Atopic derma

Pathogenesis of Atopic Dermatitis

Siti Nurul Afiqah binti Johari10-5-95

Atopic dermatitis (AD) is a highly pruritic, recurring

inflammatory skin disease. It usually develops in early childhood and is frequently seen in children with a personal history of respiratory allergy and/or a family history of atopic disease.

Barrier function of skin

Skin barrier dysfunction

1. Ceramide deficiency• Ceramides are main source of essential FA, a

key role in epidermal barrier function.• Acts as a water modulator and permeability

barrier• Decrease in ceramide level is main

attributable factor in barrier disrupted dry skin of AD

2. Filaggrin loss-of-function mutations

FLG mutations

Corneocyte deformation

Disruption of organisation of

extracellular lipid

Reduction in NMFsIncrease in pH

Impaired antimicrobial

properties (S.aureus)

Immunopathologic mechanisms

Environment