PLoS Pathogens (12/2018) 1 Carbohydrate, glutathione, and polyamine metabolism are central 2 to Aspergillus flavus oxidative stress responses over time 3 Short Title: Aspergillus flavus metabolic responses to oxidative stress 4 5 Jake C. Fountain 1,2 , Liming Yang 2,3 , Manish K. Pandey 4 , Prasad Bajaj 4 , Danny Alexander 5 , 6 Sixue Chen 6 , Robert C. Kemerait 2 , Rajeev K. Varshney 4 , Baozhu Guo 1,* 7 8 1 USDA-ARS, Crop Protection and Management Research Unit, Tifton, GA 31793, USA; 9 2 Department of Plant Pathology, University of Georgia, Tifton, GA 31793, USA; 10 3 Nanjing Forestry University, College of Biology and Environmental Science, Nanjing 210037, 11 China; 12 4 International Crop Research Institute for the Semi-Arid Tropics (ICRISAT), Hyderabad, 13 Telangana 502324, India 14 5 Metabolon, Inc., Durham, NC 27713, USA; 15 6 University of Florida, Department of Biology, Genetics Institute, and Plant Molecular & 16 Cellular Biology Program, Gainesville 32611, FL, USA. 17 18 19 20 21 Author e-mail addresses: J.C. Fountain: [email protected]; L. Yang: [email protected]; M. 22 Pandey: [email protected]; P. Bajaj: p.[email protected]; D. Alexander: 23 [email protected]; S. Chen: [email protected]; R.C. Kemerait: [email protected]; R.K. 24 Varshney: [email protected]; B. Guo: [email protected] 25 26 27 *Corresponding Author: 28 Dr. Baozhu Guo 29 [email protected] 30 31 32 Key Words: Aspergillus flavus, aflatoxin, drought stress, oxidative stress, metabolomics made available for use under a CC0 license. certified by peer review) is the author/funder. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also The copyright holder for this preprint (which was not this version posted January 3, 2019. ; https://doi.org/10.1101/511170 doi: bioRxiv preprint