Bioaccesibility of nano- and micron-sized metallic particles in simulated lung systems M.Sc. Lic. Eng. Klara Midander Inger Odnevall Wallinder, Jinshan Pan, Christofer Leygraf Div. Corrosion Science, Dept. Chemistry, KTH Hanna Karlsson, Pontus Cronholm Dept. Biosciences and Nutrition, KI MITF-seminar, Oct. 18, 2007
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Bioaccesibility of nano- and micron-sized metallic particles in simulated lung systems M.Sc. Lic. Eng. Klara Midander Inger Odnevall Wallinder, Jinshan.
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Bioaccesibility of nano- and micron-sized metallic particles in simulated lung systems
Can bioaccessibility data (metal release) reflect the toxic effect
of metallic particles?
The metal release is influenced by particle size (surface area), shape, reactivity and material type (passive/non-passive, pure/alloy/oxide) as well as the exposure environment (within the lung).
Cultivated lung cells Metal release
Metal release studies of metallic particles in-vitro
Simulated lung conditions:
ALF (artificial lysosomal fluid)
pH 4.5 - 5 (agressive) simulate conditions
following an immunologic reaction in the body
Gamble’s solution pH 7.4 (neutral) simulates a normal
health condition within the lungOther simulated biological media: