BDNF SHC SOS GRB2 PI3K P P P BAD P P Ca 2+ Ca 2+ IP3 P P BCLXL BCL2 I P 3 R PKC Pathway Cell Adhesion and Migration Cell Survival Synaptic Plasticity and Neurogenesis CREB CREB Gene Expression DAG Akt 14-3-3 Raf1 MEK1/2 ERK1/2 RSK PLCγ BAD TRKB Ras Ca 2+ GAB1 BDNF Pathway