Automated Sample Preparation Modules Better sample prep for better LC-MS data Strategies for automating sample preparation Offline sample preparation: ■ ■ Sample prep and LC-MS in separate platforms ■ ■ Sample prep and LC-MS conducted independently ■ ■ One or both operations is automated ■ ■ Manual intervention required ■ ■ Instrumentation: MassTrak OASPS Online sample preparation: ■ ■ Sample prep and LC-MS in a single platform ■ ■ Sample prep directly integrated with LC-MS ■ ■ Both operations are fully automated ■ ■ Instrumentation: ACQUITY UPLC OSM AUTOMATE AND INTEGRATE YOUR LC-MS SAMPLE PREPARATION Historically, preparing samples for LC-MS has required a great deal of time and effort as well as extensive expertise to perform well. Deployment of many sample prep techniques has been hampered by their highly complex, labor intensive, and costly workflows. However, many of these issues can be addressed through automation and direct integration with LC-MS analysis. Waters has applied its decades of experience in developing sample preparation solutions and methods for LC-MS with the MassTrak™ Offline Automated Sample Preparation System (OASPS) and the ACQUITY UPLC ® Online SPE Manager (OSM). These modules utilize powerful solid phase extraction (SPE) chemistries and techniques to efficiently and effectively prepare samples for LC-MS from a variety of sample matrices. Ideal for virtually any laboratory using LC-MS ranging from the novice user looking to efficiently deploy LC-MS with minimal expertise to the LC-MS expert looking to maximize throughput, up time and utilization of their LC-MS systems, Waters’ automated sample preparation products offer the most extensive range of choices in sample preparation. ACQUITY UPLC Online SPE Manager. MassTrak Offline Automated Sample Prep System.
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Automated Sample Preparation ModulesBetter sample prep for better LC-MS data
Strategies for automating sample preparation
Offline sample preparation:
■■ Sample prep and LC-MS
in separate platforms
■■ Sample prep and LC-MS
conducted independently
■■ One or both operations
is automated
■■ Manual intervention
required
■■ Instrumentation:
MassTrak OASPS
Online sample preparation:
■■ Sample prep and LC-MS
in a single platform
■■ Sample prep directly
integrated with LC-MS
■■ Both operations are
fully automated
■■ Instrumentation:
ACQUITY UPLC OSM
AUTOMAT E AND INT EGRAT E YOUR LC-MS SAMPLE P REPARAT ION
Historically, preparing samples for LC-MS has required a great deal of time and effort as
well as extensive expertise to perform well. Deployment of many sample prep techniques
has been hampered by their highly complex, labor intensive, and costly workflows.
However, many of these issues can be addressed through automation and direct integration
with LC-MS analysis.
Waters has applied its decades of experience in developing sample preparation solutions
and methods for LC-MS with the MassTrak™ Offline Automated Sample Preparation
System (OASPS) and the ACQUITY UPLC® Online SPE Manager (OSM). These modules
utilize powerful solid phase extraction (SPE) chemistries and techniques to efficiently
and effectively prepare samples for LC-MS from a variety of sample matrices.
Ideal for virtually any laboratory using LC-MS ranging from the novice user looking to
efficiently deploy LC-MS with minimal expertise to the LC-MS expert looking to maximize
throughput, up time and utilization of their LC-MS systems, Waters’ automated sample
preparation products offer the most extensive range of choices in sample preparation.
vacuum manifold, and plate shaking) required to perform SPE on samples from either
simple or complex matrices with a minimum of manual intervention.
Its unique software package includes a pre-written SPE pipetting script and file converter
software to facilitate quick and effective deployment of the system with a minimum of
expertise. In addition to automating sample processing to improve consistency, this
system makes sample data transfers seamless to minimize sample processing and data
transfer errors all too common with manual sample preparation.
MassTrak OASPS with ACQUITY UPLC and ACQUITY® TQD.
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Optimizes LC-MS workflow productivity■■ Full automation of all SPE
and LC-MS operations
■■ Unique direct integration
of sample prep with LC-MS
■■ Complete walk away system
■■ Overlapping Sample Prep
and LC-MS processes improve
sample throughput
Delivers superior data consistency■■ Utilizes a variety of market
tested SPE sorbents
■■ Eliminates sample carry over
and unpredictable matrix
effects with disposable
SPE cartridges
■■ Integrates with a new or
existing ACQUITY TQD
LC-MS System
Accelerates sample prep method development■■ Control of all SPE
experimental variables
■■ Tests multiple variables
simultaneously to quickly
develop SPE methods
■■ Operates with ACQUITY UPLC
Systems controlled with
intuitive MassLynx®
4.1 Software.
T HE ULT IMAT E IN LC-MS SAMPLE P REP P RODUCT IV IT Y
The ACQUITY UPLC Online SPE Manager (OSM) is a unique automated sample preparation
module designed either for routine operations and/or as an SPE method development tool.
The system is an easily integrated module for UPLC®-based systems that offers a more
efficient workflow for than slower and older, less consistent column based online SPE
systems. An excellent choice for almost any laboratory performing LC-MS analyses,
the ACQUITY UPLC OSM is the pinnacle of automation and integration of sample prep
with LC-MS.
The ACQUITY UPLC OSM’s unique design resolves many of the direct resource utilization
and method expertise issues that have prevented many laboratories from including
effective sample prep techniques in their LC-MS analysis workflows. Truly a walk away
system, it can transform LC-MS analysis into an around the clock operation to allow users
to get the most performance and productivity from their LC-MS systems.
Applicable to a wide variety of LC-MS applications, the ACQUITY UPLC OSM is excellent
at everything from providing laboratories with the capability to develop methods for low
level analytes to helping optimize current LC-MS methods to improve reproducibility,
sensitivity, and efficiency. Capable of generating very clean samples from even very
complex matrices, the ACQUITY UPLC OSM can also help keep LC-MS systems in operation
longer and improve system up time by delivering much cleaner samples for LC-MS
analysis than other sample preparation techniques.
The ACQUITY UPLC OSM is the key component in the pre-configured MassTrak Online SPE
Analyzer. This system combines the power of the ACQUITY UPLC System, ACQUITY TQD,
and intuitive MassLynx Software with the online sample preparation benefits delivered
with the ACQUITY UPLC OSM module in a single, seamless platform. With this system
configuration, many routine LC-MS applications can be addressed with a highly efficient,
integrated LC-MS system.
MassTrak Online SPE Analyzer includes ACQUITY UPLC, ACQUITY UPLC OSM, and ACQUITY TQD.
Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 1 508 478 2000 F: 1 508 872 1990 www.waters.com
Waters, ACQUITY, ACQUITY UPLC, MassLynx, Xevo, UPLC and The Science of What’s Possible are registered trademarks of Waters Corporation. MassTrak is a trademark of Waters Corporation. All other trademarks are the property of their respective owners.