Ascariasis Abby Ferrell
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Ascariasis Abby Ferrell
Ascariasis is caused by colonization of the nematode Ascaris lumbricoides
Ascaris develops in the gastrointestinal tract and lungs after larvae in fecal ma:er
are ingested.
The most severe symptoms are caused by the size of the worm, which is capable of
blocking gastrointestinal pathways
The immune system responds primarily to larvae to manage parasite load
Eosinophil mediated immunity is slow to develop, which hinders the use of
vaccines
Neuromuscular blockers paralyze Ascaris and allow it to be cleared from the bowel
Glucose uptake inhibitors prevent the effective construction of microtubules,
affecting transport
% of con
trol polym
erization
Warm, humid conditions and poor sanitation raise infection rates in the
developing world
Ascariasis is controlled in the US by sanitation and medication, but lack of
exposure may be a factor in autoimmune disease
REFERENCES Information • Andreu, Jose Manuel, and Serge N. Timasheff. "ʺTubulin bound to colchicine forms polymers
different from microtubules."ʺ Proceedings of the National Academy of Sciences 79.22 (1982): 6753-‐‑6756 • Baron, Samuel, and John H. Cross. "ʺEnteric nematodes of humans."ʺ (1996). • Barrowman, Margaret M., Susan E. Marriner, and James A. Bogan. "ʺThe binding and subsequent
inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics."ʺ Biochemical pharmacology 33.19 (1984): 3037-‐‑3040.
• Bethony, Jefferey. "ʺSoil-‐‑transmi:ed Helminth Infections: Ascariasis, Trichuriasis, and Hookworm."ʺ The Lancet 367.9521 (2006): 1521-‐‑532.The Lancet. 6 May 2006. Web. 4 Apr. 2016.
• Berger, Abi. "ʺTh1 and Th2 responses: what are they?."ʺ Bmj 321.7258 (2000): 424. • Cooper, Philip J. "ʺImmune Responses on Humans—Ascaris."ʺ The Geohelminths: Ascaris, Trichuris
and Hookworm. Springer US, 2002. 89-‐‑104. • Cuomo, Michael. "ʺChapter 5. The Nematodes (Roundworms)."ʺ USAF-‐‑ Public Health Info and
Resources. USAF, 2016. Web. 04 Apr. 2016. • "ʺDB00518 -‐‑ 'ʹAlbendazole'ʹ"ʺ Functional Therapeutic Chemical Classification System (FTC). N.p., n.d.
Web. 05 Apr. 2016. • Guy, Karen. "ʺAscaris Lumbricoides (human Intestinal Roundworm)."ʺ Animal Diversity Web.
University of Michigan, 2011. Web. 04 Apr. 2016. • Long, Sarah S., Larry K. Pickering, and Charles G. Prober. Principles and practice of pediatric
infectious disease. Elsevier Health Sciences (2012): 296. • Shapiro, Leo. "ʺGiant Roundworm -‐‑ Ascaris Lumbricoides -‐‑ Details -‐‑ Encyclopedia of
Life."ʺ Encyclopedia of Life. Encyclopedia of Life, 2012. Web. 05 Apr. 2016. • Wolstenholme, Adrian J. "ʺGlutamate-‐‑gated chloride channels."ʺ Journal of Biological Chemistry 287.48
(2012): 40232-‐‑40238 Images • h:p://www.martianherald.com/sites/default/files/styles/article_image_mobile_adaptive/adaptive-‐‑
image/public/ascaris-‐‑parasite.jpg?itok=RQsQUD8o • h:ps://upload.wikimedia.org/wikipedia/commons/thumb/a/a8/
Ascaris_lumbricoides_life_cycle.tif/lossless-‐‑page1-‐‑220px-‐‑Ascaris_lumbricoides_life_cycle.tif.png • h:ps://encrypted-‐‑tbn3.gstatic.com/images?q=tbn:ANd9GcStMmAdvhFCK3gZt_
umrZ7LUfmWJJy3U9ULjn-‐‑RfN5ZIEjrrRd • h:ps://encrypted-‐‑tbn0.gstatic.com/images?q=tbn:ANd9GcQ0PUdOGEWj3_ • 6Iy4D9cIpYmo2TyIlGyF3dPV1AOFJZfO8opfGZ • h:p://www.utmb.edu/meded/pathoimages/large/infdis/ascaris.jpg • h:p://www.nature.com/nchem/journal/v1/n8/images/nchem.427-‐‑f1.jpg • h:ps://encrypted-‐‑tbn2.gstatic.com/images?
q=tbn:ANd9GcQ0tPBrgN1tk9ld6CuqHN1nRcZY2FHohbqbJZi1NNrPCWW1KvlB6Q • h:p://www.eid.ed.ac.uk/eid/sites/sbsweb2.bio.ed.ac.uk.eid/files/common/130502-‐‑map-‐‑and-‐‑
worm2.jpg
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