal Medulla
Central Nervous System
Cortisol Liver
Glycogen
Muscle
Glycogen
STRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic HormoneAdapted from Classen and Porta, 1996.
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Adrenal Medulla
Central Nervous System
Cortisol Liver
Glycogen
Muscle
Glycogen
Epinephrine
Muscle
Glycogen
STRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic HormoneAdapted from Classen and Porta, 1996.
Epinephrine
ATP cAMP
Adapted from Coffee, 1998.
Adenylate cyclase
Epinephrine
ATP cAMP
Protein Kinase A
Phosphorylase Kinase
Phosphorylase Kinase
P
Adapted from Coffee, 1998.
Adenylate cyclase
Epinephrine
ATP cAMP
Protein Kinase A
Phosphorylase Kinase
Phosphorylase Kinase
P
Glycogen Phosphorylase
PGlycogen
Phosphorylase
Adapted from Coffee, 1998.
Adenylate cyclase
Epinephrine
ATP cAMP
Protein Kinase A
Phosphorylase Kinase
Phosphorylase Kinase
P
Glycogen Phosphorylase
PGlycogen
Phosphorylase P
Glycogen
Glucose-1-phosphate
Adapted from Coffee, 1998.
Adenylate cyclase
Epinephrine
ATP cAMP
Protein Kinase A
Phosphorylase Kinase
Phosphorylase Kinase
P
Glycogen Phosphorylase
PGlycogen
Phosphorylase P
Glycogen
Glucose-1-phosphate
GLYCOLYSISAdapted from Coffee, 1998.
Adenylate cyclase
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Adrenal Medulla
Central Nervous System
Cortisol Liver
Glycogen
Muscle
Glycogen
Epinephrine
Muscle
Glycogen
STRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic HormoneAdapted from Classen and Porta, 1996.
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Adrenal Medulla
Central Nervous System
Cortisol Liver
Glycogen
Muscle
Glycogen
Epinephrine
Muscle
Glycogen
STRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic HormoneAdapted from Classen and Porta, 1996.
Nervous Stimulation
Adapted from Coffee, 1998.
Sarcoplasmic Reticulum
Ca
Ca
Ca Ca
Ca
Ca
Ca
Ca
Ca
Ca
Nervous Stimulation
Ca2+
Adapted from Coffee, 1998.
Nervous Stimulation
Ca2+
Troponin-CCa2+
Adapted from Coffee, 1998.
Nervous Stimulation
Ca2+
Troponin-CCa2+
Muscle Contraction
Adapted from Coffee, 1998.
Nervous Stimulation
Ca2+
Troponin-CCa2+
Muscle Contraction
Lactic Acid
pHAdapted from Coffee, 1998.
Nervous Stimulation
Ca2+
Troponin-CCa2+
Muscle Contraction
Phosphorylase kinase-Ca2+
Lactic Acid
pHAdapted from Coffee, 1998.
Nervous Stimulation
Ca2+
Troponin-CCa2+
Muscle Contraction
P
Glycogen Phosphorylase
Phosphorylase kinase-Ca2+
Glycogen Phosphorylase
Lactic Acid
pHAdapted from Coffee, 1998.
Nervous Stimulation
Ca2+
Troponin-CCa2+
Muscle Contraction
P
Glucose-1-phosphate
Glycogen Phosphorylase
Phosphorylase kinase-Ca2+
Glycogen Phosphorylase
Glycogen
GLYCOLYSISLactic Acid
pHAdapted from Coffee, 1998.
Nervous Stimulation
Ca2+
Troponin-CCa2+
Muscle Contraction
P
Glucose-1-phosphate
Glycogen Phosphorylase
Phosphorylase kinase-Ca2+
Glycogen Phosphorylase
Glycogen
GLYCOLYSIS
Ca2+-calmodulin-protein kinase
Lactic Acid
pHAdapted from Coffee, 1998.
Nervous Stimulation
Ca2+
Troponin-CCa2+
Muscle Contraction
P
Glucose-1-phosphate
Glycogen Phosphorylase
Phosphorylase kinase-Ca2+
Glycogen Phosphorylase
Glycogen
GLYCOLYSIS
Ca2+-calmodulin-protein kinase
Glycogen Synthase
Glycogen Synthase P
Lactic Acid
pHAdapted from Coffee, 1998.
Nervous Stimulation
Ca2+
Troponin-CCa2+
Muscle Contraction
P
Glucose-1-phosphate
Glycogen Phosphorylase
Phosphorylase kinase-Ca2+
Glycogen Phosphorylase
Glycogen
GLYCOLYSIS
Ca2+-calmodulin-protein kinase
Glycogen Synthase
Glycogen Synthase P
Lactic Acid
pHAdapted from Coffee, 1998.
Glycogen Storage
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Adrenal Medulla
Central Nervous System
Cortisol Liver
Glycogen
Muscle
Glycogen
Epinephrine
Muscle
Glycogen
STRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic Hormone
Mg inhibits
Adapted from Classen and Porta, 1996.
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Adrenal Medulla
Central Nervous System
Cortisol Liver
Glycogen
Muscle
Glycogen
Epinephrine
Muscle
Glycogen
STRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic Hormone
Mg inhibits
Adapted from Classen and Porta, 1996.
Hypothalamus
CRF
Pituitary
ACTH
Adrenal Cortex
Adrenal Medulla
Central Nervous System
Cortisol Liver
Glycogen
Muscle
Glycogen
Epinephrine
Muscle
Glycogen
STRESS
CRF- Corticotropin Releasing Factor
ACTH-Adrenocorticotrophic Hormone
Mg inhibits
Adapted from Classen and Porta, 1996.
Nervous Stimulation
Adapted from Coffee, 1998.
Sarcoplasmic Reticulum
Ca
Ca
Ca
Ca
Ca
Ca
Mg
Ca
Ca
Ca
Mg
Mg
Mg
Mg
Mg
Mg
MgMg
Mg
Mg
Nervous Stimulation
Ca2+
Troponin-CCa2+
P
Glucose-1-phosphate
Glycogen Phosphorylase
Phosphorylase kinase-Ca2+
Glycogen Phosphorylase
Glycogen
GLYCOLYSIS
Ca2+-calmodulin-protein kinase
Glycogen Synthase
Glycogen Synthase P
Muscle Contraction
Adapted from Coffee, 1998; Fry and Hall, 1996.
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