Available Online through www.ijpbs.com (or) www.ijpbsonline.com IJPBS |Volume 3| Issue 2 |APR-JUN |2013|264-270 Research Article Biological Sciences International Journal of Pharmacy and Biological Sciences (e-ISSN: 2230-7605) Sheshidhar G Bannale* et al Int J Pharm Biol Sci www.ijpbs.com or www.ijpbsonline.com Page264 EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ACACIA CATECHU WILD IN PARACETEMOL INDUCED HEPATOTOXICITY IN ALBINO RATS Sheshidhar G Bannale 1 , Yasmeen A Maniyar 2 , Arati Chikaraddy 3 , Sangappa V kashinakunti 4 , Pundarikaksha HP 5 , Vijay Domble 6 , Manjula R 7 1, 2, 3 Department of Pharmacology S Nijalingappa Medical College Bagalkot 587102 4 Department of Biochemistry S Nijalingappa Medical College Bagalkot 587102 5 Deparment of Pharmacology Kempegowda institute of medical sciences Bangalore 560070 6 Department of Pathology S Nijalingappa Medical College Bagalkot 587102 7 Department of Community medicine S Nijalingappa Medical College Bagalkot 587102 *Corresponding Author Email: [email protected]ABSTRACT Introduction: Acacia catechu is a deciduous, thorny tree which grows up to 12-15 meter in height. In Hindi is called as Khair and in kannada Kachu. It has been used as used for the treatment of inflammation, diarrhheoa, fever. Aims: to evaluate the hepatoprotective effect of ethanolic extract of acacia catechu in paracetemol induced liver damage in experimental animals, rats was studied. Methodology: The ethanolic extract of acacia catechu was studied for its hepatoprotective effect on paracetamol induced liver damage on Wistar albino rats. The degree of hepatoprotection was measured by biochemical (serum gultamic pyruvic transaminase, serum gultamic oxaloacetic transaminase, alkaline phosphatase) markers and histological changes. Silymarin was used as positive control. Results: Pretreatment with acacia extract significantly prevented the biochemical enzyme levels and histological changes induced by paracetamol in the liver. The effects of acacia catechu were comparable to that of the standard drug silymarin. Thus ethanol extract of acacia was found to exhibit marked hepatoprotective activity (P<0.05). Discussion and conclusion: These results indicate that acacia catechu could be useful in preventing chemically induced acute liver injury. Hence from this study it can be concluded that ethanol extract of acacia catechu possess significant hepatoprotective activity. KEY WORDS Acacia catechu, hepatotoxicity, paracetemol, silymarin INTRODUCTION Liver disorders constitute serious health problems in India. Currently there are various drugs of allopathic medicine are available which show significant hepatoprotective action, yet plant products/extracts play a vital role in this scenario. India has a rich source of traditional medicines, many of which are of plant origin. Liver disorders are mainly inflammatory in nature i.e. acute, sub-acute and chronic hepatitis of various aetiologies like viral infection- hepatitis A, B, C, E, chronic alcohol consumption, toxin induced, drug induced and malignancy associated disorders. Liver disorders can vary from asymptomatic elevation of biochemical markers to symptomatic presentation like jaundice, pain abdomen, vomiting, fatigue and even go for severe organ failure and coma [1]. India is being rich source of traditional medicines, many of which are plant origin. Herbal drugs have gained importance and popularity in recent years because of their safety, efficacy and cost effectiveness. There are more than one hundred compounds of plant origin, which have shown hepatoprotective potential.
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International Journal of Pharmacy and Biological Sciences (e-ISSN: 2230-7605)
Sheshidhar G Bannale* et al Int J Pharm Biol Sci www.ijpbs.com or www.ijpbsonline.com
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e26
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EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF
ACACIA CATECHU WILD IN PARACETEMOL INDUCED HEPATOTOXICITY IN ALBINO RATS
Sheshidhar G Bannale1 , Yasmeen A Maniyar2 , Arati Chikaraddy3 , Sangappa V kashinakunti 4,
Pundarikaksha HP5, Vijay Domble6 , Manjula R7 1, 2, 3 Department of Pharmacology S Nijalingappa Medical College Bagalkot 587102
4Department of Biochemistry S Nijalingappa Medical College Bagalkot 587102 5Deparment of Pharmacology Kempegowda institute of medical sciences Bangalore 560070
6Department of Pathology S Nijalingappa Medical College Bagalkot 587102
7Department of Community medicine S Nijalingappa Medical College Bagalkot 587102
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*Corresponding Author: Dr.Sheshidhar G Bannale Assistant professor, Department of pharmacology S Nijalingappa Medical College Bagalkot, Karnataka India 587103 Email: [email protected]