8/11/17 1 Antimicrobials: An Update Katrina Viviano, DVM, PhD, DACVIM, DACVP VETgirl Webinar August 17, 2017 Garret Pachtinger, VMD, DACVECC COO, VETgirl Introduction Justine A. Lee, DVM, DACVECC, DABT CEO, VETgirl Introduction VETgirl…on the run! The tech-savvy way to get RACE-approved, online veterinary CE! A subscription-based podcast and webinar service offering veterinary RACE-approved CE 50-60 podcasts/year plus 30+ hours of webinars! $199/year 40+ hours of RACE-CE Up to 5 members: $599/year Up to 10 members: $999/year > 10 members: Ping us
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�Low MW, water soluble, low protein binding� Good penetration tissues/fluids
� In vitro susceptibility E. coli� Urinary isolates - dogs and cats� MIC90 2 µg/mL; MIC50 1 µg/mL
Hubuka and Boothe, 2011
Fosfomycin�Nephrotoxicity
�Young cats�Increased BUN/creatinine
�Young and adult cats�Renal bx – tubular necrosis�Glomerular and basement membrane normal�Neither group – systemically ill
�Dogs - no biochem or morphological changes
Fukata et al. 2008
Bacteria/Antibiotic Resistance
Increasing rate of resistance to conventional
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Development of novel-acting
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Bacteria
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Antibiotic Stewardship
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