YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION Biobanks – building the road to personalized medicine Olli Carpén Professor and Research Director University of Helsinki, Helsinki Biobank and University of Turku Upgraded Life Festival 310516
Biobanks - Building the road to personalized medicine. Olli Carpen, University of Helsinki.
Feb 12, 2017
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YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
Biobanks – building the road to personalized medicine
Olli CarpénProfessor and Research Director
University of Helsinki, Helsinki Biobank and University of Turku
Upgraded Life Festival 310516
YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
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Molecular disease mechanismsReading the human genome Plethora of new treatment methodsSurging health care costs
Patient, health care, pharma industry
The wave is coming – are we prepared?
YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
What is personalized medicine? • Personalized medicine (at its best) transfers new information and
treatment modalities without delay to clinical care• ”right treatment, at a right time, to the right patient”
• Personalized medicine requires in depth profiling of each individual’s disease
• And techniques to identify the relevant features (diagnostics)• And methods for selecting the optimal treatment for each patient
• Personalized medicine approach makes the extensive clinical trials useless (n = 1)
• And treatment recommendations at current way cannot be provided
• Artificial intelligence (e.g. Dr. Watson) will play a major role decision making
YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
Biobanks provide the roadmap for the transfer of novel information to patient care
CURRENT”reactive medicine”• Wait for symptoms or gross
evidence of diasease• Anatomic and functional
imaging, biochemistry, morphological analysis
• ICD-10 diagnosis• ”One size fits all” therapy• Evidence based = slow
changes
FUTURE”P4 medicine”• Preventive• Predictive • Personalized • Participatory• Data driven = dynamic
changes
Methods for earlier detection or prevention of individuals at risk
More specific biomarkers
More rapid drug development
Better trial design by cohort stratification based on clinical and molecular features
Population based high quality biological specimens and electronic medical records play a key role in the transition = deeper phenotyping, ”real life data”
YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
The roadmap to personalized medicine requires input from many stakeholders
YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
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YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
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YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
GENETIC ISOLATE
LONG HISTORY OF SAMPLE COLLECTION
A NETWORK OF BIOBANKS COVERING THE ENTIRE COUNTRY
ACCESS TO GENOMIC DATA AND BIOBANKS
“Tissue specimens have been collected since the 1930s and have been linked to digital data since the 1980s.”
FINNISHBIOBANK
NETWORK
YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
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YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
SOCIAL SECURITY NUMBER ALLOWS DATA MATCHING ACROSS BOARDERSRECALLING MADE EASYHIGH INVESTMENT IN DIGITAL HEALTHMODERN PERMISSIVE LEGISLATIONSTRATEGIC POSITIONING
GOVERNMENT BACKING
“We have the best biobank act in the world.”
YOUR TESTBED FOR NEXT GENERATION REASEARCH & INNOVATION
Mille viae ducunt homines per saecula Romam
(All roads lead to Rome)
All roads to personalized medicine go via (Finnish) biobanks
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