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Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/ We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact [email protected] with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.
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Page 1: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

Author(s): Gerald Abrams, M.D., 2009

License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/

We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material.

Copyright holders of content included in this material should contact [email protected] with any questions, corrections, or clarification regarding the use of content.

For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use.

Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition.

Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.

Page 2: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

Citation Keyfor more information see: http://open.umich.edu/wiki/CitationPolicy

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Creative Commons – Attribution License

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Fair Use: Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (USC 17 § 107) *laws in your jurisdiction may differ

Our determination DOES NOT mean that all uses of this 3rd-party content are Fair Uses and we DO NOT guarantee that your use of the content is Fair.

To use this content you should do your own independent analysis to determine whether or not your use will be Fair.

{ Content the copyright holder, author, or law permits you to use, share and adapt. }

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{ Content Open.Michigan has used under a Fair Use determination. }

Page 3: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

M1 Patients and Populations:

DISTURBANCES OF GROWTHNEOPLASIA I

Gerald D. Abrams MD

Fall 2008

Page 4: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

ORGANS/TISSUES SMALLER THAN NORMAL

• DEVELOPMENTAL AGENESIS APLASIA HYPOPLASIA ATRESIA

• ACQUIRED ATROPHY

Page 5: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

UNILATERAL RENAL AGENESIS

Department of Pathology, University of Michigan

Page 6: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

UNILATERAL RENAL HYPOPLASIA

Department of Pathology, University of Michigan

Page 7: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

LIVER, “BROWN ATROPHY”

G.D. Abrams, University of Michigan Medical School

Page 8: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

ORGANS / TISSUES LARGER THAN NORMAL

• HYPERTROPHY INCREASE IN CELL SIZE

• HYPERPLASIA INCREASE IN CELL NUMBER

Page 9: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

HEART, NORMAL

Department of Pathology, University of Michigan

Page 10: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

HEART, HYPERTROPHY

Department of Pathology, University of Michigan

Page 11: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

MYOCARDIUM, NORMAL

G.D. Abrams, University of Michigan Medical School

Page 12: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

MYOCARDIUM, HYPERTROPHY

G.D. Abrams, University of Michigan Medical School

Page 13: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

SKIN, NORMAL

G.D. Abrams, University of Michigan Medical School

Page 14: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

SKIN, HYPERPLASIA

G.D. Abrams, University of Michigan Medical School

Page 15: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

SKIN, HYPERKERATOSIS

G.D. Abrams, University of Michigan Medical School

Page 16: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

MAMMARY GLAND

G.D. Abrams, University of Michigan Medical School

Page 17: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

MAMMARY GLAND, LACTATING

G.D. Abrams, University of Michigan Medical School

Page 18: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

PROSTATE, HYPERPLASIA

Source Undetermined

Page 19: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

BREAST- FIBROCYSTIC CHANGE

Source Undetermined

Page 20: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

NORMAL BREAST

G.D. Abrams, University of Michigan Medical School

Page 21: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

BREAST FIBROCYSTIC CHANGE

G.D. Abrams, University of Michigan Medical School

Page 22: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

ABNORMAL PATTERNS OF CELL GROWTH / DIFFERENTIATION

• METAPLASIA

• DYSPLASIA

Page 23: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

ENDOCERVIX, SQUAMOUS METAPLASIA

G.D. Abrams, University of Michigan Medical School

Page 24: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

ENDOCERVIX, SQUAMOUS METAPLASIA

G.D. Abrams, University of Michigan Medical School

Page 25: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

SQUAMOUS EPITHELIUM, NORMAL

G.D. Abrams, University of Michigan Medical School

Page 26: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

SQUAMOUS EPITHELIUM, MODERATE DYSPLASIA

G.D. Abrams, University of Michigan Medical School

Page 27: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

SQUAMOUS EPITHELIUM, SEVERE DYSPLASIA

G.D. Abrams, University of Michigan Medical School

Page 28: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

NEOPLASM / “TUMOR”

