C U P R I N S Argument ....................................... .............. ............. ............. ............. .............. ............. ....... 1 CAPITOLUL 1 – ASPIRINA (acid acetilsalicilic) .......................................................................... 2 1.1 Scurt istoric........................................................................................................................ 2 1.2 Metode de obţinere a aspirinei ....................................................................................... .... 3 1.2.a Metoda de obţinere a substanței active...................................................................................................... 3 1.2.b Proprietăţi fizico-chimice ale substanţei active ........................................................................................... 4 1.2.c Metode de analiză a substanței active ........................................................................................................ 5 1.3 Proprietăți farmacologice ale substanţei active .................................................................... 6 1.3.a Farmacocinetica .......................................................................................................................................... 6 1.3.b Acţiuni farmacodinamice ............................................................................................................................. 8 1.3.c Farmacotoxicologie ..................................................................................................................................... 9 1.4 Forme farmaceuti ce ........................................................................................................... 13 1.5 Reguli de bună practică de fabricație ................................................................. ............. 13 CAPITOLUL 2 – EXEMPLE DE PRODUSE MEDICAMENTOASE CARE CONȚIN ACID ACETILSALICILIC ......................... ............. .................................................... .............. .......................... .......... 15 2.1 Acid Acetilsali cilic - RICHTER 500 mg, comprima te .............................................................. 15 2.2 Aspirin plus c, comprimate efervescente ..................... ...................................................... 18 2.3 Aspirin protect 100 mg ...................................................................................................... 20 2.4 Asaprin 500, comprimate .................................................................................................. 22 2.5 Alka seltzer, comprimate efervescente .............................................................................. 23 2.6 Algopirin ............................................................................................................. ............. 25 2.7 Fasconal ............................................................................................................................ 26 2.8 Aspenter ........................................................................................................................... 27 2.9 Antinevral gic ..................................................................................................................... 30 2.10 NEOLIN, comprimat e ......................................................................................................... 31 CAPITOLUL 3 – ANEXE CU IMAGINI ....................................................................................... 35 CAPITOLUL 5 - BIBLIOGRAFIE ................................................................................................ 38
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