Autism Autism Hyper- Hyper- Baric Baric Oxygen Oxygen Therapy Therapy and and Dan Rossignol, M.D Dan Rossignol, M.D DAN! Physician DAN! Physician Clinical Assistant Profess Clinical Assistant Profess University of Virginia University of Virginia Department of Family Medici Department of Family Medici
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Autism Hyper- Baric Oxygen Therapy and Dan Rossignol, M.D. DAN! Physician Clinical Assistant Professor University of Virginia Department of Family Medicine.
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Dan Rossignol, M.D.Dan Rossignol, M.D.DAN! PhysicianDAN! Physician
Clinical Assistant ProfessorClinical Assistant ProfessorUniversity of VirginiaUniversity of Virginia
Department of Family MedicineDepartment of Family Medicine
Outline• Rise in autism prevalence• Effects of HBOT• Recent autism findings:
– Cerebral Hypoperfusion and HBOT– Neuroinflammation and GI Inflammation and HBOT– Increased excretion of porphyrins and HBOT– Oxidative Stress and HBOT
• HBOT safety• HBOT dosing• HBOT case series
Prevalence of Autism
• According to the U.S. Dept. Developmental Services, the prevalence of autism spectrum disorders increased 556% from 1991 to 1997.
• Autism is now more common than childhood cancer, Down’s syndrome, spina bifida or cystic fibrosis.
• 1 in 80 boys have autism (boys are affected 4 times as often as girls).
• 1 out of 68 families will have a child with autism.• Autism is increasing by 3.8% per year worldwide.
Prevalence of Autism
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HBOT and Autism
HBOT Definition
• Hyperbaric oxygen therapy (HBOT) involves inhaling 100% oxygen at greater than 1 atmosphere absolute (ATA) in a pressurized chamber. (Feldmeier, Undersea and Hyperbaric Medical Society, 2003)
HBOT Approved Indications
• Air or gas embolism• Carbon Monoxide
Poisoning• Gas gangrene• Crush injuries and
compartment syndrome
• Decompression sickness
• Wound healing
• Severe anemia• Intracranial abscess• Necrotizing soft tissue
infections• Refractory
osteomyelitis• Skin flaps and grafts• Delayed radiation