• MASS (“NEW GROWTH”) – PROLIFERATING CELLS

• AUTONOMOUS

• NON-EQUILIBRIUM, UNCOORDINATED GROWTH

• PERSISTENT / IRREVERSIBLE

Page 29: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

NEOPLASTIC TRANSFORMATION

• SERIES OF GENETIC EVENTS

• CLONAL CHARACTERISTICS

Page 30: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

Benign Tumor: growth by expansion

Malignant Tumor: growth by invasion

Regents of The University of Michigan

Page 31: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

BENIGN AND MALIGNANT GROWTH

• BENIGN COHESIVE /EXPANSILE CIRCUMSCRIBED / LOCALIZED

• MALIGNANT POORLY CIRCUMSCRIBED / INVASIVE….METASTASIZING

Page 32: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

UTERUS, LEIOMYOMA

Department of Pathology, University of Michigan

Page 33: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

UTERUS, LEIOMYOMA

G.D. Abrams, University of Michigan Medical School

Page 34: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

BREAST CANCER

Department of Pathology, University of Michigan

Page 35: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

COLON CANCER

Department of Pathology, University of Michigan

Page 36: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

COLON CANCER

Department of Pathology, University of Michigan

Page 37: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

CANCER INVADING COLONIC WALL

G.D. Abrams, University of Michigan Medical School

Page 38: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

METASTASIS

• A COMPLEX CASCADE OF EVENTS

• VIA BLOOD

• VIA LYMPH

• DIRECT

Page 39: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

CANCER CELLS WITHIN BLOOD VESSEL

G.D. Abrams, University of Michigan Medical School

Page 40: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

CANCER CELLS WITHIN LYMPHATIC

G.D. Abrams, University of Michigan Medical School

Page 41: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

PERITONEUM, CARCINOMATOSIS

Department of Pathology, University of Michigan

Page 42: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

PERITONEAL METASTASES

Department of Pathology, University of Michigan

Page 43: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

LIVER, METASTASES

Department of Pathology, University of Michigan

Page 44: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

EYE, PRIMARY MALIGNANT MELANOMA

Department of Pathology, University of Michigan

Page 45: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

LUNG, METASTASES

Department of Pathology, University of Michigan

Page 46: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

VERTEBRAE, METASTASES

Department of Pathology, University of Michigan

Page 47: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

VERTEBRA, METASTASIS

Department of Pathology, University of Michigan

Page 48: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

BRAIN, METASTASIS

Department of Pathology, University of Michigan

Page 49: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

LIVER, METASTASES

Department of Pathology, University of Michigan

Page 50: Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share.

Slide 5: Department of Pathology, University of Michigan Slide 6: Department of Pathology, University of Michigan Slide 7: G.D. Abrams, University of Michigan Medical School Slide 9: Department of Pathology, University of Michigan Slide 10: Department of Pathology, University of Michigan Slide 11: G.D. Abrams, University of Michigan Medical School Slide 12: G.D. Abrams, University of Michigan Medical School Slide 13: G.D. Abrams, University of Michigan Medical School Slide 14: G.D. Abrams, University of Michigan Medical School Slide 15: G.D. Abrams, University of Michigan Medical School Slide 16: G.D. Abrams, University of Michigan Medical School Slide 17: G.D. Abrams, University of Michigan Medical School Slide 18: Source Undetermined Slide 19: Source Undetermined Slide 20: G.D. Abrams, University of Michigan Medical School Slide 21: G.D. Abrams, University of Michigan Medical School Slide 23: G.D. Abrams, University of Michigan Medical School Slide 24: G.D. Abrams, University of Michigan Medical School Slide 25: G.D. Abrams, University of Michigan Medical School Slide 26: G.D. Abrams, University of Michigan Medical School Slide 27: G.D. Abrams, University of Michigan Medical School Slide 30: Regents of the University of Michigan Slide 32: Department of Pathology, University of Michigan Slide 33: G.D. Abrams, University of Michigan Medical School Slide 34: Department of Pathology, University of Michigan Slide 35: Department of Pathology, University of Michigan Slide 36: Department of Pathology, University of Michigan Slide 37: G.D. Abrams, University of Michigan Medical School Slide 39: G.D. Abrams, University of Michigan Medical School Slide 40: G.D. Abrams, University of Michigan Medical School Slide 41: Department of Pathology, University of Michigan Slide 42: Department of Pathology, University of Michigan Slide 43: Department of Pathology, University of Michigan Slide 44: Department of Pathology, University of Michigan Slide 45: Department of Pathology, University of Michigan Slide 46: Department of Pathology, University of Michigan Slide 47: Department of Pathology, University of Michigan Slide 48: Department of Pathology, University of Michigan Slide 49: Department of Pathology, University of Michigan

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