BCIT Applied Research Group NRG

• 1. APPLIED RESEARCH NATURAL HEALTH & FOOD PRODUCT RESEARCH GROUPPaula N. Brown, PhD Director of Applied Research Canadian Research Chair in Phytoanalytics

2. What we do Facilitate innovation in the agriculture, food and natural health product sectors. advance the state of practice support development novel therapeutics develop tools to improve the quality & safety of products inform policy for regulation of products 3. How we do it Development & validation of analyticalmethodology Application of metabolomics as a quality assurance tool 2 3 1200 1000 800 600 400 200 05Isoquercetin Quercetin Rutin Chlorogenic Acid43 123451 4. FARM WISE Sustainable Agricultural Practices to Grow Value-added Agri-food Products West Kootenay Herb Growers Association Hawthorn Farm Trials 2005-2012 Dr. Paula N. Brown Director of Applied Research, NRG BC Institute of Technology 5. Rural BC Community Economic Development Environmentally sound & sustainable Development of new and improved medicinal crops for the NHP sector Funding: Western Diversification Canada, BC Investment Agriculture Foundation, Columbia Basin Trust, industry sponsors 6. Hawthorn Agro-Forestry Farm Trials Agroforestry: an integrated approach combining trees and shrubs with crops and/or livestock to create more diverse, productive, prof itable, healthy and sustainable land-use systems. 7. Hawthorn Agro-Forestry Farm Trials The 3 trial sites each have 4 test plots 5-8 years to maturity Both native & the two medicinal European Crataegeus spp. Macroscopic and chemical techniques to guide development of best practices 8. Hawthorn Agro-Forestry Farm Trials Established agricultural managementpractices for Hawthorn cultivation; selected varietals for propagation Developed products from hawthorn; both berries and leaf/flower Supported 5 BCIT students, 1 Grad Intern NSERC Strategic Grant: Dickinson, ROM; Proctor, UofA; Shipley, UBC; Brown, BCIT 9. SEED TO SHELF Establishing Provenance, Traceability, & Quality of Agriculture & Agrifood Growing Forward A Joint Initiative between the BC Ministry of Agriculture & Agriculture & Agrifood Canada Dr. Paula N. Brown Director of Applied Research, NRG BC Institute of Technology 10. Provenance &Traceability of Ginseng Indigenous to southeastern Canada & eastern United States. Cultivated in Ontario and BC; Wisconsin and the Liaoning, Jilin and Heilongjiang Provinces of Northeast China. CanWest Media Works Publications Inc AUGUST 8, 2007 11. Provenance, Traceability, Authentication Once BCs most profitable crop, the last ginseng grower in BC pulled out in 2009. 2007 cultivated ginseng sold for 18.3$/lb compared to 162.9$/lb for wild. Decline attributed to increase in Chinese production; hundreds of acres are grown. 12. American ginseng: Endangered & RegulatedThe Convention on International Trade in Endangered Species (CITES) Appendix II, added American ginseng in 1977.The Ginseng Harvest Labeling Act was added to 2008 Farm Bill on Country of Origin labeling. Final Rule Mandatory Country of Origin Labeling came into effect March 16th, 2009. 13. Challenge: Branding on provenance requires products be traceable to their origins. Country of Origin labeling is only effective if you can prove it. Solution: Support for development tool to establish provenance of agri-products. Approach: Use state-of-theart technology to establish trace elemental fingerprints; conduct multi-variate analysis to link fingerprint to geographic origin. 14. PLS-DA Score plot with 95% Confidence Interval for differentiating American ginseng from Ontario (Green) and China (red)This work will contribute to development of a Trade Certification for Canadian ginseng.Acknowledgement: Ontario Ginseng Growers Association, the Chamber of Chinese Herbal Medicine of Canada and Dr. James Harnly (USDA) for provision of American ginseng materials. 15. RIVER TO PLATE Building in Traceability, Food Safety, & Quality Demonstration 2010 Sockeye Fishery Chehalis Indian BandLanding Site and Processing StationRebecca Robertson Research Program Head BC Institute of Technology 16. Traceability Weigh the fishcoming into the fishery 17. Traceability Sign the fishinto the fishery Record the weight Tag the fish 18. Food Safety Set up hygienicfacilities 19. Food Safety & Quality Make sure there is enough icefor the fishery Clean and line the totes 20. Quality Treat thefish well 21. Traceability, Food Safety & Quality Training 22. Traceability QR Codes 23. NRG RESEARCH Product Formulation: improvement, development, scale up Traceability, QAQC, Analytical testing Regulatory Compliance, Licensing Bioanalysis, therapeutic monitoringPaula N. Brown, PhD Canadian Research Chair in Phytoanalytics My research investigates the wide range of chemicals produced by plants, how these compounds are synthesized, regulated and allocated within plant tissues, the stability, extractability and activity of phytochemicals in plant products, and the role of plant chemicals in human health.