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BI420 – Course information
Web site: http://bioinformatics.bc.edu/~marth/BI420
Instructor: Gabor Marth
Teaching assistant: Aaron Quinlan
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BI420 – Material
Lectures (PowerPoints posted on web site)
Text
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BI420 – Discovery questions
http://www.aw-bc.com/geneticsplace/
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BI420 – Discovery questions
Page 36, Discovery question #1.
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BI420 – Discovery questions
GGGCTCAGCTGTATCAGCCACGTGCCTACAACAATCTGCCCCT
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BI420 – Discovery questions
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BI420 – Discovery questions
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Genome organization
and Bioinformatics
Gabor T. Marth
Department of Biology, Boston [email protected]
BI420 – Introduction to Bioinformatics
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DNA – the carrier of the genetic code
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DNA organization – chromosomes
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DNA organization – mitochondria
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Translation of genetic information
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Gene organization
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mRNA splicing – alternative splicing
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Protein structure
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Mechanisms of molecular evolution
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Evolution of chromosome organization
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Evolution of gene structure
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Evolution of DNA sequence
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Genetic variations
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1. The informatics of DNA sequencing
DNA sequencing informatics
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2. Gene prediction, genome annotation
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3. Polymorphism discovery and analysis
• look at multiple sequences from the same genome region
• use base quality values to decide if mismatches are true polymorphisms or sequencing errors
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4. Gene/DNA expression analysis
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6. Storage/retrieval of Biological data
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7. Sequence alignment/similarity search
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9. Evolutionary Genomics
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10. Medical Genomics
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11. Practical Bioinformatics
using LINUX
programming in PERL
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12. Practical Bioinformatics
HITid cloneID hspID start end1 1 1 1 179572 2 1 96912 114891
CLONEid name received masked1 NH0260K08 12-25-99 12-26-992 NH0407F02 12-28-99 01-03-00
ALLELEid hitID nucleotide1 1 C2 2 T
using and building databases