1 Atherosclerosis Atherosclerosis Ath l ti C di l Di Atherosclerotic Cardiovascular Disease (ASCVD) Endothelial injury Lipids (cholesterol) Smooth m. proliferation Pathogenesis of Pathogenesis of atherosclerosis Normal Artery Structure Lipoprotein particle x 180,000 x 180,000 X 60,000 X 60,000 Robert Hamilton, Ph.D. Cardiovascular Research Inst., UCSF EM: Negative staining
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Atherosclerosis - Columbia University...Atherosclerosis is a chronic inflammatory response of the arterial wall to endothelial injury. 1. Chronic endothelial injury 2. Accumulation
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1
AtherosclerosisAtherosclerosis
Ath l ti C di l DiAtherosclerotic Cardiovascular Disease(ASCVD)
Endothelialinjury
Lipids(cholesterol)
Smooth m.proliferation
Pathogenesis ofPathogenesis ofatherosclerosis
Normal Artery Structure
Lipoprotein particle
x 180,000x 180,000X 60,000X 60,000
Robert Hamilton, Ph.D.Cardiovascular Research Inst., UCSFEM: Negative staining