Assessing effects of PAH exposure on birt and neurocognitive d among a cohort of Po mothers and newborns *, Wieslaw Jedrychowski**, Robin Whyatt*, nn***, John Spengler***, Tom Dumyahn***, Perera* for Children’s Environmental Health, niversity, New York, USA f Epidemiology and Preventive Medicine, Jagiellonian University, Krakow, Poland
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Assessing effects of prenatal PAH exposure on birth outcomes and neurocognitive development among a cohort of Polish mothers and newborns. Ulka Bawle*,
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Assessing effects of prenatal PAH exposure on birth outcomes and neurocognitive development among a cohort of Polish mothers and newborns.
Ulka Bawle*, Wieslaw Jedrychowski**, Robin Whyatt*,David Camann***, John Spengler***, Tom Dumyahn***, Frederica Perera*
*/ Center for Children’s Environmental Health,Columbia University, New York, USA**/Chair of Epidemiology and Preventive Medicine, Coll.Med.. Jagiellonian University, Krakow, Poland***/
What is the role of early life exposures to PAH?
D - Developmental C - Cancer G - Genetic damage
Vulnerability of the Fetus and Child
Lead (Needleman et al.,1979) D
Radiation (Shimizu et al., 1991) C
Pestic ides (NAS, 1993) D,C
PCBs (J acobsen and J acobsen, 1996) D
Polycyc lic aromatic hydrocarbons (PAH) D,G(Perera, Whyatt et al., 1998)
Impairment of fetaland early childhoodgrowth and development
A. SPECIFIC AIMS OF THE STUDY
1.To test the hypothesis that prenatal exposure to airbornepolycyclic aromatic hydrocarbons (PAH) adversely affects fetalgrowth, after controlling for non-PAH components of particulatematter < 2.5 m (PM2.5), environmental tobacco smoke ( ETS),nutritional status and other potential confounders.
2. To test the hypothesis that prenatal exposure to airborne PAHadversely affects early childhood growth and development, aftercontrolling for non-PAH components of PM2.5, ETS and otherpotential confounders
3. To explore whether non-PAH components of PM2.5, and ETS haveindependent effects on birth outcomes and childhood growth anddevelopment, after controlling for PAH, and to explore possibleinteractions between PAH, PM2.5 and ETS.
4. To estimate the relative contribution of ambient PAH pollution vs.ETS and other indoor PAH sources to a) personal PAH exposure andPAH-DNA adducts; and b) impairment of fetal growth and early childdevelopment
1. Questionnaires: a. Prenatal I, II Trimester (mother)